EE03029B1 - [(Bensodioksaan-, bensofuraan- või bensopüraan-)alküülamino]-alküülasendatud guanidiinid, nende valmistamismeetodid, soolad ja kompositsioonid - Google Patents

[(Bensodioksaan-, bensofuraan- või bensopüraan-)alküülamino]-alküülasendatud guanidiinid, nende valmistamismeetodid, soolad ja kompositsioonid

Info

Publication number
EE03029B1
EE03029B1 EE9400432A EE9400432A EE03029B1 EE 03029 B1 EE03029 B1 EE 03029B1 EE 9400432 A EE9400432 A EE 9400432A EE 9400432 A EE9400432 A EE 9400432A EE 03029 B1 EE03029 B1 EE 03029B1
Authority
EE
Estonia
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkylamino
salts
Prior art date
Application number
EE9400432A
Other languages
English (en)
Estonian (et)
Inventor
Rosalie Eug�ne Van Lommen Guy
Frans Leopold De Bruyn Marcel
Jacobus Joseph Janssens Walter
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE03029B1 publication Critical patent/EE03029B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
EE9400432A 1992-02-27 1994-11-21 [(Bensodioksaan-, bensofuraan- või bensopüraan-)alküülamino]-alküülasendatud guanidiinid, nende valmistamismeetodid, soolad ja kompositsioonid EE03029B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (1)

Publication Number Publication Date
EE03029B1 true EE03029B1 (et) 1997-08-15

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400432A EE03029B1 (et) 1992-02-27 1994-11-21 [(Bensodioksaan-, bensofuraan- või bensopüraan-)alküülamino]-alküülasendatud guanidiinid, nende valmistamismeetodid, soolad ja kompositsioonid

Country Status (37)

Country Link
US (4) US5541180A (lt)
EP (1) EP0639192B1 (lt)
JP (1) JP2779268B2 (lt)
KR (1) KR100190300B1 (lt)
CN (1) CN1038032C (lt)
AP (1) AP416A (lt)
AT (1) ATE138064T1 (lt)
AU (1) AU664237B2 (lt)
BG (1) BG62052B1 (lt)
CA (1) CA2117483C (lt)
CZ (1) CZ282092B6 (lt)
DE (1) DE69302687T2 (lt)
DK (1) DK0639192T3 (lt)
EE (1) EE03029B1 (lt)
ES (1) ES2087721T3 (lt)
FI (1) FI109122B (lt)
GR (1) GR3019927T3 (lt)
HR (1) HRP930235B1 (lt)
HU (2) HU222495B1 (lt)
IL (1) IL104868A (lt)
LT (1) LT3049B (lt)
LV (1) LV10715B (lt)
MX (1) MX9301053A (lt)
MY (1) MY110627A (lt)
NO (1) NO306255B1 (lt)
NZ (1) NZ249124A (lt)
OA (1) OA10095A (lt)
PH (1) PH31295A (lt)
PL (1) PL174736B1 (lt)
RO (1) RO115630B1 (lt)
RU (1) RU2121999C1 (lt)
SG (1) SG47763A1 (lt)
SI (1) SI9300097B (lt)
SK (1) SK280166B6 (lt)
TW (1) TW225531B (lt)
WO (1) WO1993017017A1 (lt)
ZA (1) ZA931404B (lt)

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HU228673B1 (en) * 1993-08-19 2013-05-28 Janssen Pharmaceutica Nv Vasoconstrictive substituted dihydropyranopyridines, process for producing them and pharmaceutical compositions containing them
PL181385B1 (pl) * 1993-08-19 2001-07-31 Janssen Pharmaceutica Nv Nowe pochodne dihydrobenzopiranu o wlasciwosciach naczyniozwezajacych, kompozycja farmaceutyczna i sposób wytwarzania pochodnych dihydrobenzopiranu PL PL PL PL PL PL
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
AU6003896A (en) * 1995-06-08 1997-01-09 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ATE256125T1 (de) 1999-06-02 2003-12-15 Janssen Pharmaceutica Nv Aminoalkyl substituierte (benzodioxane, benzofurane oder benzopyrane) derivate
ATE279409T1 (de) * 1999-06-02 2004-10-15 Janssen Pharmaceutica Nv Pyrrolidinyl, piperidinyl oder homopiperidinyl substituierte (benzodioxan, benzofuran oder benzopyran) derivate
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JP2004517081A (ja) * 2000-11-29 2004-06-10 イーライ・リリー・アンド・カンパニー １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物
KR100849839B1 (ko) * 2001-02-23 2008-08-01 머크 앤드 캄파니 인코포레이티드 Ｎ-치환된 비-아릴-헤테로사이클릭 ｎｍｄａ/ｎｒ2ｂ 길항제 및 이를 포함하는 약제학적 조성물
WO2003009835A2 (en) 2001-07-26 2003-02-06 Merck Patent Gmbh Novel use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
KR100912911B1 (ko) * 2001-09-19 2009-08-20 메르크 파텐트 게엠베하 치환된 아미노메틸 크로만의 신규한 용도
WO2004069296A1 (en) * 2003-01-31 2004-08-19 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
CN100451004C (zh) * 2003-03-31 2009-01-14 大正制药株式会社 嘧啶衍生物
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EP1976509B1 (en) * 2006-01-18 2014-12-17 Evolva SA Ppar modulators
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

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US4405622A (en) * 1980-10-16 1983-09-20 Syntex (U.S.A.) Inc. [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
CA2011899A1 (en) * 1989-03-13 1990-09-13 Masaaki Toda Benzopyran derivatives
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DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
CS202094A3 (en) 1995-01-18
PH31295A (en) 1998-07-06
JPH07504408A (ja) 1995-05-18
FI943928A (fi) 1994-08-26
MX9301053A (es) 1994-03-31
CA2117483C (en) 2001-01-09
US5688952A (en) 1997-11-18
WO1993017017A1 (en) 1993-09-02
HU9402464D0 (en) 1994-10-28
IL104868A (en) 1998-01-04
RU94041210A (ru) 1996-07-10
BG62052B1 (bg) 1999-01-29
DE69302687T2 (de) 1996-11-14
JP2779268B2 (ja) 1998-07-23
CN1038032C (zh) 1998-04-15
AP9300493A0 (en) 1993-04-30
CN1079470A (zh) 1993-12-15
SK102994A3 (en) 1995-07-11
ZA931404B (en) 1994-08-26
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
DE69302687D1 (de) 1996-06-20
FI943928A0 (fi) 1994-08-26
AU3499193A (en) 1993-09-13
NO943186D0 (no) 1994-08-29
MY110627A (en) 1998-09-30
LT3049B (en) 1994-10-25
ES2087721T3 (es) 1996-07-16
HRP930235B1 (en) 1999-04-30
US5607949A (en) 1997-03-04
LV10715B (en) 1995-12-20
LV10715A (lv) 1995-06-20
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
RU2121999C1 (ru) 1998-11-20
SI9300097B (en) 2001-12-31
HU222495B1 (hu) 2003-07-28
NZ249124A (en) 1995-08-28
CZ282092B6 (cs) 1997-05-14
FI109122B (fi) 2002-05-31
US5541180A (en) 1996-07-30
NO943186L (no) 1994-08-29
GR3019927T3 (en) 1996-08-31
US5624952A (en) 1997-04-29
AU664237B2 (en) 1995-11-09
ATE138064T1 (de) 1996-06-15
CA2117483A1 (en) 1993-09-02
RO115630B1 (ro) 2000-04-28
NO306255B1 (no) 1999-10-11
PL174736B1 (pl) 1998-09-30
BG98870A (bg) 1995-03-31
AP416A (en) 1995-09-29
HRP930235A2 (en) 1997-10-31
TW225531B (lt) 1994-06-21
OA10095A (en) 1996-12-18
SI9300097A (en) 1993-09-30
SK280166B6 (sk) 1999-09-10
IL104868A0 (en) 1993-06-10
HUT71129A (en) 1995-11-28
SG47763A1 (en) 1998-04-17
EP0639192B1 (en) 1996-05-15
DK0639192T3 (da) 1996-08-19

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