LU86540A1 - Sels de cephalosporine et compositions injectables - Google Patents

Sels de cephalosporine et compositions injectables Download PDF

Info

Publication number
LU86540A1
LU86540A1 LU86540A LU86540A LU86540A1 LU 86540 A1 LU86540 A1 LU 86540A1 LU 86540 A LU86540 A LU 86540A LU 86540 A LU86540 A LU 86540A LU 86540 A1 LU86540 A1 LU 86540A1
Authority
LU
Luxembourg
Prior art keywords
mixture
crystalline
salts
sulfuric acid
ion
Prior art date
Application number
LU86540A
Other languages
English (en)
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of LU86540A1 publication Critical patent/LU86540A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
LU86540A 1985-08-05 1986-08-04 Sels de cephalosporine et compositions injectables LU86540A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05
US76223585 1985-08-05

Publications (1)

Publication Number Publication Date
LU86540A1 true LU86540A1 (fr) 1987-03-06

Family

ID=25064475

Family Applications (2)

Application Number Title Priority Date Filing Date
LU86540A LU86540A1 (fr) 1985-08-05 1986-08-04 Sels de cephalosporine et compositions injectables
LU88574C LU88574I2 (fr) 1985-08-05 1986-08-04 CEFEPIME et ses sels pharmaceutiquement acceptables (Maxipime R)

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU88574C LU88574I2 (fr) 1985-08-05 1986-08-04 CEFEPIME et ses sels pharmaceutiquement acceptables (Maxipime R)

Country Status (34)

Country Link
JP (1) JPH0615548B2 (es)
KR (1) KR930003121B1 (es)
AR (1) AR243894A1 (es)
AT (1) AT390957B (es)
AU (1) AU597262B2 (es)
BE (1) BE905219A (es)
CA (1) CA1284994C (es)
CH (1) CH675581A5 (es)
CS (2) CS276849B6 (es)
CY (1) CY1614A (es)
DD (2) DD254941A5 (es)
DE (1) DE3626375A1 (es)
DK (1) DK162053C (es)
EG (1) EG18003A (es)
ES (1) ES2002112A6 (es)
FI (1) FI84484C (es)
FR (1) FR2585705B1 (es)
GB (1) GB2179936B (es)
GR (1) GR862055B (es)
HK (1) HK99691A (es)
HU (1) HU196602B (es)
IE (1) IE59222B1 (es)
IL (1) IL79608A (es)
IT (1) IT1197067B (es)
LU (2) LU86540A1 (es)
MY (1) MY102212A (es)
NL (1) NL8601991A (es)
OA (1) OA08672A (es)
PT (1) PT83134B (es)
SE (1) SE469633B (es)
SG (1) SG79791G (es)
SU (1) SU1516013A3 (es)
YU (1) YU45793B (es)
ZA (1) ZA865842B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0321562B1 (en) * 1987-06-25 1993-11-24 Banyu Pharmaceutical Co., Ltd. Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
DE602004011685T2 (de) 2003-12-23 2009-02-05 Sandoz Gmbh Verfahren zur herstellung von zwischenprodukten für die verwendung bei der cefalosporinsynthese
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
SE8603308D0 (sv) 1986-08-04
CS276717B6 (en) 1992-08-12
IE59222B1 (en) 1994-01-26
KR930003121B1 (ko) 1993-04-19
SE8603308L (sv) 1987-02-06
FR2585705B1 (fr) 1989-01-13
DE3626375A1 (de) 1987-02-12
AU597262B2 (en) 1990-05-31
FR2585705A1 (fr) 1987-02-06
JPH0615548B2 (ja) 1994-03-02
IT8621409A1 (it) 1988-02-04
ZA865842B (en) 1987-04-29
DK162053C (da) 1992-02-10
DD254941A5 (de) 1988-03-16
FI84484B (fi) 1991-08-30
IL79608A0 (en) 1986-11-30
AT390957B (de) 1990-07-25
YU45793B (sh) 1992-07-20
HU196602B (en) 1988-12-28
FI84484C (fi) 1991-12-10
PT83134B (pt) 1989-07-31
GB2179936B (en) 1989-04-26
CA1284994C (en) 1991-06-18
DD268395A5 (de) 1989-05-31
IL79608A (en) 1991-07-18
GB8618989D0 (en) 1986-09-17
GR862055B (en) 1986-12-24
BE905219A (fr) 1987-02-04
IE862078L (en) 1987-02-05
FI863155A0 (fi) 1986-08-01
IT1197067B (it) 1988-11-25
FI863155A (fi) 1987-02-06
SG79791G (en) 1991-11-15
JPS62103090A (ja) 1987-05-13
DK162053B (da) 1991-09-09
CH675581A5 (es) 1990-10-15
OA08672A (en) 1989-03-31
IT8621409A0 (it) 1986-08-04
PT83134A (en) 1986-09-01
SU1516013A3 (ru) 1989-10-15
CS276849B6 (en) 1992-08-12
SE469633B (sv) 1993-08-09
AR243894A1 (es) 1993-09-30
LU88574I2 (fr) 1995-03-01
AU6069486A (en) 1987-02-12
ES2002112A6 (es) 1988-07-16
DK371886A (da) 1987-02-06
GB2179936A (en) 1987-03-18
HK99691A (en) 1991-12-13
CY1614A (en) 1992-07-10
MY102212A (en) 1992-05-15
NL8601991A (nl) 1987-03-02
DK371886D0 (da) 1986-08-04
HUT41802A (en) 1987-05-28
KR880002530A (ko) 1988-05-09
EG18003A (en) 1991-08-30
ATA211086A (de) 1990-01-15
YU137186A (en) 1987-12-31

Similar Documents

Publication Publication Date Title
FR2626003A1 (fr) Sels de cephalosporine, melanges contenant ces sels et procede de preparation du sel d'addition d'acide sulfurique
US20070244315A1 (en) Process for the preparation of cefdinir
LU86540A1 (fr) Sels de cephalosporine et compositions injectables
JPH0471073B2 (es)
CA1121343A (fr) Procede de preparation d'une forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino thiazolyl acetamido cephalosporanique
EP0070024B1 (en) The crystalline anhydrous form of (3s-(3 alpha(z),4 beta))-3-(((2-amino-4-thiazolyl)(1-carboxy-1-methylethoxy)-imino)-acetyl)-amino)-4-methyl-2-oxo-1-azetidinesulfonic acid, method for its preparation, mixture and pharmaceutical composition containing it
FR2466469A1 (fr) Bischlorhydrate de cephalosporine, son procede de preparation et ses applications, notamment en therapeutique
US20060276463A1 (en) Pure levofloxacin hemihydrate and processes for preparation thereof
US4456753A (en) Process for the manufacture of highly crystalline sodium cefoperazone
JPH10511377A (ja) セフォタキシムの製造
US5244891A (en) Injectable compositions of cefepime dihydrochloride hydrate
KR910010002B1 (ko) 소듐 세펨 카르복실레이트의 결정의 제조방법
US4994451A (en) Cephalosporin salts and injectable compositions
FI75169C (fi) Foerfarande foer framstaellning av kristallint natriumcefoperazon.
CA2101571A1 (en) Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
FR2610627A1 (fr) Sels cristallins de l'acide (3s(z))-2(((1-(2-amino-4-thiazolyl)-2-((2,2-dimethyl-4-oxo-1-(sulfo-oxy)-3-azetidinyl)amino)-2-oxoethylidene)-amino)oxy)acetique, a action therapeutique
JPS6115885A (ja) セフタジイムの製造
JP2010059068A (ja) ピオグリタゾンの製造方法
JPS5885892A (ja) 新規な結晶性３−セフエム−４−カルボン酸塩および精製法
JPS58172381A (ja) テトラゾ−ル酢酸チオエステルの製造方法
JPS6136506B2 (es)
JPH04244088A (ja) セファロスポリン誘導体
DE2404592A1 (de) Antibakterielle mittel und deren herstellung
JPH06506209A (ja) 結晶性チアガビン塩酸塩−水和物、その製造方法および用途
EP0101386A1 (fr) Nouveaux dérivés de la céphalosporine et leur préparation