CA2045433A1 - Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation - Google Patents

Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation

Info

Publication number
CA2045433A1
CA2045433A1 CA002045433A CA2045433A CA2045433A1 CA 2045433 A1 CA2045433 A1 CA 2045433A1 CA 002045433 A CA002045433 A CA 002045433A CA 2045433 A CA2045433 A CA 2045433A CA 2045433 A1 CA2045433 A1 CA 2045433A1
Authority
CA
Canada
Prior art keywords
preparation
molecular weight
low molecular
weight polysaccharide
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002045433A
Other languages
English (en)
Other versions
CA2045433C (fr
Inventor
Roger Debrie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2045433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of CA2045433A1 publication Critical patent/CA2045433A1/fr
Application granted granted Critical
Publication of CA2045433C publication Critical patent/CA2045433C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

BREVET D'INVENTION MELANGES DE POLYSACCHARIDES DE PAS POIDS MOLECULAIRES PROCEDE DE PREPARATION ET UTILISATION RHONE-POULENC RORER S.A. La présente invention concerne des mélanges de polysaccharides sulfatés de poids moléculaire moyen inférieur à celui de l'héparine. L'invention concerne aussi un procédé de préparation de ces mélanges, et leur utilisation.
CA002045433A 1990-06-26 1991-06-25 Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation Expired - Lifetime CA2045433C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR9008013 1990-06-26

Publications (2)

Publication Number Publication Date
CA2045433A1 true CA2045433A1 (fr) 1991-12-27
CA2045433C CA2045433C (fr) 2002-07-30

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002045433A Expired - Lifetime CA2045433C (fr) 1990-06-26 1991-06-25 Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation

Country Status (26)

Country Link
US (1) US5389618A (fr)
JP (1) JP3287363B2 (fr)
KR (1) KR0185586B1 (fr)
AT (1) AT398976B (fr)
AU (1) AU643531B2 (fr)
BE (1) BE1006827A3 (fr)
CA (1) CA2045433C (fr)
CH (1) CH682236A5 (fr)
DK (1) DK176524B1 (fr)
ES (1) ES2036922B9 (fr)
FI (1) FI104490B (fr)
FR (1) FR2663639B1 (fr)
GB (1) GB2245898B (fr)
GR (1) GR1000763B (fr)
HU (1) HU210925B (fr)
IE (1) IE66341B1 (fr)
IL (1) IL98604A (fr)
IT (1) IT1248557B (fr)
LU (1) LU87957A1 (fr)
MX (1) MX25829A (fr)
NL (1) NL194947C (fr)
NO (1) NO304991B1 (fr)
NZ (1) NZ238691A (fr)
PT (1) PT98102B (fr)
SE (1) SE506267C2 (fr)
ZA (1) ZA914869B (fr)

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EP1190364A2 (fr) 1999-04-23 2002-03-27 Massachusetts Institute Of Technology Systeme et procede de notation de polymeres
CA2377734A1 (fr) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Compositions d'heparine qui inhibent des facteurs de coagulation associes aux caillots
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
AU1594801A (en) * 1999-11-12 2001-06-06 Emisphere Technologies, Inc. Liquid heparin formulation
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
HUP0300939A2 (hu) * 2000-09-08 2003-09-29 Hamilton Civic Hospitals Research Development, Inc. Antitrombotikus készítmények
WO2002047696A1 (fr) 2000-12-16 2002-06-20 Aventis Pharma Deutschland Gmbh Utilisation d'heparine de faible masse moleculaire pour le traitement de l'osteoarthrose
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
WO2003018032A1 (fr) * 2001-08-28 2003-03-06 Leo Pharma A/S Compositions antithrombotiques comportant de l'heparine de faible poids molecule et du dermatane sulfate de poids moleculaire
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2402753A1 (fr) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analyse de polysaccharides sulfatés
US20030236221A1 (en) * 2002-06-20 2003-12-25 Chemi Spa Process for the preparation of esters of heparin
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FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CA2510250A1 (fr) * 2002-12-20 2004-08-12 Momenta Pharmaceuticals, Inc. Marqueurs de glycane utilises dans le diagnostic et la surveillance d'une maladie
EA200501846A1 (ru) * 2003-06-05 2007-12-28 Сентельон Плазмида, кодирующая фактор роста фибробластов, для лечения ангиогенных дефектов, ассоциированных с гиперхолестеринемией или диабетом
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
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US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP1582531A1 (fr) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Procédé d'oxydation d'héparines non-fractionnées et la détection de la présence ou de l'absence de glycosérine dans l'héparine et les produits dérivés de l'héparine.
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) * 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
WO2007140231A2 (fr) 2006-05-25 2007-12-06 Momenta Pharmaceutical, Inc. Composition d'héparine de bas poids moléculaire et utilisations de celle-ci
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
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FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
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CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
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Also Published As

Publication number Publication date
GR1000763B (el) 1992-12-30
SE9101957L (sv) 1991-12-27
AU7928891A (en) 1992-01-02
HUT57796A (en) 1991-12-30
LU87957A1 (fr) 1993-01-15
GR910100270A (en) 1992-08-25
GB9113589D0 (en) 1991-08-14
JPH04226101A (ja) 1992-08-14
IE66341B1 (en) 1995-12-27
IT1248557B (it) 1995-01-19
SE9101957D0 (sv) 1991-06-25
CA2045433C (fr) 2002-07-30
FI104490B (fi) 2000-02-15
PT98102A (pt) 1992-03-31
ITMI911757A1 (it) 1992-12-26
NL9101049A (nl) 1992-01-16
GB2245898A (en) 1992-01-15
FI913101A0 (fi) 1991-06-25
NZ238691A (en) 1992-07-28
ES2036922B9 (es) 2012-07-30
BE1006827A3 (fr) 1995-01-03
CH682236A5 (fr) 1993-08-13
FR2663639B1 (fr) 1994-03-18
FR2663639A1 (fr) 1991-12-27
SE506267C2 (sv) 1997-11-24
DK124391D0 (da) 1991-06-25
DK176524B1 (da) 2008-07-14
KR0185586B1 (ko) 1999-04-01
HU210925B (en) 1995-09-28
NO912485L (no) 1991-12-27
ES2036922A1 (es) 1993-06-01
FI913101A (fi) 1991-12-27
JP3287363B2 (ja) 2002-06-04
US5389618A (en) 1995-02-14
MX25829A (es) 1993-10-01
ES2036922B1 (es) 1994-03-01
KR920000792A (ko) 1992-01-29
NO912485D0 (no) 1991-06-25
ITMI911757A0 (it) 1991-06-26
IL98604A0 (en) 1992-07-15
IE912216A1 (en) 1992-01-01
IL98604A (en) 1998-08-15
ZA914869B (en) 1992-04-29
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
AU643531B2 (en) 1993-11-18
AT398976B (de) 1995-02-27
DK124391A (da) 1991-12-27
ATA128191A (de) 1994-07-15
NO304991B1 (no) 1999-03-15
PT98102B (pt) 1998-11-30
GB2245898B (en) 1993-10-06

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