ES2036922A1 - Procedimiento de obtencion de mezclas de polisacaridos de bajos pesos moleculares. - Google Patents

Procedimiento de obtencion de mezclas de polisacaridos de bajos pesos moleculares.

Info

Publication number
ES2036922A1
ES2036922A1 ES9101505A ES9101505A ES2036922A1 ES 2036922 A1 ES2036922 A1 ES 2036922A1 ES 9101505 A ES9101505 A ES 9101505A ES 9101505 A ES9101505 A ES 9101505A ES 2036922 A1 ES2036922 A1 ES 2036922A1
Authority
ES
Spain
Prior art keywords
low molecular
process
molecular weight
obtaining mixtures
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9101505A
Other languages
English (en)
Other versions
ES2036922B1 (es
ES2036922B9 (es
Inventor
Roger Debrie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to FR9008013 priority Critical
Priority to FR9008013A priority patent/FR2663639B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of ES2036922A1 publication Critical patent/ES2036922A1/es
Application granted granted Critical
Publication of ES2036922B1 publication Critical patent/ES2036922B1/es
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2036922(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Anticipated expiration legal-status Critical
Publication of ES2036922B9 publication Critical patent/ES2036922B9/es
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products

Abstract

PROCEDIMIENTO DE OBTENCION DE MEZCLAS DE POLISACARIDOS DE BAJOS PESOS MOLECULARES, SULFATADOS Y QUE PRESENTAN LA ESTRUCTURA GENERAL DE LOS POLISACARIDOS QUE CONSTITUYEN LA HEPARINA. COMPRENDE SALIFICAR, EN MEDIO ACUOSO, UNA HEPARINA POR MEDIO DE UNA SAL DE AMONIO CUATERNARIO DE CADENA LARGA; ESTERIFICAR LA SAL ASI OBTENIDA PARA FORMAR UN ESTER QUE TIENE UN GRADO DE ESTERIFICACION COMPRENDIDO ENTRE EL 9,5 Y EL 14%; Y DESPOLIMERIZAR DICHO ESTER. LOS POLISACARIDOS RESULTANTES TIENEN APLICACION EN LA PROFILAXIS Y TRATAMIENTO DE ACCIDENTES TROMBOTICOS.
ES9101505A 1990-06-26 1991-06-25 Procedimiento de obtención de mezclas de polisacáridos de bajos pesos moleculares Expired - Fee Related ES2036922B9 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR9008013 1990-06-26
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.

Publications (3)

Publication Number Publication Date
ES2036922A1 true ES2036922A1 (es) 1993-06-01
ES2036922B1 ES2036922B1 (es) 1994-03-01
ES2036922B9 ES2036922B9 (es) 2012-07-30

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101505A Expired - Fee Related ES2036922B9 (es) 1990-06-26 1991-06-25 Procedimiento de obtención de mezclas de polisacáridos de bajos pesos moleculares

Country Status (26)

Country Link
US (1) US5389618A (es)
JP (1) JP3287363B2 (es)
KR (1) KR0185586B1 (es)
AT (1) AT398976B (es)
AU (1) AU643531B2 (es)
BE (1) BE1006827A3 (es)
CA (1) CA2045433C (es)
CH (1) CH682236A5 (es)
DK (1) DK176524B1 (es)
ES (1) ES2036922B9 (es)
FI (1) FI104490B (es)
FR (1) FR2663639B1 (es)
GB (1) GB2245898B (es)
GR (1) GR1000763B (es)
HU (1) HU210925B (es)
IE (1) IE66341B1 (es)
IL (1) IL98604A (es)
IT (1) IT1248557B (es)
LU (1) LU87957A1 (es)
MX (1) MX25829A (es)
NL (1) NL194947C (es)
NO (1) NO304991B1 (es)
NZ (1) NZ238691A (es)
PT (1) PT98102B (es)
SE (1) SE506267C2 (es)
ZA (1) ZA9104869B (es)

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USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
FR2687158B1 (fr) * 1992-02-07 1995-06-30 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
SG67928A1 (en) * 1993-09-30 1999-10-19 Seikagaku Kogyo Co Ltd Antithrombotic
WO2000065521A2 (en) 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
WO2001002443A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc Heparin compositions that inhibit clot associated coagulation factors
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
AU1594801A (en) * 1999-11-12 2001-06-06 Emisphere Technologies, Inc. Liquid heparin formulation
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1473061A (zh) * 2000-09-08 2004-02-04 汉密尔顿市医院研究发展有限公司 抗血栓形成的组合物
MXPA03004965A (es) 2000-12-16 2003-09-25 Aventis Pharma Gmbh El uso de heparina de bajo peso molecular para el tratamiento de osteoartrosis.
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
CA2458852A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
JP4828795B2 (ja) * 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
EP1375524B1 (en) * 2002-06-20 2007-03-07 CHEMI S.p.A. Process for the preparation of esters of heparin
US20030236221A1 (en) * 2002-06-20 2003-12-25 Chemi Spa Process for the preparation of esters of heparin
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US20040147033A1 (en) * 2002-12-20 2004-07-29 Zachary Shriver Glycan markers for diagnosing and monitoring disease
JP2006526592A (ja) * 2003-06-05 2006-11-24 センテリオンCentelion 血管由来の欠損に関連する高コレステロール血症または糖尿病の治療のための、線維芽細胞成長因子をコードするプラスミド
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
AT552004T (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
CA2652205A1 (en) 2006-05-25 2007-12-06 Mallik Sundaram Low molecular weight heparin composition and uses thereof
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2283045A1 (en) * 2008-05-20 2011-02-16 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
EP2233145A1 (en) 2009-03-19 2010-09-29 Sanofi-Aventis A dose of AVE5026 for the treatment of venous thromboembolism in patients with severe renal impairment
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
UA112070C2 (uk) 2011-01-28 2016-07-25 Хангжоу Джіуюан Джін Енджініерінг Ко., Лтд Спосіб капілярного електрофорезу для аналізу тонкої структури еноксапарину натрію
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
AR085961A1 (es) 2011-04-11 2013-11-06 Sanofi Sa Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法
CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8206555A1 (es) * 1980-05-14 1982-08-16 Pharmindustrie Procedimiento de preparacion de mezclas de polisacaridos sulfatados.
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
ES2006891A6 (es) * 1988-04-09 1989-05-16 Bioiberica Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.

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FR2739M (fr) * Roussel Uclaf Nouveau médicament notamment pour le traitement des troubles de la coagulabilité sanguine.
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
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US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
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IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
ES8206555A1 (es) * 1980-05-14 1982-08-16 Pharmindustrie Procedimiento de preparacion de mezclas de polisacaridos sulfatados.
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
ES2006891A6 (es) * 1988-04-09 1989-05-16 Bioiberica Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.

Non-Patent Citations (1)

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Title
THROMBOSIS AND HAEMOSTASIS, vol. 61, n‘ 1, pßg. 30-34, 1989 Stuttgart, Alemania; S. BEGUIN et al.: "The mode of action of low molecular weight heparin preparation (PK10169) and two of its major components on thrombin generation in plasma". *

Also Published As

Publication number Publication date
ITMI911757A1 (it) 1991-12-27
MX25829A (es) 1993-10-01
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
KR920000792A (ko) 1992-01-29
GR1000763B (el) 1992-12-30
LU87957A1 (fr) 1993-01-15
FR2663639B1 (fr) 1994-03-18
AU7928891A (en) 1992-01-02
DK176524B1 (da) 2008-07-14
BE1006827A3 (fr) 1995-01-03
FI913101D0 (es)
FR2663639A1 (fr) 1991-12-27
DK124391A (da) 1991-12-27
JPH04226101A (en) 1992-08-14
ZA9104869B (en) 1992-04-29
ITMI911757D0 (it) 1991-06-26
IL98604D0 (en) 1992-07-15
NO912485L (no) 1991-12-27
FI913101A0 (fi) 1991-06-25
ES2036922B9 (es) 2012-07-30
IE66341B1 (en) 1995-12-27
AU643531B2 (en) 1993-11-18
IL98604A (en) 1998-08-15
GB2245898B (en) 1993-10-06
FI104490B (fi) 2000-02-15
GB2245898A (en) 1992-01-15
ES2036922B1 (es) 1994-03-01
SE506267C2 (sv) 1997-11-24
NO304991B1 (no) 1999-03-15
NZ238691A (en) 1992-07-28
AT398976B (de) 1995-02-27
HU210925B (en) 1995-09-28
NL9101049A (nl) 1992-01-16
KR0185586B1 (ko) 1999-04-01
NO912485D0 (no) 1991-06-25
PT98102A (pt) 1992-03-31
CH682236A5 (es) 1993-08-13
ATA128191A (de) 1994-07-15
FI913101A (fi) 1991-12-27
HUT57796A (en) 1991-12-30
SE9101957D0 (sv) 1991-06-25
IE912216A1 (en) 1992-01-01
FI104490B1 (es)
PT98102B (pt) 1998-11-30
CA2045433C (fr) 2002-07-30
GR910100270A (en) 1992-08-25
DK124391D0 (da) 1991-06-25
GB9113589D0 (en) 1991-08-14
CA2045433A1 (fr) 1991-12-27
IT1248557B (it) 1995-01-19
JP3287363B2 (ja) 2002-06-04
SE9101957L (sv) 1991-12-27
US5389618A (en) 1995-02-14

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