LTIP367A - [benzodioksano, benzofurano ar benzopirano)alkilamino] alkilpakeisti guanidinai - Google Patents

[benzodioksano, benzofurano ar benzopirano)alkilamino] alkilpakeisti guanidinai

Info

Publication number
LTIP367A
LTIP367A LTIP367A LTIP367A LTIP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A
Authority
LT
Lithuania
Prior art keywords
radical
alkyl
hydrogen
benzopyran
benzofuran
Prior art date
Application number
LTIP367A
Other languages
English (en)
Inventor
Rosalia Eugene Guy VANLOMMEN
Frans Leopold Marcel Debruyn
Jacobus Joseph Walter JANSSENS
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of LTIP367A publication Critical patent/LTIP367A/lt
Publication of LT3049B publication Critical patent/LT3049B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pyrane Compounds (AREA)

Abstract

Šis išradimas siejamas su [(benzodioksano, benzofurano arba benzopirano) alkil-pakeistais guanidinais, turinčiais formulę@@@@@jų farmacijai tinkančiomis druskomis su rūgštimis bei jų stereocheminėmisizomerinėmis formomis, kurioje X yra O, CH2 arba jungtis.@R yra vandenilis, halogeno C1-6 alkilo, C1-4 alkoksi, hidroksi, ciano, karboksilo, C1-4, alkoksikarbonilo arba aminokarbonilo radikalas,@R1 yra vandenilis arba C1-6 alkilas,@R2 ir R3 atskirai yra vandenilis arba C1-6 alkilas, arba kartu gali sudaryti dvivalentį -(CH2)m-radikalą, kuriame m yra 4 arba 5, @arba@R1 ir R2 kartu gali sudaryti dvivalentį -(CH2)n-arba -CH=CH- radikalą, kur n yra 2,3 arba 4,@arba R3 gali būti laisva jungtis , o R1 ir R2 kartu gali sudaryti radikalą =CH-CH=CH-,@R4 yra vandenilis arba C1-6 alkilas,@Alk1 yra dvivalentis C1-3 alkandiilo radikalas,@A yra dvivalentis radikalas, turintis du azoto atomus;@su vaistais, kurie naudingi kaip vazokonstriktoriai su preparatais, į kuriuos kaip aktyvūs komponentai įeina minėti guanidino dariniai, ir su šių guanidino darinių bei preparatų gamybos metodais; ir su vazodiletacijos sukeliamų ligų gydymo metodu.
LTIP367A 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines LT3049B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (2)

Publication Number Publication Date
LTIP367A true LTIP367A (lt) 1994-04-25
LT3049B LT3049B (en) 1994-10-25

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP367A LT3049B (en) 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines

Country Status (37)

Country Link
US (4) US5541180A (lt)
EP (1) EP0639192B1 (lt)
JP (1) JP2779268B2 (lt)
KR (1) KR100190300B1 (lt)
CN (1) CN1038032C (lt)
AP (1) AP416A (lt)
AT (1) ATE138064T1 (lt)
AU (1) AU664237B2 (lt)
BG (1) BG62052B1 (lt)
CA (1) CA2117483C (lt)
CZ (1) CZ282092B6 (lt)
DE (1) DE69302687T2 (lt)
DK (1) DK0639192T3 (lt)
EE (1) EE03029B1 (lt)
ES (1) ES2087721T3 (lt)
FI (1) FI109122B (lt)
GR (1) GR3019927T3 (lt)
HR (1) HRP930235B1 (lt)
HU (2) HU222495B1 (lt)
IL (1) IL104868A (lt)
LT (1) LT3049B (lt)
LV (1) LV10715B (lt)
MX (1) MX9301053A (lt)
MY (1) MY110627A (lt)
NO (1) NO306255B1 (lt)
NZ (1) NZ249124A (lt)
OA (1) OA10095A (lt)
PH (1) PH31295A (lt)
PL (1) PL174736B1 (lt)
RO (1) RO115630B1 (lt)
RU (1) RU2121999C1 (lt)
SG (1) SG47763A1 (lt)
SI (1) SI9300097B (lt)
SK (1) SK280166B6 (lt)
TW (1) TW225531B (lt)
WO (1) WO1993017017A1 (lt)
ZA (1) ZA931404B (lt)

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SK282402B6 (sk) * 1993-08-19 2002-01-07 Janssen Pharmaceutica N. V. Deriváty dihydrobenzopyránu, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutický prostriedok na ich báze
BR9407298A (pt) * 1993-08-19 1996-10-01 Janssen Pharmaceutica Nv Diidropiranopiridinas vasoconstritoras substituidas
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
AU6003896A (en) * 1995-06-08 1997-01-09 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
HUP0201404A3 (en) * 1999-06-02 2005-02-28 Janssen Pharmaceutica Nv Aminoalkyl substituted benzodioxan, benzofuran or benzopyran derivatives, pharmaceutical compositions containing them and their use and process for their preparations
DE60014896T2 (de) 1999-06-02 2006-02-02 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl oder homopiperidinyl substituierte (benzodioxan, benzofuran oder benzopyran) derivate
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
ATE374192T1 (de) * 2000-11-29 2007-10-15 Lilly Co Eli 1-(2-m-methansulfonamidophenylethyl)-4-(m- trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
SI1379520T1 (sl) * 2001-02-23 2006-08-31 Merck & Co Inc N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti
CA2455621C (en) 2001-07-26 2010-11-16 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of (r/s)-(-/+) or (s)-(+)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane for the treatment of extrapyramidal movement disorders
AU2002331229B2 (en) * 2001-09-19 2008-05-15 Merck Patent Gmbh Novel use of substituted aminomethyl chromans
AU2004208821B2 (en) * 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
ZA200507112B (en) * 2003-03-31 2007-03-28 Taisho Pharmaceutical Co Ltd Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US20110178112A1 (en) * 2006-01-18 2011-07-21 Evolva Sa PPAR Modulators
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

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DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
EE03029B1 (et) 1997-08-15
KR100190300B1 (ko) 1999-06-01
LT3049B (en) 1994-10-25
ZA931404B (en) 1994-08-26
HUT71129A (en) 1995-11-28
BG98870A (bg) 1995-03-31
MY110627A (en) 1998-09-30
PL174736B1 (pl) 1998-09-30
NO306255B1 (no) 1999-10-11
US5624952A (en) 1997-04-29
CN1038032C (zh) 1998-04-15
WO1993017017A1 (en) 1993-09-02
RU94041210A (ru) 1996-07-10
JP2779268B2 (ja) 1998-07-23
AU3499193A (en) 1993-09-13
SG47763A1 (en) 1998-04-17
TW225531B (lt) 1994-06-21
AU664237B2 (en) 1995-11-09
NO943186L (no) 1994-08-29
CA2117483C (en) 2001-01-09
CZ282092B6 (cs) 1997-05-14
AP9300493A0 (en) 1993-04-30
JPH07504408A (ja) 1995-05-18
FI943928A (fi) 1994-08-26
NO943186D0 (no) 1994-08-29
SI9300097B (en) 2001-12-31
DK0639192T3 (da) 1996-08-19
CA2117483A1 (en) 1993-09-02
HU9402464D0 (en) 1994-10-28
GR3019927T3 (en) 1996-08-31
HRP930235A2 (en) 1997-10-31
RU2121999C1 (ru) 1998-11-20
HU222495B1 (hu) 2003-07-28
SI9300097A (en) 1993-09-30
DE69302687T2 (de) 1996-11-14
SK280166B6 (sk) 1999-09-10
EP0639192A1 (en) 1995-02-22
SK102994A3 (en) 1995-07-11
OA10095A (en) 1996-12-18
DE69302687D1 (de) 1996-06-20
CN1079470A (zh) 1993-12-15
EP0639192B1 (en) 1996-05-15
PH31295A (en) 1998-07-06
US5607949A (en) 1997-03-04
RO115630B1 (ro) 2000-04-28
US5688952A (en) 1997-11-18
HU211742A9 (en) 1995-12-28
IL104868A (en) 1998-01-04
HRP930235B1 (en) 1999-04-30
ATE138064T1 (de) 1996-06-15
AP416A (en) 1995-09-29
IL104868A0 (en) 1993-06-10
FI109122B (fi) 2002-05-31
US5541180A (en) 1996-07-30
LV10715B (en) 1995-12-20
LV10715A (lv) 1995-06-20
FI943928A0 (fi) 1994-08-26
BG62052B1 (bg) 1999-01-29
NZ249124A (en) 1995-08-28
ES2087721T3 (es) 1996-07-16
MX9301053A (es) 1994-03-31
CS202094A3 (en) 1995-01-18

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Effective date: 20130226