YU46603B - Novi gangliozidni derivati i postupak za njihovo dobijanje - Google Patents

Novi gangliozidni derivati i postupak za njihovo dobijanje

Info

Publication number
YU46603B
YU46603B YU107285A YU107285A YU46603B YU 46603 B YU46603 B YU 46603B YU 107285 A YU107285 A YU 107285A YU 107285 A YU107285 A YU 107285A YU 46603 B YU46603 B YU 46603B
Authority
YU
Yugoslavia
Prior art keywords
sialic acid
ganglioside
acid residues
peracylated
derivative
Prior art date
Application number
YU107285A
Other languages
English (en)
Other versions
YU107285A (en
Inventor
F. Dela Valle
A. Romeo
Original Assignee
Fidia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia S.P.A. filed Critical Fidia S.P.A.
Publication of YU107285A publication Critical patent/YU107285A/xx
Publication of YU46603B publication Critical patent/YU46603B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

NOVI GANGLIOZIDNI DERIVATI I POSTUPAK ZA NJIHOVO DOBIJANJE, koji obuhvata oligosaharid ceramidni ostatak i bar jedan sialinsko kiselinski ostatak, naznačen time, što se bira iz grupe koju čine estar karboksilnih grupa sialinsko kiselinskih ostataka gde hidroksilne grupe oligosaharidnog dela, ceramidnog dela i sialinsko kiselinskih ostataka mogu biti po izboru peracilovane; amid karboksilnih grupa sialinsko kiselinskih ostataka gde hidroksilne grupe oligosaharidnog dela, ceramidnog ostatka i sialinskih kiselinskih ostataka mogu biti po izboru peracilovane; i peracilovan derivat pomenutih hidroksilnih grupa gde sialinsko kiselinski ostaci imaju slobodne karboksilne grupe uz pred-postavku da pomenuti gangliozidni derivat nije metil estar gangliozida GM1 ili njegov peracilovan derivat, metil estar gangliozida GM3 ili njegov peracilovan derivat. Prijava sadrži još 5 nezavisnih i 24 zavisna zahteva.
YU107285A 1984-07-03 1985-06-26 Novi gangliozidni derivati i postupak za njihovo dobijanje YU46603B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48492/84A IT1199116B (it) 1984-07-03 1984-07-03 Derivati di gangliosidi

Publications (2)

Publication Number Publication Date
YU107285A YU107285A (en) 1988-08-31
YU46603B true YU46603B (sh) 1994-01-20

Family

ID=11266890

Family Applications (1)

Application Number Title Priority Date Filing Date
YU107285A YU46603B (sh) 1984-07-03 1985-06-26 Novi gangliozidni derivati i postupak za njihovo dobijanje

Country Status (31)

Country Link
US (2) US4713374A (sh)
EP (1) EP0167449B1 (sh)
JP (1) JPS6163691A (sh)
KR (1) KR880001232B1 (sh)
CN (2) CN1021574C (sh)
AR (1) AR242219A1 (sh)
AT (1) ATE58739T1 (sh)
AU (1) AU578706B2 (sh)
BE (1) BE902750A (sh)
CA (1) CA1263954A (sh)
CH (1) CH670645A5 (sh)
DE (1) DE3580710D1 (sh)
DK (2) DK289885A (sh)
ES (3) ES8706711A1 (sh)
FI (1) FI84074C (sh)
FR (1) FR2567131B1 (sh)
GR (1) GR851573B (sh)
HU (2) HUT38652A (sh)
IE (1) IE59376B1 (sh)
IL (1) IL75640A0 (sh)
IN (1) IN164786B (sh)
IT (1) IT1199116B (sh)
LU (1) LU85972A1 (sh)
MX (1) MX163384B (sh)
NO (1) NO164545C (sh)
NZ (1) NZ212540A (sh)
PH (1) PH27021A (sh)
PL (2) PL151829B1 (sh)
PT (1) PT80724B (sh)
YU (1) YU46603B (sh)
ZA (1) ZA854807B (sh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177863B (it) * 1984-07-03 1987-08-26 Fidia Farmaceutici Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
JPS6168418A (ja) * 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
FR2598434B1 (fr) * 1986-05-12 1988-09-16 Pf Medicament Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae
EP0508493A1 (en) * 1986-08-06 1992-10-14 Mect Corporation Ganglioside related compounds and method of producing the same
JPS6368526A (ja) * 1986-09-11 1988-03-28 Mect Corp シアリルグリセライドからなる神経障害疾患治療剤
NZ222192A (en) * 1986-10-20 1991-03-26 Kanto Ishi Pharma Co Ltd Glycolipid containing n-glycolylneuraminic acid, and preparation thereof
FR2614306B1 (fr) * 1987-04-22 1989-07-28 Pf Medicament Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
JP2517293B2 (ja) * 1987-06-25 1996-07-24 メクト株式会社 細胞、組織修復剤
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
US5169636A (en) * 1988-03-17 1992-12-08 Nippon Fine Chemical Co., Ltd. Liposomes
IT1224513B (it) * 1988-07-19 1990-10-04 Fidia Farmaceutici Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US6407072B1 (en) * 1988-12-02 2002-06-18 Fidia S.P.A. Lysoganglioside derivatives
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IN172427B (sh) * 1989-11-14 1993-07-24 Fidia Spa
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
DK238190D0 (da) * 1990-10-03 1990-10-03 Lundbeck & Co As H Depotderivater
IT1251540B (it) * 1991-05-31 1995-05-17 Fidia Spa Uso di un derivato gangliosidico.
WO1993002686A1 (en) * 1991-07-31 1993-02-18 The Regents Of The University Of California Gangliosides with immunosuppressive ceramide moieties
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
ATE155477T1 (de) * 1991-11-11 1997-08-15 Symbicom Ab Gangliosideanaloge
IT1254706B (it) 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
DE4204907A1 (de) * 1992-02-14 1993-08-19 Reutter Werner Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems
IT1254280B (it) 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
AU7831594A (en) * 1993-09-09 1995-03-27 Duke University A method of promoting cellular function
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives
IT1302530B1 (it) * 1998-12-16 2000-09-05 Fidia Spa In Amministrazione S Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1.
US20050032742A1 (en) 2001-08-17 2005-02-10 Defrees Shawn Chemo-enzymatic synthesis of sialylated oligosaccharides
JP2005527467A (ja) 2001-08-29 2005-09-15 ネオーズ テクノロジーズ， インコーポレイテッド 新規な合成ガングリオシド誘導体およびその組成物
WO2004080960A2 (en) 2003-03-06 2004-09-23 Neose Technologies Inc. Methods and compositions for the enzymatic synthesis of gangliosides
JP2007003173A (ja) * 2005-05-26 2007-01-11 Matsushita Electric Ind Co Ltd 冷蔵庫
US7943750B2 (en) 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
JP5702600B2 (ja) * 2007-07-03 2015-04-15 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド オリゴシアル酸誘導体、製造方法および免疫学的使用
EP2183261A4 (en) 2007-07-03 2010-09-15 Childrens Hosp & Res Ct Oak POLYSIALYLIC ACID DERIVATIVES, MANUFACTURING METHODS AND APPLICATIONS FOR INCREASING THE PRODUCTION AND TARGETING OF CANCER ANIMALS
CA2692419C (en) * 2007-07-03 2017-12-05 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-n-acetylase and methods for using the same
EP2410846B1 (en) 2009-03-25 2016-09-07 Seneb Biosciences, Inc. Glycolipids as treatment for disease
ES2581523T3 (es) 2009-09-01 2016-09-06 Lz Therapeutics, Inc. Producción en cultivo celular (no bovino, no porcino) de GM1
US9556467B2 (en) 2012-01-20 2017-01-31 Garnet Bio Therapeutics, Inc. Methods of ganglioside production
SG11201506311YA (en) * 2013-03-15 2015-09-29 Garnet Biotherapeutics Inc Ganglioside compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098995A (en) * 1976-07-12 1978-07-04 American Cyanamid Company Polygalactosido-sucrose poly(h-)sulfate salts
FR2478104B1 (fr) * 1980-03-17 1986-08-08 Merieux Inst Nouveaux derives de gangliosides, leur preparation et leur application
US4435389A (en) * 1980-07-07 1984-03-06 Kabushiki Kaisha Yakult Honsha Composition for promoting growth of bifidobacteria
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4476119A (en) * 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4469795A (en) * 1981-08-26 1984-09-04 Edward Ginns Radioassay for monosialoglycosphingolipid (GM1) ganglioside concentration
NL8104293A (nl) * 1981-09-17 1983-04-18 Ihc Holland Nv Werkwijze voor het opzuigen van grond of slib met een sleepzuiger alsmede sleepzuiger voor het toepassen van de werkwijze.
CH658458A5 (fr) * 1981-12-17 1986-11-14 Lucchini Lab Sa Procede pour l'obtention du lacto-n-norhexaosyl ceramide.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi

Also Published As

Publication number Publication date
DK289885D0 (da) 1985-06-26
PH27021A (en) 1993-02-01
MX163384B (es) 1992-05-07
GR851573B (sh) 1985-11-25
FI84074C (fi) 1991-10-10
CH670645A5 (sh) 1989-06-30
IT8448492A0 (it) 1984-07-03
CN1021574C (zh) 1993-07-14
ZA854807B (en) 1987-09-30
NO164545C (no) 1990-10-17
FI852515L (fi) 1986-01-04
IT1199116B (it) 1988-12-30
PL151829B1 (en) 1990-10-31
EP0167449A2 (en) 1986-01-08
CN1021333C (zh) 1993-06-23
ES552826A0 (es) 1988-04-01
IL75640A0 (en) 1985-10-31
EP0167449B1 (en) 1990-11-28
DK78592D0 (da) 1992-06-12
PL261619A1 (en) 1988-02-04
IE851608L (en) 1986-01-03
HUT38652A (en) 1986-06-30
NZ212540A (en) 1989-01-27
CA1263954A (en) 1989-12-19
DK78592A (da) 1992-06-12
BE902750A (fr) 1985-12-30
IN164786B (sh) 1989-06-03
KR880001232B1 (ko) 1988-07-12
US4849413A (en) 1989-07-18
JPS6163691A (ja) 1986-04-01
YU107285A (en) 1988-08-31
CN85104937A (zh) 1987-01-07
KR860000310A (ko) 1986-01-27
PT80724B (pt) 1987-08-19
ATE58739T1 (de) 1990-12-15
AR242219A1 (es) 1993-03-31
LU85972A1 (fr) 1986-01-22
PL254207A1 (en) 1987-02-09
ES8706711A1 (es) 1987-07-01
PL151289B1 (en) 1990-08-31
PT80724A (en) 1985-07-01
IE59376B1 (en) 1994-02-23
AU4420885A (en) 1986-01-02
ES557807A0 (es) 1988-03-16
HU199860B (en) 1990-03-28
CN1055741A (zh) 1991-10-30
ES8801925A1 (es) 1988-03-16
FR2567131A1 (fr) 1986-01-10
FR2567131B1 (fr) 1991-06-07
FI852515A0 (fi) 1985-06-26
US4713374A (en) 1987-12-15
EP0167449A3 (en) 1987-10-21
ES8802055A1 (es) 1988-04-01
DK289885A (da) 1986-01-04
NO852565L (no) 1986-01-06
DE3580710D1 (de) 1991-01-10
AU578706B2 (en) 1988-11-03
ES544574A0 (es) 1987-07-01
FI84074B (fi) 1991-06-28
NO164545B (no) 1990-07-09

Similar Documents

Publication Publication Date Title
YU46603B (sh) Novi gangliozidni derivati i postupak za njihovo dobijanje
IL73521A (en) Preparation of 1,3,5-tri-o-acyl-2-deoxy-2-fluoroarabinofuranoside intermediate compounds for the synthesis of nucleosides and the 1,3,5-triaroyl esters thereof
BE894024A (fr) Procede de preparation de derives d'esters internes de gangliosides et compositions pharmaceutiques contenant ces derives
DK137983D0 (da) Metode til at tilberede terapeutiske sammensaetninger med langvarig udloesning baseret pa hydroksylpropylmetylcellulose med hoej molekylarvaegt
FI855055A (fi) Foerening, som baserar sig pao aotminstone ett cellulosa-estergrupp innehaollande derivat, foerfarande foer erhaollande av foereningen och cellulosa-estergrupper innehaollande fiber.
DE69125331D1 (de) Zelluloseesterzusammensetzungen und verfahren zu deren herstellung
THARANATHAN et al. Structural studies on the d‐arabinose‐containing lipid A from Rhodospirillum tenue 2761
IL81952A0 (en) Process for the preparation of l-phosphinothricine derivatives and of their alkyl esters
KR830000911A (ko) X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액
DK256380A (da) Fremgangsmaade til fremstilling af 5!deoxy-5-fluoruridin
DK0609643T3 (da) Fremgangsmåde til fremstilling af L-(-)carnitin ud fra et spildprodukt med modsat konfiguration
BE860052A (fr) Procede de preparation de derives organiques d'etain d'esters mercaptoalcooliques
YU108691A (sh) Nove 3,3'-ditiobis (propionske kiseline) i njihovi estri
NO931731L (no) Anvendelse av spesielle karboksylsyreestere som anti-skummingsmiddel
FOURNIE et al. Absolute configuration of the unique 2, 6‐dideoxy‐4‐O‐methyl‐arabino‐hexopyranose of the major phenolic glycolipid antigen from Mycobacterium kansasii
IT1235161B (it) Derivati di lisogangliosidi
ES8300663A1 (es) Un procedimiento para la preparacion de derivados de bis-hidroxibencilo.
SE8103367L (sv) Estrar av alkoxi-acylderivat av karnitin, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma
Aspinall et al. Arabinogalactan A from Japanese larch (Larix leptolepis)
Meyer et al. Syntheses of benzyl 6-O-sulfo-. beta.-D-glucopyranoside salts and their 6S-deuterated analogs. Conformational preferences of their (sulfonyloxy) methyl group
DE69031448D1 (de) Halbsynthetische Gangliosidanaloge
Neszmélyi et al. Empirical 13C-NMR-correlations between the Escherichia coli K 13 and LP 1092 capsular polysaccharides and model oligosaccharides containing d-ribose and 3-deoxy-d-manno-2-octulosonic acid
Bundle et al. Synthesis of 2-acetamido-6-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-D-glucopyranose
SE8400305D0 (sv) Metod for tverbindning av agarprodukter
IT8421922A1 (it) Procedimento per produrre l-aminoacidi da alfa-chetoacidi mediante fermentazione