LU85972A1 - Nouveaux derives de ganglioside - Google Patents

Nouveaux derives de ganglioside Download PDF

Info

Publication number
LU85972A1
LU85972A1 LU85972A LU85972A LU85972A1 LU 85972 A1 LU85972 A1 LU 85972A1 LU 85972 A LU85972 A LU 85972A LU 85972 A LU85972 A LU 85972A LU 85972 A1 LU85972 A1 LU 85972A1
Authority
LU
Luxembourg
Prior art keywords
ganglioside
mixture
gangliosides
ester
groups
Prior art date
Application number
LU85972A
Other languages
English (en)
French (fr)
Inventor
Aurelio Romeo
Francesco Della Valle
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of LU85972A1 publication Critical patent/LU85972A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU85972A 1984-07-03 1985-06-26 Nouveaux derives de ganglioside LU85972A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT4849284 1984-07-03
IT48492/84A IT1199116B (it) 1984-07-03 1984-07-03 Derivati di gangliosidi

Publications (1)

Publication Number Publication Date
LU85972A1 true LU85972A1 (fr) 1986-01-22

Family

ID=11266890

Family Applications (1)

Application Number Title Priority Date Filing Date
LU85972A LU85972A1 (fr) 1984-07-03 1985-06-26 Nouveaux derives de ganglioside

Country Status (31)

Country Link
US (2) US4713374A (da)
EP (1) EP0167449B1 (da)
JP (1) JPS6163691A (da)
KR (1) KR880001232B1 (da)
CN (2) CN1021333C (da)
AR (1) AR242219A1 (da)
AT (1) ATE58739T1 (da)
AU (1) AU578706B2 (da)
BE (1) BE902750A (da)
CA (1) CA1263954A (da)
CH (1) CH670645A5 (da)
DE (1) DE3580710D1 (da)
DK (2) DK289885A (da)
ES (3) ES8706711A1 (da)
FI (1) FI84074C (da)
FR (1) FR2567131B1 (da)
GR (1) GR851573B (da)
HU (2) HU199860B (da)
IE (1) IE59376B1 (da)
IL (1) IL75640A0 (da)
IN (1) IN164786B (da)
IT (1) IT1199116B (da)
LU (1) LU85972A1 (da)
MX (1) MX163384B (da)
NO (1) NO164545C (da)
NZ (1) NZ212540A (da)
PH (1) PH27021A (da)
PL (2) PL151289B1 (da)
PT (1) PT80724B (da)
YU (1) YU46603B (da)
ZA (1) ZA854807B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
IT1177863B (it) * 1984-07-03 1987-08-26 Fidia Farmaceutici Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
JPS6168418A (ja) * 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
FR2598434B1 (fr) * 1986-05-12 1988-09-16 Pf Medicament Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae
EP0508493A1 (en) * 1986-08-06 1992-10-14 Mect Corporation Ganglioside related compounds and method of producing the same
JPS6368526A (ja) * 1986-09-11 1988-03-28 Mect Corp シアリルグリセライドからなる神経障害疾患治療剤
NZ222192A (en) * 1986-10-20 1991-03-26 Kanto Ishi Pharma Co Ltd Glycolipid containing n-glycolylneuraminic acid, and preparation thereof
FR2614306B1 (fr) * 1987-04-22 1989-07-28 Pf Medicament Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
JP2517293B2 (ja) * 1987-06-25 1996-07-24 メクト株式会社 細胞、組織修復剤
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
WO1989008499A1 (en) * 1988-03-17 1989-09-21 Nippon Fine Chemical Co., Ltd. Liposome
IT1224513B (it) * 1988-07-19 1990-10-04 Fidia Farmaceutici Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US6407072B1 (en) * 1988-12-02 2002-06-18 Fidia S.P.A. Lysoganglioside derivatives
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IN172427B (da) * 1989-11-14 1993-07-24 Fidia Spa
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
DK238190D0 (da) * 1990-10-03 1990-10-03 Lundbeck & Co As H Depotderivater
IT1251540B (it) * 1991-05-31 1995-05-17 Fidia Spa Uso di un derivato gangliosidico.
WO1993002686A1 (en) * 1991-07-31 1993-02-18 The Regents Of The University Of California Gangliosides with immunosuppressive ceramide moieties
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
WO1993010134A1 (en) * 1991-11-11 1993-05-27 Symbicom Aktiebolag Ganglioside analogs
IT1254706B (it) 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
DE4204907A1 (de) * 1992-02-14 1993-08-19 Reutter Werner Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
AU7831594A (en) * 1993-09-09 1995-03-27 Duke University A method of promoting cellular function
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives
IT1302530B1 (it) * 1998-12-16 2000-09-05 Fidia Spa In Amministrazione S Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1.
NZ531093A (en) 2001-08-17 2007-12-21 Neose Technologies Inc Chemo-enzymatic synthesis of sialylated oligosaccharides
JP2005527467A (ja) 2001-08-29 2005-09-15 ネオーズ テクノロジーズ， インコーポレイテッド 新規な合成ガングリオシド誘導体およびその組成物
MXPA05009480A (es) 2003-03-06 2006-02-22 Neose Technologies Inc Metodos y composiciones para la sintesis enzimatica de gangliosidos.
JP2007003173A (ja) * 2005-05-26 2007-01-11 Matsushita Electric Ind Co Ltd 冷蔵庫
US7943750B2 (en) 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
AU2008272792B2 (en) 2007-07-03 2014-03-06 Children's Hospital & Research Center At Oakland Oligosialic acid derivatives, methods of manufacture, and immunological uses
US8999954B2 (en) * 2007-07-03 2015-04-07 Childern's Hospital & Research Center at Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
CA2692417C (en) 2007-07-03 2017-03-21 Children's Hospital & Research Center At Oakland Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
EP3175857A1 (en) 2009-03-25 2017-06-07 Seneb Biosciences Inc. Glycolipids as treatment for disease
CA2772876C (en) 2009-09-01 2019-01-15 Lz Therapeutics, Inc. Methods for extraction and purification of gangliosides
EP2804871B1 (en) 2012-01-20 2017-04-12 Garnet BioTherapeutics, Inc Methods of ganglioside production
CA2905700A1 (en) * 2013-03-15 2014-09-18 Garnet Biotherapeutics, Inc. Ganglioside compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098995A (en) * 1976-07-12 1978-07-04 American Cyanamid Company Polygalactosido-sucrose poly(h-)sulfate salts
FR2478104B1 (fr) * 1980-03-17 1986-08-08 Merieux Inst Nouveaux derives de gangliosides, leur preparation et leur application
US4435389A (en) * 1980-07-07 1984-03-06 Kabushiki Kaisha Yakult Honsha Composition for promoting growth of bifidobacteria
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4476119A (en) * 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4469795A (en) * 1981-08-26 1984-09-04 Edward Ginns Radioassay for monosialoglycosphingolipid (GM1) ganglioside concentration
NL8104293A (nl) * 1981-09-17 1983-04-18 Ihc Holland Nv Werkwijze voor het opzuigen van grond of slib met een sleepzuiger alsmede sleepzuiger voor het toepassen van de werkwijze.
CH658458A5 (fr) * 1981-12-17 1986-11-14 Lucchini Lab Sa Procede pour l'obtention du lacto-n-norhexaosyl ceramide.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi

Also Published As

Publication number Publication date
IN164786B (da) 1989-06-03
FI84074B (fi) 1991-06-28
DK78592A (da) 1992-06-12
CH670645A5 (da) 1989-06-30
FR2567131B1 (fr) 1991-06-07
EP0167449B1 (en) 1990-11-28
CN1055741A (zh) 1991-10-30
IT8448492A0 (it) 1984-07-03
CN85104937A (zh) 1987-01-07
FI852515L (fi) 1986-01-04
DK289885D0 (da) 1985-06-26
PT80724B (pt) 1987-08-19
PL151289B1 (en) 1990-08-31
NO164545B (no) 1990-07-09
EP0167449A3 (en) 1987-10-21
AU578706B2 (en) 1988-11-03
FR2567131A1 (fr) 1986-01-10
PT80724A (en) 1985-07-01
IT1199116B (it) 1988-12-30
IL75640A0 (en) 1985-10-31
FI84074C (fi) 1991-10-10
PL254207A1 (en) 1987-02-09
AR242219A1 (es) 1993-03-31
NO852565L (no) 1986-01-06
DK78592D0 (da) 1992-06-12
YU46603B (sh) 1994-01-20
NZ212540A (en) 1989-01-27
ZA854807B (en) 1987-09-30
IE59376B1 (en) 1994-02-23
ES544574A0 (es) 1987-07-01
AU4420885A (en) 1986-01-02
CN1021333C (zh) 1993-06-23
ES557807A0 (es) 1988-03-16
ATE58739T1 (de) 1990-12-15
KR860000310A (ko) 1986-01-27
EP0167449A2 (en) 1986-01-08
US4713374A (en) 1987-12-15
ES8802055A1 (es) 1988-04-01
JPS6163691A (ja) 1986-04-01
MX163384B (es) 1992-05-07
GR851573B (da) 1985-11-25
US4849413A (en) 1989-07-18
FI852515A0 (fi) 1985-06-26
PL151829B1 (en) 1990-10-31
CA1263954A (en) 1989-12-19
IE851608L (en) 1986-01-03
NO164545C (no) 1990-10-17
ES8801925A1 (es) 1988-03-16
HUT38652A (en) 1986-06-30
ES8706711A1 (es) 1987-07-01
KR880001232B1 (ko) 1988-07-12
DE3580710D1 (de) 1991-01-10
CN1021574C (zh) 1993-07-14
PL261619A1 (en) 1988-02-04
HU199860B (en) 1990-03-28
ES552826A0 (es) 1988-04-01
PH27021A (en) 1993-02-01
DK289885A (da) 1986-01-04
YU107285A (en) 1988-08-31
BE902750A (fr) 1985-12-30

Similar Documents

Publication Publication Date Title
LU85972A1 (fr) Nouveaux derives de ganglioside
JPH09124679A (ja) セレクチンアンタゴニストとしての新規な糖模擬体およびそれから製造される抗炎症活性薬剤
TW204300B (da)
HU193151B (en) Process for producing ganglyoside derivatives and pharmaceutical compositions containing them as active agents
JP2518739B2 (ja) 腫瘍抑制サツカライド包合体
US20120028915A1 (en) 6"-amino-6"-deoxygalactosylceramides
CA2519568C (en) 6"-amino-6"-deoxygalactosylceramides
US4868292A (en) Preparation of monosialoganglioside
JPH09169792A (ja) セレクチンアンタゴニストとしての糖模擬体および抗炎症活性を有する医薬
EP0373039B1 (en) New lysoganglioside derivatives
LU86491A1 (fr) Nouveaux disaccharides,leur preparatione et leur utilisation comme medicaments
FR2949114A1 (fr) OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
EP0410883B1 (en) Di-lysogangliosides derivatives
JP4555466B2 (ja) 置換されたテトラヒドロピラン誘導体、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬
HU210923B (en) Process to prepare semisynthetic ganglioside analogues and pharmaceutical compns. conts. them as active agent
US6407072B1 (en) Lysoganglioside derivatives
Compostella et al. The mammalian sulfated glycolipid sulfatide: Synthesis and biological implications
FI83423B (fi) Foerfarande foer framstaellning av gangliosidderivat.
JPH02200696A (ja) スフィンゴ糖脂質
JP2002531462A (ja) 炭水化物とその合成方法
FR2728263A1 (fr) Composes intermediaires pour la synthese de glucolipides acides

Legal Events

Date Code Title Description
DT Application date
TA Annual fee