HUP0401149A2 - Piruvát-dehigrogenáz-aktivitást növelő szubsztituált N-fenil-2-hidroxi-2-metil-3,3,3-trifluor-propánamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Piruvát-dehigrogenáz-aktivitást növelő szubsztituált N-fenil-2-hidroxi-2-metil-3,3,3-trifluor-propánamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0401149A2
HUP0401149A2 HU0401149A HUP0401149A HUP0401149A2 HU P0401149 A2 HUP0401149 A2 HU P0401149A2 HU 0401149 A HU0401149 A HU 0401149A HU P0401149 A HUP0401149 A HU P0401149A HU P0401149 A2 HUP0401149 A2 HU P0401149A2
Authority
HU
Hungary
Prior art keywords
methyl
hydroxy
phenyl
substituted
preparation
Prior art date
Application number
HU0401149A
Other languages
English (en)
Inventor
Roger John Butlin
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0401149A2 publication Critical patent/HUP0401149A2/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány (I) általános képletű vegyületekre - a képletben R metil-vagy mezilcsoportot jelent - továbbá azok gyógyászatilag alkalmazhatósóira és in vivo körülmények között hidrolizálható észtereirevonatkozik. A vegyületek előállítása, valamint a vegyületekettartalmazó gyógyászati készítmények is a találmány tárgyát képezik. Avegyületek melegvérűeken a PDH-aktivitás növelésére alkalmasak. Ó
HU0401149A 2001-08-23 2002-08-21 Piruvát-dehigrogenáz-aktivitást növelő szubsztituált N-fenil-2-hidroxi-2-metil-3,3,3-trifluor-propánamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0401149A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0120471.8A GB0120471D0 (en) 2001-08-23 2001-08-23 Chemical compounds
PCT/GB2002/003867 WO2003017995A1 (en) 2001-08-23 2002-08-21 Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluropropanamide derivatives which elevate pyruvate dehydrogenase activity

Publications (1)

Publication Number Publication Date
HUP0401149A2 true HUP0401149A2 (hu) 2004-12-28

Family

ID=9920849

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401149A HUP0401149A2 (hu) 2001-08-23 2002-08-21 Piruvát-dehigrogenáz-aktivitást növelő szubsztituált N-fenil-2-hidroxi-2-metil-3,3,3-trifluor-propánamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Country Status (23)

Country Link
US (2) US20050026931A1 (hu)
EP (1) EP1425003A1 (hu)
JP (1) JP2005506976A (hu)
KR (1) KR20040030164A (hu)
CN (2) CN1571665A (hu)
AR (1) AR037497A1 (hu)
AU (1) AU2002321520B2 (hu)
BR (1) BR0212043A (hu)
CA (1) CA2458121A1 (hu)
CO (1) CO5560539A2 (hu)
GB (1) GB0120471D0 (hu)
HU (1) HUP0401149A2 (hu)
IL (1) IL160455A0 (hu)
IS (1) IS7157A (hu)
MX (1) MXPA04001552A (hu)
NO (1) NO326745B1 (hu)
NZ (1) NZ531261A (hu)
PL (1) PL368615A1 (hu)
RU (1) RU2301805C2 (hu)
SA (1) SA02230268B1 (hu)
UA (1) UA77967C2 (hu)
WO (1) WO2003017995A1 (hu)
ZA (1) ZA200401375B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101108196B1 (ko) * 2009-11-04 2012-01-31 (주)유로파 쓰레기 자동 집하시설의 관로 전환기
WO2015007615A1 (en) * 2013-07-18 2015-01-22 Fondazione Istituto Italiano Di Tecnologia Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (faah) enzyme and modulators of the d3 dopamine receptor (d3dr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537618A (en) * 1982-05-26 1985-08-27 Ciba Geigy Corporation N-phenylsulfonyl-N'-pyrimidinylureas
EP0539329A1 (de) * 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
GB9310095D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Therapeutic compounds
GB9804648D0 (en) * 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
KR100692232B1 (ko) * 1999-09-04 2007-03-09 아스트라제네카 아베 피루베이트 탈수소효소 활성을 증가시키는 치환된 n-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체

Also Published As

Publication number Publication date
CN1571665A (zh) 2005-01-26
IS7157A (is) 2004-02-19
EP1425003A1 (en) 2004-06-09
GB0120471D0 (en) 2001-10-17
AU2002321520B2 (en) 2008-06-12
BR0212043A (pt) 2004-08-17
IL160455A0 (en) 2004-07-25
CN101328157A (zh) 2008-12-24
NZ531261A (en) 2005-09-30
US20050026931A1 (en) 2005-02-03
UA77967C2 (en) 2007-02-15
NO20040725L (no) 2004-02-19
JP2005506976A (ja) 2005-03-10
SA02230268B1 (ar) 2007-02-17
KR20040030164A (ko) 2004-04-08
ZA200401375B (en) 2004-11-17
RU2301805C2 (ru) 2007-06-27
PL368615A1 (en) 2005-04-04
AR037497A1 (es) 2004-11-17
WO2003017995A1 (en) 2003-03-06
NO326745B1 (no) 2009-02-09
MXPA04001552A (es) 2004-05-17
RU2004108466A (ru) 2005-09-20
CA2458121A1 (en) 2003-03-06
US20070208032A1 (en) 2007-09-06
CO5560539A2 (es) 2005-09-30

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HUP0401149A2 (hu) Piruvát-dehigrogenáz-aktivitást növelő szubsztituált N-fenil-2-hidroxi-2-metil-3,3,3-trifluor-propánamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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