LU86248A1 - Derives a cycle imidique de 2-(4-butylpiperazine-1-yl)pyridines et leur application antipsychotique - Google Patents

Derives a cycle imidique de 2-(4-butylpiperazine-1-yl)pyridines et leur application antipsychotique Download PDF

Info

Publication number
LU86248A1
LU86248A1 LU86248A LU86248A LU86248A1 LU 86248 A1 LU86248 A1 LU 86248A1 LU 86248 A LU86248 A LU 86248A LU 86248 A LU86248 A LU 86248A LU 86248 A1 LU86248 A1 LU 86248A1
Authority
LU
Luxembourg
Prior art keywords
compound according
group
pyridinyl
lower alkyl
hydrogen atom
Prior art date
Application number
LU86248A
Other languages
English (en)
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of LU86248A1 publication Critical patent/LU86248A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
LU86248A 1985-01-16 1986-01-15 Derives a cycle imidique de 2-(4-butylpiperazine-1-yl)pyridines et leur application antipsychotique LU86248A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/691,952 US4619930A (en) 1985-01-16 1985-01-16 Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
US69195285 1985-01-16

Publications (1)

Publication Number Publication Date
LU86248A1 true LU86248A1 (fr) 1986-08-04

Family

ID=24778661

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86248A LU86248A1 (fr) 1985-01-16 1986-01-15 Derives a cycle imidique de 2-(4-butylpiperazine-1-yl)pyridines et leur application antipsychotique

Country Status (29)

Country Link
US (1) US4619930A (de)
JP (1) JPH0780873B2 (de)
KR (1) KR900000366B1 (de)
CN (1) CN1016691B (de)
AT (1) AT391698B (de)
AU (1) AU591473B2 (de)
BE (1) BE904047A (de)
CA (1) CA1284325C (de)
CH (1) CH666269A5 (de)
DE (1) DE3601143C2 (de)
DK (1) DK19286A (de)
EG (1) EG17759A (de)
ES (2) ES8705869A1 (de)
FI (1) FI90077C (de)
FR (1) FR2580282B1 (de)
GB (1) GB2191772B (de)
HU (1) HU198202B (de)
IE (1) IE58866B1 (de)
IL (1) IL77577A (de)
IT (1) IT1214497B (de)
LU (1) LU86248A1 (de)
NL (1) NL8600071A (de)
NZ (1) NZ214790A (de)
OA (1) OA08187A (de)
PT (1) PT81843B (de)
SE (1) SE466310B (de)
SU (1) SU1521282A3 (de)
YU (1) YU45757B (de)
ZA (1) ZA859692B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4812567A (en) * 1985-10-16 1989-03-14 American Home Products Corporation Polycyclic spiroimides with psychotropic activity
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
EP0316723B1 (de) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituierte-4-Piperazinyl)butyl]-4-Thiazolidinone, Verfahren zu deren Herstellung und ihre Anwendung als Arzneimittel
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
DK0482696T3 (da) * 1990-10-23 1996-05-20 Akzo Nobel Nv 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN104230915B (zh) * 2014-08-29 2016-08-17 南京大学 含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途
CN104513198A (zh) * 2014-11-29 2015-04-15 南京红太阳生物化学有限责任公司 一种2-氯烟酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
AT330777B (de) * 1973-09-08 1976-07-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4456756A (en) * 1981-08-03 1984-06-26 Mead Johnson & Company Spirothiazolidinyl piperazine derivatives
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
DE3135532A1 (de) * 1981-09-08 1983-03-24 NPL po Dvigateli s Vatrešno Gorene, Varna Brennkraftmaschine
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
DE3529872A1 (de) * 1985-08-21 1987-02-26 Kali Chemie Pharma Gmbh Neue tetraoxoverbindungen

Also Published As

Publication number Publication date
ZA859692B (en) 1986-07-14
JPH0780873B2 (ja) 1995-08-30
HU198202B (en) 1989-08-28
FR2580282A1 (fr) 1986-10-17
AU5229486A (en) 1986-07-24
FI90077C (fi) 1993-12-27
AT391698B (de) 1990-11-12
GB8614686D0 (en) 1986-07-23
ES8801822A1 (es) 1988-02-16
BE904047A (fr) 1986-07-15
FI860136A0 (fi) 1986-01-13
CH666269A5 (de) 1988-07-15
SU1521282A3 (ru) 1989-11-07
ES557390A0 (es) 1988-02-16
DK19286A (da) 1986-07-17
IE860125L (en) 1986-07-16
DK19286D0 (da) 1986-01-15
IL77577A (en) 1990-02-09
GB2191772B (en) 1990-05-23
NZ214790A (en) 1989-04-26
HUT39743A (en) 1986-10-29
OA08187A (fr) 1987-10-30
YU45757B (sh) 1992-07-20
ATA10086A (de) 1990-05-15
SE466310B (sv) 1992-01-27
DE3601143C2 (de) 1994-05-11
DE3601143A1 (de) 1986-07-17
CA1284325C (en) 1991-05-21
IT8619081A0 (it) 1986-01-15
FR2580282B1 (fr) 1992-10-16
JPS61167682A (ja) 1986-07-29
US4619930A (en) 1986-10-28
IT1214497B (it) 1990-01-18
PT81843A (en) 1986-02-01
SE8600173D0 (sv) 1986-01-15
EG17759A (en) 1991-03-30
KR860005808A (ko) 1986-08-13
FI90077B (fi) 1993-09-15
CN1016691B (zh) 1992-05-20
PT81843B (pt) 1988-05-27
CN86100224A (zh) 1986-11-19
AU591473B2 (en) 1989-12-07
NL8600071A (nl) 1986-08-18
SE8600173L (sv) 1986-07-17
ES8705869A1 (es) 1987-05-16
FI860136A (fi) 1986-07-17
IE58866B1 (en) 1993-11-17
KR900000366B1 (ko) 1990-01-25
ES550829A0 (es) 1987-05-16
YU4186A (en) 1987-10-31
GB2191772A (en) 1987-12-23

Similar Documents

Publication Publication Date Title
KR101214665B1 (ko) 트리아졸 유도체 또는 그의 염
AU751139B2 (en) Amide derivative
CA2766873C (en) Therapeutic compositions and related methods of use
AP128A (en) Bis-aza-bicyclic anxiolytic agents.
US11180490B2 (en) Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists
JPS6084282A (ja) １−ヘテロアリ−ル−４−〔（２．５−ピロリジンジオン−１−イル）アルキル〕ピペラジン誘導体
EP2142533B1 (de) Imidazolidinonderivate
FR2518993A1 (fr) 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl))-1-piperazinyl) pyrimidines, leur preparation et leur application pharmacologique
WO1998022459A1 (fr) Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments
LU85796A1 (fr) Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine
JPH01249769A (ja) 向精神性ヘテロビシクロアルキルピペラジン誘導体
LU86248A1 (fr) Derives a cycle imidique de 2-(4-butylpiperazine-1-yl)pyridines et leur application antipsychotique
JPS60100560A (ja) 抗抑うつ剤１，２，４−トリアゾロン化合物
FR2518994A1 (fr) 2-(4-(4,4-dialkyl-2,6-piperidinedion-1-yl) butyl)-1-pyperazinyl) pyridines et leur application pharmacologique
JP5049134B2 (ja) ドーパミンｄ３受容体の調節に応答する障害の治療に好適なトリアゾール化合物
JPH0761968A (ja) ヘテロ環を含有する尿素誘導体
FR2537584A1 (fr) Pyrazoloquinoleines substituees particulieres, procede pour leur preparation, preparations pharmaceutiques contenant ces composes et leur application therapeutique
FR2489823A1 (fr) Nouvelles n-((4-(3-pyridyle substitue en position 3)-piperazino)alkyl)azaspirodecanediones, leur procede de preparation et medicament les contenant
US4757073A (en) Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
JPH01168677A (ja) 向精神性非環式アミド誘導体
WO1996004268A1 (fr) Compose de 1,4-dihydropyridine et composition medicinale contenant ledit compose
EP0084993B1 (de) Benzodioxin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
JP2008523155A (ja) ピリジル置換スピロ−ヒダントイン化合物およびその使用
EP3154944A2 (de) Substituierte pyridinone als mgat2-inhibitoren
FR2581385A1 (fr) Derives de piperazine 1,4-disubstitues, composition pharmaceutique les contenant; leur procede d'obtention