LT3265102T - Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui - Google Patents

Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui

Info

Publication number
LT3265102T
LT3265102T LTEPPCT/US2016/021276T LTUS2016021276T LT3265102T LT 3265102 T LT3265102 T LT 3265102T LT US2016021276 T LTUS2016021276 T LT US2016021276T LT 3265102 T LT3265102 T LT 3265102T
Authority
LT
Lithuania
Prior art keywords
beta
substituted
hcv
deoxy
fluoro
Prior art date
Application number
LTEPPCT/US2016/021276T
Other languages
English (en)
Lithuanian (lt)
Inventor
Jean-Pierre Sommadossi
Adel Moussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of LT3265102T publication Critical patent/LT3265102T/lt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
LTEPPCT/US2016/021276T 2015-03-06 2016-03-07 Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui LT3265102T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562129319P 2015-03-06 2015-03-06
US201562253958P 2015-11-11 2015-11-11
US201662276597P 2016-01-08 2016-01-08
PCT/US2016/021276 WO2016144918A1 (en) 2015-03-06 2016-03-07 β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT

Publications (1)

Publication Number Publication Date
LT3265102T true LT3265102T (lt) 2025-10-27

Family

ID=56850466

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2016/021276T LT3265102T (lt) 2015-03-06 2016-03-07 Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui

Country Status (32)

Country Link
US (12) US9828410B2 (cg-RX-API-DMAC10.html)
EP (2) EP3265102B1 (cg-RX-API-DMAC10.html)
JP (4) JP6776273B2 (cg-RX-API-DMAC10.html)
KR (2) KR102363946B1 (cg-RX-API-DMAC10.html)
CN (2) CN112209980B (cg-RX-API-DMAC10.html)
AU (5) AU2016229966B2 (cg-RX-API-DMAC10.html)
CA (2) CA2978085C (cg-RX-API-DMAC10.html)
CO (1) CO2017010162A2 (cg-RX-API-DMAC10.html)
DK (1) DK3265102T3 (cg-RX-API-DMAC10.html)
EA (1) EA037098B1 (cg-RX-API-DMAC10.html)
ES (1) ES3049645T3 (cg-RX-API-DMAC10.html)
FI (1) FI3265102T3 (cg-RX-API-DMAC10.html)
GE (5) GEAP202114600A (cg-RX-API-DMAC10.html)
HR (1) HRP20251450T1 (cg-RX-API-DMAC10.html)
IL (3) IL295418B2 (cg-RX-API-DMAC10.html)
LT (1) LT3265102T (cg-RX-API-DMAC10.html)
MD (1) MD3265102T2 (cg-RX-API-DMAC10.html)
MX (2) MX2017011386A (cg-RX-API-DMAC10.html)
MY (2) MY190867A (cg-RX-API-DMAC10.html)
NZ (1) NZ773652A (cg-RX-API-DMAC10.html)
PH (1) PH12017501598B1 (cg-RX-API-DMAC10.html)
PL (1) PL3265102T3 (cg-RX-API-DMAC10.html)
PT (1) PT3265102T (cg-RX-API-DMAC10.html)
RS (1) RS67412B1 (cg-RX-API-DMAC10.html)
RU (1) RU2764767C2 (cg-RX-API-DMAC10.html)
SA (1) SA517382236B1 (cg-RX-API-DMAC10.html)
SG (1) SG11201706841PA (cg-RX-API-DMAC10.html)
SI (1) SI3265102T1 (cg-RX-API-DMAC10.html)
SM (1) SMT202500392T1 (cg-RX-API-DMAC10.html)
UA (1) UA124966C2 (cg-RX-API-DMAC10.html)
WO (1) WO2016144918A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201705852B (cg-RX-API-DMAC10.html)

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