AR247728A1 - Procedimiento para separar el isomero activo del cimaterol y procedimiento para preparar las sales diastereoisomeras de dicho isomero - Google Patents

Procedimiento para separar el isomero activo del cimaterol y procedimiento para preparar las sales diastereoisomeras de dicho isomero

Info

Publication number
AR247728A1
AR247728A1 AR91319603A AR31960391A AR247728A1 AR 247728 A1 AR247728 A1 AR 247728A1 AR 91319603 A AR91319603 A AR 91319603A AR 31960391 A AR31960391 A AR 31960391A AR 247728 A1 AR247728 A1 AR 247728A1
Authority
AR
Argentina
Prior art keywords
cimaterol
tartarico
fenil
ciano
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
AR91319603A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Boehringer Ingelheim Vetmedica de C V SA
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Boehringer Ingelheim Vetmedica de C V SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH, Boehringer Ingelheim Vetmedica de C V SA filed Critical Boehringer Ingelheim Vetmedica GmbH
Application granted granted Critical
Publication of AR247728A1 publication Critical patent/AR247728A1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)

Abstract

PROCEDIMIENTO PARA SEPARAR (-)-1-(4'-AMINO-3'-CIANO-FENIL)-2-ISOPROPILAMINO ETANOL Y (+)-1-4'-AMINO-3'-CIANO-FENIL-2-ISOPROPILAMINO-ETANOL, DONDE SE DISUELVEN 1-(4'-AMINO-3'-CIANO-FENIL)-2-ISOPROPILAMINO-ETANOL Y UN ACIDO AUXILIAR, DIBASICO, OPTICAMENTE ACTIVO, COMO EL (-)-O, O'-DIBENZOIL-L- TARTARICO, EL (+)-O, O'-DIBENSOIL-D-TARTARICO, EL (-)-O, O'-DITOLIL-L- TARTARICO O EL (+)-O, O'-DITOLIL-D-TARTARICO, EN UN DISOLVENTE ADECUADO, Y SE HACEN CRISTALIZAR; LA SAL DIASTEREOISOMERA QUE SE SEPARA; A CONTINUACION SE LIBERA LA BASE ENANTIOMERA QUE, SI SE DESEA, SE TRANSFORMA SEGUIDAMENTE EN SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE TOLERABLES.
AR91319603A 1990-05-04 1991-05-03 Procedimiento para separar el isomero activo del cimaterol y procedimiento para preparar las sales diastereoisomeras de dicho isomero Expired - Lifetime AR247728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4014252A DE4014252A1 (de) 1990-05-04 1990-05-04 Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer

Publications (1)

Publication Number Publication Date
AR247728A1 true AR247728A1 (es) 1995-03-31

Family

ID=6405664

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91319603A Expired - Lifetime AR247728A1 (es) 1990-05-04 1991-05-03 Procedimiento para separar el isomero activo del cimaterol y procedimiento para preparar las sales diastereoisomeras de dicho isomero

Country Status (27)

Country Link
US (4) US5248695A (es)
EP (2) EP0455155B1 (es)
JP (1) JP2944777B2 (es)
KR (1) KR0183024B1 (es)
AR (1) AR247728A1 (es)
AT (2) ATE124932T1 (es)
AU (1) AU645313B2 (es)
BG (1) BG60743B1 (es)
CA (1) CA2041818C (es)
CZ (1) CZ286389B6 (es)
DE (3) DE4014252A1 (es)
DK (2) DK0455155T3 (es)
ES (2) ES2075255T3 (es)
FI (1) FI109600B (es)
GR (2) GR3017064T3 (es)
HU (1) HU214335B (es)
ID (1) ID966B (es)
IE (2) IE69017B1 (es)
IL (1) IL98030A (es)
NO (1) NO174803B (es)
NZ (1) NZ238032A (es)
PT (1) PT97544B (es)
RU (1) RU2002737C1 (es)
SG (1) SG45439A1 (es)
SK (1) SK279258B6 (es)
TW (1) TW197415B (es)
ZA (1) ZA913337B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4014252A1 (de) * 1990-05-04 1991-11-07 Boehringer Ingelheim Vetmed Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer
GB9107196D0 (en) * 1991-04-05 1991-05-22 Sandoz Ag Improvements in or relating to organic compounds
GB2289842B (en) * 1991-04-05 1996-01-31 Sepracor Inc Improved use of ß2 bronchodilator drugs
EP0892639A4 (en) * 1996-01-29 1999-06-09 Savor Evelyn PROCESS FOR THE TREATMENT OF UNWANTED UTERINE CONTRACTIONS USING OPTICALLY PURE R OR RR ISOMERS OF AGONIST -g (b) -2 ADRENERGIC AGONISTS
EP1787529A3 (en) * 1997-04-30 2009-11-18 Courage Corporation Pty Ltd. Composition and methods using an eutomer
JP2001527545A (ja) 1997-04-30 2001-12-25 ブリッジ ファーマ，インコーポレーテッド ユートマーを使用する組成物および方法
ZA994264B (en) 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
US7232837B2 (en) 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
IL152140A0 (en) * 2000-04-27 2003-05-29 Boehringer Ingelheim Pharma Novel, slow-acting betamimetics, a method for their production and their use as medicaments
US20030162459A1 (en) * 2002-02-27 2003-08-28 Osbon Robert Lindsay Method for producing a nonwoven fabric with enhanced characteristics
US20040235922A1 (en) * 2003-05-15 2004-11-25 Baile Clifton A. Compositions and methods for inducing adipose tissue cell death
PL1663197T3 (pl) * 2003-09-09 2008-09-30 Biogen Idec Int Gmbh Zastosowanie pochodnych kwasu fumarowego do leczenia niewydolności serca oraz astmy
SG124283A1 (en) * 2004-03-24 2006-08-30 Trusted Hub Ltd Document signature method & system
EP1719507B1 (en) * 2005-04-13 2010-07-14 Astion Development A/S Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin
WO2006128180A2 (en) * 2005-05-27 2006-11-30 Children's Medical Center Corporation Methods for the treatment of disease
US20090305225A1 (en) * 2005-06-13 2009-12-10 Galbraith Richard A Inhibition of Creatine Uptake to Promote Weight Loss
CA2891234C (en) 2012-12-03 2017-03-07 Pfizer Inc. Selective androgen receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL136601C (es) * 1967-06-15
US4119710A (en) * 1972-12-18 1978-10-10 Boehringer Ingelheim Gmbh Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts
US4407819A (en) * 1980-08-25 1983-10-04 American Cyanamid Company Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals
US4814350A (en) * 1986-09-10 1989-03-21 American Cyanamid Company Method of treating diabetes with 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile
US4792546A (en) * 1986-12-05 1988-12-20 American Cyanamid Company Method for increasing weight gains and reducing deposition of fat in animals
DE4014252A1 (de) * 1990-05-04 1991-11-07 Boehringer Ingelheim Vetmed Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer

Also Published As

Publication number Publication date
DE59105957D1 (de) 1995-08-17
IL98030A0 (en) 1992-06-21
ZA913337B (en) 1993-01-27
FI912151A (fi) 1991-11-05
NO174803C (es) 1994-07-13
US5248695A (en) 1993-09-28
ATE124932T1 (de) 1995-07-15
CZ286389B6 (cs) 2000-03-15
BG94342A (en) 1994-06-30
KR0183024B1 (ko) 1999-05-15
PT97544B (pt) 1998-08-31
DK0455155T3 (da) 1995-11-13
JP2944777B2 (ja) 1999-09-06
AU645313B2 (en) 1994-01-13
US5292753A (en) 1994-03-08
PT97544A (pt) 1992-01-31
ES2109412T3 (es) 1998-01-16
DE4014252A1 (de) 1991-11-07
GR3017064T3 (en) 1995-11-30
IE69017B1 (en) 1996-07-24
US5395957A (en) 1995-03-07
ID966B (id) 1996-09-30
KR910019966A (ko) 1991-12-19
TW197415B (es) 1993-01-01
RU2002737C1 (ru) 1993-11-15
IL98030A (en) 1995-12-31
ES2075255T3 (es) 1995-10-01
DK0589488T3 (da) 1998-05-04
EP0589488B1 (de) 1997-09-17
DE59108853D1 (de) 1997-10-23
HU911502D0 (en) 1991-11-28
HUT60999A (en) 1992-11-30
AU7611191A (en) 1991-11-07
SK279258B6 (sk) 1998-08-05
IE911507A1 (en) 1991-11-06
NO911746D0 (no) 1991-05-03
FI912151A0 (fi) 1991-05-03
EP0589488A1 (de) 1994-03-30
EP0455155A1 (de) 1991-11-06
ATE158277T1 (de) 1997-10-15
CA2041818C (en) 2003-02-11
BG60743B1 (bg) 1996-02-29
HU214335B (hu) 1998-03-02
CS129291A3 (en) 1991-11-12
SG45439A1 (en) 1998-01-16
CA2041818A1 (en) 1991-11-05
NO911746L (no) 1991-11-05
GR3025547T3 (en) 1998-03-31
JPH04225944A (ja) 1992-08-14
EP0455155B1 (de) 1995-07-12
IE80651B1 (en) 1998-11-04
FI109600B (fi) 2002-09-13
US5648386A (en) 1997-07-15
NZ238032A (en) 1996-02-27
NO174803B (no) 1994-04-05

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