LTIP367A - [(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidines - Google Patents
[(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidinesInfo
- Publication number
- LTIP367A LTIP367A LTIP367A LTIP367A LTIP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A
- Authority
- LT
- Lithuania
- Prior art keywords
- radical
- alkyl
- hydrogen
- benzopyran
- benzofuran
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 6
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 4
- 150000002357 guanidines Chemical class 0.000 title abstract 4
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical group C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 title 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- -1 cyano, carboxyl Chemical group 0.000 abstract 2
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Šis išradimas siejamas su [(benzodioksano, benzofurano arba benzopirano) alkil-pakeistais guanidinais, turinčiais formulę@@@@@jų farmacijai tinkančiomis druskomis su rūgštimis bei jų stereocheminėmisizomerinėmis formomis, kurioje X yra O, CH2 arba jungtis.@R yra vandenilis, halogeno C1-6 alkilo, C1-4 alkoksi, hidroksi, ciano, karboksilo, C1-4, alkoksikarbonilo arba aminokarbonilo radikalas,@R1 yra vandenilis arba C1-6 alkilas,@R2 ir R3 atskirai yra vandenilis arba C1-6 alkilas, arba kartu gali sudaryti dvivalentį -(CH2)m-radikalą, kuriame m yra 4 arba 5, @arba@R1 ir R2 kartu gali sudaryti dvivalentį -(CH2)n-arba -CH=CH- radikalą, kur n yra 2,3 arba 4,@arba R3 gali būti laisva jungtis , o R1 ir R2 kartu gali sudaryti radikalą =CH-CH=CH-,@R4 yra vandenilis arba C1-6 alkilas,@Alk1 yra dvivalentis C1-3 alkandiilo radikalas,@A yra dvivalentis radikalas, turintis du azoto atomus;@su vaistais, kurie naudingi kaip vazokonstriktoriai su preparatais, į kuriuos kaip aktyvūs komponentai įeina minėti guanidino dariniai, ir su šių guanidino darinių bei preparatų gamybos metodais; ir su vazodiletacijos sukeliamų ligų gydymo metodu.The present invention relates to [(benzodioxane, benzofuran or benzopyran) alkyl substituted guanidines of the formula @@@@@ their pharmaceutically acceptable salts and their stereochemically isomeric forms wherein X is O, CH 2 or a bond. @ R is hydrogen, halogen. C 1-6 alkyl, C 1-4 alkoxy, hydroxy, cyano, carboxyl, C 1-4, alkoxycarbonyl or aminocarbonyl, R 1 is hydrogen or C 1-6 alkyl, R 2 and R 3 are independently hydrogen or C 1-6 alkyl, or together can form a bivalent - (CH2) m-radical in which m is 4 or 5, or @ R1 and R2 together can form a bivalent - (CH2) n-or -CH = CH- radical where n is 2,3 or 4 , @ or R 3 may be a free bond, and R 1 and R 2 together may form a radical = CH-CH = CH -, @ R 4 is hydrogen or C 1-6 alkyl, @ Alk 1 is a divalent C1-3 alkanediyl radical, @ A is a bivalent radical having two nitrogen atoms; @su medicines that are useful as vasoconstrictors with preparations into which active comics these include guanidine derivatives and methods for producing these guanidine derivatives and preparations; and the method of treating vasodilatory diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84256092A | 1992-02-27 | 1992-02-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP367A true LTIP367A (en) | 1994-04-25 |
| LT3049B LT3049B (en) | 1994-10-25 |
Family
ID=25287639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP367A LT3049B (en) | 1992-02-27 | 1993-02-26 | £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US5541180A (en) |
| EP (1) | EP0639192B1 (en) |
| JP (1) | JP2779268B2 (en) |
| KR (1) | KR100190300B1 (en) |
| CN (1) | CN1038032C (en) |
| AP (1) | AP416A (en) |
| AT (1) | ATE138064T1 (en) |
| AU (1) | AU664237B2 (en) |
| BG (1) | BG62052B1 (en) |
| CA (1) | CA2117483C (en) |
| CZ (1) | CZ282092B6 (en) |
| DE (1) | DE69302687T2 (en) |
| DK (1) | DK0639192T3 (en) |
| EE (1) | EE03029B1 (en) |
| ES (1) | ES2087721T3 (en) |
| FI (1) | FI109122B (en) |
| GR (1) | GR3019927T3 (en) |
| HR (1) | HRP930235B1 (en) |
| HU (2) | HU222495B1 (en) |
| IL (1) | IL104868A (en) |
| LT (1) | LT3049B (en) |
| LV (1) | LV10715B (en) |
| MX (1) | MX9301053A (en) |
| MY (1) | MY110627A (en) |
| NO (1) | NO306255B1 (en) |
| NZ (1) | NZ249124A (en) |
| OA (1) | OA10095A (en) |
| PH (1) | PH31295A (en) |
| PL (1) | PL174736B1 (en) |
| RO (1) | RO115630B1 (en) |
| RU (1) | RU2121999C1 (en) |
| SG (1) | SG47763A1 (en) |
| SI (1) | SI9300097B (en) |
| SK (1) | SK280166B6 (en) |
| TW (1) | TW225531B (en) |
| WO (1) | WO1993017017A1 (en) |
| ZA (1) | ZA931404B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU226525B1 (en) * | 1993-08-19 | 2009-03-30 | Janssen Pharmaceutica Nv | Vasocontrictive dihydrobenzopyran derivatives, pharmaceutical compositions containing them and process for preparing them |
| DE69417560T2 (en) * | 1993-08-19 | 1999-11-11 | Janssen Pharmaceutica N.V., Beerse | VASCARIATING SUBTITUATED DIHYDROPYRANOPYRIDINE |
| PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
| US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
| FR2724383B1 (en) * | 1994-09-13 | 1996-10-18 | Synthelabo | 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| KR19990021931A (en) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | Antimigraine Composition of Microspherical Starch |
| FR2752735B1 (en) * | 1996-09-05 | 1998-10-02 | Synthelabo | USE OF BENZOFURANE DERIVATIVES FOR OBTAINING A MEDICAMENT FOR THE TREATMENT OF VENOUS INSUFFICIENCY AND VENOUS Ulcer |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| RU2134108C1 (en) * | 1998-10-06 | 1999-08-10 | Заславская Рина Михайловна | Agent for treatment of patient with arterial hypertension, method of treatment of patient with arterial hypertension |
| FR2787789B1 (en) * | 1998-12-29 | 2002-06-14 | Lipha | BENZOPYRANES AND BENZOXEPINS FOR USE IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF PREPARATION |
| EP1187829B1 (en) * | 1999-06-02 | 2003-12-10 | Janssen Pharmaceutica N.V. | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
| CN1131862C (en) * | 1999-06-02 | 2003-12-24 | 詹森药业有限公司 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for treating fundic disaccomodation |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Polyarylcarboxamides useful as lipid lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Biphenylcarboxamides useful as lipid lowering agents |
| CA2427098A1 (en) * | 2000-11-29 | 2002-06-06 | John Mehnert Schaus | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence |
| HRP20030669A2 (en) * | 2001-02-23 | 2005-06-30 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
| DE60217870T2 (en) | 2001-07-26 | 2007-11-15 | Merck Patent Gmbh | USE OF 2-5- (4-FLUORPHENYL) -3-PYRIDYLMETHYLAMINOMETHYL-CHROMANE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS |
| MXPA04002492A (en) * | 2001-09-19 | 2004-05-31 | Merck Patent Ges Mit Baschrank | Novel use of substituted aminomethyl chromans. |
| AU2004208821B2 (en) * | 2003-01-31 | 2009-01-15 | Zimmer Orthobiologics Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| US20050197350A1 (en) * | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| CN100451004C (en) * | 2003-03-31 | 2009-01-14 | 大正制药株式会社 | Pyrimidine derivatives |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| CN105061392B (en) * | 2015-07-20 | 2017-07-18 | 上海现代哈森（商丘）药业有限公司 | A kind of guanoxan sulfate synthetic method |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE636238A (en) * | 1962-08-20 | |||
| FR1366479A (en) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Process for the production of novel piperidine derivatives and their salts |
| FR1366472A (en) * | 1962-09-29 | 1964-07-10 | Glaverbel | Device for the production of sheet glass |
| GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GR71865B (en) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
| US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| FR2524887A1 (en) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | NOVEL CYANOGUANIDINES, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
| CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
| CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| WO1994017017A1 (en) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Benzene removal from gasoline boiling range streams |
| DE4303657A1 (en) * | 1993-02-09 | 1994-08-11 | Bayer Ag | New quinolone and naphthyridonecarboxylic acid derivatives |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/en unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 RO RO94-01432A patent/RO115630B1/en unknown
- 1993-02-19 CA CA002117483A patent/CA2117483C/en not_active Expired - Lifetime
- 1993-02-19 AT AT93904017T patent/ATE138064T1/en active
- 1993-02-19 NZ NZ249124A patent/NZ249124A/en not_active IP Right Cessation
- 1993-02-19 EP EP93904017A patent/EP0639192B1/en not_active Expired - Lifetime
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-19 ES ES93904017T patent/ES2087721T3/en not_active Expired - Lifetime
- 1993-02-19 SK SK1029-94A patent/SK280166B6/en not_active IP Right Cessation
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/en unknown
- 1993-02-19 HU HU9402464A patent/HU222495B1/en active IP Right Grant
- 1993-02-19 RU RU94041210A patent/RU2121999C1/en active
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/en not_active Expired - Lifetime
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/en active IP Right Grant
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/en active
- 1993-02-19 DE DE69302687T patent/DE69302687T2/en not_active Expired - Lifetime
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-19 JP JP5514541A patent/JP2779268B2/en not_active Expired - Lifetime
- 1993-02-19 PL PL93304902A patent/PL174736B1/en unknown
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/en unknown
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/en not_active IP Right Cessation
- 1993-02-26 ZA ZA931404A patent/ZA931404B/en unknown
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-26 LT LTIP367A patent/LT3049B/en not_active IP Right Cessation
- 1993-02-26 CN CN93103671A patent/CN1038032C/en not_active Expired - Lifetime
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
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1994
- 1994-06-24 BG BG98870A patent/BG62052B1/en unknown
- 1994-08-19 OA OA60555A patent/OA10095A/en unknown
- 1994-08-26 FI FI943928A patent/FI109122B/en not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/en not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/en unknown
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1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/en unknown
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1996
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/en unknown
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| Date | Code | Title | Description |
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| MK9A | Expiry of a patent |
Effective date: 20130226 |