AU513636B2 - Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors - Google Patents

Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Info

Publication number
AU513636B2
AU513636B2 AU36838/78A AU3683878A AU513636B2 AU 513636 B2 AU513636 B2 AU 513636B2 AU 36838/78 A AU36838/78 A AU 36838/78A AU 3683878 A AU3683878 A AU 3683878A AU 513636 B2 AU513636 B2 AU 513636B2
Authority
AU
Australia
Prior art keywords
dioxides
beta
penicillanic acid
lactamase inhibitors
lactamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU36838/78A
Other languages
English (en)
Other versions
AU3683878A (en
Inventor
Wayne Ernest Barth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU513636(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU3683878A publication Critical patent/AU3683878A/en
Application granted granted Critical
Publication of AU513636B2 publication Critical patent/AU513636B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU36838/78A 1977-06-07 1978-06-02 Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors Ceased AU513636B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US804320 1977-06-07
US87938178A 1978-02-21 1978-02-21
US879381 1978-02-21

Related Child Applications (3)

Application Number Title Priority Date Filing Date
AU48465/79A Addition AU514926B2 (en) 1977-06-07 1979-06-27 Combination of derivatives of pencillin and cephalosporan
AU64030/80A Division AU522487B2 (en) 1977-06-07 1980-10-31 Intermediate compounds to penicillanic and 11-dioxides
AU64031/80A Division AU522465B2 (en) 1977-06-07 1980-10-31 Intermediate compounds to penicillanic and 11-dioxides

Publications (2)

Publication Number Publication Date
AU3683878A AU3683878A (en) 1979-12-06
AU513636B2 true AU513636B2 (en) 1980-12-11

Family

ID=27122691

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36838/78A Ceased AU513636B2 (en) 1977-06-07 1978-06-02 Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Country Status (35)

Country Link
AR (1) AR224111A1 (fr)
AT (2) AT360649B (fr)
AU (1) AU513636B2 (fr)
BE (1) BE867859A (fr)
BG (2) BG34615A3 (fr)
CH (1) CH634073A5 (fr)
CS (1) CS208472B2 (fr)
DD (2) DD148585A5 (fr)
DE (2) DE2824535C3 (fr)
DK (1) DK155740C (fr)
EG (1) EG13869A (fr)
FI (1) FI66003C (fr)
FR (2) FR2393804A1 (fr)
GB (1) GB2000138B (fr)
GR (1) GR72255B (fr)
HK (1) HK13184A (fr)
HU (1) HU180042B (fr)
IE (1) IE47079B1 (fr)
IL (2) IL54867A (fr)
IN (1) IN149747B (fr)
IT (1) IT1096381B (fr)
KE (1) KE3355A (fr)
LU (1) LU79774A1 (fr)
MY (1) MY8500092A (fr)
NL (2) NL180009C (fr)
NO (2) NO151746C (fr)
NZ (1) NZ187476A (fr)
OA (1) OA05964A (fr)
PH (3) PH26810A (fr)
PL (1) PL114501B1 (fr)
PT (1) PT68146A (fr)
SE (2) SE436206B (fr)
SG (1) SG65383G (fr)
SU (1) SU860706A1 (fr)
YU (1) YU41829B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (fr) * 1977-05-09 1979-01-18
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
US4241050A (en) * 1978-09-01 1980-12-23 Pfizer Inc. Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (fr) * 1978-12-11 1983-12-13 Eric M. Gordon Acide 6-bromopenicillanique sulfone
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
IL59948A0 (en) * 1979-05-21 1980-06-30 Rech Applications Therap Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
DE3051044C2 (fr) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4432903A (en) * 1980-09-08 1984-02-21 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
DE3261759D1 (en) * 1981-07-15 1985-02-14 Kanebo Ltd Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76526B (en) * 1982-04-19 1986-01-21 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
EP0139047A1 (fr) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Procédé de préparation de 1,1-dioxyde d'acide 6,6-dibromopénicillanique
US4647457A (en) * 1983-12-16 1987-03-03 Hoffmann-La Roche Inc. Penicillanic acid derivatives
WO1987006230A1 (fr) * 1986-04-10 1987-10-22 Leo Pharmaceutical Products Ltd. A/S Procede servant a preparer des derives d'acide penicillanique
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
CN102977120B (zh) * 2012-12-14 2015-05-27 江西富祥药业股份有限公司 一种舒巴坦匹酯制备及结晶方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process
LU77306A1 (fr) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones

Also Published As

Publication number Publication date
BG34615A3 (en) 1983-10-15
IT7824270A0 (it) 1978-06-06
GR72255B (fr) 1983-10-06
NO152448B (no) 1985-06-24
EG13869A (en) 1983-03-31
BE867859A (fr) 1978-12-06
PL207396A1 (pl) 1979-06-04
NZ187476A (en) 1982-08-17
DE2824535B2 (de) 1980-05-14
FI66003B (fi) 1984-04-30
FR2393804A1 (fr) 1979-01-05
SE8305916D0 (sv) 1983-10-27
HU180042B (en) 1983-01-28
DD148585A5 (de) 1981-06-03
GB2000138B (en) 1982-03-03
IL54867A0 (en) 1978-08-31
DK155740C (da) 1989-10-23
GB2000138A (en) 1979-01-04
NL7806126A (nl) 1978-12-11
DK155740B (da) 1989-05-08
CS208472B2 (en) 1981-09-15
SE8305916L (sv) 1983-10-27
IE781140L (en) 1978-12-07
MY8500092A (en) 1985-12-31
KE3355A (en) 1983-12-16
IN149747B (fr) 1982-04-03
AU3683878A (en) 1979-12-06
IL54867A (en) 1981-11-30
DE2824535A1 (de) 1978-12-14
AT364084B (de) 1981-09-25
ATA128580A (de) 1981-02-15
BG34614A3 (en) 1983-10-15
PH16465A (en) 1983-10-20
NL930064I2 (nl) 1994-04-18
NO151746C (no) 1985-06-05
FR2393805B1 (fr) 1984-02-24
NO151746B (no) 1985-02-18
IE47079B1 (en) 1983-12-14
CH634073A5 (en) 1983-01-14
FI66003C (fi) 1984-08-10
PH26810A (en) 1992-11-05
FI781800A (fi) 1978-12-08
DD140888A5 (de) 1980-04-02
NL930064I1 (nl) 1993-09-01
HK13184A (en) 1984-02-24
IT1096381B (it) 1985-08-26
DK251478A (da) 1978-12-08
FR2393805A1 (fr) 1979-01-05
ATA411278A (de) 1980-06-15
SU860706A1 (ru) 1981-08-30
LU79774A1 (fr) 1980-01-22
OA05964A (fr) 1981-06-30
NO823126L (no) 1978-12-08
SE447995B (sv) 1987-01-12
IL62168A0 (en) 1981-03-31
FR2393804B1 (fr) 1980-11-07
DE2824535C3 (de) 1981-01-22
YU41829B (en) 1988-02-29
YU117078A (en) 1983-01-21
NO152448C (no) 1985-10-02
NL180009C (nl) 1986-12-16
AT360649B (de) 1981-01-26
DE2857263C3 (de) 1981-12-17
PL114501B1 (en) 1981-02-28
NO781970L (no) 1978-12-08
PT68146A (en) 1978-07-01
DE2857263B2 (de) 1981-04-23
PH21116A (en) 1987-07-16
AR224111A1 (es) 1981-10-30
SG65383G (en) 1985-03-29
SE7806628L (sv) 1978-12-08
SE436206B (sv) 1984-11-19

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