MX9301505A - Metodo para preparar homo-beta-aminoacidos opticamente activos. - Google Patents

Metodo para preparar homo-beta-aminoacidos opticamente activos.

Info

Publication number
MX9301505A
MX9301505A MX9301505A MX9301505A MX9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A
Authority
MX
Mexico
Prior art keywords
beta
amino acids
homo
optically active
preparing optically
Prior art date
Application number
MX9301505A
Other languages
English (en)
Inventor
John Jeffrey Talley
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of MX9301505A publication Critical patent/MX9301505A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención está dirigida a la síntesis de homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica cuando se efectúa el rearreglo de Curtius de hemiéster ácido de succinato 3-mono-substituido de una pureza óptica suficiente para exhibir actividad óptica y se atrapa el isocianato incipiente con un alcohol primario o secundario. Los homo-beta-aminoésteres protegidos por carbamato resultantes se saponifican después para producir los correspondientes homo-beta-aminoácidos protegidos por carbamato que se desprotegen para producir homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica.
MX9301505A 1992-03-18 1993-03-17 Metodo para preparar homo-beta-aminoacidos opticamente activos. MX9301505A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85356192A 1992-03-18 1992-03-18

Publications (1)

Publication Number Publication Date
MX9301505A true MX9301505A (es) 1993-12-01

Family

ID=25316357

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301505A MX9301505A (es) 1992-03-18 1993-03-17 Metodo para preparar homo-beta-aminoacidos opticamente activos.

Country Status (5)

Country Link
EP (1) EP0561758A3 (es)
JP (1) JPH069515A (es)
CA (1) CA2091788A1 (es)
ES (1) ES2049710T1 (es)
MX (1) MX9301505A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4524015B2 (ja) * 1999-11-17 2010-08-11 キッセイ薬品工業株式会社 （２ｓ）−２−ベンジルコハク酸モノエステルの有機アミン塩およびその製造方法
GB0025310D0 (en) * 2000-10-16 2000-11-29 Pfizer Ltd Process
US6452041B1 (en) 2000-10-16 2002-09-17 Pfizer Inc. Olefination process to itaconate and succinate derivatives
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
JP2007506729A (ja) 2003-09-25 2007-03-22 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー α２δタンパク質に親和性を有するアミノ酸のプロドラッグ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306947A (ja) * 1989-05-01 1990-12-20 Monsanto Co キラルβ―アミノ酸の製造方法

Also Published As

Publication number Publication date
ES2049710T1 (es) 1994-05-01
JPH069515A (ja) 1994-01-18
EP0561758A2 (en) 1993-09-22
CA2091788A1 (en) 1993-09-19
EP0561758A3 (en) 1995-04-05

Similar Documents

Publication Publication Date Title
MX163284A (es) Bases de liberacion controlada para productos farmaceuticos
ES2153355T3 (es) Procedimiento para la preparacion de microesferas que contienen compuestos biologicamente activos.
UA6308A1 (uk) Спосіб одержання заміщених амінокислот, їх рацематів або оптичних ізомерів, або їх фармацевтично прийнятних солей
MX9308041A (es) Mezclas de nonanoles y decanoles isomericos, su elaboracion, los esteres de acido ftalico obtenibles a partir de los mismos y su empleo como reblandeceedores.
ES2094479T3 (es) Uso de esteres de l-2-oxotiazolidina-4-carboxilato para la preparacion de un medicamento para estimular la sintesis intracelular de glutation.
ES2084073T3 (es) Aclarados finales libres de cromo para metal fosfatado.
AR223505A1 (es) Esteres indoxilicos y tiondoxilicos de aminoacidos y peptidos,procedimiento para producirlos y dispositivo de diagnostico que los contiene
YU104777A (en) Process for the transformation of the optically active asymmetrical ester of the structure (r)alpha-cyano-sec.alcohol into the ester of an asymmetric acid with an (alpha)-cyano sec.alcohol of the structure (s)
ES2107621T3 (es) Sistema optico re-formador de imagenes.
DE3874619T2 (de) Herstellungsverfahren eines optisch aktiven alkohols.
AR247728A1 (es) Procedimiento para separar el isomero activo del cimaterol y procedimiento para preparar las sales diastereoisomeras de dicho isomero
ES2127312T3 (es) Lipopeptidos de actinoplanes sp. con actividad farmacologica, procedimiento para su preparacion y utilizacion de los mismos.
ES2090217T3 (es) Laca fotosensible.
MX9301505A (es) Metodo para preparar homo-beta-aminoacidos opticamente activos.
MY114765A (en) Preparation for epidermis
DE3874627T2 (de) Herstellungsverfahren eines optisch aktiven alkohols.
NO177531C (no) Fremgangsmåte ved fremstilling av 1-(aminometyl) cykloheksaneddiksyre, samt et mellomprodukt til anvendelse i denne fremgangsmåten
MX168547B (es) Procedimiento para la preparacion de colorantes azo
MX9200843A (es) Esteres del acido acrilico triazinil-substituidos y procedimiento para su obtencion.
MX9102518A (es) Dicarbonatos y uretanos de acido 4,5,-dihidroxi y 4,5,8,-trihidroxi-9,10-dihidro-9,10-dioxi-2-1-antracencarboxilico que tiene actividad terapeutica.
ES2039318T1 (es) Metodo de preparacion de beta-aminoacidos quirales.
DE3883973T2 (de) 1-2-dehydrierung von steroid-21-estern mit a. simplex.
ES2091390T3 (es) Un procedimiento para preparar poliamidas para espuma basada en poliisocianatos de color mas claro.
MX9305375A (es) Procedimiento para la produccion de inhibidores deproteasa.
ES2183860T3 (es) Procedimiento para producir n-terc butil-2-pirazincarboxamida y n-ter-butil-2-piperazincarboxamida.