DK0639192T3 - (Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning - Google Patents
(Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkningInfo
- Publication number
- DK0639192T3 DK0639192T3 DK93904017.6T DK93904017T DK0639192T3 DK 0639192 T3 DK0639192 T3 DK 0639192T3 DK 93904017 T DK93904017 T DK 93904017T DK 0639192 T3 DK0639192 T3 DK 0639192T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzodioxane
- benzopyran
- benzofuran
- alkyl substituted
- alkylamino alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Phenolic Resins Or Amino Resins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84256092A | 1992-02-27 | 1992-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0639192T3 true DK0639192T3 (da) | 1996-08-19 |
Family
ID=25287639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93904017.6T DK0639192T3 (da) | 1992-02-27 | 1993-02-19 | (Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US5541180A (da) |
| EP (1) | EP0639192B1 (da) |
| JP (1) | JP2779268B2 (da) |
| KR (1) | KR100190300B1 (da) |
| CN (1) | CN1038032C (da) |
| AP (1) | AP416A (da) |
| AT (1) | ATE138064T1 (da) |
| AU (1) | AU664237B2 (da) |
| BG (1) | BG62052B1 (da) |
| CA (1) | CA2117483C (da) |
| CZ (1) | CZ282092B6 (da) |
| DE (1) | DE69302687T2 (da) |
| DK (1) | DK0639192T3 (da) |
| EE (1) | EE03029B1 (da) |
| ES (1) | ES2087721T3 (da) |
| FI (1) | FI109122B (da) |
| GR (1) | GR3019927T3 (da) |
| HR (1) | HRP930235B1 (da) |
| HU (2) | HU222495B1 (da) |
| IL (1) | IL104868A (da) |
| LT (1) | LT3049B (da) |
| LV (1) | LV10715B (da) |
| MX (1) | MX9301053A (da) |
| MY (1) | MY110627A (da) |
| NO (1) | NO306255B1 (da) |
| NZ (1) | NZ249124A (da) |
| OA (1) | OA10095A (da) |
| PH (1) | PH31295A (da) |
| PL (1) | PL174736B1 (da) |
| RO (1) | RO115630B1 (da) |
| RU (1) | RU2121999C1 (da) |
| SG (1) | SG47763A1 (da) |
| SI (1) | SI9300097B (da) |
| SK (1) | SK280166B6 (da) |
| TW (1) | TW225531B (da) |
| WO (1) | WO1993017017A1 (da) |
| ZA (1) | ZA931404B (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100330697B1 (ko) * | 1993-08-19 | 2002-10-04 | 얀센 파마슈티카 엔.브이. | 혈관수축성치환된디하이드로피라노피리딘 |
| DE69433401T2 (de) * | 1993-08-19 | 2004-09-16 | Janssen Pharmaceutica N.V. | Gefässverengende dihydrobenzopyranderivate |
| PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
| US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
| FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| KR19990021931A (ko) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | 미세구형 전분의 항편두통 조성물 |
| FR2752735B1 (fr) * | 1996-09-05 | 1998-10-02 | Synthelabo | Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| EP1187829B1 (en) * | 1999-06-02 | 2003-12-10 | Janssen Pharmaceutica N.V. | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
| CZ20014167A3 (cs) | 1999-06-02 | 2002-06-12 | Janssen Pharmaceutica N. V. | Pyrrolidinylem, piperidinylem nebo homopiperidinylem substituované deriváty benzodioxanu, benzofuranu nebo benzopyranu |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| JO2352B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| EP1341777B1 (en) * | 2000-11-29 | 2007-09-26 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence |
| US7217716B2 (en) * | 2001-02-23 | 2007-05-15 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists |
| CN1292749C (zh) | 2001-07-26 | 2007-01-03 | 默克专利股份有限公司 | 2－[5－(4－氟苯基)－3－吡啶基甲氨基甲基]苯并二氢吡喃及其生理学上可接受的盐的新用途 |
| PT1427724E (pt) * | 2001-09-19 | 2006-09-29 | Merck Patent Gmbh | Utilizacao nova de aminometilcromanos substituidos |
| JP2006518256A (ja) * | 2003-01-31 | 2006-08-10 | ジンマー オーソバイオロジクス，インコーポレイティド | 髄核組織（ｎｕｃｌｅｕｓｐｕｌｐｏｓｕｓｔｉｓｓｕｅ）を含むヒドロゲル組成物 |
| EP1464335A3 (en) * | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
| CN100451004C (zh) * | 2003-03-31 | 2009-01-14 | 大正制药株式会社 | 嘧啶衍生物 |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| CA2637803A1 (en) * | 2006-01-18 | 2007-12-06 | Evolva Sa | Ppar modulators |
| CN105061392B (zh) * | 2015-07-20 | 2017-07-18 | 上海现代哈森（商丘）药业有限公司 | 一种硫酸胍生合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1366479A (fr) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels |
| BE636238A (da) * | 1962-08-20 | |||
| GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GR71865B (da) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
| US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| FR2524887A1 (fr) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
| CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| WO1994017017A1 (en) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Benzene removal from gasoline boiling range streams |
| DE4303657A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/sl unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-19 CA CA002117483A patent/CA2117483C/en not_active Expired - Lifetime
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/en active IP Right Grant
- 1993-02-19 HU HU9402464A patent/HU222495B1/hu active IP Right Grant
- 1993-02-19 JP JP5514541A patent/JP2779268B2/ja not_active Expired - Lifetime
- 1993-02-19 AT AT93904017T patent/ATE138064T1/de active
- 1993-02-19 PL PL93304902A patent/PL174736B1/pl unknown
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/ko not_active IP Right Cessation
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/da active
- 1993-02-19 RO RO94-01432A patent/RO115630B1/ro unknown
- 1993-02-19 DE DE69302687T patent/DE69302687T2/de not_active Expired - Lifetime
- 1993-02-19 RU RU94041210A patent/RU2121999C1/ru active
- 1993-02-19 SK SK1029-94A patent/SK280166B6/sk not_active IP Right Cessation
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 NZ NZ249124A patent/NZ249124A/xx not_active IP Right Cessation
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/cs unknown
- 1993-02-19 EP EP93904017A patent/EP0639192B1/en not_active Expired - Lifetime
- 1993-02-19 ES ES93904017T patent/ES2087721T3/es not_active Expired - Lifetime
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/xx not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/es unknown
- 1993-02-26 LT LTIP367A patent/LT3049B/lt not_active IP Right Cessation
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-26 ZA ZA931404A patent/ZA931404B/xx unknown
- 1993-02-26 CN CN93103671A patent/CN1038032C/zh not_active Expired - Lifetime
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
-
1994
- 1994-06-24 BG BG98870A patent/BG62052B1/bg not_active Expired - Lifetime
- 1994-08-19 OA OA60555A patent/OA10095A/fr unknown
- 1994-08-26 FI FI943928A patent/FI109122B/fi not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/no not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/xx unknown
-
1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/hu unknown
-
1996
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/el unknown
Also Published As
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