NO943186L - [(Benzodioksan, benzofuran eller benzopyran)-alkylaminoÅ-alkylsubstituert guanidiner som selektive vasokonstriktorer - Google Patents

[(Benzodioksan, benzofuran eller benzopyran)-alkylaminoÅ-alkylsubstituert guanidiner som selektive vasokonstriktorer

Info

Publication number
NO943186L
NO943186L NO943186A NO943186A NO943186L NO 943186 L NO943186 L NO 943186L NO 943186 A NO943186 A NO 943186A NO 943186 A NO943186 A NO 943186A NO 943186 L NO943186 L NO 943186L
Authority
NO
Norway
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkylamino
alkyl
Prior art date
Application number
NO943186A
Other languages
English (en)
Other versions
NO306255B1 (no
NO943186D0 (no
Inventor
Guy Rosalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO943186L publication Critical patent/NO943186L/no
Publication of NO943186D0 publication Critical patent/NO943186D0/no
Publication of NO306255B1 publication Critical patent/NO306255B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
NO943186A 1992-02-27 1994-08-29 [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer NO306255B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27
PCT/EP1993/000435 WO1993017017A1 (en) 1992-02-27 1993-02-19 [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors

Publications (3)

Publication Number Publication Date
NO943186L true NO943186L (no) 1994-08-29
NO943186D0 NO943186D0 (no) 1994-08-29
NO306255B1 NO306255B1 (no) 1999-10-11

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943186A NO306255B1 (no) 1992-02-27 1994-08-29 [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer

Country Status (37)

Country Link
US (4) US5541180A (no)
EP (1) EP0639192B1 (no)
JP (1) JP2779268B2 (no)
KR (1) KR100190300B1 (no)
CN (1) CN1038032C (no)
AP (1) AP416A (no)
AT (1) ATE138064T1 (no)
AU (1) AU664237B2 (no)
BG (1) BG62052B1 (no)
CA (1) CA2117483C (no)
CZ (1) CZ282092B6 (no)
DE (1) DE69302687T2 (no)
DK (1) DK0639192T3 (no)
EE (1) EE03029B1 (no)
ES (1) ES2087721T3 (no)
FI (1) FI109122B (no)
GR (1) GR3019927T3 (no)
HR (1) HRP930235B1 (no)
HU (2) HU222495B1 (no)
IL (1) IL104868A (no)
LT (1) LT3049B (no)
LV (1) LV10715B (no)
MX (1) MX9301053A (no)
MY (1) MY110627A (no)
NO (1) NO306255B1 (no)
NZ (1) NZ249124A (no)
OA (1) OA10095A (no)
PH (1) PH31295A (no)
PL (1) PL174736B1 (no)
RO (1) RO115630B1 (no)
RU (1) RU2121999C1 (no)
SG (1) SG47763A1 (no)
SI (1) SI9300097B (no)
SK (1) SK280166B6 (no)
TW (1) TW225531B (no)
WO (1) WO1993017017A1 (no)
ZA (1) ZA931404B (no)

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US5824682A (en) * 1993-08-18 1998-10-20 Janssen Pharmaceutica, N.V. Vasoconstrictive dihydrobenzopyran derivatives
ES2132424T3 (es) * 1993-08-19 1999-08-16 Janssen Pharmaceutica Nv Dihidropiranopiridinas sustituidas como vasoconstrictoras.
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
WO1996041632A1 (en) * 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
JP2003501428A (ja) 1999-06-02 2003-01-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロリジニル、ピペリジニルもしくはホモピペリジニル置換（ベンゾジオキサン、ベンゾフランもしくはベンゾピラン）誘導体
TR200103430T2 (tr) * 1999-06-02 2002-06-21 Janssen Pharmaceutica N.V. Aminoalkil ile ikame edilmiş (benzodioksan, benzofuran veya benzopiran) türevleri
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
EP1341777B1 (en) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence
EA005974B1 (ru) * 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
JP2004538289A (ja) 2001-07-26 2004-12-24 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ２−［５−（４−フルオロフェニル）−３−ピリジルメチルアミノメチル］−クロマンおよびその生理学的に許容し得る塩の新規な使用
PL208787B1 (pl) * 2001-09-19 2011-06-30 Merck Patent Gmbh (2R, 4R/S)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol i (2R, 4R)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol, sposoby ich otrzymywania i zastosowanie do wytwarzania preparatów medycznych oraz zawierająca je kompozycja farmaceutyczna
EP1594558A1 (en) * 2003-01-31 2005-11-16 Zimmer Orthobiologics, Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EP2363127A1 (en) * 2006-01-18 2011-09-07 Evolva SA PPAR Modulators
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

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FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
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FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
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WO1994017017A1 (en) * 1991-07-15 1994-08-04 Exxon Research And Engineering Company Benzene removal from gasoline boiling range streams
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
HUT71129A (en) 1995-11-28
NO306255B1 (no) 1999-10-11
EP0639192A1 (en) 1995-02-22
MX9301053A (es) 1994-03-31
EE03029B1 (et) 1997-08-15
RU2121999C1 (ru) 1998-11-20
BG62052B1 (bg) 1999-01-29
LV10715B (en) 1995-12-20
SI9300097A (en) 1993-09-30
WO1993017017A1 (en) 1993-09-02
HU9402464D0 (en) 1994-10-28
DE69302687T2 (de) 1996-11-14
RO115630B1 (ro) 2000-04-28
HU211742A9 (en) 1995-12-28
RU94041210A (ru) 1996-07-10
LV10715A (lv) 1995-06-20
CN1038032C (zh) 1998-04-15
OA10095A (en) 1996-12-18
DE69302687D1 (de) 1996-06-20
TW225531B (no) 1994-06-21
SI9300097B (en) 2001-12-31
US5607949A (en) 1997-03-04
PH31295A (en) 1998-07-06
ES2087721T3 (es) 1996-07-16
CA2117483C (en) 2001-01-09
AP416A (en) 1995-09-29
FI109122B (fi) 2002-05-31
SK102994A3 (en) 1995-07-11
IL104868A (en) 1998-01-04
HU222495B1 (hu) 2003-07-28
DK0639192T3 (da) 1996-08-19
MY110627A (en) 1998-09-30
PL174736B1 (pl) 1998-09-30
US5541180A (en) 1996-07-30
FI943928A (fi) 1994-08-26
GR3019927T3 (en) 1996-08-31
IL104868A0 (en) 1993-06-10
LT3049B (en) 1994-10-25
JP2779268B2 (ja) 1998-07-23
CZ282092B6 (cs) 1997-05-14
BG98870A (bg) 1995-03-31
US5688952A (en) 1997-11-18
NO943186D0 (no) 1994-08-29
SG47763A1 (en) 1998-04-17
ATE138064T1 (de) 1996-06-15
CA2117483A1 (en) 1993-09-02
AP9300493A0 (en) 1993-04-30
CN1079470A (zh) 1993-12-15
US5624952A (en) 1997-04-29
EP0639192B1 (en) 1996-05-15
AU664237B2 (en) 1995-11-09
NZ249124A (en) 1995-08-28
FI943928A0 (fi) 1994-08-26
ZA931404B (en) 1994-08-26
HRP930235B1 (en) 1999-04-30
HRP930235A2 (en) 1997-10-31
SK280166B6 (sk) 1999-09-10
JPH07504408A (ja) 1995-05-18
AU3499193A (en) 1993-09-13
CS202094A3 (en) 1995-01-18

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