KR910019966A - 시마테롤의 거울상이성체의 분리, (-)-시마테롤 및 약학 조성물 또는 능률 증진제로서 이들의 용도 - Google Patents

시마테롤의 거울상이성체의 분리, (-)-시마테롤 및 약학 조성물 또는 능률 증진제로서 이들의 용도 Download PDF

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KR910019966A
KR910019966A KR1019910007085A KR910007085A KR910019966A KR 910019966 A KR910019966 A KR 910019966A KR 1019910007085 A KR1019910007085 A KR 1019910007085A KR 910007085 A KR910007085 A KR 910007085A KR 910019966 A KR910019966 A KR 910019966A
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tartaric acid
isopropylamino
cyano
phenyl
ethanol
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레제만 볼프강
뒤르 아돌프
엥겔하르츠 귄터
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에베르하르트 리히터, 칼 요트. 슐테
베링거 인겔하임 베트메디카 게엠베하
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Abstract

내용 없음

Description

시마테롤의 거울상이성체의 분리, (-)-시마테롤 및 약학 조성물 또는 능률 증진제로서 이들의 용도.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. (-)-1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올 및 이의 산부가염.
  2. 제1항에 있어서, 본질상 광학적으로 순수한 것임을 특징으로 하는 화합물.
  3. 제1항에 있어서, 적어도 ee=90%의 광학적 순도를 가짐을 특징으로 하는 화합물.
  4. 제1항에 있어서, 적어도 ee=94%의 광학적 순도를 가짐을 특징으로 하는 화합물.
  5. 제1내지 4항중 적어도 한 항에 따른 화합물의 생릭적으로 허용되는 산부가염.
  6. 임의로 하나이상의 불활성 담체 및/또는 희석제와 함께 제1내지 4항중 적어도 한 항에 따른 화합물 또는 제5항에 따른 생리적으로 허용되는 산부가염을 함유하는 약학 조성물.
  7. 비만증, 폐색성 폐 변화, 알레르기성 기관지 천식, 경련성 기관지염, 염증 또는 조산을 치료하는데 적합한 약학 조성물을 제조하는데 제 1내지 5항중 적어도 한 항에 따른 화합물을 사용하는 용도.
  8. 제 1내지 5항중 적어도 한 항에 따른 화합물을 비-회학적 방법에 의해 하나이상의 불활성 담체 및/또는 희석제에 혼입함을 특징으로 하는 제6항에 따른 약학 조성물을 제조하는 방법.
  9. 동물의 능률 증진제로서 제 1내지 5항중 적어도 한 항에 따른 화합물을 사용하는 용도
  10. 제 1내지 5항중 적어도 한 항에 따른 화합물을 함유하는, 동물사료제조용 도물 사료 및 전혼합물.
  11. 제 1내지 5항중 적어도 한 항에 따른 화합물을 함유하는 동물에 대한 능률 증진제.
  12. 제 1내지 5항중 적어도 한 항에 따른 화합물을 증량제, 희석제와 영양제 및 임의로 다른 애주번트와 혼합함을 특징으로 하여, 동물에 대한 능률 증진제를 제조하는 방법.
  13. 1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올과 적어도 2당량의 광학적으로 활성적인 이염기성 보조산, 예컨대 (-)-0,0′-디벤조일-L-타르타르산,(+)-0,0′-디벤조일-D-타르타르산,(-)-0,0′-디톨릴-L-타르타르산 또는 (+)-0,0′-디톨릴-D-타르타르산을 각각의 보조산에 특징적인 온도범위 아래로 온도가 내려가지 않도록 하면서 적합한 용매에 용해시켜 1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올을 결정시키고 결정된 부분 입체 이성체염을 분리시킨 후 거울상 이성체 염기를 유리시키고 필요에 따라 이렇게 수득된 거울상 이성체 염기를 이의 생리적으로 허용되는 산부가염으로 전환시킴을 특징으로 하여, (-)-1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올과 (+)-1(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올을 제조하는 방법.
  14. 제13항에 있어서, 보조산으로서 (+)-0,0′-디벤조일-L-타르타르산을 25℃이상의 온도에서 사용함을 특징으로 하는 방법.
  15. 1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올과 광학적으로 활성적인 이염기성 보조산, 예컨대 (-)-0,0′-디벤조일-L-타르타르산 또는 (+)-0,0′-디벤조일-D-타르타르산, (-)-0,0′-디톨릴-L-타르타르산 또는 (+)-0,0-디톨릴-D-타르타르산의 부분 입체 이성체 염.
  16. (-)-1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올-(+)-0,0′-디벤조일-D-타르타르산 수소염
  17. 1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올과 적어도 2당량의 광학적으로 활성적인 이염기성 보조산, 예컨대 (-)-0,0′-디벤조일-L-타르타르산 (+)-0,0′-디벤조일-D-타르타르산, (-)-0,0′-디톨릴-L-타르타르산 또는 (+)-0,0-디톨릴-D-타르타르산을 각각의 보조산에 특징적인 온도범위 이하로 온도가 내려가지 않도록 하면서 적합한 용매에 용해시켜 1-(4′-아미노-3′-시아노-페닐)-2-이소프로필아미노-에탄올을 결정시킨후, 결정된 부분입체 이성체염을 분리함을 특징으로 하여, 제15항 또는 제16항에 따른 부붑 입체 이성체염을 제조하는 방법.
  18. 제13항 또는 제17항에 있어서, 20℃이상, 바람직하게는 25내지 30℃에서 결정화 과정을 수행함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007085A 1990-05-04 1991-05-02 시마테롤의 거울상이성체의 분리, (-)-시마테롤 및 약학 조성물 또는 능률 증진제로서 이들의 용도 KR0183024B1 (ko)

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DEP4014252.3 1990-05-04
DE4014252A DE4014252A1 (de) 1990-05-04 1990-05-04 Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer

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US5248695A (en) 1993-09-28
ATE124932T1 (de) 1995-07-15
CZ286389B6 (cs) 2000-03-15
BG94342A (en) 1994-06-30
KR0183024B1 (ko) 1999-05-15
PT97544B (pt) 1998-08-31
DK0455155T3 (da) 1995-11-13
JP2944777B2 (ja) 1999-09-06
AU645313B2 (en) 1994-01-13
US5292753A (en) 1994-03-08
PT97544A (pt) 1992-01-31
ES2109412T3 (es) 1998-01-16
DE4014252A1 (de) 1991-11-07
GR3017064T3 (en) 1995-11-30
IE69017B1 (en) 1996-07-24
US5395957A (en) 1995-03-07
ID966B (id) 1996-09-30
TW197415B (ko) 1993-01-01
RU2002737C1 (ru) 1993-11-15
IL98030A (en) 1995-12-31
ES2075255T3 (es) 1995-10-01
DK0589488T3 (da) 1998-05-04
EP0589488B1 (de) 1997-09-17
DE59108853D1 (de) 1997-10-23
HU911502D0 (en) 1991-11-28
HUT60999A (en) 1992-11-30
AU7611191A (en) 1991-11-07
SK279258B6 (sk) 1998-08-05
IE911507A1 (en) 1991-11-06
NO911746D0 (no) 1991-05-03
FI912151A0 (fi) 1991-05-03
AR247728A1 (es) 1995-03-31
EP0589488A1 (de) 1994-03-30
EP0455155A1 (de) 1991-11-06
ATE158277T1 (de) 1997-10-15
CA2041818C (en) 2003-02-11
BG60743B1 (bg) 1996-02-29
HU214335B (hu) 1998-03-02
CS129291A3 (en) 1991-11-12
SG45439A1 (en) 1998-01-16
CA2041818A1 (en) 1991-11-05
NO911746L (no) 1991-11-05
GR3025547T3 (en) 1998-03-31
JPH04225944A (ja) 1992-08-14
EP0455155B1 (de) 1995-07-12
IE80651B1 (en) 1998-11-04
FI109600B (fi) 2002-09-13
US5648386A (en) 1997-07-15
NZ238032A (en) 1996-02-27
NO174803B (no) 1994-04-05

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