LTIP367A - [benzodioksano, benzofurano ar benzopirano)alkilamino] alkilpakeisti guanidinai - Google Patents

[benzodioksano, benzofurano ar benzopirano)alkilamino] alkilpakeisti guanidinai

Info

Publication number
LTIP367A
LTIP367A LTIP367A LTIP367A LTIP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A
Authority
LT
Lithuania
Prior art keywords
radical
alkyl
hydrogen
benzopyran
benzofuran
Prior art date
Application number
LTIP367A
Other languages
English (en)
Inventor
Rosalia Eugene Guy VANLOMMEN
Frans Leopold Marcel Debruyn
Jacobus Joseph Walter JANSSENS
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of LTIP367A publication Critical patent/LTIP367A/lt
Publication of LT3049B publication Critical patent/LT3049B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26Separation; Purification; Stabilisation; Use of additives
    • C07C319/28Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Šis išradimas siejamas su [(benzodioksano, benzofurano arba benzopirano) alkil-pakeistais guanidinais, turinčiais formulę@@@@@jų farmacijai tinkančiomis druskomis su rūgštimis bei jų stereocheminėmisizomerinėmis formomis, kurioje X yra O, CH2 arba jungtis.@R yra vandenilis, halogeno C1-6 alkilo, C1-4 alkoksi, hidroksi, ciano, karboksilo, C1-4, alkoksikarbonilo arba aminokarbonilo radikalas,@R1 yra vandenilis arba C1-6 alkilas,@R2 ir R3 atskirai yra vandenilis arba C1-6 alkilas, arba kartu gali sudaryti dvivalentį -(CH2)m-radikalą, kuriame m yra 4 arba 5, @arba@R1 ir R2 kartu gali sudaryti dvivalentį -(CH2)n-arba -CH=CH- radikalą, kur n yra 2,3 arba 4,@arba R3 gali būti laisva jungtis , o R1 ir R2 kartu gali sudaryti radikalą =CH-CH=CH-,@R4 yra vandenilis arba C1-6 alkilas,@Alk1 yra dvivalentis C1-3 alkandiilo radikalas,@A yra dvivalentis radikalas, turintis du azoto atomus;@su vaistais, kurie naudingi kaip vazokonstriktoriai su preparatais, į kuriuos kaip aktyvūs komponentai įeina minėti guanidino dariniai, ir su šių guanidino darinių bei preparatų gamybos metodais; ir su vazodiletacijos sukeliamų ligų gydymo metodu.
LTIP367A 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines LT3049B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (2)

Publication Number Publication Date
LTIP367A true LTIP367A (lt) 1994-04-25
LT3049B LT3049B (en) 1994-10-25

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP367A LT3049B (en) 1992-02-27 1993-02-26 £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines

Country Status (37)

Country Link
US (4) US5541180A (lt)
EP (1) EP0639192B1 (lt)
JP (1) JP2779268B2 (lt)
KR (1) KR100190300B1 (lt)
CN (1) CN1038032C (lt)
AP (1) AP416A (lt)
AT (1) ATE138064T1 (lt)
AU (1) AU664237B2 (lt)
BG (1) BG62052B1 (lt)
CA (1) CA2117483C (lt)
CZ (1) CZ282092B6 (lt)
DE (1) DE69302687T2 (lt)
DK (1) DK0639192T3 (lt)
EE (1) EE03029B1 (lt)
ES (1) ES2087721T3 (lt)
FI (1) FI109122B (lt)
GR (1) GR3019927T3 (lt)
HR (1) HRP930235B1 (lt)
HU (2) HU222495B1 (lt)
IL (1) IL104868A (lt)
LT (1) LT3049B (lt)
LV (1) LV10715B (lt)
MX (1) MX9301053A (lt)
MY (1) MY110627A (lt)
NO (1) NO306255B1 (lt)
NZ (1) NZ249124A (lt)
OA (1) OA10095A (lt)
PH (1) PH31295A (lt)
PL (1) PL174736B1 (lt)
RO (1) RO115630B1 (lt)
RU (1) RU2121999C1 (lt)
SG (1) SG47763A1 (lt)
SI (1) SI9300097B (lt)
SK (1) SK280166B6 (lt)
TW (1) TW225531B (lt)
WO (1) WO1993017017A1 (lt)
ZA (1) ZA931404B (lt)

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AU677428B2 (en) * 1993-08-19 1997-04-24 Janssen Pharmaceutica N.V. Vasoconstrictive dihydrobenzopyran derivatives
ATE178330T1 (de) * 1993-08-19 1999-04-15 Janssen Pharmaceutica Nv Gefässverengende subtituierte dihydropyranopyridine
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
AU6003896A (en) * 1995-06-08 1997-01-09 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
RU2134108C1 (ru) * 1998-10-06 1999-08-10 Заславская Рина Михайловна Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии
FR2787789B1 (fr) * 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
EP1187831B1 (en) * 1999-06-02 2004-10-13 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
MXPA01012330A (es) * 1999-06-02 2002-07-30 Janssen Pharmaceutica Nv Derivados (benzodioxano, benzofurano o benzopirano) aminoalquil sustituidos.
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JP2004517081A (ja) * 2000-11-29 2004-06-10 イーライ・リリー・アンド・カンパニー 1−(2−m−メタンスルホンアミドフェニルエチル)−4−(m−トリフルオロメチルフェニル)ピペラジンならびにその医薬的に許容しうる塩および溶媒和物
HUP0303258A3 (en) * 2001-02-23 2004-06-28 Merck & Co Inc N-substituted nonaryl-heterocyclic nmda/nr2b antagonists and pharmaceutical compositions containing them
MXPA04000775A (es) 2001-07-26 2004-04-20 Merck Patent Ges Mit Baschrank Uso novedoso del 2 -[5-(4-fluorofenil) -3-piridilmetilamino-metil] -cromano y sus sales fisiologicamente aceptables.
EP1427724B1 (en) * 2001-09-19 2006-05-03 MERCK PATENT GmbH Novel use of substituted aminomethyl chromans
WO2004069296A1 (en) * 2003-01-31 2004-08-19 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
CN100451004C (zh) * 2003-03-31 2009-01-14 大正制药株式会社 嘧啶衍生物
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森(商丘)药业有限公司 一种硫酸胍生合成方法

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DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
US5607949A (en) 1997-03-04
SK102994A3 (en) 1995-07-11
NO306255B1 (no) 1999-10-11
JP2779268B2 (ja) 1998-07-23
US5541180A (en) 1996-07-30
CA2117483A1 (en) 1993-09-02
RU94041210A (ru) 1996-07-10
HRP930235A2 (en) 1997-10-31
CN1038032C (zh) 1998-04-15
WO1993017017A1 (en) 1993-09-02
LV10715B (en) 1995-12-20
CN1079470A (zh) 1993-12-15
EP0639192B1 (en) 1996-05-15
AU3499193A (en) 1993-09-13
DE69302687T2 (de) 1996-11-14
HU211742A9 (en) 1995-12-28
AP9300493A0 (en) 1993-04-30
HU222495B1 (hu) 2003-07-28
SI9300097B (en) 2001-12-31
LV10715A (lv) 1995-06-20
NO943186L (no) 1994-08-29
CA2117483C (en) 2001-01-09
DK0639192T3 (da) 1996-08-19
RU2121999C1 (ru) 1998-11-20
DE69302687D1 (de) 1996-06-20
CZ282092B6 (cs) 1997-05-14
EP0639192A1 (en) 1995-02-22
US5624952A (en) 1997-04-29
SI9300097A (en) 1993-09-30
MY110627A (en) 1998-09-30
FI943928A0 (fi) 1994-08-26
HU9402464D0 (en) 1994-10-28
EE03029B1 (et) 1997-08-15
RO115630B1 (ro) 2000-04-28
SG47763A1 (en) 1998-04-17
BG62052B1 (bg) 1999-01-29
ATE138064T1 (de) 1996-06-15
FI943928A7 (fi) 1994-08-26
US5688952A (en) 1997-11-18
TW225531B (lt) 1994-06-21
NO943186D0 (no) 1994-08-29
LT3049B (en) 1994-10-25
HUT71129A (en) 1995-11-28
HRP930235B1 (en) 1999-04-30
PL174736B1 (pl) 1998-09-30
FI109122B (fi) 2002-05-31
BG98870A (bg) 1995-03-31
IL104868A (en) 1998-01-04
AP416A (en) 1995-09-29
KR100190300B1 (ko) 1999-06-01
PH31295A (en) 1998-07-06
JPH07504408A (ja) 1995-05-18
OA10095A (en) 1996-12-18
CS202094A3 (en) 1995-01-18
MX9301053A (es) 1994-03-31
AU664237B2 (en) 1995-11-09
ES2087721T3 (es) 1996-07-16
GR3019927T3 (en) 1996-08-31
NZ249124A (en) 1995-08-28
SK280166B6 (sk) 1999-09-10
ZA931404B (en) 1994-08-26
IL104868A0 (en) 1993-06-10

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Effective date: 20130226