CA2045433A1 - Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation - Google Patents

Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation

Info

Publication number
CA2045433A1
CA2045433A1 CA002045433A CA2045433A CA2045433A1 CA 2045433 A1 CA2045433 A1 CA 2045433A1 CA 002045433 A CA002045433 A CA 002045433A CA 2045433 A CA2045433 A CA 2045433A CA 2045433 A1 CA2045433 A1 CA 2045433A1
Authority
CA
Canada
Prior art keywords
preparation
molecular weight
low molecular
weight polysaccharide
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002045433A
Other languages
English (en)
Other versions
CA2045433C (fr
Inventor
Roger Debrie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2045433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of CA2045433A1 publication Critical patent/CA2045433A1/fr
Application granted granted Critical
Publication of CA2045433C publication Critical patent/CA2045433C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

BREVET D'INVENTION MELANGES DE POLYSACCHARIDES DE PAS POIDS MOLECULAIRES PROCEDE DE PREPARATION ET UTILISATION RHONE-POULENC RORER S.A. La présente invention concerne des mélanges de polysaccharides sulfatés de poids moléculaire moyen inférieur à celui de l'héparine. L'invention concerne aussi un procédé de préparation de ces mélanges, et leur utilisation.
CA002045433A 1990-06-26 1991-06-25 Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation Expired - Lifetime CA2045433C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR9008013 1990-06-26

Publications (2)

Publication Number Publication Date
CA2045433A1 true CA2045433A1 (fr) 1991-12-27
CA2045433C CA2045433C (fr) 2002-07-30

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002045433A Expired - Lifetime CA2045433C (fr) 1990-06-26 1991-06-25 Melanges de polysaccharides de bas poids moleculaires; procede de preparation et utilisation

Country Status (26)

Country Link
US (1) US5389618A (fr)
JP (1) JP3287363B2 (fr)
KR (1) KR0185586B1 (fr)
AT (1) AT398976B (fr)
AU (1) AU643531B2 (fr)
BE (1) BE1006827A3 (fr)
CA (1) CA2045433C (fr)
CH (1) CH682236A5 (fr)
DK (1) DK176524B1 (fr)
ES (1) ES2036922B9 (fr)
FI (1) FI104490B (fr)
FR (1) FR2663639B1 (fr)
GB (1) GB2245898B (fr)
GR (1) GR1000763B (fr)
HU (1) HU210925B (fr)
IE (1) IE66341B1 (fr)
IL (1) IL98604A (fr)
IT (1) IT1248557B (fr)
LU (1) LU87957A1 (fr)
MX (1) MX25829A (fr)
NL (1) NL194947C (fr)
NO (1) NO304991B1 (fr)
NZ (1) NZ238691A (fr)
PT (1) PT98102B (fr)
SE (1) SE506267C2 (fr)
ZA (1) ZA914869B (fr)

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USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
FR2687158B1 (fr) * 1992-02-07 1995-06-30 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
HU219339B (en) * 1993-09-30 2001-03-28 Seikagaku Kogyo Co Ltd Dermatan sulphate with low heparin or heparane sulphate content and pharmaceutical compositions comprising them
CA2643162C (fr) 1999-04-23 2018-01-02 Massachusetts Institute Of Technology Systeme et procede d'identification et de sequencage de polymeres, et d'analyse de leur composition par comparaison des proprietes
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
WO2001034114A1 (fr) * 1999-11-12 2001-05-17 Emisphere Technologies, Inc. Formulation d'heparine liquide
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
MXPA03001986A (es) * 2000-09-08 2004-03-19 Hamilton Civic Hospitals Res Composiciones antitromboticas.
WO2002047696A1 (fr) 2000-12-16 2002-06-20 Aventis Pharma Deutschland Gmbh Utilisation d'heparine de faible masse moleculaire pour le traitement de l'osteoarthrose
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
WO2003018032A1 (fr) * 2001-08-28 2003-03-06 Leo Pharma A/S Compositions antithrombotiques comportant de l'heparine de faible poids molecule et du dermatane sulfate de poids moleculaire
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2284535A1 (fr) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Héparines de poids moléculaire faible
US20030236221A1 (en) * 2002-06-20 2003-12-25 Chemi Spa Process for the preparation of esters of heparin
ATE356150T1 (de) * 2002-06-20 2007-03-15 Chemi Spa Verfahren zur herstellung von heparinestern
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US20040147033A1 (en) * 2002-12-20 2004-07-29 Zachary Shriver Glycan markers for diagnosing and monitoring disease
JP2006526592A (ja) * 2003-06-05 2006-11-24 センテリオン 血管由来の欠損に関連する高コレステロール血症または糖尿病の治療のための、線維芽細胞成長因子をコードするプラスミド
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP1582531A1 (fr) 2004-03-24 2005-10-05 Aventis Pharma S.A. Procédé d'oxydation d'héparines non-fractionnées et la détection de la présence ou de l'absence de glycosérine dans l'héparine et les produits dérivés de l'héparine.
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) * 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
JP2009538386A (ja) 2006-05-25 2009-11-05 モメンタ ファーマシューティカルズ インコーポレイテッド 低分子量ヘパリン組成物およびその使用
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2283045A1 (fr) * 2008-05-20 2011-02-16 Crystal Clear Partnership Séparation de polysaccharides par un gradient de densité de charge
EP2233145A1 (fr) 2009-03-19 2010-09-29 Sanofi-Aventis Dose de AVE5026 pour le traitement de thrombo-embolie veineuse chez des patients atteints d'une insuffisance rénale grave
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012100733A1 (fr) 2011-01-28 2012-08-02 杭州九源基因工程有限公司 Procédé de détermination d'une structure fine d'énoxaparine sodique par électrophorèse capillaire
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AR085961A1 (es) 2011-04-11 2013-11-06 Sanofi Sa Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法
CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
WO2016118625A1 (fr) 2015-01-20 2016-07-28 Incarda Therapeutics, Inc. Doses aérosols unitaires pour anticoagulation
CN109666086B (zh) * 2018-11-05 2020-12-22 上海宝维医药技术有限公司 一种高纯度肝素季铵盐的制备方法及其应用
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A1 (fr) 2020-07-14 2023-05-24 Optimvia, LLC Procédés de synthèse de sulfate d'héparane non anticoagulant

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DK108622C (da) * 1963-01-18 1968-01-15 Roussel Uclaf Fremgangsmåde til fremstilling af benzylheparinat eller dets alkalimetalsalte.
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (fr) * 1988-04-09 1989-10-18 Bioiberica, S.A. Procédé de préparation de fractions oligosaccharides par une dépolymérisation chimique réglée d'héparine
ES2006891A6 (es) * 1988-04-09 1989-05-16 Bioiberica Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
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IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina

Also Published As

Publication number Publication date
SE9101957L (sv) 1991-12-27
MX25829A (es) 1993-10-01
FI913101A0 (fi) 1991-06-25
HUT57796A (en) 1991-12-30
CA2045433C (fr) 2002-07-30
IL98604A (en) 1998-08-15
US5389618A (en) 1995-02-14
CH682236A5 (fr) 1993-08-13
IE912216A1 (en) 1992-01-01
FR2663639A1 (fr) 1991-12-27
AT398976B (de) 1995-02-27
KR920000792A (ko) 1992-01-29
JP3287363B2 (ja) 2002-06-04
GB2245898B (en) 1993-10-06
NO912485D0 (no) 1991-06-25
ZA914869B (en) 1992-04-29
GB2245898A (en) 1992-01-15
BE1006827A3 (fr) 1995-01-03
PT98102A (pt) 1992-03-31
IE66341B1 (en) 1995-12-27
FI913101A (fi) 1991-12-27
PT98102B (pt) 1998-11-30
ITMI911757A1 (it) 1992-12-26
NL9101049A (nl) 1992-01-16
IL98604A0 (en) 1992-07-15
SE506267C2 (sv) 1997-11-24
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
KR0185586B1 (ko) 1999-04-01
ES2036922A1 (es) 1993-06-01
IT1248557B (it) 1995-01-19
DK124391A (da) 1991-12-27
NZ238691A (en) 1992-07-28
JPH04226101A (ja) 1992-08-14
ES2036922B1 (es) 1994-03-01
GR910100270A (en) 1992-08-25
ATA128191A (de) 1994-07-15
HU210925B (en) 1995-09-28
DK124391D0 (da) 1991-06-25
SE9101957D0 (sv) 1991-06-25
NO912485L (no) 1991-12-27
ES2036922B9 (es) 2012-07-30
AU7928891A (en) 1992-01-02
FR2663639B1 (fr) 1994-03-18
LU87957A1 (fr) 1993-01-15
FI104490B (fi) 2000-02-15
ITMI911757A0 (it) 1991-06-26
DK176524B1 (da) 2008-07-14
GR1000763B (el) 1992-12-30
GB9113589D0 (en) 1991-08-14
NO304991B1 (no) 1999-03-15
AU643531B2 (en) 1993-11-18

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