LV10715B - £(benzodioxane-, benzofurane- or benzopyrane)alkylamino|alkylsubstituted guanidines - Google Patents
£(benzodioxane-, benzofurane- or benzopyrane)alkylamino|alkylsubstituted guanidines Download PDFInfo
- Publication number
- LV10715B LV10715B LVP-93-149A LV930149A LV10715B LV 10715 B LV10715 B LV 10715B LV 930149 A LV930149 A LV 930149A LV 10715 B LV10715 B LV 10715B
- Authority
- LV
- Latvia
- Prior art keywords
- formula
- alkyl
- hydrogen
- amino
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84256092A | 1992-02-27 | 1992-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
LV10715A LV10715A (lv) | 1995-06-20 |
LV10715B true LV10715B (en) | 1995-12-20 |
Family
ID=25287639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-93-149A LV10715B (en) | 1992-02-27 | 1993-02-26 | £(benzodioxane-, benzofurane- or benzopyrane)alkylamino|alkylsubstituted guanidines |
Country Status (37)
Country | Link |
---|---|
US (4) | US5541180A (fr) |
EP (1) | EP0639192B1 (fr) |
JP (1) | JP2779268B2 (fr) |
KR (1) | KR100190300B1 (fr) |
CN (1) | CN1038032C (fr) |
AP (1) | AP416A (fr) |
AT (1) | ATE138064T1 (fr) |
AU (1) | AU664237B2 (fr) |
BG (1) | BG62052B1 (fr) |
CA (1) | CA2117483C (fr) |
CZ (1) | CZ282092B6 (fr) |
DE (1) | DE69302687T2 (fr) |
DK (1) | DK0639192T3 (fr) |
EE (1) | EE03029B1 (fr) |
ES (1) | ES2087721T3 (fr) |
FI (1) | FI109122B (fr) |
GR (1) | GR3019927T3 (fr) |
HR (1) | HRP930235B1 (fr) |
HU (2) | HU222495B1 (fr) |
IL (1) | IL104868A (fr) |
LT (1) | LT3049B (fr) |
LV (1) | LV10715B (fr) |
MX (1) | MX9301053A (fr) |
MY (1) | MY110627A (fr) |
NO (1) | NO306255B1 (fr) |
NZ (1) | NZ249124A (fr) |
OA (1) | OA10095A (fr) |
PH (1) | PH31295A (fr) |
PL (1) | PL174736B1 (fr) |
RO (1) | RO115630B1 (fr) |
RU (1) | RU2121999C1 (fr) |
SG (1) | SG47763A1 (fr) |
SI (1) | SI9300097B (fr) |
SK (1) | SK280166B6 (fr) |
TW (1) | TW225531B (fr) |
WO (1) | WO1993017017A1 (fr) |
ZA (1) | ZA931404B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824682A (en) * | 1993-08-18 | 1998-10-20 | Janssen Pharmaceutica, N.V. | Vasoconstrictive dihydrobenzopyran derivatives |
RU2135501C1 (ru) * | 1993-08-19 | 1999-08-27 | Жансен Фармасетика Н.В. | Замещенные дигидропиранопиридины, способ их получения, промежуточные соединения, фармацевтическая композиция и способ ее получения |
PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
EP1123933A1 (fr) * | 1994-10-14 | 2001-08-16 | MERCK PATENT GmbH | 2-[5-(4-fluorophényl)-3-pyridylméthylaminométhyl]chromane agissant sur le système nerveux central |
US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
KR19990021931A (ko) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | 미세구형 전분의 항편두통 조성물 |
FR2752735B1 (fr) * | 1996-09-05 | 1998-10-02 | Synthelabo | Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
UA73123C2 (en) | 1999-06-02 | 2005-06-15 | Janssen Pharmaceutica Nv | Derivatives of benzodioxane, benzofuran or benzopyran substituted by pyrolidinyl, piperidinyl or homopiperidinyl |
CZ20014177A3 (cs) | 1999-06-02 | 2002-05-15 | Janssen Pharmaceutica N. V. | Aminoalkyl substituované (benzodioxanové, benzofuranové nebo benzopyranové) deriváty |
UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
WO2002044159A2 (fr) * | 2000-11-29 | 2002-06-06 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine, ses sels acceptables sur le plan pharmaceutique et ses solvants |
DE60210944T3 (de) * | 2001-02-23 | 2015-07-23 | Merck Sharp & Dohme Corp. | N-substituierte nichtaryl-heterocyclische nmda/nr2b antagonisten |
SI1408964T1 (sl) | 2001-07-26 | 2007-06-30 | Merck Patent Gmbh | Uporaba 2- 5-(4-fluorofenil)-3-piridilmetil-aminometil -kromana in njegovih fizioloĺ ko sprejemljivih soli |
SI1427724T1 (sl) * | 2001-09-19 | 2006-10-31 | Merck Patent Gmbh | Nova uporaba substituiranih aminometil-kromanov |
CA2513055A1 (fr) * | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics, Inc. | Compositions de matrices hydrogel composites et procedes pour la reparation ou le traitement de tissus mammaliens |
CN100451004C (zh) * | 2003-03-31 | 2009-01-14 | 大正制药株式会社 | 嘧啶衍生物 |
US20050197350A1 (en) * | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
ES2533652T3 (es) * | 2006-01-18 | 2015-04-13 | Evolva Sa | Moduladores de PPAR |
CN105061392B (zh) * | 2015-07-20 | 2017-07-18 | 上海现代哈森(商丘)药业有限公司 | 一种硫酸胍生合成方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1366479A (fr) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels |
NL296841A (fr) * | 1962-08-20 | |||
GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
GR71865B (fr) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
FR2524887A1 (fr) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
CA1338012C (fr) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Amines possedant des proprietes pharmaceutiques |
CA2011899A1 (fr) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Derives de benzopyran |
WO1994017017A1 (fr) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Elimination du benzene des courants a limites d'ebullition de l'essence |
DE4303657A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/sl unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-19 HU HU9402464A patent/HU222495B1/hu active IP Right Grant
- 1993-02-19 ES ES93904017T patent/ES2087721T3/es not_active Expired - Lifetime
- 1993-02-19 DE DE69302687T patent/DE69302687T2/de not_active Expired - Lifetime
- 1993-02-19 SK SK1029-94A patent/SK280166B6/sk not_active IP Right Cessation
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/da active
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 JP JP5514541A patent/JP2779268B2/ja not_active Expired - Lifetime
- 1993-02-19 EP EP93904017A patent/EP0639192B1/fr not_active Expired - Lifetime
- 1993-02-19 RO RO94-01432A patent/RO115630B1/ro unknown
- 1993-02-19 CA CA002117483A patent/CA2117483C/fr not_active Expired - Lifetime
- 1993-02-19 AT AT93904017T patent/ATE138064T1/de active
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/fr active IP Right Grant
- 1993-02-19 PL PL93304902A patent/PL174736B1/pl unknown
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/ko not_active IP Right Cessation
- 1993-02-19 RU RU94041210A patent/RU2121999C1/ru active
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/cs unknown
- 1993-02-19 NZ NZ249124A patent/NZ249124A/xx not_active IP Right Cessation
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/es unknown
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/xx not_active IP Right Cessation
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-26 LT LTIP367A patent/LT3049B/lt not_active IP Right Cessation
- 1993-02-26 CN CN93103671A patent/CN1038032C/zh not_active Expired - Lifetime
- 1993-02-26 ZA ZA931404A patent/ZA931404B/xx unknown
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
-
1994
- 1994-06-24 BG BG98870A patent/BG62052B1/bg not_active Expired - Lifetime
- 1994-08-19 OA OA60555A patent/OA10095A/fr unknown
- 1994-08-26 FI FI943928A patent/FI109122B/fi not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/no not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/xx unknown
-
1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/hu unknown
-
1996
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/el unknown
Also Published As
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AU677428B2 (en) | Vasoconstrictive dihydrobenzopyran derivatives | |
CA2168023C (fr) | Derives de substitution de diamines aryloxyalkyliques, vasoconstricteurs | |
US5703115A (en) | (benzodioxan, benzofuran or benzopyran) alkylamino! alkyl substituted guanidines | |
US5691344A (en) | Vasoconstrictive substituted dihydropyranopyridines |