LU79774A1 - Procede de preparation de 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase - Google Patents

Procede de preparation de 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase Download PDF

Info

Publication number
LU79774A1
LU79774A1 LU79774A LU79774A LU79774A1 LU 79774 A1 LU79774 A1 LU 79774A1 LU 79774 A LU79774 A LU 79774A LU 79774 A LU79774 A LU 79774A LU 79774 A1 LU79774 A1 LU 79774A1
Authority
LU
Luxembourg
Prior art keywords
penicillanate
acid
formula
dioxide
oxide
Prior art date
Application number
LU79774A
Other languages
English (en)
French (fr)
Inventor
W Barth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU79774(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of LU79774A1 publication Critical patent/LU79774A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LU79774A 1977-06-07 1978-06-06 Procede de preparation de 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase LU79774A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US80432077 1977-06-07
US87938178A 1978-02-21 1978-02-21
US87938178 1978-02-21

Publications (1)

Publication Number Publication Date
LU79774A1 true LU79774A1 (fr) 1980-01-22

Family

ID=27122691

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79774A LU79774A1 (fr) 1977-06-07 1978-06-06 Procede de preparation de 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase

Country Status (35)

Country Link
AR (1) AR224111A1 (ko)
AT (2) AT360649B (ko)
AU (1) AU513636B2 (ko)
BE (1) BE867859A (ko)
BG (2) BG34614A3 (ko)
CH (1) CH634073A5 (ko)
CS (1) CS208472B2 (ko)
DD (2) DD140888A5 (ko)
DE (2) DE2824535C3 (ko)
DK (1) DK155740C (ko)
EG (1) EG13869A (ko)
FI (1) FI66003C (ko)
FR (2) FR2393804A1 (ko)
GB (1) GB2000138B (ko)
GR (1) GR72255B (ko)
HK (1) HK13184A (ko)
HU (1) HU180042B (ko)
IE (1) IE47079B1 (ko)
IL (2) IL54867A (ko)
IN (1) IN149747B (ko)
IT (1) IT1096381B (ko)
KE (1) KE3355A (ko)
LU (1) LU79774A1 (ko)
MY (1) MY8500092A (ko)
NL (2) NL180009C (ko)
NO (2) NO151746C (ko)
NZ (1) NZ187476A (ko)
OA (1) OA05964A (ko)
PH (3) PH26810A (ko)
PL (1) PL114501B1 (ko)
PT (1) PT68146A (ko)
SE (2) SE436206B (ko)
SG (1) SG65383G (ko)
SU (1) SU860706A1 (ko)
YU (1) YU41829B (ko)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (ko) * 1977-05-09 1979-01-18
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
US4241050A (en) * 1978-09-01 1980-12-23 Pfizer Inc. Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE49768B1 (en) * 1979-05-21 1985-12-11 Leo Pharm Prod Ltd 6beta-halopenicillanic acid derivatives
DE3051044C2 (ko) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4432903A (en) * 1980-09-08 1984-02-21 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
EP0069962B1 (en) * 1981-07-15 1985-01-02 Kanebo, Ltd. Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76527B (en) * 1982-04-19 1985-12-09 Gist Brocades Nv A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4647457A (en) * 1983-12-16 1987-03-03 Hoffmann-La Roche Inc. Penicillanic acid derivatives
WO1987006230A1 (en) * 1986-04-10 1987-10-22 Leo Pharmaceutical Products Ltd. A/S Method for preparing penicillanic acid derivatives
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
CN102977120B (zh) * 2012-12-14 2015-05-27 江西富祥药业股份有限公司 一种舒巴坦匹酯制备及结晶方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process
LU77306A1 (ko) * 1977-05-09 1979-01-18
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation

Also Published As

Publication number Publication date
DD140888A5 (de) 1980-04-02
IL54867A (en) 1981-11-30
IL54867A0 (en) 1978-08-31
GB2000138B (en) 1982-03-03
AT360649B (de) 1981-01-26
SE7806628L (sv) 1978-12-08
PH26810A (en) 1992-11-05
NL930064I1 (nl) 1993-09-01
GB2000138A (en) 1979-01-04
PL207396A1 (pl) 1979-06-04
DK155740C (da) 1989-10-23
SU860706A1 (ru) 1981-08-30
NO823126L (no) 1978-12-08
IL62168A0 (en) 1981-03-31
IT1096381B (it) 1985-08-26
SE8305916L (sv) 1983-10-27
PT68146A (en) 1978-07-01
BE867859A (fr) 1978-12-06
PH21116A (en) 1987-07-16
ATA411278A (de) 1980-06-15
FI781800A (fi) 1978-12-08
NO151746C (no) 1985-06-05
SG65383G (en) 1985-03-29
DE2824535A1 (de) 1978-12-14
IN149747B (ko) 1982-04-03
CS208472B2 (en) 1981-09-15
ATA128580A (de) 1981-02-15
NL180009C (nl) 1986-12-16
NO151746B (no) 1985-02-18
DE2824535C3 (de) 1981-01-22
PL114501B1 (en) 1981-02-28
YU41829B (en) 1988-02-29
DE2857263B2 (de) 1981-04-23
DK251478A (da) 1978-12-08
FR2393805A1 (fr) 1979-01-05
FR2393804A1 (fr) 1979-01-05
BG34614A3 (en) 1983-10-15
NL930064I2 (nl) 1994-04-18
DE2857263C3 (de) 1981-12-17
AU513636B2 (en) 1980-12-11
BG34615A3 (en) 1983-10-15
DK155740B (da) 1989-05-08
CH634073A5 (en) 1983-01-14
NZ187476A (en) 1982-08-17
PH16465A (en) 1983-10-20
NO781970L (no) 1978-12-08
FR2393804B1 (ko) 1980-11-07
SE436206B (sv) 1984-11-19
SE447995B (sv) 1987-01-12
YU117078A (en) 1983-01-21
FR2393805B1 (ko) 1984-02-24
NO152448B (no) 1985-06-24
EG13869A (en) 1983-03-31
IE781140L (en) 1978-12-07
NL7806126A (nl) 1978-12-11
KE3355A (en) 1983-12-16
NO152448C (no) 1985-10-02
DD148585A5 (de) 1981-06-03
SE8305916D0 (sv) 1983-10-27
FI66003C (fi) 1984-08-10
AT364084B (de) 1981-09-25
HK13184A (en) 1984-02-24
FI66003B (fi) 1984-04-30
IE47079B1 (en) 1983-12-14
MY8500092A (en) 1985-12-31
AR224111A1 (es) 1981-10-30
OA05964A (fr) 1981-06-30
HU180042B (en) 1983-01-28
GR72255B (ko) 1983-10-06
IT7824270A0 (it) 1978-06-06
AU3683878A (en) 1979-12-06
DE2824535B2 (de) 1980-05-14

Similar Documents

Publication Publication Date Title
LU79774A1 (fr) Procede de preparation de 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase
US4234579A (en) Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
LU82164A1 (fr) -lactames derives de l acide penicillanique, leur preparation et leurs utilisations therapeutiques
LU82880A1 (fr) Derives d'acides 6 beta-hydroxyalkylpenicillaniques,leur procede de production et compositions pharmaceutiques les contenant
US4276285A (en) Combinations of penicillanic acid 1,1-dioxide with 7-(D-2-[4-ethylpiperazin-2,3-dione-1-carboxamido]-2-[4-hydroxyphenyl]acetamido)-3-([1-methyl-5-tetrazolyl]thiomethyl)-3-desacetoxymethylcephalosporanic acid
LU82468A1 (fr) Derives de l'acide penicillanique utiles comme medicaments,compositions therapeutiques les contenant et procedes de leur preparation
US4256733A (en) Acetoxymethyl penam compounds as β-lactamase inhibitors
CH621125A5 (ko)
US4420426A (en) 6-Alpha-halopenicillanic acid 1,1-dioxides
LU82215A1 (fr) Procede et composes intermediaires pour la prouduction du 1,1-dioxyde d'acide penicillanique et de ses esters
DD149366A5 (de) Verfahren zur herstellung von penicillansaeure-derivaten
FR2610629A2 (fr) Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
CA1094547A (fr) Procede de preparation de derives de l'acide 3- carbamoyloxymethyl 7-(amino thiazolyl acetamido) cephalosporanique
BE875054A (fr) Composes analogues aux cephalosporines
LU82163A1 (fr) Nouveaux derives d'acide penicillanique utile notamment comme antibiotiques et leurs procedes de preparation
CA1270814A (en) 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
FR2482103A1 (fr) Sulfone d'acide 2b-chloromethyl-2a-methylpename-3a-carboxylique, son procede de preparation et son utilisation en association avec des antibiotiques de la classe des b-lactamines
FR2520362A1 (fr) Nouveaux composes de type b-lactame, y compris leurs sels formes avec des acides ou des bases acceptables en pharmacie, procedes pour produire ces composes, medicaments les contenant et leur utilisation pour combattre les maladies infectieuses
CH687205A5 (fr) Dérivés de thioalkylthiocarbacephalosporine.
LU81795A1 (fr) Nouvelle penicilline semi-synthetique,son procede de production et composition pharmaceutique la contenant
BE897183A (fr) Esters carboxyliques aisement clivables et leur utilisation dans la synthese de penems et autres antibiotiques de beta -lactame
FR2539130A1 (fr) Esters de type penem, procede pour les preparer, medicament les contenant
KR820000740B1 (ko) 페니실란산 1, 1-디옥사이드의 제조방법
FR2485540A1 (fr) Nouveaux derives antibiotiques des cephalosporines, leur procede de preparation et les medicaments en contenant
FR2483925A1 (fr) Procede de preparation de derives de l'acide peneme-3-carboxylique