KR910011247A - 신규한 단일층 경피 약제 투여시스템 - Google Patents

신규한 단일층 경피 약제 투여시스템 Download PDF

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KR910011247A
KR910011247A KR1019900019842A KR900019842A KR910011247A KR 910011247 A KR910011247 A KR 910011247A KR 1019900019842 A KR1019900019842 A KR 1019900019842A KR 900019842 A KR900019842 A KR 900019842A KR 910011247 A KR910011247 A KR 910011247A
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patch
mammal
matrix
albuterol
skin
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KR1019900019842A
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파라디에 바아람
다타트레이 고크해일 라제브
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폴 디. 매튜카이티스
지.디.썰 앤드 캄파니
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Publication of KR910011247A publication Critical patent/KR910011247A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

신규한 단일층 경피 약제 투여시스템
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 각종 보조제가 알부테롤의 흐름에 어떻게 영향을 끼치는가를 나타내는, 시간에 대한 일부테롤의 전달을 나타내는 도면이다.

Claims (13)

  1. a.소정두께와 면적의 엘라스토머 매트릭스;b.상기한 매트릭스에 두루 분산된 활성약제 성분; 및 c.상기한 매트릭스에 두루 분산된 확산증강제로 이루어지는, 액제를 경피 투여하기 위한 비적층 단일층 첩제.
  2. 제1항에 있어서, a.글리세롤과 같은 가소제;b.n-헥산올과 같은 가용화제; 및 c.상기한 엘라스토머 매트릭스용 경화 촉매로 더 이루어지는 것을 특징으로 하는 첩제.
  3. 제1항에 있어서, 상기한 확산 증강제가 n-도데칸올과 같은 직쇄상 탄화수소 알코올인 것을 특징으로 하는 첩제.
  4. 제1항에 있어서, 상기한 활성 약제 성분이 β2아드레날린성 수용체 길항체, 기관지 확장제 또는 알부테롤인 것을 특징으로 하는 첩제.
  5. a.소정 두께와 면적의 실리콘 엘라스토머 매트릭스;b.약리학적으로 충분한 양의 알부테롤; 및 c.상기한 매트릭스에 두루 분산된, 상기한 알부테롤용 확산 증강제로서의 n-도데칸올로 이루어지는, 약제를 경피 투여하기 위한 비적층 단일층 첩제.
  6. 제5항에 있어서, 상기한 엘라스토머 매트릭스가 약45내지 약95%, w/w의 양으로 존재하는 것을 특징으로 하는 첩제.
  7. 제5항에 있어서, 상기한 알부테롤이 약2내지 30%, w/w의 양으로 존재하는 것을 특징으로 하는 첩제.
  8. 제5항에 있어서, 상기한n-도데칸올이 약3 내지 약30%, w/w의 양으로 존재하는 것을 특징으로 하는 첩제.
  9. 제5항에 있어서, 상기한 활성 약제성분을 1일 첩제 cm2당 약0.2 내지 약 2mg의 방출속도로 공급할 수 있는 것을 특징으로 하는 첩제.
  10. 포유동물의 피부 또는 점막 지역에 제1항의 경피 투여 첩제를 투여하는 단계로 이루어지는 것을 특징으로 하는, 교감 신경 약제를 그것을 필요로하는 포유동물에 투여하는 방법.
  11. 포유동물의 피부 또는 점막 지역에 제1항의 첩제를 가하는 단계로 이루어지는 것을 특징으로 하는, 포유동물의 기관지 협착을 치료하는 방법.
  12. 포유동물의 피부 또는 점막 지역에 제1항의 첩제를 가하는 단계로 이루어지는 것을 특징으로 하는, 임신한 포유동물의 조기 자궁 수축을 지연시키는 방법.
  13. 포유동물의 피부 또는 점막 지역에 제1항의 첩제를 가하는 단계로 이루어지는 것을 특징으로 하는, 포유동물의 담마진을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019842A 1989-12-04 1990-12-04 신규한 단일층 경피 약제 투여시스템 KR910011247A (ko)

Applications Claiming Priority (2)

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US42576689A 1989-12-04 1989-12-04
US07425766 1989-12-04

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KR910011247A true KR910011247A (ko) 1991-08-07

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US (2) US5164189A (ko)
EP (1) EP0431519B1 (ko)
JP (1) JPH07133230A (ko)
KR (1) KR910011247A (ko)
AT (1) ATE107176T1 (ko)
CA (1) CA2031376A1 (ko)
DE (1) DE69009946T2 (ko)
DK (1) DK0431519T3 (ko)
ES (1) ES2055280T3 (ko)
IE (1) IE66203B1 (ko)
PT (1) PT96059B (ko)

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EP0431519B1 (en) 1994-06-15
DE69009946D1 (de) 1994-07-21
PT96059B (pt) 1998-07-31
IE66203B1 (en) 1995-12-13
ES2055280T3 (es) 1994-08-16
ATE107176T1 (de) 1994-07-15
EP0431519A1 (en) 1991-06-12
US5290561A (en) 1994-03-01
DK0431519T3 (da) 1994-07-04
DE69009946T2 (de) 1994-11-03
PT96059A (pt) 1991-09-30
JPH07133230A (ja) 1995-05-23
US5164189A (en) 1992-11-17
CA2031376A1 (en) 1991-06-05

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