LU81470A1 - Complexes platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu - Google Patents
Complexes platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu Download PDFInfo
- Publication number
- LU81470A1 LU81470A1 LU81470A LU81470A LU81470A1 LU 81470 A1 LU81470 A1 LU 81470A1 LU 81470 A LU81470 A LU 81470A LU 81470 A LU81470 A LU 81470A LU 81470 A1 LU81470 A1 LU 81470A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- platinum
- formula
- diamine
- obtaining
- cis
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 16
- 201000011510 cancer Diseases 0.000 title claims description 15
- 239000003814 drug Substances 0.000 title claims description 7
- 229940126601 medicinal product Drugs 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 24
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- -1 platinum diamine Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 23
- 239000000460 chlorine Substances 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 14
- 210000003734 kidney Anatomy 0.000 description 11
- 239000000203 mixture Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 6
- 231100000417 nephrotoxicity Toxicity 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000001093 anti-cancer Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 150000003057 platinum Chemical class 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 101710134784 Agnoprotein Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 201000008228 Ependymoblastoma Diseases 0.000 description 2
- 206010014968 Ependymoma malignant Diseases 0.000 description 2
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- PTGRNMGGKQUEGN-UHFFFAOYSA-N [Pt+2].NCC1CCCCC1 Chemical compound [Pt+2].NCC1CCCCC1 PTGRNMGGKQUEGN-UHFFFAOYSA-N 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 208000003747 lymphoid leukemia Diseases 0.000 description 2
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229910020427 K2PtCl4 Inorganic materials 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- ZBLACDIKXKCJGF-UHFFFAOYSA-N [2-(aminomethyl)cyclobutyl]methanamine Chemical compound NCC1CCC1CN ZBLACDIKXKCJGF-UHFFFAOYSA-N 0.000 description 1
- CHKXDMWKXWDMPF-UHFFFAOYSA-N [Pt+2].NCC1CCC1 Chemical compound [Pt+2].NCC1CCC1 CHKXDMWKXWDMPF-UHFFFAOYSA-N 0.000 description 1
- LZUBKTANOIDDEC-UHFFFAOYSA-N [Pt+2].NCC1CCCC1 Chemical compound [Pt+2].NCC1CCCC1 LZUBKTANOIDDEC-UHFFFAOYSA-N 0.000 description 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- DRKSWVBADUVKBW-UHFFFAOYSA-N cyclopentanamine;platinum(2+) Chemical compound [Pt+2].NC1CCCC1 DRKSWVBADUVKBW-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 150000002690 malonic acid derivatives Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 150000003058 platinum compounds Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7807334A NL7807334A (nl) | 1978-07-06 | 1978-07-06 | Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel. |
NL7807334 | 1978-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU81470A1 true LU81470A1 (fr) | 1980-02-14 |
Family
ID=19831207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU81470A LU81470A1 (fr) | 1978-07-06 | 1979-07-05 | Complexes platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu |
Country Status (36)
Country | Link |
---|---|
US (1) | US4410544A (xx) |
JP (1) | JPS5513280A (xx) |
AR (1) | AR226709A1 (xx) |
AT (1) | AT377251B (xx) |
AU (1) | AU533539B2 (xx) |
BE (1) | BE877527A (xx) |
CA (1) | CA1152088A (xx) |
CH (2) | CH641758A5 (xx) |
CS (1) | CS235301B2 (xx) |
CY (1) | CY1320A (xx) |
DD (1) | DD144780A5 (xx) |
DE (1) | DE2927056A1 (xx) |
DK (1) | DK153540C (xx) |
ES (3) | ES482240A1 (xx) |
FI (1) | FI76350C (xx) |
FR (2) | FR2430406A1 (xx) |
GB (1) | GB2024823B (xx) |
GR (1) | GR69248B (xx) |
HK (1) | HK9986A (xx) |
HU (1) | HU183014B (xx) |
IE (1) | IE48519B1 (xx) |
IL (1) | IL57717A (xx) |
IT (1) | IT1122011B (xx) |
KE (1) | KE3590A (xx) |
LU (1) | LU81470A1 (xx) |
MY (1) | MY8600400A (xx) |
NL (1) | NL7807334A (xx) |
NO (1) | NO163898C (xx) |
NZ (1) | NZ190923A (xx) |
PH (1) | PH21386A (xx) |
PT (1) | PT69877A (xx) |
SE (1) | SE7905927L (xx) |
SG (1) | SG91685G (xx) |
SU (2) | SU1160937A3 (xx) |
YU (1) | YU41652B (xx) |
ZA (1) | ZA793394B (xx) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8204067A (nl) * | 1982-10-21 | 1984-05-16 | Tno | Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
JPS56154493A (en) * | 1980-04-30 | 1981-11-30 | Shionogi & Co Ltd | Novel platinum complex |
AU538863B2 (en) * | 1980-05-27 | 1984-08-30 | Bristol-Myers Company | Platinum complex salts have anti-tumor property |
JPS5716895A (en) * | 1980-07-05 | 1982-01-28 | Otsuka Chem Co Ltd | Platinum 2 complex and antitumor agent containing the same as active principle |
NL8101026A (nl) * | 1981-03-03 | 1982-10-01 | Tno | Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel. |
JPS57156416A (en) * | 1981-03-24 | 1982-09-27 | Otsuka Chem Co Ltd | Platinum (2) complex and antitumor agent comprising it as active ingredient |
US4786725A (en) * | 1982-06-28 | 1988-11-22 | Engelhard Corporation | Solubilized platinum (II) complexes |
DE3305248C2 (de) * | 1983-02-16 | 1987-04-09 | Degussa Ag, 6000 Frankfurt | Verfahren zur Reinigung von cis-Platin-(II)-diammin-dichlorid |
US4598091A (en) * | 1983-02-18 | 1986-07-01 | Degussa Aktiengesellschaft | (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds |
EP0137900B1 (en) * | 1983-05-10 | 1990-05-09 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
US4720504A (en) * | 1983-05-10 | 1988-01-19 | Andrulis Research Corporation | Use of bis-platinum complexes as antitumor agents |
US4758588A (en) * | 1983-06-20 | 1988-07-19 | Research Corporation Technologies | Diaminocyclohexane platinum complexes |
US4661516A (en) * | 1983-06-20 | 1987-04-28 | Research Corporation | Diaminocyclohexane platinum complexes |
US4562275A (en) * | 1984-03-23 | 1985-12-31 | Bristol-Myers Co. | Antitumor platinum complexes |
EP0169645A1 (en) * | 1984-06-27 | 1986-01-29 | Johnson Matthey Public Limited Company | Platinum co-ordination compounds |
US4952676A (en) * | 1984-06-27 | 1990-08-28 | Johnson Matthey Plc | Monoclonal antibody-platinum co-ordination compound complex |
DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
HU193809B (en) * | 1984-09-12 | 1987-12-28 | Chugai Pharmaceutical Co Ltd | Process for producing new platinum complexes |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
US4739087A (en) * | 1985-01-10 | 1988-04-19 | Bristol-Myers Company | Antineoplastic platinum complexes |
US4567285A (en) * | 1985-07-10 | 1986-01-28 | Yoshinori Kidani | Complex compounds of platinum |
JPS6345290A (ja) * | 1985-08-27 | 1988-02-26 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
US4970324A (en) * | 1985-12-24 | 1990-11-13 | Hoeschele James D | Aminoalkyl-substituted azetidine platinum(II) complexes |
US5116831A (en) * | 1985-12-24 | 1992-05-26 | Warner-Lambert Company | Aminoalkyl-substituted cycloalkylamine platinum (II) complexes |
US4760157A (en) * | 1986-01-31 | 1988-07-26 | American Cyanamid Company | (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes |
US4880790A (en) * | 1986-01-31 | 1989-11-14 | American Cyanamid Company | (Gem-heterocyclodimethanamine-N,N')platinum complexes |
US4716157A (en) * | 1986-03-20 | 1987-12-29 | American Cyanamid Company | Heterocyclic-1,2-diamine platinum complexes |
JPH05345792A (ja) * | 1986-07-01 | 1993-12-27 | Nippon Kayaku Co Ltd | 新規白金錯体 |
DE3630497A1 (de) * | 1986-09-08 | 1988-03-10 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4870070A (en) * | 1987-08-10 | 1989-09-26 | American Cyanamid Company | Water soluble platinum complexes of novel malonate derivatives |
AT390065B (de) * | 1987-10-08 | 1990-03-12 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
DE3843571A1 (de) * | 1988-01-09 | 1989-07-20 | Asta Pharma Ag | 1,2-bis(aminomethyl)cyclobutan-platin-komplexe |
NL8802149A (nl) * | 1988-08-31 | 1990-03-16 | Tno | Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking. |
NL8802150A (nl) * | 1988-08-31 | 1990-03-16 | Tno | Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking. |
US4895960A (en) * | 1989-01-23 | 1990-01-23 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
JPH0776230B2 (ja) * | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
DE4415263C1 (de) * | 1994-04-15 | 1995-11-30 | Asta Medica Ag | Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1432562A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum co-ordination compounds |
GB1432563A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum- co-ordination compounds |
CH605550A5 (xx) * | 1972-06-08 | 1978-09-29 | Research Corp | |
JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
-
1978
- 1978-07-06 NL NL7807334A patent/NL7807334A/xx not_active Application Discontinuation
-
1979
- 1979-07-03 CY CY1320A patent/CY1320A/xx unknown
- 1979-07-03 GB GB7923073A patent/GB2024823B/en not_active Expired
- 1979-07-04 IL IL57717A patent/IL57717A/xx not_active IP Right Cessation
- 1979-07-04 DE DE19792927056 patent/DE2927056A1/de active Granted
- 1979-07-04 HU HU79NE613A patent/HU183014B/hu not_active IP Right Cessation
- 1979-07-04 IT IT24099/79A patent/IT1122011B/it active
- 1979-07-05 DK DK284979A patent/DK153540C/da not_active IP Right Cessation
- 1979-07-05 PT PT69877A patent/PT69877A/pt not_active IP Right Cessation
- 1979-07-05 ES ES482240A patent/ES482240A1/es not_active Expired
- 1979-07-05 CA CA000331212A patent/CA1152088A/en not_active Expired
- 1979-07-05 GR GR59517A patent/GR69248B/el unknown
- 1979-07-05 FI FI792127A patent/FI76350C/fi not_active IP Right Cessation
- 1979-07-05 NZ NZ190923A patent/NZ190923A/xx unknown
- 1979-07-05 NO NO792240A patent/NO163898C/no unknown
- 1979-07-05 AT AT0469079A patent/AT377251B/de not_active IP Right Cessation
- 1979-07-05 CS CS794751A patent/CS235301B2/cs unknown
- 1979-07-05 LU LU81470A patent/LU81470A1/fr unknown
- 1979-07-05 AU AU48679/79A patent/AU533539B2/en not_active Ceased
- 1979-07-05 JP JP8448979A patent/JPS5513280A/ja active Granted
- 1979-07-05 FR FR7917524A patent/FR2430406A1/fr active Granted
- 1979-07-06 SE SE7905927A patent/SE7905927L/ unknown
- 1979-07-06 YU YU1662/79A patent/YU41652B/xx unknown
- 1979-07-06 DD DD79214180A patent/DD144780A5/de unknown
- 1979-07-06 CH CH636579A patent/CH641758A5/de not_active IP Right Cessation
- 1979-07-06 BE BE0/196165A patent/BE877527A/nl not_active IP Right Cessation
- 1979-07-06 SU SU792788104A patent/SU1160937A3/ru active
- 1979-07-06 CH CH5787/83A patent/CH649525A5/de not_active IP Right Cessation
- 1979-07-06 ZA ZA793394A patent/ZA793394B/xx unknown
- 1979-08-08 IE IE1271/79A patent/IE48519B1/en not_active IP Right Cessation
-
1980
- 1980-04-16 ES ES490629A patent/ES490629A0/es active Granted
- 1980-04-16 ES ES490630A patent/ES8101080A1/es not_active Expired
- 1980-11-24 AR AR283341A patent/AR226709A1/es active
-
1981
- 1981-07-27 US US06/287,531 patent/US4410544A/en not_active Expired - Fee Related
- 1981-08-04 PH PH26006A patent/PH21386A/en unknown
-
1982
- 1982-09-14 FR FR8215536A patent/FR2511685B1/fr not_active Expired
-
1983
- 1983-05-04 SU SU833585700A patent/SU1414850A1/ru active
-
1985
- 1985-12-02 SG SG916/85A patent/SG91685G/en unknown
- 1985-12-06 KE KE3590A patent/KE3590A/xx unknown
-
1986
- 1986-02-05 HK HK99/86A patent/HK9986A/xx unknown
- 1986-12-30 MY MY400/86A patent/MY8600400A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU81470A1 (fr) | Complexes platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu | |
FR2473046A1 (fr) | Complexes de platine (iv)-diamine et leur application comme medicament pour le traitement du cancer | |
FR2501197A1 (fr) | Complexes de platine-diamine, procede d'obtention, application therapeutique et compositions pharmaceutiques contenant un tel complexe | |
EP2268652B1 (fr) | Dérivés platine - carbene n-heterocyclique, leur préparation et leur application en thérapeutique | |
CH644516A5 (fr) | Composition therapeutique renfermant des composes du platine. | |
EP0039272B1 (fr) | Composé complexe isocitraté du platine, son procédé de préparation et son application thérapeutique | |
FR2534907A1 (fr) | Complexes diamine-platine, un procede pour leur preparation, un procede pour la preparation d'une composition medicinale utilisant un tel complexe diamine platine pour le traitement du cancer ainsi que la composition ainsi formee | |
FR2459246A1 (fr) | Complexes cis-lactate de platine (ii) amine, medicaments et compositions pharmaceutiques les contenant | |
FR2580642A1 (fr) | 5-pyrimidinecarboxamides et traitement de la leucemie et des tumeurs en les utilisant | |
JPH03151396A (ja) | 強い抗腫瘍活性を有する水及び溶媒に可溶なアキシャルヒドロキシ及びモノ及びジカルボン酸誘導体 | |
US5008419A (en) | Novel platinum complex | |
LU84365A1 (fr) | Complexes de platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu | |
FR2459247A1 (fr) | Complexe de cis-ascorbate de platine (ii) amine | |
EP0897389A1 (fr) | Complexes de platine dinucleaires, procede pour leur preparation et compositions pharmaceutiques en contenant | |
LU83713A1 (fr) | Derives de la pyrimidine,leur procede de preparation et les compositions pharmaceutiques les contenant | |
FR2563524A1 (fr) | Complexes mixtes carboxylatoplatine (ii) et procede de preparation desdits complexes | |
EP0986390B1 (fr) | Compositions pharmaceutiques contenant du dichlorhydrate de cinchonine | |
WO2003106469A1 (de) | Tumorhemmende platin(ii)-oxalato-komplexe | |
LU81797A1 (fr) | Combinations antivirales | |
LU83398A1 (fr) | Composes d'etain utiles comme medicament,medicament obtenu et procede de preparation dudit medicament | |
BE875740A (fr) | Compositions comprenant du platine | |
EP0766692B1 (fr) | Derives de l'acide guanylique et applications comme medicaments | |
CA2193096C (fr) | Derives de l'acide guanylique et applications comme medicaments | |
FR2516085A1 (fr) | Sels quaternaires de n,n3-di(b-bromopropionyl)-n1,n2-dispirotripiperazinium, procede de preparation desdits sels et medicament a action antitumorale a base d'un tel sel | |
FR2465716A1 (fr) | 1-(alkyle ramifie)-3-(2-haloethyl)-3-nitroso-urees utilisables comme agents antitumoraux |