KR970014759A - 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 - Google Patents

블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 Download PDF

Info

Publication number
KR970014759A
KR970014759A KR1019950030981A KR19950030981A KR970014759A KR 970014759 A KR970014759 A KR 970014759A KR 1019950030981 A KR1019950030981 A KR 1019950030981A KR 19950030981 A KR19950030981 A KR 19950030981A KR 970014759 A KR970014759 A KR 970014759A
Authority
KR
South Korea
Prior art keywords
drug
hydrophobic
group
block copolymer
disease treatment
Prior art date
Application number
KR1019950030981A
Other languages
English (en)
Other versions
KR0180334B1 (ko
Inventor
장은옥
김성철
송인숙
배철민
Original Assignee
김상응
주식회사 삼양사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1019950030981A priority Critical patent/KR0180334B1/ko
Application filed by 김상응, 주식회사 삼양사 filed Critical 김상응
Priority to PCT/KR1996/000163 priority patent/WO1997010849A1/en
Priority to AU70980/96A priority patent/AU699988B2/en
Priority to CNB961971347A priority patent/CN1214818C/zh
Priority to ES96932066T priority patent/ES2188787T3/es
Priority to CA002231886A priority patent/CA2231886C/en
Priority to DE69625921T priority patent/DE69625921T2/de
Priority to JP51260897A priority patent/JP3634377B2/ja
Priority to EP96932066A priority patent/EP0854731B1/en
Publication of KR970014759A publication Critical patent/KR970014759A/ko
Priority to MX9802156A priority patent/MX9802156A/es
Application granted granted Critical
Publication of KR0180334B1 publication Critical patent/KR0180334B1/ko
Priority to US09/547,545 priority patent/US6322805B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법에 관한 것으로, 생분해성 소수성 고분자로서 폴리락티드, 폴리글리콜리드, 폴리락티드글리콜리드, 폴리카프로락톤 및 이들의 유도체로 구성되는 그룹으로부터 선택된 적어도 하나와, 친수서 고분자로서 폴리알킬렌옥시드로 구성된 2중 또는 3중 블럭 공중합체로부터 약물 전달 미셀을 형성하고, 여기서 물에 난용성인 약물을 교반, 가열, 초음파조사, 용매증발, 투석 등의 물리적인 방법을 통하여 봉입하는 것으로 구성되며 소수성 약물의 용해성을 향상시켜 효과적으로 체내 전달이 이루어지고 약물의 약리효과를 현저히 증대시키기 위한 약물 전달 시스템으로 이용될 수 있다.

Description

블록 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 폴리락티드-폴리에틸렌글리콜-폴리락티드 3중 블럭 공중합체(EL-3L-1)의 겔투과 크로마토그래피 결과를 나타낸 그래프이고,
제2A 및 2B도는 각각 폴리락티드-폴리에틸렌글리콜-폴리락티드 3중 블럭 공중합체 (EL-3L-1)와 폴리에틸렌글리콜-폴리락티드 2중 블럭 공중합체 (EL-2L-2) 미셀(micelle)의 직경 분포 상태를 동적 광산란법 (dynamic light scattering method)에 의해 측정한 결과를 나타낸 그래프이고.
제3A 및 3B도는 각각 상기 EL-3L-1과 EL-2L-2의 농도 변화와 교반법에 의해 봉입된 탁솔의 양의 관계를 나타낸 그래프이며;
제4A 및 4B도는 각각 3중 블럭 공중합체 및 2중 블럭 공중합체의 종류와 교반법에 의해 봉입된 탁솔의 양의 관계를 나티낸 그래프이고,
제5A 및 5B도는 각각 탁솔이 봉입된 폴리락티드-폴리에틸렌글리콜-폴리락티드 3중 블럭 공중합체 (EL-3L-1)와 폴리에틸렌글리콜-폴리락티드 2중 블럭 공중합체 (EL-2L-2) 미셀의 직경 분포 상태를 동적 광산란법 (dynamic light scattering method)에 의해 측정한 결과를 나타낸 그래프이다.

Claims (9)

  1. 생분해성 소수성 고분자로서 폴리락티드, 폴리글리콜리드, 폴리락티드글리콜리드, 폴리카프로락톤 및 이들의 유도체로 구성되는 그룹으로부터 선택된 적어도 하나와, 친수서 고분자로서 폴리알킬렌옥시드로 구성된 2중 또는 3중 블럭 공중합체로부터 형성되는 미셀에 적어도 하나의 소수성 약물이 봉입된 고분자 미셀형 약문 절단체.
  2. 제1항에 있어서, 상기 블럭 공중합체가 하기 식 (Ⅰ) 또는 (Ⅱ)인 것을 특징으로 하는 약물전달체 :
    여기에서, R1은 수소, 또는 탄소수 1 내지 20의 직쇄 또는 측쇄 알킬 그룹이고, m은 2내지 3,000의 정수이고, X는 100내지 100,000의 분자량을 갖는, 폴리락티드, 폴리글리콜리드, 폴리락티드글리콜리드, 폴리카프로락톤 및 이들의 유도체로 구성되는 그룹으로부터 선택된 적어도 하나이다.
  3. 제1항에 있어서, 상기 블럭 공중합체가 친수성 부분으로서 폴리에틸렌옥시드와 소수성 부분으로서 폴리락티드를 포함하는 하기 식 (Ⅲ) 또는 (Ⅳ)인 것을 특징으로 하는 약물전달체 :
    여기에서 i, j 및 k는 각각 독립적으로 2 내지 1,000의 정수이며, m은 2 내지 3,000의 정수이다.
  4. 제1항에 있어서, 상기 소수성 약물이 항암제, 소염진통제, 면역억제제, 간장 질환 치료제, 호르몬제, 항생제, 화학요법제, 대사성 의약품, 소화기 질환 치료제, 호흡기 질환 치료제, 항알러지약, 중추신경계 질환 치료제, 말초 질환 치료제, 순화기 질환 치료제로 이루어진 그룹중에서 선택된 적어도 하나인 것을 특징으로 약물전달체.
  5. 제1항 또는 제4항에 있어서, 상기 소수성 약물이 탁솔(taxol), 아드리아마이신(adriamycin) 테니포사드(teniposide), 에토포사이드(etoposide), 다우노마이신 (daunomycin), 메토트레세이트(methotrexate) 또는 미토마이신 C(mitomycin C), 인도메타신 (indomethacin), 이부프로팬 (ibuprofen), 사이클로스포린(cyclosporine), 비페닐디메틸카르복실레이트로 이루어진 그룹중에서 선택된 적어도 하나인 것을 특징으로 하는 약물전 달체.
  6. 제1항 또는 제4항에 있어서, 상기 소수성 약물이 탁솔, 사이클로스포린 및 아드리아마이신으로 이루어진 그룹중에서 선택된 적어도 하나인 것을 특징으로 하는 약물전달체.
  7. 제1항에 있어서, 동결건조후 수용액을 가했을 때 투명하게 재분산되는 것을 특징으로 하는 약물전달체.
  8. 1) 생분해성 소수성 고분자로서 폴리락티드, 폴리글리콜리드, 폴리락터드글리콜리드, 폴리카프로락톤 및 이들의 유도체로 구성되는 그룹으로부터 선택된 적어도 하나와, 친수성 고분자로서 폴리알킬렌옥시드로 구성된 2종 또는 3종 블럭 공중합체를 용매에 용해시켜 공중합체 용액을 만드는 단계; 2) 상기 공중합체 용액에 소수성 약물을 혼합하여 상기 공중합체로된 미셀에 상기 소수성 약물이 봉입되도록 하는 단계를 포함하는, 블럭 공중합체 미셀에 소수성 약물을 봉입시키는 방법.
  9. 제8항에 있어서, 상기 공중합체 용액에 상기 소수성 약물을 혼합시킨 후 교반, 가열 초음파조사, 용매 증발 또는 투석하여 소수성 약물을 봉입시키는 것을 특징으로 하는 방법,
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950030981A 1995-09-21 1995-09-21 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 KR0180334B1 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1019950030981A KR0180334B1 (ko) 1995-09-21 1995-09-21 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
AU70980/96A AU699988B2 (en) 1995-09-21 1996-09-21 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof
CNB961971347A CN1214818C (zh) 1995-09-21 1996-09-21 共聚物胶束药物组合物及其制备方法
ES96932066T ES2188787T3 (es) 1995-09-21 1996-09-21 Compuesto medicamentoso de micela copolimera y metodo para su preparacion.
PCT/KR1996/000163 WO1997010849A1 (en) 1995-09-21 1996-09-21 Copolymeric micelle drug composition and method for the preparation thereof
CA002231886A CA2231886C (en) 1995-09-21 1996-09-21 Copolymeric micelle drug composition and method for the preparation thereof
DE69625921T DE69625921T2 (de) 1995-09-21 1996-09-21 Arzneimittel auf der basis copolymerer mizellen und verfahren zu deren herstellung
JP51260897A JP3634377B2 (ja) 1995-09-21 1996-09-21 生分解性高分子ミセル−タイプ薬物組成物およびその製造方法
EP96932066A EP0854731B1 (en) 1995-09-21 1996-09-21 Copolymeric micelle drug composition and method for the preparation thereof
MX9802156A MX9802156A (es) 1995-09-21 1998-03-19 Composicion de droga de micela copolimerica y metodo para la preparacion de la misma.
US09/547,545 US6322805B1 (en) 1995-09-21 2000-04-12 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950030981A KR0180334B1 (ko) 1995-09-21 1995-09-21 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법

Publications (2)

Publication Number Publication Date
KR970014759A true KR970014759A (ko) 1997-04-28
KR0180334B1 KR0180334B1 (ko) 1999-03-20

Family

ID=19427413

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950030981A KR0180334B1 (ko) 1995-09-21 1995-09-21 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법

Country Status (11)

Country Link
US (1) US6322805B1 (ko)
EP (1) EP0854731B1 (ko)
JP (1) JP3634377B2 (ko)
KR (1) KR0180334B1 (ko)
CN (1) CN1214818C (ko)
AU (1) AU699988B2 (ko)
CA (1) CA2231886C (ko)
DE (1) DE69625921T2 (ko)
ES (1) ES2188787T3 (ko)
MX (1) MX9802156A (ko)
WO (1) WO1997010849A1 (ko)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100492805B1 (ko) * 2001-10-18 2005-06-07 주식회사 삼양사 안정성이 향상된 고분자 미셀 조성물
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
KR100773078B1 (ko) * 2001-06-21 2007-11-02 주식회사 삼양사 결정성이 높은 난용성 약물을 함유하는 고분자 미셀형약물 조성물
KR100789008B1 (ko) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. 신규 약물 제제

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP1024790A4 (en) * 1997-08-08 2000-10-25 Univ Utah Res Found BLOCK COPOLYMERS INJECTABLE AND BIODEGRADABLE GELS FOR ADMINISTERING A MEDICAMENT
KR20010030891A (ko) * 1997-10-03 2001-04-16 마크로메드 인코퍼레이션 가역적 열 겔화 성질을 갖는 생분해성 저분자량 트리블럭폴리(락티드-코-글리콜리드) 폴리에틸렌 글리콜 공중합체
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
GB9721367D0 (en) 1997-10-09 1997-12-10 Univ Liverpool Delivery system
DE19814739A1 (de) * 1998-04-02 1999-10-07 Basf Ag Verwendung von Polyalkylenoxid-haltigen Pfropfpolymerisaten als Solubilisatoren
SE9801288D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
ES2187195T3 (es) 1998-09-11 2003-05-16 Gerhard Dr Schmidmaier Implantes biologicamente activos.
DE19851777A1 (de) * 1998-11-10 2000-05-11 Basf Ag Verwendung von Estern oder Amiden hydroxylierter Carbonsäuren als Solubilisatoren
US6365191B1 (en) 1999-02-17 2002-04-02 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
AU7599900A (en) * 1999-09-23 2001-04-24 Dabur Research Foundation Formulations of paclitaxel entrapped into nanoparticles of polymeric micelles
AU2001225432A1 (en) * 2000-01-20 2001-07-31 Supratek Pharma, Inc. Novel podophyllotoxin compositions
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
EP1267946A4 (en) * 2000-02-28 2008-07-02 Genesegues Inc SYSTEM AND METHOD FOR ENCAPSULATING NANOCAPSULES
US7550157B2 (en) * 2000-05-12 2009-06-23 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
KR100391487B1 (ko) * 2000-11-08 2003-07-16 주식회사 한국코러스제약 비페닐디메틸디카르복실레이트(ｄｄｂ) 주사제 조성물
CA2428784A1 (en) * 2000-11-09 2002-05-16 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
GB0029750D0 (en) 2000-12-06 2001-01-17 Laporte Performance Chemicals Alkylene oxide-lactone copolymers
EP1418945A2 (en) * 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Micellar drug delivery vehicles and uses thereof
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
AU2002257116A1 (en) * 2001-03-30 2002-10-15 Trustees Of Princeton University A process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
KR100566911B1 (ko) * 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
US6623729B2 (en) * 2001-07-09 2003-09-23 Korea Advanced Institute Of Science And Technology Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
GB0116920D0 (en) * 2001-07-11 2001-09-05 Sulzer Vascutek Ltd Delivery system
JP4063510B2 (ja) * 2001-07-13 2008-03-19 ナノキャリア株式会社 薬物含有高分子ミセルの凍結乾燥用組成物およびその凍結乾燥製剤
MXPA04000317A (es) 2001-07-14 2004-05-04 Samyang Corp Un copolimero de bloque amfifilico cargado positivamente como un vehiculo de medicamento y complejo del mismo con un medicamento cargado negativamente.
WO2003017972A2 (en) * 2001-08-27 2003-03-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)
US6878693B2 (en) 2001-09-28 2005-04-12 Solubest Ltd. Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
IL160957A0 (en) * 2001-09-28 2004-08-31 Solubest Ltd Water soluble nanoparticles of hydrophilic and hydrophobic active materials
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US7482018B2 (en) 2001-12-21 2009-01-27 Soane Family Trust Use of oligomers and polymers for drug solubilization, stabilization, and delivery
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
WO2003082303A1 (en) * 2002-03-29 2003-10-09 Wisconsin Alumni Research Foundation Polymeric micelle formulations of hydrophobic compounds and methods
CN1290893C (zh) * 2002-05-03 2006-12-20 詹森药业有限公司 聚合物微乳状液
JP2003342168A (ja) * 2002-05-24 2003-12-03 Nano Career Kk 注射用薬物含有ポリマーミセル製剤の製造方法
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
ES2301846T3 (es) * 2002-10-21 2008-07-01 L'oreal Proceso para disolver compuestos lipofilos en fase acuosa con copolimeros de bloque anfifilico; y composiciones cosmeticas.
FR2845930B1 (fr) * 2002-10-21 2006-05-26 Oreal Procede de solubilisation de composes lipophiles en solution aqueuse par des copolymeres blocs amphiphiles et composition cosmetique
KR20040047056A (ko) * 2002-11-29 2004-06-05 한미약품 주식회사 비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
US20040197408A1 (en) * 2002-12-30 2004-10-07 Angiotech International Ag Amino acids in micelle preparation
US7279181B2 (en) * 2003-06-03 2007-10-09 Ferro Corporation Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
TWI248947B (en) * 2003-07-21 2006-02-11 Ind Tech Res Inst Biodegradable copolymer, and polymeric micelle composition containing the copolymer
WO2005040247A1 (en) * 2003-10-24 2005-05-06 Samyang Corporation Polymeric composition for drug delivery
CN100471886C (zh) * 2003-10-10 2009-03-25 株式会社三养社 两亲嵌段共聚物以及包含它的用于给药的聚合组合物
US7311901B2 (en) * 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
KR100577514B1 (ko) * 2003-10-21 2006-05-10 한미약품 주식회사 비페닐디메틸디카복실레이트, 및 카르두스 마리아누스추출물 또는 이로부터 정제된 실리빈을 함유하는 경구용마이크로에멀젼 조성물
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
KR20050054129A (ko) 2003-12-04 2005-06-10 주식회사 삼양사 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도
KR100967114B1 (ko) * 2003-12-16 2010-07-05 (주)아모레퍼시픽 폴리카프로락톤에 기반한 양친성 고분자를 이용한 에멀전타입의 피부외용제 조성물
DE60308711T2 (de) * 2003-12-22 2007-09-06 Industrial Technology Research Institute, Chutung Bioabbaubare Copolymere und diese Copolymere enthaltende polymere Micellen- Zusammensetzung
CA2549524A1 (en) * 2004-01-02 2005-07-28 Wisconsin Alumni Research Foundation Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers
US20050226932A1 (en) * 2004-04-09 2005-10-13 Samyang Corporation Pharmaceutical formulations for itraconazole
ES2375715T3 (es) * 2004-05-06 2012-03-05 Samyang Corporation Sistema de liberación para agentes bioactivos sobre la base de un portador polimérico de f�?rmacos que comprende un pol�?mero de bloques anf�?filo y un derivado de poli(�?cido l�?ctico).
CA2580305A1 (en) * 2004-06-02 2005-12-15 The Governors Of The University Of Alberta Polymer based nano-carriers for the solubilization and delivery of hydrophobic drugs
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
CN1320927C (zh) * 2005-01-27 2007-06-13 浙江大学 仿细胞膜的聚合物胶束载药体系
US20060257493A1 (en) * 2005-04-28 2006-11-16 Amiji Mansoor M Nanoparticulate delivery systems for treating multi-drug resistance
US8124128B2 (en) * 2005-11-08 2012-02-28 Industrial Technology Research Institute Amphiphilic block copolymers and nano particles comprising the same
DK1979407T5 (en) 2006-01-19 2014-12-01 Allexcel Inc Solubilization and targeted delivery of drugs with self-forming amphiphilic polymers
AR054215A1 (es) * 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
EP2730604B1 (en) * 2006-03-21 2018-10-24 The Governors of the University of Alberta Functionalized caprolactone monomers useful for making poly(ethylene oxide)-block-poly(ester) block copolymers
WO2007136134A1 (ja) * 2006-05-23 2007-11-29 Nanocarrier Co., Ltd. 疎水性薬物内包ポリマーミセルの製造方法
KR20090080046A (ko) * 2006-09-22 2009-07-23 라보팜 인코포레이트 ｐＨ 표적화된 약물 운반용 조성물 및 방법
US9000048B2 (en) * 2006-11-28 2015-04-07 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
US7662883B2 (en) * 2006-12-28 2010-02-16 The Goodyear Tire & Rubber Company Rubbery block polymers containing polylactone and rubber compounds including the same
US8900562B2 (en) * 2007-01-12 2014-12-02 Wisconsin Alumni Research Foundation Semi-fluorinated block copolymers for delivery of therapeutic agents
US7537532B2 (en) * 2007-05-16 2009-05-26 Young Carl D Handle for implement and method
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
AR063111A1 (es) 2007-10-03 2008-12-30 Eriochem Sa Una formulacion farmaceutica de taxano
DE112008002914A5 (de) * 2007-11-06 2010-09-30 B. Braun Melsungen Ag Einen hydrophoben Wirkstoff enthaltende wässrige Emulsionen
US9801818B2 (en) * 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
KR101005562B1 (ko) * 2008-05-01 2011-01-05 한국생명공학연구원 난용성 약물을 함유하는 균일한 크기의 고분자 나노입자제조방법
WO2010047765A2 (en) 2008-10-20 2010-04-29 Massachussetts Institute Of Technology Nanostructures for drug delivery
KR20110091515A (ko) * 2008-11-21 2011-08-11 주식회사 삼양사 내성암 치료용 고분자 미셀 조성물 및 그 제조방법
EP2201935B1 (en) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same
AU2009330859B2 (en) 2008-12-26 2013-06-20 Samyang Holdings Corporation Pharmaceutical composition containing an anionic drug, and a production method therefor
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
CN101810560B (zh) * 2009-02-20 2013-07-10 北京大学 环孢a聚合物胶束组合物
JP2010208955A (ja) * 2009-03-06 2010-09-24 Makoto Yuasa 疾患治療薬
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
AU2010234916A1 (en) * 2009-03-30 2011-10-13 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
EP2424359A4 (en) 2009-04-30 2014-01-15 Intezyne Technologies Inc POLYMIC MICELLES WITH ANTHRACYCLINES FOR THE TREATMENT OF CANCER
WO2011038278A2 (en) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
US20110081293A1 (en) * 2009-10-07 2011-04-07 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
EA201290506A1 (ru) * 2009-12-16 2013-03-29 Брихэм Энд Уимен'З Хоспитал, Инк. Частицы для доставки множества агентов
KR101267813B1 (ko) 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
CN101732723B (zh) * 2009-12-30 2012-07-25 上海市肿瘤研究所 聚乙二醇-聚乳酸羟基乙酸-聚赖氨酸纳米递送系统、制备方法及其应用
EP2382966A1 (en) 2010-03-12 2011-11-02 DSM IP Assets B.V. Micelle compositions and process for the preparation thereof
CN102198085B (zh) * 2010-05-27 2012-07-18 四川大学 三嵌段聚合物负载紫杉烷类药物的胶束和冻干制剂、制法及应用
CN101880265A (zh) * 2010-06-09 2010-11-10 江南大学 酸敏感聚合物胶束药物组合物及制备方法
US9675521B2 (en) 2010-09-02 2017-06-13 Nippon Kayaku Kabushiki Kaisha Process for producing drug-block copolymer composite and pharmaceutical preparation containing same
US8834861B2 (en) 2011-03-10 2014-09-16 International Business Machines Corporation Polycarbonates for delivery of drugs and methods of preparation thereof
US8945627B2 (en) 2011-05-05 2015-02-03 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
GB201111439D0 (en) * 2011-07-04 2011-08-17 Syngenta Ltd Formulation
KR101286854B1 (ko) * 2011-09-29 2013-07-17 중앙대학교 산학협력단 폴리락트산（ａ）과 폴리에틸렌글리콜（ｂ）로 이루어진 ｂａｂ형 삼중 블록 공중합체, 이의 제조방법 및 이를 이용한 약물전달체
ES2836279T3 (es) 2012-04-04 2021-06-24 Samyang Biopharmaceuticals Método de preparación de una composición para administrar un fármaco aniónico
ES2782507T3 (es) * 2012-04-23 2020-09-15 Nanoproteagen Ltd Nanopartículas poliméricas y un proceso para su preparación
EP3778696A1 (en) 2012-04-23 2021-02-17 NanoProteagen Ltd. Polymeric nanoparticles and a process of preparation thereof
CU24287B1 (es) * 2012-06-27 2017-12-08 Medincell Suministro de fármaco biodegradable para las composiciones hidrofóbicas
US8633296B1 (en) * 2012-09-12 2014-01-21 International Business Machines Corporation Composite hydrogels for delivery of biologically active materials
US20150174254A1 (en) * 2013-12-23 2015-06-25 Mcneil-Ppc, Inc. Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent
EP3177669B1 (en) 2014-08-08 2021-03-17 DSM IP Assets B.V. Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides
KR20170054429A (ko) 2014-09-03 2017-05-17 제네세규스 인코포레이티드 치료용 나노입자 및 관련 조성물, 방법, 및 시스템
CN104887627A (zh) * 2015-05-15 2015-09-09 海南圣欣医药科技有限公司 一种共聚物在抗肿瘤药物中的应用
US9763892B2 (en) 2015-06-01 2017-09-19 Autotelic Llc Immediate release phospholipid-coated therapeutic agent nanoparticles and related methods
KR101726728B1 (ko) 2015-07-28 2017-04-14 주식회사 삼양바이오팜 고분자 담체 함유 약학 조성물의 유연물질 분석 방법
KR101748191B1 (ko) 2015-07-28 2017-06-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
US20170027866A1 (en) * 2015-07-29 2017-02-02 Samyang Biopharmaceuticals Corporation Pharmaceutical composition with improved storage stability and method for preparing the same
US20170028067A1 (en) * 2015-07-29 2017-02-02 Samyang Biopharmaceuticals Corporation Pharmaceutical composition with improved storage stability and method for preparing the same
US20170028068A1 (en) 2015-07-29 2017-02-02 Samyang Biopharmaceuticals Corporation Pharmaceutical composition with improved storage stability and method for preparing the same
SG11201802073YA (en) 2015-09-15 2018-04-27 Samyang Biopharmaceuticals Pharmaceutical composition containing anionic drug, and preparation method therefor
WO2017085561A1 (en) 2015-11-16 2017-05-26 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
CN106928461A (zh) * 2015-12-28 2017-07-07 上海鑫淼医药科技有限公司 一种pla-peg-pla树枝状聚合物的制备方法及其应用
KR102420468B1 (ko) 2016-03-14 2022-07-13 위스콘신 얼럼나이 리서어치 화운데이션 올리고락트산 컨쥬게이트 및 향상된 항암 효능을 갖는 마이셀
CA3032457A1 (en) 2016-08-12 2018-02-15 Purdue Research Foundation Polymer lung surfactants
AU2017327392B9 (en) * 2016-09-13 2023-10-12 Tiziana Life Sciences Plc Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
CN107137350A (zh) * 2017-05-02 2017-09-08 辽宁大学 一种紫杉醇聚合物胶束及其制备方法
WO2018227293A1 (en) * 2017-06-13 2018-12-20 The University Of British Columbia Polymeric paste compositions for drug delivery
CA3095788A1 (en) 2018-04-02 2019-10-10 Wisconsin Alumni Research Foundation Stereocomplex of oligolactic acid conjugates in micelles for improved physical stability and enhanced antitumor efficacy
CN110917149A (zh) * 2018-12-26 2020-03-27 银谷制药有限责任公司 一种包载难溶性抗肿瘤药物的聚合物胶束冻干制剂
CN110652595B (zh) * 2019-10-21 2022-11-29 南通大学附属医院 一种聚亮氨酸-聚天冬氨酸嵌段共聚物立构复合载药胶束及其制备方法
KR102172987B1 (ko) 2019-10-23 2020-11-02 가톨릭대학교 산학협력단 엽산 수용체 표적능 및 엔도솜막 분해능을 갖는 엽산-폴리(입실론-카프로락톤)-엽산 고분자 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
FR2678168B1 (fr) 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
ES2171186T3 (es) 1994-04-08 2002-09-01 Atrix Lab Inc Composiciones liquidas de difusion.
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100789008B1 (ko) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. 신규 약물 제제
KR100923172B1 (ko) * 1997-06-27 2009-10-22 아브락시스 바이오사이언스, 엘엘씨 신규 약물 제제
KR100773078B1 (ko) * 2001-06-21 2007-11-02 주식회사 삼양사 결정성이 높은 난용성 약물을 함유하는 고분자 미셀형약물 조성물
KR100492805B1 (ko) * 2001-10-18 2005-06-07 주식회사 삼양사 안정성이 향상된 고분자 미셀 조성물
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물

Also Published As

Publication number Publication date
AU7098096A (en) 1997-04-09
MX9802156A (es) 1998-11-30
JP3634377B2 (ja) 2005-03-30
KR0180334B1 (ko) 1999-03-20
CA2231886A1 (en) 1997-03-27
CN1197396A (zh) 1998-10-28
CA2231886C (en) 2002-03-19
WO1997010849A1 (en) 1997-03-27
DE69625921D1 (de) 2003-02-27
ES2188787T3 (es) 2003-07-01
DE69625921T2 (de) 2003-08-07
US6322805B1 (en) 2001-11-27
CN1214818C (zh) 2005-08-17
AU699988B2 (en) 1998-12-17
EP0854731A1 (en) 1998-07-29
EP0854731B1 (en) 2003-01-22
JPH10512287A (ja) 1998-11-24

Similar Documents

Publication Publication Date Title
KR970014759A (ko) 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
Kwon et al. Polymeric micelles as new drug carriers
Blanco et al. β-Lapachone-containing PEG–PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells
Li et al. A bio‐inspired rod‐shaped nanoplatform for strongly infecting tumor cells and enhancing the delivery efficiency of anticancer drugs
Mokhtarzadeh et al. Bacterial-derived biopolymers: Advanced natural nanomaterials for drug delivery and tissue engineering
Rabiee et al. Carbosilane dendrimers: Drug and gene delivery applications
Mitra et al. Tumour targeted delivery of encapsulated dextran–doxorubicin conjugate using chitosan nanoparticles as carrier
Jung et al. Characterization of hydrophobized pullulan with various hydrophobicities
Hariharan et al. Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy
Son et al. Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect
Liu et al. Antitumor drug effect of betulinic acid mediated by polyethylene glycol modified liposomes
ES2271039T3 (es) Composiciones que comprenden micelas polimericas.
Jeong et al. Preparation of poly (DL-lactide-co-glycolide) microspheres encapsulating all-trans retinoic acid
Lu et al. A method for the preparation of polymeric nanocapsules without stabilizer
US20030180363A1 (en) Method for the preparation of polymeric micelle via phase separation of block copolymer
CN101415442B (zh) 控释凝胶
Senthilkumar et al. Long circulating PEGylated poly (D, L-lactide-co-glycolide) nanoparticulate delivery of Docetaxel to solid tumors
CN101910274A (zh) 含紫杉烷的两亲嵌段共聚物胶束组合物及其制备方法
Sundararajan et al. Synthesis and characterization of chrysin-loaded β-cyclodextrin-based nanosponges to enhance in-vitro solubility, photostability, drug release, antioxidant effects and antitumorous efficacy
EP1415648B1 (en) Lyophilizing composition of drug-encapsulating polymer micelle and method for preparation thereof
Prompruk et al. Synthesis of a novel PEG-block-poly (aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier
CN113683541B (zh) 一种基于双硫仑的两亲性嵌段共聚物前药及其制备方法和应用
Cui et al. A comparative in vitro evaluation of self-assembled PTX-PLA and PTX-MPEG-PLA nanoparticles
Mahajan et al. Paclitaxel loaded nanoliposomes in thermosensitive hydrogel: A dual approach for sustained and localized delivery
KR20040021760A (ko) 약물 담지능력이 우수한 블록 공중합체 미셀 조성물

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20120928

Year of fee payment: 15

FPAY Annual fee payment

Payment date: 20130830

Year of fee payment: 16

FPAY Annual fee payment

Payment date: 20140919

Year of fee payment: 17

FPAY Annual fee payment

Payment date: 20150903

Year of fee payment: 18

FPAY Annual fee payment

Payment date: 20160902

Year of fee payment: 19

FPAY Annual fee payment

Payment date: 20170905

Year of fee payment: 20