LT3049B - £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines - Google Patents

£(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines Download PDF

Info

Publication number
LT3049B
LT3049B LTIP367A LTIP367A LT3049B LT 3049 B LT3049 B LT 3049B LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT 3049 B LT3049 B LT 3049B
Authority
LT
Lithuania
Prior art keywords
formula
hydrogen
radical
alkyl
benzopyran
Prior art date
Application number
LTIP367A
Other languages
English (en)
Lithuanian (lt)
Inventor
Guy Rosalia Eugene Vanlommen
Marcel Frans Leopold Debruyn
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LTIP367A publication Critical patent/LTIP367A/lt
Publication of LT3049B publication Critical patent/LT3049B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTIP367A 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines LT3049B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (2)

Publication Number Publication Date
LTIP367A LTIP367A (lt) 1994-04-25
LT3049B true LT3049B (en) 1994-10-25

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP367A LT3049B (en) 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines

Country Status (37)

Country Link
US (4) US5541180A (fr)
EP (1) EP0639192B1 (fr)
JP (1) JP2779268B2 (fr)
KR (1) KR100190300B1 (fr)
CN (1) CN1038032C (fr)
AP (1) AP416A (fr)
AT (1) ATE138064T1 (fr)
AU (1) AU664237B2 (fr)
BG (1) BG62052B1 (fr)
CA (1) CA2117483C (fr)
CZ (1) CZ282092B6 (fr)
DE (1) DE69302687T2 (fr)
DK (1) DK0639192T3 (fr)
EE (1) EE03029B1 (fr)
ES (1) ES2087721T3 (fr)
FI (1) FI109122B (fr)
GR (1) GR3019927T3 (fr)
HR (1) HRP930235B1 (fr)
HU (2) HU222495B1 (fr)
IL (1) IL104868A (fr)
LT (1) LT3049B (fr)
LV (1) LV10715B (fr)
MX (1) MX9301053A (fr)
MY (1) MY110627A (fr)
NO (1) NO306255B1 (fr)
NZ (1) NZ249124A (fr)
OA (1) OA10095A (fr)
PH (1) PH31295A (fr)
PL (1) PL174736B1 (fr)
RO (1) RO115630B1 (fr)
RU (1) RU2121999C1 (fr)
SG (1) SG47763A1 (fr)
SI (1) SI9300097B (fr)
SK (1) SK280166B6 (fr)
TW (1) TW225531B (fr)
WO (1) WO1993017017A1 (fr)
ZA (1) ZA931404B (fr)

Families Citing this family (29)

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NZ271383A (en) * 1993-08-19 1997-05-26 Janssen Pharmaceutica Nv 3,4-dihydro-2h-pyrano[2,3-b]-pyridinyl derivatives; intermediates
EP0714396B1 (fr) * 1993-08-19 2003-12-10 Janssen Pharmaceutica N.V. Derives de dihydrobenzopyrane vasoconstricteurs
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
PT707007E (pt) * 1994-10-14 2002-06-28 Merck Patent Gmbh Derivados amino(tio)eter como agentes activos no snc
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
WO1996041632A1 (fr) * 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Composition de microspheres d'amidon contre la migraine
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
CA2374905C (fr) 1999-06-02 2010-02-23 Janssen Pharmaceutica N.V. Derives de benzopyrane substitues par un pyrrolidinyle, un piperidinyle ou un homopiperidinyle permettant de traiter la relaxation fundique alteree
KR100699512B1 (ko) * 1999-06-02 2007-03-26 얀센 파마슈티카 엔.브이. 아미노알킬 치환된 (벤조디옥산, 벤조푸란 또는 벤조피란)유도체
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
ATE374192T1 (de) * 2000-11-29 2007-10-15 Lilly Co Eli 1-(2-m-methansulfonamidophenylethyl)-4-(m- trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
UA75392C2 (en) * 2001-02-23 2006-04-17 Merck & Co Inc N-substituted non-aryl heterocyclic antagonists nmda/nr2b
ES2280602T3 (es) 2001-07-26 2007-09-16 Merck Patent Gmbh Uso de 2-(5-(4-fluorofenil)-3-piridilmetilaminometil)-cromano y sus sales fisiologicamente aceptables.
DK1427724T3 (da) * 2001-09-19 2006-08-21 Merck Patent Gmbh Hidtil ukendt anvendelse af substituerede aminomethylchromaner
WO2004069296A1 (fr) * 2003-01-31 2004-08-19 Zimmer Orthobiologics Inc. Compositions de matrices hydrogel composites et procedes pour la reparation ou le traitement de tissus mammaliens
EP1464335A3 (fr) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Derivés de quinolines, tetrahydroquinolines et pyrimidines comme antagonistes du MCH
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EP2363127A1 (fr) * 2006-01-18 2011-09-07 Evolva SA Modulateurs de PPAR
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387771A2 (fr) 1989-03-13 1990-09-19 Ono Pharmaceutical Co., Ltd. Dérivés de benzopyrannes

Family Cites Families (10)

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FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
BE636238A (fr) * 1962-08-20
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
GR71865B (fr) * 1978-03-20 1983-07-07 Ciba Geigy
US4405922A (en) * 1979-05-23 1983-09-20 Hitachi Koki Company, Limited Failure detection circuit for impact printers or the like
US4405622A (en) * 1980-10-16 1983-09-20 Syntex (U.S.A.) Inc. [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CA1338012C (fr) * 1987-04-27 1996-01-30 John Michael Mccall Amines possedant des proprietes pharmaceutiques
WO1994017017A1 (fr) * 1991-07-15 1994-08-04 Exxon Research And Engineering Company Elimination du benzene des courants a limites d'ebullition de l'essence
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387771A2 (fr) 1989-03-13 1990-09-19 Ono Pharmaceutical Co., Ltd. Dérivés de benzopyrannes

Also Published As

Publication number Publication date
MX9301053A (es) 1994-03-31
SK102994A3 (en) 1995-07-11
IL104868A0 (en) 1993-06-10
HRP930235B1 (en) 1999-04-30
CS202094A3 (en) 1995-01-18
IL104868A (en) 1998-01-04
NZ249124A (en) 1995-08-28
AU664237B2 (en) 1995-11-09
AP9300493A0 (en) 1993-04-30
WO1993017017A1 (fr) 1993-09-02
HU211742A9 (en) 1995-12-28
US5624952A (en) 1997-04-29
EP0639192A1 (fr) 1995-02-22
SK280166B6 (sk) 1999-09-10
RO115630B1 (ro) 2000-04-28
PH31295A (en) 1998-07-06
AP416A (en) 1995-09-29
HUT71129A (en) 1995-11-28
FI109122B (fi) 2002-05-31
CA2117483A1 (fr) 1993-09-02
HRP930235A2 (en) 1997-10-31
BG62052B1 (bg) 1999-01-29
CA2117483C (fr) 2001-01-09
NO306255B1 (no) 1999-10-11
ES2087721T3 (es) 1996-07-16
FI943928A (fi) 1994-08-26
HU222495B1 (hu) 2003-07-28
FI943928A0 (fi) 1994-08-26
US5607949A (en) 1997-03-04
JPH07504408A (ja) 1995-05-18
NO943186L (no) 1994-08-29
JP2779268B2 (ja) 1998-07-23
ZA931404B (en) 1994-08-26
RU94041210A (ru) 1996-07-10
TW225531B (fr) 1994-06-21
LV10715B (en) 1995-12-20
US5541180A (en) 1996-07-30
ATE138064T1 (de) 1996-06-15
BG98870A (bg) 1995-03-31
EP0639192B1 (fr) 1996-05-15
DE69302687D1 (de) 1996-06-20
CN1079470A (zh) 1993-12-15
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
LV10715A (lv) 1995-06-20
OA10095A (en) 1996-12-18
NO943186D0 (no) 1994-08-29
DE69302687T2 (de) 1996-11-14
AU3499193A (en) 1993-09-13
RU2121999C1 (ru) 1998-11-20
CZ282092B6 (cs) 1997-05-14
SG47763A1 (en) 1998-04-17
US5688952A (en) 1997-11-18
SI9300097A (en) 1993-09-30
DK0639192T3 (da) 1996-08-19
GR3019927T3 (en) 1996-08-31
EE03029B1 (et) 1997-08-15
HU9402464D0 (en) 1994-10-28
MY110627A (en) 1998-09-30
SI9300097B (en) 2001-12-31
CN1038032C (zh) 1998-04-15
PL174736B1 (pl) 1998-09-30

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Effective date: 20130226