ES2189782T3 - Derivados de pteridina opticamente activos. - Google Patents

Derivados de pteridina opticamente activos.

Info

Publication number
ES2189782T3
ES2189782T3 ES87307803T ES87307803T ES2189782T3 ES 2189782 T3 ES2189782 T3 ES 2189782T3 ES 87307803 T ES87307803 T ES 87307803T ES 87307803 T ES87307803 T ES 87307803T ES 2189782 T3 ES2189782 T3 ES 2189782T3
Authority
ES
Spain
Prior art keywords
dioestereoisomero
substantially pure
new
optically active
dioestereoisomeros
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87307803T
Other languages
English (en)
Inventor
Hamish Christopher Swan Wood
Lilias Rees
Colin James Suckling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Strathclyde
Original Assignee
University of Strathclyde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10603634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2189782(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Strathclyde filed Critical University of Strathclyde
Application granted granted Critical
Publication of ES2189782T3 publication Critical patent/ES2189782T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Optical Communication System (AREA)
  • Cyclones (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA OBTENCION DE DIESTEREOISOMEROS SUSTANCIALMENTE PUROS DE DERIVADOS DE TETRAHIDROFOLATO Y AL USO DE DICHOS DIOESTEREOISOMEROS. MAS PARTICULARMENTE, LA PRESENTE INVENCION OFRECE UN PROCEDIMIENTO PARA LA OBTENCION DE UN DIOESTEREOISOMERO (6R O 6S) DESEADO, SUSTANCIALMENTE PURO, DE UN DERIVADO DEL ACIDO TETRAHIDROFOLICO O SAL O ESTER DEL MISMO. EL PROCEDIMIENTO COMPRENDE LAS ETAPAS DE: UNIR UN GRUPO AUXILIAR QUIRAL AL N-5 O AL N-10 DE UNA MEZCLA DE DIOESTEREOISOMEROS 6R Y 6S DE ACIDO TETRAHIDROFOLICO, SEPARAR LOS NUEVOS DIOESTEREOISOMEROS, RECUPERAR EL NUEVO DIOESTEREOISOMERO (6R O 6S) DESEADO QUE CORRESPONDE AL DIOESTEREOISOMERO (6R O 6S) DESEADO, Y CONVERTIR EL NUEVO DIOESTEREOISOMERO SUSTANCIALMENTE PURO RECUPERADO EN EL CORRESPONDIENTE DIASTEREOISOMERO.
ES87307803T 1986-09-03 1987-09-03 Derivados de pteridina opticamente activos. Expired - Lifetime ES2189782T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868621268A GB8621268D0 (en) 1986-09-03 1986-09-03 Separation of substances

Publications (1)

Publication Number Publication Date
ES2189782T3 true ES2189782T3 (es) 2003-07-16

Family

ID=10603634

Family Applications (3)

Application Number Title Priority Date Filing Date
ES87307803T Expired - Lifetime ES2189782T3 (es) 1986-09-03 1987-09-03 Derivados de pteridina opticamente activos.
ES02018955T Expired - Lifetime ES2241933T3 (es) 1986-09-03 1987-09-03 Formulacion farmaceutica que contiene un derivado de la pteridina.
ES94102875T Expired - Lifetime ES2191669T3 (es) 1986-09-03 1987-09-03 Compuestos opticamente activos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES02018955T Expired - Lifetime ES2241933T3 (es) 1986-09-03 1987-09-03 Formulacion farmaceutica que contiene un derivado de la pteridina.
ES94102875T Expired - Lifetime ES2191669T3 (es) 1986-09-03 1987-09-03 Compuestos opticamente activos.

Country Status (10)

Country Link
US (3) US4959472A (es)
EP (3) EP1275393B1 (es)
JP (3) JP2844532B2 (es)
AT (3) ATE295173T1 (es)
AU (1) AU598024B2 (es)
CA (1) CA1339368C (es)
DE (3) DE3752384T2 (es)
ES (3) ES2189782T3 (es)
GB (1) GB8621268D0 (es)
ZA (1) ZA876562B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (es) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
MY106598A (en) * 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.
CH676981A5 (es) * 1988-11-11 1991-03-28 Eprova Ag
IT1229517B (it) * 1989-01-31 1991-09-03 Bioresearch Spa Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative.
ES2090075T3 (es) * 1989-12-11 1996-10-16 American Cyanamid Co Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofolato.
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (es) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5245053A (en) * 1990-05-04 1993-09-14 American Cyanamid Company Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxoles
US5153309A (en) * 1990-07-27 1992-10-06 The United States Of America As Represented By The Department Of Health And Human Services Process of making tetrahydropteroylpoly-l-glutamic acid derivatives
CH681303A5 (es) * 1991-01-16 1993-02-26 Eprova Ag
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
CH684644A5 (de) * 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
US5498719A (en) * 1994-01-31 1996-03-12 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Diastereoselective process leading to a key intermediate for the preparation of fluorinated reverse transcriptase inhibitors
US5550128A (en) * 1994-09-09 1996-08-27 Nair; Madhavan G. Enantiomers of gamma methylene 10-deaza aminopterin and process for preparing the same
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
JP3330903B2 (ja) * 1999-08-05 2002-10-07 ダイセル化学工業株式会社 フォトレジスト用高分子化合物及びフォトレジスト用樹脂組成物
US20040266732A1 (en) * 2002-09-20 2004-12-30 Jorge Galvez Therapeutic agents, methods, and treatments
WO2005113833A2 (en) * 2004-05-21 2005-12-01 Duke University Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
DE602005026352D1 (de) * 2004-09-15 2011-03-31 Nipro Corp Wässrige, stabile (6S)-Folinsäurelösung zur Injektion
JP4956942B2 (ja) * 2004-09-15 2012-06-20 ニプロ株式会社 安定化された注射用水溶液製剤
WO2008096795A1 (ja) * 2007-02-07 2008-08-14 Hitachi Metals, Ltd. 低損失フェライト及びこれを用いた電子部品
WO2010057515A1 (en) * 2008-11-21 2010-05-27 Synthon B.V. Levocetirizine by menthyl intermediate
EP2629615B1 (en) 2010-10-22 2018-10-10 Duke University Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies
CN102329318B (zh) * 2011-10-20 2013-07-10 浙江圣达药业有限公司 一种高纯度四氢叶酸的制备方法
CN105399747A (zh) * 2015-10-30 2016-03-16 天津药物研究院药业有限责任公司 左旋5，10-亚甲基四氢叶酸的制备方法
CN114516874A (zh) * 2022-03-11 2022-05-20 国药一心制药有限公司 一种甲氨蝶呤新晶型及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
GB1560372A (en) * 1977-03-21 1980-02-06 Wellcome Found Preparation of calcium folinate
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
AU2816384A (en) * 1983-04-11 1984-11-07 University Of South Alabama Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted- tetrahydropteridines
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
CH676981A5 (es) * 1988-11-11 1991-03-28 Eprova Ag

Also Published As

Publication number Publication date
EP0266042A2 (en) 1988-05-04
AU7777587A (en) 1988-03-31
DE3752362T2 (de) 2003-11-20
US6849628B2 (en) 2005-02-01
EP1275393B1 (en) 2005-05-11
ATE231150T1 (de) 2003-02-15
ES2241933T3 (es) 2005-11-01
ES2191669T3 (es) 2003-09-16
DE3752362D1 (de) 2003-02-20
JP2000136135A (ja) 2000-05-16
DE3752361T2 (de) 2003-10-30
EP0608002B1 (en) 2003-01-15
US4959472A (en) 1990-09-25
EP0266042B1 (en) 2003-01-08
DE3752384T2 (de) 2006-01-19
EP0608002A1 (en) 1994-07-27
JPH11106342A (ja) 1999-04-20
JPS63115880A (ja) 1988-05-20
DE3752361D1 (de) 2003-02-13
DE3752384D1 (de) 2005-06-16
CA1339368C (en) 1997-08-26
JP2844532B2 (ja) 1999-01-06
US20020198212A1 (en) 2002-12-26
US6500829B1 (en) 2002-12-31
EP0266042A3 (en) 1989-11-15
ZA876562B (en) 1989-06-28
ATE230746T1 (de) 2003-01-15
EP1275393A1 (en) 2003-01-15
ATE295173T1 (de) 2005-05-15
AU598024B2 (en) 1990-06-14
GB8621268D0 (en) 1986-10-08

Similar Documents

Publication Publication Date Title
ES2189782T3 (es) Derivados de pteridina opticamente activos.
ES2084073T3 (es) Aclarados finales libres de cromo para metal fosfatado.
DK254688D0 (da) Fremgangsmaade til fremstilling af folininsyre
ES2045180T3 (es) Nuevo procedimiento para la obtencion de 4-aciloxi-3-hidroxietil-azetidinonas.
ES2082755T3 (es) Derivados de acido 3-desmetil-mevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su utilizacion asi como productos intermedios.
MX9303441A (es) Procedimiento para la preparacion de acido clavulanico.
ES2037013T3 (es) Procedimiento para preparar tieno-1,4-diazepinas.
ES2089416T3 (es) Procedimiento de produccion de intermedios para uso en la produccion de alcoxiiminoacetamidas.
DK32684A (da) Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
DK148183D0 (da) Fremgangsmade til fremstilling af imidazolylphenyl-tetrahydropyridaziner
ES557516A0 (es) Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
BR1100379A (pt) Composto, uso de um composto, preparação farmacêutica e processo para preparação de um composto
BG42835A3 (en) Method for preparing derivatives of thiazolylacetic acid
DK321888D0 (da) Anvendelse af jordalkalisalte af ethercarboxylsyr er som katalysatorer til alkoxylering
AR247327A1 (es) Una composicion herbicida
ES2020925B3 (es) Nuevas sales cristalinas de ariloxipropanolaminas, procedimiento para su preparacion y utilizacion de las mismas.
ES2051731T3 (es) Un procedimiento para preparar antibioticos macrolidos y su uso.
PT88116A (pt) Process for preparing naphthalenepropionic acid derivatives useful as anti-inflammatory/antiallergic agents
PT85100A (pt) Processo para a preparacao de novos tetra-hidro-benzotiazois e de composicoes farmaceuticas que os contem
PT91873A (pt) Processo para a preparacao de composicoes farmaceuticas contendo acidos oxapenem-3-carboxilicos estaveis uteis como inibidores de beta-lactamase
ES2149247T3 (es) Nuevos compuestos de n-bencil-piperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los incluyen.
BG44029A3 (en) Method for preparing of n- dimethyl morphinanic derivatives
UA12840A1 (uk) Спосіб одержаhhя правообертових похідhих оксиізоіhдоліhіла або їх фармацевтичhо прийhятhих солей
PT88551A (pt) Process for the preparation of curable compositions suitable for use as sealants
MX9304608A (es) Nuevas (n-metanosulfonil)-quinolilmetoxifenil-cicoalquilacetamidas sustituidas por isobutilo, procedimiento para su preparacion y medicamentos que las contienen.