RU94041210A - [/бензодиоксан, бензофуран или бензопиран/-алкиламино]-алкилзамещенные гуанидины в качестве селективных сосудосуживающих средств, способ их получения, промежуточное для них, композиция и способ ее получения - Google Patents

[/бензодиоксан, бензофуран или бензопиран/-алкиламино]-алкилзамещенные гуанидины в качестве селективных сосудосуживающих средств, способ их получения, промежуточное для них, композиция и способ ее получения

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Publication number
RU94041210A
RU94041210A RU94041210/04A RU94041210A RU94041210A RU 94041210 A RU94041210 A RU 94041210A RU 94041210/04 A RU94041210/04 A RU 94041210/04A RU 94041210 A RU94041210 A RU 94041210A RU 94041210 A RU94041210 A RU 94041210A
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RU
Russia
Prior art keywords
alkyl
formula
ris hydrogen
ris
benzodioxane
Prior art date
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RU94041210/04A
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English (en)
Other versions
RU2121999C1 (ru
Inventor
Розалиа Ожен Ван Ломман Ги
Be]
Фран Леопольд де Брюйен Марсель
Жакобюс Жозеф Жанссен Вальтер
Original Assignee
Жансен Фармасетика Н.В. (BE)
Жансен Фармасетика Н.В.
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Application filed by Жансен Фармасетика Н.В. (BE), Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В. (BE)
Publication of RU94041210A publication Critical patent/RU94041210A/ru
Application granted granted Critical
Publication of RU2121999C1 publication Critical patent/RU2121999C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

Изобретение относится к сосудосуживающим (бензодиоксан, бензофуран или бензопиран)-алкиламино-алкил-замещенным гуанидинам формулы I, приведенной в описании, их фармацевтически приемлемым солям присоединения кислот и их стереохимически изомерным формам. Фармацевтические препараты пригодны в качестве сосудосуживающих средств. Предложены композиции, содержащие указанные производные гуанидина в качестве активных ингредиентов, способы получения вышеуказанных производных гуанидина и новый N-цианогуанидин, промежуточные соединения и использование в качестве лекарственных средств.

Claims (1)

  1. Изобретение относится к сосудосуживающим (бензодиоксан, бензофуран или бензопиран)-алкиламино-алкил-замещенным гуанидинам формулы I, приведенной в описании, их фармацевтически приемлемым солям присоединения кислот и их стереохимически изомерным формам. Фармацевтические препараты пригодны в качестве сосудосуживающих средств. Предложены композиции, содержащие указанные производные гуанидина в качестве активных ингредиентов, способы получения вышеуказанных производных гуанидина и новый N-цианогуанидин, промежуточные соединения и использование в качестве лекарственных средств.
RU94041210A 1992-02-27 1993-02-19 [(бензодиоксан, бензофуран или бензопиран)-алкиламино]-алкил-замещенные гуанидины в качестве селективных сосудосуживающих средств, способы их получения, промежуточное для них, фармацевтическая композиция и способ ее получения RU2121999C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27
US842,560 1992-02-27
US842560 1992-02-27

Publications (2)

Publication Number Publication Date
RU94041210A true RU94041210A (ru) 1996-07-10
RU2121999C1 RU2121999C1 (ru) 1998-11-20

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94041210A RU2121999C1 (ru) 1992-02-27 1993-02-19 [(бензодиоксан, бензофуран или бензопиран)-алкиламино]-алкил-замещенные гуанидины в качестве селективных сосудосуживающих средств, способы их получения, промежуточное для них, фармацевтическая композиция и способ ее получения

Country Status (37)

Country Link
US (4) US5541180A (ru)
EP (1) EP0639192B1 (ru)
JP (1) JP2779268B2 (ru)
KR (1) KR100190300B1 (ru)
CN (1) CN1038032C (ru)
AP (1) AP416A (ru)
AT (1) ATE138064T1 (ru)
AU (1) AU664237B2 (ru)
BG (1) BG62052B1 (ru)
CA (1) CA2117483C (ru)
CZ (1) CZ282092B6 (ru)
DE (1) DE69302687T2 (ru)
DK (1) DK0639192T3 (ru)
EE (1) EE03029B1 (ru)
ES (1) ES2087721T3 (ru)
FI (1) FI109122B (ru)
GR (1) GR3019927T3 (ru)
HR (1) HRP930235B1 (ru)
HU (2) HU222495B1 (ru)
IL (1) IL104868A (ru)
LT (1) LT3049B (ru)
LV (1) LV10715B (ru)
MX (1) MX9301053A (ru)
MY (1) MY110627A (ru)
NO (1) NO306255B1 (ru)
NZ (1) NZ249124A (ru)
OA (1) OA10095A (ru)
PH (1) PH31295A (ru)
PL (1) PL174736B1 (ru)
RO (1) RO115630B1 (ru)
RU (1) RU2121999C1 (ru)
SG (1) SG47763A1 (ru)
SI (1) SI9300097B (ru)
SK (1) SK280166B6 (ru)
TW (1) TW225531B (ru)
WO (1) WO1993017017A1 (ru)
ZA (1) ZA931404B (ru)

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FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
KR19990021931A (ko) * 1995-06-08 1999-03-25 디르크 반테 미세구형 전분의 항편두통 조성물
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
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Also Published As

Publication number Publication date
SI9300097A (en) 1993-09-30
NO943186L (no) 1994-08-29
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
NO943186D0 (no) 1994-08-29
HRP930235A2 (en) 1997-10-31
SK102994A3 (en) 1995-07-11
DE69302687T2 (de) 1996-11-14
GR3019927T3 (en) 1996-08-31
CN1079470A (zh) 1993-12-15
US5624952A (en) 1997-04-29
CS202094A3 (en) 1995-01-18
ZA931404B (en) 1994-08-26
JP2779268B2 (ja) 1998-07-23
SK280166B6 (sk) 1999-09-10
DK0639192T3 (da) 1996-08-19
FI109122B (fi) 2002-05-31
PH31295A (en) 1998-07-06
HUT71129A (en) 1995-11-28
CZ282092B6 (cs) 1997-05-14
SI9300097B (en) 2001-12-31
IL104868A (en) 1998-01-04
US5607949A (en) 1997-03-04
LT3049B (en) 1994-10-25
HU9402464D0 (en) 1994-10-28
AU3499193A (en) 1993-09-13
FI943928A0 (fi) 1994-08-26
FI943928A (fi) 1994-08-26
JPH07504408A (ja) 1995-05-18
CA2117483C (en) 2001-01-09
HRP930235B1 (en) 1999-04-30
AP9300493A0 (en) 1993-04-30
DE69302687D1 (de) 1996-06-20
US5688952A (en) 1997-11-18
SG47763A1 (en) 1998-04-17
NO306255B1 (no) 1999-10-11
EE03029B1 (et) 1997-08-15
PL174736B1 (pl) 1998-09-30
BG98870A (bg) 1995-03-31
ES2087721T3 (es) 1996-07-16
US5541180A (en) 1996-07-30
HU222495B1 (hu) 2003-07-28
MX9301053A (es) 1994-03-31
AU664237B2 (en) 1995-11-09
MY110627A (en) 1998-09-30
LV10715A (lv) 1995-06-20
LV10715B (en) 1995-12-20
WO1993017017A1 (en) 1993-09-02
NZ249124A (en) 1995-08-28
AP416A (en) 1995-09-29
EP0639192B1 (en) 1996-05-15
TW225531B (ru) 1994-06-21
IL104868A0 (en) 1993-06-10
RU2121999C1 (ru) 1998-11-20
BG62052B1 (bg) 1999-01-29
CN1038032C (zh) 1998-04-15
OA10095A (en) 1996-12-18
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
CA2117483A1 (en) 1993-09-02
ATE138064T1 (de) 1996-06-15
RO115630B1 (ro) 2000-04-28

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