KR890011585A - 경피식 피임약제제형 - Google Patents

경피식 피임약제제형 Download PDF

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Publication number
KR890011585A
KR890011585A KR1019880011854A KR880011854A KR890011585A KR 890011585 A KR890011585 A KR 890011585A KR 1019880011854 A KR1019880011854 A KR 1019880011854A KR 880011854 A KR880011854 A KR 880011854A KR 890011585 A KR890011585 A KR 890011585A
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KR
South Korea
Prior art keywords
reservoir
levonorgestrel
permeation enhancer
aforementioned
ethynyl estradiol
Prior art date
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KR1019880011854A
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English (en)
Inventor
베르케 디안 디. 네드
파트리카 에스. 캄프렐
로버트 엠. 게일
염수일
Original Assignee
에드 워드 엘.맨델
알자 코포레이숀
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Application filed by 에드 워드 엘.맨델, 알자 코포레이숀 filed Critical 에드 워드 엘.맨델
Publication of KR890011585A publication Critical patent/KR890011585A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/14—Topical contraceptives and spermacides

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

경피식 피임약 제제형
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 경피식 약물 투여시스템의 한구체예의 단면도.
제2도는 본 발명의 경피식 약물 투여 시스템의 단면도.

Claims (11)

  1. 에티린 에스트라디올과 레보노르게스트렐과 피부투과 증대제로 구성된 약물제제형을 장기간 경피식 투여하는 의료장치에 있어서: 전술한 약물 제제형과 전술한 투과 증대제를 포함하는 저장기 수단 : 그리고 피부에 약물 제제형과 투과 증대제를 전달하는 관계로 전술한 저장기를 유지하는 수단을 병용으로 포함하는 의료장치.
  2. 제1항에 있어서, 전술한 저장기 수단이 에티닐 에스트라디올, 레보노르게스트렐과 피부투과 증대제로 구성된 단일의 저장기인 장치.
  3. 제2항에 있어서, 전술한 투과 증대제가 모노라우린산 글리세롤(glycerol monlaurate)인 장치.
  4. 제1항에 있어서, 전술한 저장기 수단이 이중의 저장기 시스템으로서 제1저장기는 에티닐 에스트라디올과 레보노르게스트렐로 구성되고 제2저장기는 피부투과 증대제로 구성된 장치.
  5. 제4항에 있어서, 전술한 투과 증대제가 모노라우린산 글리세롤인 장치.
  6. 제1항에 있어서, 에티닐 에스트라디올과 레보노르게스트렐이 전술한 저장기에 이들의 포화농도보다 과잉의 양으로, 전술한 기간을 통하여 최소한 포화 레벨로 에티닐 에스트라디올과 레보노르게스트렐의 농도를 유지하는데 충분한 양으로 존재하는 장치.
  7. 제4항에 있어서, 전술한 제2저장기로부터의 투과 증대제의 배출을 조절하는 수단을 추가로 포함하는 장치.
  8. 제1항에 있어서, 전술한 저장기 수단이 최고 7일까지의 장기간에 최소한 15ug/일의 율로 피부를 통한 투여를 제공하는데 충분한 양으로 에티닐 에스트라디올을 포함하는 장치.
  9. 제1항에 있어서, 전술한 저장기 수단이 최고 7일까지의 장기간에 최소한 50ug/일의 율로 피부를 통한 투여를 제공하기에 충분한 양으로 레보노르게스트렐을 포함하는 장치.
  10. 제1항에 있어서, 전술한 장기간이 전술한 장치의 유효 수명이 되는 장치.
  11. 제10항에 있어서, 전술한 유효 수명이 최고 7일인 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880011854A 1987-02-26 1988-09-14 경피식 피임약제제형 KR890011585A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/019163 1987-02-26
US07/019,163 US4816258A (en) 1987-02-26 1987-02-26 Transdermal contraceptive formulations

Publications (1)

Publication Number Publication Date
KR890011585A true KR890011585A (ko) 1989-08-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880011854A KR890011585A (ko) 1987-02-26 1988-09-14 경피식 피임약제제형

Country Status (7)

Country Link
US (1) US4816258A (ko)
EP (1) EP0279982A1 (ko)
JP (1) JPS63225319A (ko)
KR (1) KR890011585A (ko)
AU (1) AU594908B2 (ko)
NZ (1) NZ222761A (ko)
ZA (1) ZA878499B (ko)

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EP0279982A1 (en) 1988-08-31
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