FR2393805A1 - 1-oxyde de l'acide penicillanique et de ses esters utiles comme intermediaires chimiques - Google Patents

1-oxyde de l'acide penicillanique et de ses esters utiles comme intermediaires chimiques

Info

Publication number
FR2393805A1
FR2393805A1 FR787826789A FR7826789A FR2393805A1 FR 2393805 A1 FR2393805 A1 FR 2393805A1 FR 787826789 A FR787826789 A FR 787826789A FR 7826789 A FR7826789 A FR 7826789A FR 2393805 A1 FR2393805 A1 FR 2393805A1
Authority
FR
France
Prior art keywords
oxide
penicillanic acid
esters useful
chemical
intermediaries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR787826789A
Other languages
English (en)
Other versions
FR2393805B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2393805(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2393805A1 publication Critical patent/FR2393805A1/fr
Application granted granted Critical
Publication of FR2393805B1 publication Critical patent/FR2393805B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La présente invention se situe dans l'art chimique. Elle a pour objet le 1-oxyde de l'acide pénicillanique et de ses esters. Ces composés sont utiles dans la synthèse du 1,1-dioxyde de l'acide pénicillanique et de ses esters.
FR787826789A 1977-06-07 1978-09-19 1-oxyde de l'acide penicillanique et de ses esters utiles comme intermediaires chimiques Granted FR2393805A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US87938178A 1978-02-21 1978-02-21

Publications (2)

Publication Number Publication Date
FR2393805A1 true FR2393805A1 (fr) 1979-01-05
FR2393805B1 FR2393805B1 (fr) 1984-02-24

Family

ID=27122691

Family Applications (2)

Application Number Title Priority Date Filing Date
FR787816893A Granted FR2393804A1 (fr) 1974-12-05 1978-06-06 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase
FR787826789A Granted FR2393805A1 (fr) 1977-06-07 1978-09-19 1-oxyde de l'acide penicillanique et de ses esters utiles comme intermediaires chimiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR787816893A Granted FR2393804A1 (fr) 1974-12-05 1978-06-06 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase

Country Status (35)

Country Link
AR (1) AR224111A1 (fr)
AT (2) AT360649B (fr)
AU (1) AU513636B2 (fr)
BE (1) BE867859A (fr)
BG (2) BG34614A3 (fr)
CH (1) CH634073A5 (fr)
CS (1) CS208472B2 (fr)
DD (2) DD148585A5 (fr)
DE (2) DE2857263C3 (fr)
DK (1) DK155740C (fr)
EG (1) EG13869A (fr)
FI (1) FI66003C (fr)
FR (2) FR2393804A1 (fr)
GB (1) GB2000138B (fr)
GR (1) GR72255B (fr)
HK (1) HK13184A (fr)
HU (1) HU180042B (fr)
IE (1) IE47079B1 (fr)
IL (2) IL54867A (fr)
IN (1) IN149747B (fr)
IT (1) IT1096381B (fr)
KE (1) KE3355A (fr)
LU (1) LU79774A1 (fr)
MY (1) MY8500092A (fr)
NL (2) NL180009C (fr)
NO (2) NO151746C (fr)
NZ (1) NZ187476A (fr)
OA (1) OA05964A (fr)
PH (3) PH26810A (fr)
PL (1) PL114501B1 (fr)
PT (1) PT68146A (fr)
SE (2) SE436206B (fr)
SG (1) SG65383G (fr)
SU (1) SU860706A1 (fr)
YU (1) YU41829B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405950A1 (fr) * 1977-05-09 1979-05-11 Ciba Geigy Ag Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
EP0061315A1 (fr) * 1981-03-23 1982-09-29 Pfizer Inc. Procédé de préparation de dérivés du 1,1-dioxyde de l'acide pénicillanique et certains intermédiaires utiles dans ce procédé

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
US4241050A (en) * 1978-09-01 1980-12-23 Pfizer Inc. Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (fr) * 1978-12-11 1983-12-13 Eric M. Gordon Acide 6-bromopenicillanique sulfone
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
IL59948A0 (en) * 1979-05-21 1980-06-30 Rech Applications Therap Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
DE3051044C2 (fr) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4432903A (en) * 1980-09-08 1984-02-21 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
DE3261759D1 (en) * 1981-07-15 1985-02-14 Kanebo Ltd Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76527B (en) * 1982-04-19 1985-12-09 Gist Brocades Nv A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
EP0139047A1 (fr) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Procédé de préparation de 1,1-dioxyde d'acide 6,6-dibromopénicillanique
US4647457A (en) * 1983-12-16 1987-03-03 Hoffmann-La Roche Inc. Penicillanic acid derivatives
ATE77821T1 (de) * 1986-04-10 1992-07-15 Leo Pharm Prod Ltd Verfahren zur herstellung von penicillansaeurederivaten.
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
CN102977120B (zh) * 2012-12-14 2015-05-27 江西富祥药业股份有限公司 一种舒巴坦匹酯制备及结晶方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
FR2405950A1 (fr) * 1977-05-09 1979-05-11 Ciba Geigy Ag Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405950A1 (fr) * 1977-05-09 1979-05-11 Ciba Geigy Ag Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405950A1 (fr) * 1977-05-09 1979-05-11 Ciba Geigy Ag Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
EP0061315A1 (fr) * 1981-03-23 1982-09-29 Pfizer Inc. Procédé de préparation de dérivés du 1,1-dioxyde de l'acide pénicillanique et certains intermédiaires utiles dans ce procédé

Also Published As

Publication number Publication date
NO151746C (no) 1985-06-05
HU180042B (en) 1983-01-28
OA05964A (fr) 1981-06-30
FI66003B (fi) 1984-04-30
AU3683878A (en) 1979-12-06
IT7824270A0 (it) 1978-06-06
YU117078A (en) 1983-01-21
IL54867A0 (en) 1978-08-31
DK155740B (da) 1989-05-08
SE7806628L (sv) 1978-12-08
AT360649B (de) 1981-01-26
NO152448B (no) 1985-06-24
NL930064I1 (nl) 1993-09-01
NO823126L (no) 1978-12-08
ATA128580A (de) 1981-02-15
GB2000138B (en) 1982-03-03
IN149747B (fr) 1982-04-03
GB2000138A (en) 1979-01-04
SE436206B (sv) 1984-11-19
KE3355A (en) 1983-12-16
NL7806126A (nl) 1978-12-11
PH26810A (en) 1992-11-05
NL180009C (nl) 1986-12-16
SU860706A1 (ru) 1981-08-30
FR2393804A1 (fr) 1979-01-05
DE2824535C3 (de) 1981-01-22
PL207396A1 (pl) 1979-06-04
DD140888A5 (de) 1980-04-02
IT1096381B (it) 1985-08-26
IL62168A0 (en) 1981-03-31
ATA411278A (de) 1980-06-15
CS208472B2 (en) 1981-09-15
IE47079B1 (en) 1983-12-14
AR224111A1 (es) 1981-10-30
PT68146A (en) 1978-07-01
SE8305916L (sv) 1983-10-27
BE867859A (fr) 1978-12-06
NO152448C (no) 1985-10-02
CH634073A5 (en) 1983-01-14
FR2393804B1 (fr) 1980-11-07
DE2857263B2 (de) 1981-04-23
SE447995B (sv) 1987-01-12
DK155740C (da) 1989-10-23
DE2857263C3 (de) 1981-12-17
YU41829B (en) 1988-02-29
DD148585A5 (de) 1981-06-03
EG13869A (en) 1983-03-31
AT364084B (de) 1981-09-25
FI781800A (fi) 1978-12-08
FR2393805B1 (fr) 1984-02-24
SE8305916D0 (sv) 1983-10-27
LU79774A1 (fr) 1980-01-22
IL54867A (en) 1981-11-30
HK13184A (en) 1984-02-24
PH16465A (en) 1983-10-20
DE2824535A1 (de) 1978-12-14
NO151746B (no) 1985-02-18
PL114501B1 (en) 1981-02-28
GR72255B (fr) 1983-10-06
NL930064I2 (nl) 1994-04-18
NO781970L (no) 1978-12-08
BG34614A3 (en) 1983-10-15
SG65383G (en) 1985-03-29
MY8500092A (en) 1985-12-31
PH21116A (en) 1987-07-16
DK251478A (da) 1978-12-08
NZ187476A (en) 1982-08-17
DE2824535B2 (de) 1980-05-14
IE781140L (en) 1978-12-07
BG34615A3 (en) 1983-10-15
FI66003C (fi) 1984-08-10
AU513636B2 (en) 1980-12-11

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