LU87957A1 - Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation - Google Patents

Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation Download PDF

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Publication number
LU87957A1
LU87957A1 LU87957A LU87957A LU87957A1 LU 87957 A1 LU87957 A1 LU 87957A1 LU 87957 A LU87957 A LU 87957A LU 87957 A LU87957 A LU 87957A LU 87957 A1 LU87957 A1 LU 87957A1
Authority
LU
Luxembourg
Prior art keywords
molecular weight
heparin
mixtures
daltons
ester
Prior art date
Application number
LU87957A
Other languages
English (en)
French (fr)
Inventor
Debrie Roger
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU87957(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of LU87957A1 publication Critical patent/LU87957A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU87957A 1990-06-26 1991-06-20 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation LU87957A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.

Publications (1)

Publication Number Publication Date
LU87957A1 true LU87957A1 (fr) 1993-01-15

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
LU87957A LU87957A1 (fr) 1990-06-26 1991-06-20 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation

Country Status (26)

Country Link
US (1) US5389618A (pt)
JP (1) JP3287363B2 (pt)
KR (1) KR0185586B1 (pt)
AT (1) AT398976B (pt)
AU (1) AU643531B2 (pt)
BE (1) BE1006827A3 (pt)
CA (1) CA2045433C (pt)
CH (1) CH682236A5 (pt)
DK (1) DK176524B1 (pt)
ES (1) ES2036922B9 (pt)
FI (1) FI104490B (pt)
FR (1) FR2663639B1 (pt)
GB (1) GB2245898B (pt)
GR (1) GR1000763B (pt)
HU (1) HU210925B (pt)
IE (1) IE66341B1 (pt)
IL (1) IL98604A (pt)
IT (1) IT1248557B (pt)
LU (1) LU87957A1 (pt)
MX (1) MX25829A (pt)
NL (1) NL194947C (pt)
NO (1) NO304991B1 (pt)
NZ (1) NZ238691A (pt)
PT (1) PT98102B (pt)
SE (1) SE506267C2 (pt)
ZA (1) ZA914869B (pt)

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US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
CA2150552C (en) * 1993-09-30 1999-12-21 Akikazu Takada Antithrombotic
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
HUP0201712A3 (en) * 1999-06-30 2003-03-28 Weitz Jeffrey I Ancaster Clot associated coagulation factors inhibiting heparin compositions
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
DE20022960U1 (de) * 1999-11-12 2002-07-25 Emisphere Technologies, Inc., Tarrytown, N.Y. Flüssige Heparinformulierung
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
ES2238383T3 (es) 2000-12-16 2005-09-01 Aventis Pharma Deutschland Gmbh Uso de heparina de bajo peso molecular para el tratamiento de la osteoartrosis.
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
EP1423130A1 (en) * 2001-08-28 2004-06-02 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
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FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
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US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
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US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) * 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
EP2019843A2 (en) 2006-05-25 2009-02-04 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
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WO2009141821A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
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UA112070C2 (uk) 2011-01-28 2016-07-25 Хангжоу Джіуюан Джін Енджініерінг Ко., Лтд Спосіб капілярного електрофорезу для аналізу тонкої структури еноксапарину натрію
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CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
EP3247332A1 (en) * 2015-01-20 2017-11-29 Incarda Therapeutics, Inc. Unit aerosol doses for anticoagulation
CN109666086B (zh) * 2018-11-05 2020-12-22 上海宝维医药技术有限公司 一种高纯度肝素季铵盐的制备方法及其应用
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A4 (en) 2020-07-14 2024-07-31 Optimvia Llc METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE

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Also Published As

Publication number Publication date
IL98604A (en) 1998-08-15
SE9101957D0 (sv) 1991-06-25
PT98102A (pt) 1992-03-31
NZ238691A (en) 1992-07-28
IT1248557B (it) 1995-01-19
ES2036922B9 (es) 2012-07-30
ZA914869B (en) 1992-04-29
FI104490B (fi) 2000-02-15
AT398976B (de) 1995-02-27
CA2045433C (fr) 2002-07-30
FI913101A0 (fi) 1991-06-25
IL98604A0 (en) 1992-07-15
US5389618A (en) 1995-02-14
AU7928891A (en) 1992-01-02
NO304991B1 (no) 1999-03-15
GR1000763B (el) 1992-12-30
ES2036922B1 (es) 1994-03-01
FR2663639A1 (fr) 1991-12-27
IE912216A1 (en) 1992-01-01
NL9101049A (nl) 1992-01-16
FR2663639B1 (fr) 1994-03-18
KR920000792A (ko) 1992-01-29
GB9113589D0 (en) 1991-08-14
PT98102B (pt) 1998-11-30
MX25829A (es) 1993-10-01
JPH04226101A (ja) 1992-08-14
NO912485L (no) 1991-12-27
DK176524B1 (da) 2008-07-14
ITMI911757A0 (it) 1991-06-26
ITMI911757A1 (it) 1992-12-26
JP3287363B2 (ja) 2002-06-04
DK124391A (da) 1991-12-27
ATA128191A (de) 1994-07-15
DK124391D0 (da) 1991-06-25
KR0185586B1 (ko) 1999-04-01
HUT57796A (en) 1991-12-30
IE66341B1 (en) 1995-12-27
GB2245898A (en) 1992-01-15
FI913101A (fi) 1991-12-27
SE9101957L (sv) 1991-12-27
ES2036922A1 (es) 1993-06-01
CA2045433A1 (fr) 1991-12-27
GR910100270A (en) 1992-08-25
CH682236A5 (pt) 1993-08-13
SE506267C2 (sv) 1997-11-24
GB2245898B (en) 1993-10-06
AU643531B2 (en) 1993-11-18
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
HU210925B (en) 1995-09-28
NO912485D0 (no) 1991-06-25
BE1006827A3 (fr) 1995-01-03

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