LTIP367A - [(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidines - Google Patents
[(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidinesInfo
- Publication number
- LTIP367A LTIP367A LTIP367A LTIP367A LTIP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A LT IP367 A LTIP367 A LT IP367A
- Authority
- LT
- Lithuania
- Prior art keywords
- radical
- alkyl
- hydrogen
- benzopyran
- benzofuran
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Šis išradimas siejamas su [(benzodioksano, benzofurano arba benzopirano) alkil-pakeistais guanidinais, turinčiais formulę@@@@@jų farmacijai tinkančiomis druskomis su rūgštimis bei jų stereocheminėmisizomerinėmis formomis, kurioje X yra O, CH2 arba jungtis.@R yra vandenilis, halogeno C1-6 alkilo, C1-4 alkoksi, hidroksi, ciano, karboksilo, C1-4, alkoksikarbonilo arba aminokarbonilo radikalas,@R1 yra vandenilis arba C1-6 alkilas,@R2 ir R3 atskirai yra vandenilis arba C1-6 alkilas, arba kartu gali sudaryti dvivalentį -(CH2)m-radikalą, kuriame m yra 4 arba 5, @arba@R1 ir R2 kartu gali sudaryti dvivalentį -(CH2)n-arba -CH=CH- radikalą, kur n yra 2,3 arba 4,@arba R3 gali būti laisva jungtis , o R1 ir R2 kartu gali sudaryti radikalą =CH-CH=CH-,@R4 yra vandenilis arba C1-6 alkilas,@Alk1 yra dvivalentis C1-3 alkandiilo radikalas,@A yra dvivalentis radikalas, turintis du azoto atomus;@su vaistais, kurie naudingi kaip vazokonstriktoriai su preparatais, į kuriuos kaip aktyvūs komponentai įeina minėti guanidino dariniai, ir su šių guanidino darinių bei preparatų gamybos metodais; ir su vazodiletacijos sukeliamų ligų gydymo metodu.The present invention relates to [(benzodioxane, benzofuran or benzopyran) alkyl substituted guanidines of the formula @@@@@ their pharmaceutically acceptable salts and their stereochemically isomeric forms wherein X is O, CH 2 or a bond. @ R is hydrogen, halogen. C 1-6 alkyl, C 1-4 alkoxy, hydroxy, cyano, carboxyl, C 1-4, alkoxycarbonyl or aminocarbonyl, R 1 is hydrogen or C 1-6 alkyl, R 2 and R 3 are independently hydrogen or C 1-6 alkyl, or together can form a bivalent - (CH2) m-radical in which m is 4 or 5, or @ R1 and R2 together can form a bivalent - (CH2) n-or -CH = CH- radical where n is 2,3 or 4 , @ or R 3 may be a free bond, and R 1 and R 2 together may form a radical = CH-CH = CH -, @ R 4 is hydrogen or C 1-6 alkyl, @ Alk 1 is a divalent C1-3 alkanediyl radical, @ A is a bivalent radical having two nitrogen atoms; @su medicines that are useful as vasoconstrictors with preparations into which active comics these include guanidine derivatives and methods for producing these guanidine derivatives and preparations; and the method of treating vasodilatory diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84256092A | 1992-02-27 | 1992-02-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP367A true LTIP367A (en) | 1994-04-25 |
| LT3049B LT3049B (en) | 1994-10-25 |
Family
ID=25287639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP367A LT3049B (en) | 1992-02-27 | 1993-02-26 | £(benzodioxan, benzofuran or benzopyran)alkylamino|alkyl substituted guanidines |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US5541180A (en) |
| EP (1) | EP0639192B1 (en) |
| JP (1) | JP2779268B2 (en) |
| KR (1) | KR100190300B1 (en) |
| CN (1) | CN1038032C (en) |
| AP (1) | AP416A (en) |
| AT (1) | ATE138064T1 (en) |
| AU (1) | AU664237B2 (en) |
| BG (1) | BG62052B1 (en) |
| CA (1) | CA2117483C (en) |
| CZ (1) | CZ282092B6 (en) |
| DE (1) | DE69302687T2 (en) |
| DK (1) | DK0639192T3 (en) |
| EE (1) | EE03029B1 (en) |
| ES (1) | ES2087721T3 (en) |
| FI (1) | FI109122B (en) |
| GR (1) | GR3019927T3 (en) |
| HR (1) | HRP930235B1 (en) |
| HU (2) | HU222495B1 (en) |
| IL (1) | IL104868A (en) |
| LT (1) | LT3049B (en) |
| LV (1) | LV10715B (en) |
| MX (1) | MX9301053A (en) |
| MY (1) | MY110627A (en) |
| NO (1) | NO306255B1 (en) |
| NZ (1) | NZ249124A (en) |
| OA (1) | OA10095A (en) |
| PH (1) | PH31295A (en) |
| PL (1) | PL174736B1 (en) |
| RO (1) | RO115630B1 (en) |
| RU (1) | RU2121999C1 (en) |
| SG (1) | SG47763A1 (en) |
| SI (1) | SI9300097B (en) |
| SK (1) | SK280166B6 (en) |
| TW (1) | TW225531B (en) |
| WO (1) | WO1993017017A1 (en) |
| ZA (1) | ZA931404B (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005383A1 (en) * | 1993-08-19 | 1995-02-23 | Janssen Pharmaceutica N.V. | Vasocontrictive dihydrobenzopyran derivatives |
| HU228673B1 (en) * | 1993-08-19 | 2013-05-28 | Janssen Pharmaceutica Nv | Vasoconstrictive substituted dihydropyranopyridines, process for producing them and pharmaceutical compositions containing them |
| PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
| HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
| FR2724383B1 (en) * | 1994-09-13 | 1996-10-18 | Synthelabo | 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| ES2169102T3 (en) * | 1994-10-14 | 2002-07-01 | Merck Patent Gmbh | (R) - (-) - 2- (5- (4-FLUORFENIL) -3-PIRIDILMETILAMINOMETIL) -CROMANO AS ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM. |
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| KR19990021931A (en) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | Antimigraine Composition of Microspherical Starch |
| FR2752735B1 (en) * | 1996-09-05 | 1998-10-02 | Synthelabo | USE OF BENZOFURANE DERIVATIVES FOR OBTAINING A MEDICAMENT FOR THE TREATMENT OF VENOUS INSUFFICIENCY AND VENOUS Ulcer |
| TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| BR0011237A (en) * | 1999-06-02 | 2002-03-05 | Janssen Pharmaceutica Nv | Benzodioxane, benzofuran or benzopyran derivatives substituted with aminoalkyl |
| JP2003501428A (en) | 1999-06-02 | 2003-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxane, benzofuran or benzopyran) derivatives |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for treating fundic disaccomodation |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Polyarylcarboxamides useful as lipid lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Biphenylcarboxamides useful as lipid lowering agents |
| EP1341777B1 (en) * | 2000-11-29 | 2007-09-26 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence |
| CZ20032258A3 (en) * | 2001-02-23 | 2004-01-14 | Merck & Co., Inc. | N-substituted non-aryl heterocyclic compounds |
| DK1408964T3 (en) | 2001-07-26 | 2007-05-21 | Merck Patent Gmbh | Hitherto unknown use of 2-5- (4-fluorophenyl) -3-pyridylmethylaminomethyl-chroman and physiologically acceptable salts thereof |
| WO2003024960A1 (en) * | 2001-09-19 | 2003-03-27 | Merck Patent Gmbh | Novel use of substituted aminomethyl chromans |
| WO2004069296A1 (en) * | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| EP1464335A3 (en) * | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
| ZA200507112B (en) * | 2003-03-31 | 2007-03-28 | Taisho Pharmaceutical Co Ltd | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| US20110178112A1 (en) * | 2006-01-18 | 2011-07-21 | Evolva Sa | PPAR Modulators |
| CN105061392B (en) * | 2015-07-20 | 2017-07-18 | 上海现代哈森（商丘）药业有限公司 | A kind of guanoxan sulfate synthetic method |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1366479A (en) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Process for the production of novel piperidine derivatives and their salts |
| NL296841A (en) * | 1962-08-20 | |||
| GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GR71865B (en) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
| US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| FR2524887A1 (en) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | NOVEL CYANOGUANIDINES, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
| CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
| CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| WO1994017017A1 (en) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Benzene removal from gasoline boiling range streams |
| DE4303657A1 (en) * | 1993-02-09 | 1994-08-11 | Bayer Ag | New quinolone and naphthyridonecarboxylic acid derivatives |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/en unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 NZ NZ249124A patent/NZ249124A/en not_active IP Right Cessation
- 1993-02-19 DE DE69302687T patent/DE69302687T2/en not_active Expired - Lifetime
- 1993-02-19 ES ES93904017T patent/ES2087721T3/en not_active Expired - Lifetime
- 1993-02-19 SK SK1029-94A patent/SK280166B6/en not_active IP Right Cessation
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/en active
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-19 CA CA002117483A patent/CA2117483C/en not_active Expired - Lifetime
- 1993-02-19 RO RO94-01432A patent/RO115630B1/en unknown
- 1993-02-19 PL PL93304902A patent/PL174736B1/en unknown
- 1993-02-19 AT AT93904017T patent/ATE138064T1/en active
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/en unknown
- 1993-02-19 HU HU9402464A patent/HU222495B1/en active IP Right Grant
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/en active IP Right Grant
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 RU RU94041210A patent/RU2121999C1/en active
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/en not_active IP Right Cessation
- 1993-02-19 JP JP5514541A patent/JP2779268B2/en not_active Expired - Lifetime
- 1993-02-19 EP EP93904017A patent/EP0639192B1/en not_active Expired - Lifetime
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/en unknown
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/en not_active IP Right Cessation
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-26 CN CN93103671A patent/CN1038032C/en not_active Expired - Lifetime
- 1993-02-26 ZA ZA931404A patent/ZA931404B/en unknown
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-26 LT LTIP367A patent/LT3049B/en not_active IP Right Cessation
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
-
1994
- 1994-06-24 BG BG98870A patent/BG62052B1/en not_active Expired - Lifetime
- 1994-08-19 OA OA60555A patent/OA10095A/en unknown
- 1994-08-26 FI FI943928A patent/FI109122B/en not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/en not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/en unknown
-
1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/en unknown
-
1996
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Expiry of a patent |
Effective date: 20130226 |