FI943928A0 - (Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina - Google Patents

(Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina

Info

Publication number
FI943928A0
FI943928A0 FI943928A FI943928A FI943928A0 FI 943928 A0 FI943928 A0 FI 943928A0 FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A FI 943928 A0 FI943928 A0 FI 943928A0
Authority
FI
Finland
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkylamino
blood vessel
Prior art date
Application number
FI943928A
Other languages
English (en)
Swedish (sv)
Other versions
FI109122B (fi
FI943928A (fi
Inventor
Lommen Guy Rosalia Eugene Van
Bruyn Marcel Frans Leopold De
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI943928A publication Critical patent/FI943928A/fi
Publication of FI943928A0 publication Critical patent/FI943928A0/fi
Application granted granted Critical
Publication of FI109122B publication Critical patent/FI109122B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26Separation; Purification; Stabilisation; Use of additives
    • C07C319/28Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
FI943928A 1992-02-27 1994-08-26 Menetelmä verisuonia supistavana aineena käyttökelpoisten [(bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino]alkyylisubstituoitujen guanidiinien valmistamiseksi ja välituote FI109122B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27
US84256092 1992-02-27
PCT/EP1993/000435 WO1993017017A1 (en) 1992-02-27 1993-02-19 [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
EP9300435 1993-02-19

Publications (3)

Publication Number Publication Date
FI943928A FI943928A (fi) 1994-08-26
FI943928A0 true FI943928A0 (fi) 1994-08-26
FI109122B FI109122B (fi) 2002-05-31

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943928A FI109122B (fi) 1992-02-27 1994-08-26 Menetelmä verisuonia supistavana aineena käyttökelpoisten [(bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino]alkyylisubstituoitujen guanidiinien valmistamiseksi ja välituote

Country Status (37)

Country Link
US (4) US5541180A (fi)
EP (1) EP0639192B1 (fi)
JP (1) JP2779268B2 (fi)
KR (1) KR100190300B1 (fi)
CN (1) CN1038032C (fi)
AP (1) AP416A (fi)
AT (1) ATE138064T1 (fi)
AU (1) AU664237B2 (fi)
BG (1) BG62052B1 (fi)
CA (1) CA2117483C (fi)
CZ (1) CZ282092B6 (fi)
DE (1) DE69302687T2 (fi)
DK (1) DK0639192T3 (fi)
EE (1) EE03029B1 (fi)
ES (1) ES2087721T3 (fi)
FI (1) FI109122B (fi)
GR (1) GR3019927T3 (fi)
HR (1) HRP930235B1 (fi)
HU (2) HU222495B1 (fi)
IL (1) IL104868A (fi)
LT (1) LT3049B (fi)
LV (1) LV10715B (fi)
MX (1) MX9301053A (fi)
MY (1) MY110627A (fi)
NO (1) NO306255B1 (fi)
NZ (1) NZ249124A (fi)
OA (1) OA10095A (fi)
PH (1) PH31295A (fi)
PL (1) PL174736B1 (fi)
RO (1) RO115630B1 (fi)
RU (1) RU2121999C1 (fi)
SG (1) SG47763A1 (fi)
SI (1) SI9300097B (fi)
SK (1) SK280166B6 (fi)
TW (1) TW225531B (fi)
WO (1) WO1993017017A1 (fi)
ZA (1) ZA931404B (fi)

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ES2132424T3 (es) * 1993-08-19 1999-08-16 Janssen Pharmaceutica Nv Dihidropiranopiridinas sustituidas como vasoconstrictoras.
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
WO1996041632A1 (en) * 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
JP2003501428A (ja) 1999-06-02 2003-01-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロリジニル、ピペリジニルもしくはホモピペリジニル置換(ベンゾジオキサン、ベンゾフランもしくはベンゾピラン)誘導体
TR200103430T2 (tr) * 1999-06-02 2002-06-21 Janssen Pharmaceutica N.V. Aminoalkil ile ikame edilmiş (benzodioksan, benzofuran veya benzopiran) türevleri
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
EP1341777B1 (en) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence
EA005974B1 (ru) * 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
JP2004538289A (ja) 2001-07-26 2004-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 2−[5−(4−フルオロフェニル)−3−ピリジルメチルアミノメチル]−クロマンおよびその生理学的に許容し得る塩の新規な使用
PL208787B1 (pl) * 2001-09-19 2011-06-30 Merck Patent Gmbh (2R, 4R/S)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol i (2R, 4R)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol, sposoby ich otrzymywania i zastosowanie do wytwarzania preparatów medycznych oraz zawierająca je kompozycja farmaceutyczna
EP1594558A1 (en) * 2003-01-31 2005-11-16 Zimmer Orthobiologics, Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EP2363127A1 (en) * 2006-01-18 2011-09-07 Evolva SA PPAR Modulators
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森(商丘)药业有限公司 一种硫酸胍生合成方法

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Also Published As

Publication number Publication date
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
HUT71129A (en) 1995-11-28
NO306255B1 (no) 1999-10-11
EP0639192A1 (en) 1995-02-22
MX9301053A (es) 1994-03-31
EE03029B1 (et) 1997-08-15
RU2121999C1 (ru) 1998-11-20
BG62052B1 (bg) 1999-01-29
LV10715B (en) 1995-12-20
SI9300097A (en) 1993-09-30
WO1993017017A1 (en) 1993-09-02
HU9402464D0 (en) 1994-10-28
DE69302687T2 (de) 1996-11-14
RO115630B1 (ro) 2000-04-28
HU211742A9 (en) 1995-12-28
RU94041210A (ru) 1996-07-10
LV10715A (lv) 1995-06-20
CN1038032C (zh) 1998-04-15
OA10095A (en) 1996-12-18
DE69302687D1 (de) 1996-06-20
NO943186L (no) 1994-08-29
TW225531B (fi) 1994-06-21
SI9300097B (en) 2001-12-31
US5607949A (en) 1997-03-04
PH31295A (en) 1998-07-06
ES2087721T3 (es) 1996-07-16
CA2117483C (en) 2001-01-09
AP416A (en) 1995-09-29
FI109122B (fi) 2002-05-31
SK102994A3 (en) 1995-07-11
IL104868A (en) 1998-01-04
HU222495B1 (hu) 2003-07-28
DK0639192T3 (da) 1996-08-19
MY110627A (en) 1998-09-30
PL174736B1 (pl) 1998-09-30
US5541180A (en) 1996-07-30
FI943928A (fi) 1994-08-26
GR3019927T3 (en) 1996-08-31
IL104868A0 (en) 1993-06-10
LT3049B (en) 1994-10-25
JP2779268B2 (ja) 1998-07-23
CZ282092B6 (cs) 1997-05-14
BG98870A (bg) 1995-03-31
US5688952A (en) 1997-11-18
NO943186D0 (no) 1994-08-29
SG47763A1 (en) 1998-04-17
ATE138064T1 (de) 1996-06-15
CA2117483A1 (en) 1993-09-02
AP9300493A0 (en) 1993-04-30
CN1079470A (zh) 1993-12-15
US5624952A (en) 1997-04-29
EP0639192B1 (en) 1996-05-15
AU664237B2 (en) 1995-11-09
NZ249124A (en) 1995-08-28
ZA931404B (en) 1994-08-26
HRP930235B1 (en) 1999-04-30
HRP930235A2 (en) 1997-10-31
SK280166B6 (sk) 1999-09-10
JPH07504408A (ja) 1995-05-18
AU3499193A (en) 1993-09-13
CS202094A3 (en) 1995-01-18

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