AR037497A1 - Derivado de (r)-n-[2-cloro-4-etilsulfonil-3-(4-piperazin-1il)fenil]-2-hidroxi-2-metil-3,3,3-trifluoropropanamida, composicion farmaceutica, proceso para su preparacion y su uso en la fabricacion de un medicamento - Google Patents

Derivado de (r)-n-[2-cloro-4-etilsulfonil-3-(4-piperazin-1il)fenil]-2-hidroxi-2-metil-3,3,3-trifluoropropanamida, composicion farmaceutica, proceso para su preparacion y su uso en la fabricacion de un medicamento

Info

Publication number
AR037497A1
AR037497A1 ARP020103172A ARP020103172A AR037497A1 AR 037497 A1 AR037497 A1 AR 037497A1 AR P020103172 A ARP020103172 A AR P020103172A AR P020103172 A ARP020103172 A AR P020103172A AR 037497 A1 AR037497 A1 AR 037497A1
Authority
AR
Argentina
Prior art keywords
methyl
preparation
etilsulfonil
trifluoropropanamide
hydroxi
Prior art date
Application number
ARP020103172A
Other languages
English (en)
Inventor
Roger Butlin
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR037497A1 publication Critical patent/AR037497A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de la fórmula (1): donde R es metilo o mesilo; y sales aceptables para uso farmacéutico y ésteres hidrolizables in vivo del mismo. También se describen procesos para su preparación, preparaciones farmacéuticas que lo contienen y su uso con el fin de producir un aumento de actividad de la PDH en un animal de sangre caliente.
ARP020103172A 2001-08-23 2002-08-23 Derivado de (r)-n-[2-cloro-4-etilsulfonil-3-(4-piperazin-1il)fenil]-2-hidroxi-2-metil-3,3,3-trifluoropropanamida, composicion farmaceutica, proceso para su preparacion y su uso en la fabricacion de un medicamento AR037497A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0120471.8A GB0120471D0 (en) 2001-08-23 2001-08-23 Chemical compounds

Publications (1)

Publication Number Publication Date
AR037497A1 true AR037497A1 (es) 2004-11-17

Family

ID=9920849

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103172A AR037497A1 (es) 2001-08-23 2002-08-23 Derivado de (r)-n-[2-cloro-4-etilsulfonil-3-(4-piperazin-1il)fenil]-2-hidroxi-2-metil-3,3,3-trifluoropropanamida, composicion farmaceutica, proceso para su preparacion y su uso en la fabricacion de un medicamento

Country Status (23)

Country Link
US (2) US20050026931A1 (es)
EP (1) EP1425003A1 (es)
JP (1) JP2005506976A (es)
KR (1) KR20040030164A (es)
CN (2) CN101328157A (es)
AR (1) AR037497A1 (es)
AU (1) AU2002321520B2 (es)
BR (1) BR0212043A (es)
CA (1) CA2458121A1 (es)
CO (1) CO5560539A2 (es)
GB (1) GB0120471D0 (es)
HU (1) HUP0401149A2 (es)
IL (1) IL160455A0 (es)
IS (1) IS7157A (es)
MX (1) MXPA04001552A (es)
NO (1) NO326745B1 (es)
NZ (1) NZ531261A (es)
PL (1) PL368615A1 (es)
RU (1) RU2301805C2 (es)
SA (1) SA02230268B1 (es)
UA (1) UA77967C2 (es)
WO (1) WO2003017995A1 (es)
ZA (1) ZA200401375B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101108196B1 (ko) * 2009-11-04 2012-01-31 (주)유로파 쓰레기 자동 집하시설의 관로 전환기
RU2693457C2 (ru) * 2013-07-18 2019-07-03 Фондацьоне Иституто Итальяно Ди Текнолоджия Фенилкарбаматы и их применения в качестве ингибиторов фермента гидролазы амидов жирных кислот (faah) и модуляторов d3 допаминового рецептора (d3dr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537618A (en) * 1982-05-26 1985-08-27 Ciba Geigy Corporation N-phenylsulfonyl-N'-pyrimidinylureas
EP0539329A1 (de) * 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
GB9310095D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Therapeutic compounds
GB9804648D0 (en) * 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
DK1214296T3 (da) * 1999-09-04 2004-07-05 Astrazeneca Ab Substituerede N-phenyl-2-hydroxy-2-methyl-3,3,3-trifluorpropanamidderivater, der forhöjer pyruvatdehydrogenaseaktivitet

Also Published As

Publication number Publication date
KR20040030164A (ko) 2004-04-08
CN101328157A (zh) 2008-12-24
ZA200401375B (en) 2004-11-17
GB0120471D0 (en) 2001-10-17
UA77967C2 (en) 2007-02-15
RU2004108466A (ru) 2005-09-20
RU2301805C2 (ru) 2007-06-27
US20050026931A1 (en) 2005-02-03
IL160455A0 (en) 2004-07-25
CO5560539A2 (es) 2005-09-30
WO2003017995A1 (en) 2003-03-06
BR0212043A (pt) 2004-08-17
JP2005506976A (ja) 2005-03-10
NZ531261A (en) 2005-09-30
EP1425003A1 (en) 2004-06-09
NO20040725L (no) 2004-02-19
IS7157A (is) 2004-02-19
HUP0401149A2 (hu) 2004-12-28
US20070208032A1 (en) 2007-09-06
CN1571665A (zh) 2005-01-26
SA02230268B1 (ar) 2007-02-17
AU2002321520B2 (en) 2008-06-12
NO326745B1 (no) 2009-02-09
MXPA04001552A (es) 2004-05-17
CA2458121A1 (en) 2003-03-06
PL368615A1 (en) 2005-04-04

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