KR890003413A - 이중 침투증대제를 가진 경피식 약물투여장치 - Google Patents

이중 침투증대제를 가진 경피식 약물투여장치 Download PDF

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KR890003413A
KR890003413A KR1019880009918A KR880009918A KR890003413A KR 890003413 A KR890003413 A KR 890003413A KR 1019880009918 A KR1019880009918 A KR 1019880009918A KR 880009918 A KR880009918 A KR 880009918A KR 890003413 A KR890003413 A KR 890003413A
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dosage form
drug
unit dosage
skin
base surface
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KR1019880009918A
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KR960014996B1 (ko
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에프. 샌더스 하롤드
쳉 유-링
제이. 엔스코레 데이비드
비. 리빅키 샤리
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에드워드 엘. 맨델
알자 코포레이숀
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

이중 침투증대제를 가진 경피식 약물투여장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 모노라우린산 글리세롤과 에탄올의 단독시의 및 결합시의 두가지 모두에 대한 닐파디핀 대 시간의 경피식 약물플럭스(35℃에서의 시제 피부를 가로질러)의 그래프. 제2도는 본 발명에 따르로 율조절막을 사용하는 경피식 약물투여시스템의 한구체예의 단면도. 제3도는 본 발며의 경피식 약물투여시스템의 또다른 구체예의 횡단면도.

Claims (11)

  1. 예정된 시간동안 환자의 찢기지 않은 피부의 예정된 면에 약물과 그리고 투과증대제인 에탄올과 모노라우린산 글리세롤을 동시 투여하기 위한 단위 투여형에 있어서, 이 투약형이 피부의 면과 최소한 같은 면으로 되고, 전술한 기간동안 피부의 면과 접촉하게 되고 그리고 이 면을 통하여 약물과 그리고 투과증대제인 에탄올과 모노라우린산 글리세롤이 이에 의한 흡수를 위하여 피부의 면에 제시되게된 기본표면을 가지며 : 전술한 기간동안 기본표면에서 약물을 제공하기 위하여 기본표면과 통하는 약물의 공급을 포함하고 ; 전술한 기간동안 기본표면과 통하는 에탄올의 공급을 포함하고 ; 그리고 전술한 기간동안 기본표면과 통하는 모노라우린산 글리세롤의 공급을 포함하는 단위 투약형.
  2. 제1항에 있어서, 약물의 전술한 공급으로 전술한 기간동안의 실질적인 부분에 걸쳐 제공된 약물의 양이 피부의 면이 흡수할 수 있는 양보다 과잉으로 되도록 약을 제공하는 단위 투약형.
  3. 제1항에 있어서, 최소한 하나의 투과증대제가 기본표면에서 기간의 실질적인 부분에 걸쳐 실질적으로 일정하게 제공되는 율을 유지하는 수단을 추가로 포함하는 단위 투약형.
  4. 제3항에 있어서, 전술한 수단이 전술한 율에 피부가 흡수할 수 있는 최대율 이하로 되고 약물에 대해서 피부의 면의 투과성을 실질적으로 증가시키는 다른 투과증대제와 함께 충분하게된 기본표면에 최소한 하나의 증대제를 제공하는 율을 유지하는 바의 단위 투약형.
  5. 제4항에 있어서, 전술한 수단이 에탄올을 기본표면에 제공하는 율을 하는 수단.
  6. 제1항에 있어서, 기본표면에 피부의 면에 접착되는 단위 투약형.
  7. 제1항에 있어서, 약물 에탄올 및 모노라우린산 글리세롤의 공급을 혼합하여 같은 저장기에 포함시키는 단위 투약형.
  8. 제1항에 있어서, 약물의 공급에탄올 및 모노라우린산 글리세롤의 공급을 별도의 저장기에 유지시키는 단위 투약형.
  9. 제3항에 있어서, 수단이 에탄올과 모노라우린산 글리세롤의 공급과 기본표면 사이에 위치한 율조절 막이고 이를 통하여 에탄올과 모노라우린산 글리세롤이 투과하여 기본표면에 도달해야만 하는 단위 투약형.
  10. 제3항에 있어서, 기본표면에서 에탄올과 모노라우린산 글리세롤의 제공되는 율이 피부의 면에 의한 약물의 흡수율이 율로 기본표면에 제공되는 율이 증대제가 제공되는 율같이 현저히 증가되는 것을 증가시키도록 증가되는 단위 투약형.
  11. 제1항에 있어서, 전술한 약물이 닐바디핀인 단위 투약형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880009918A 1987-08-24 1988-08-03 이중 침투증대제를 가진 경피식 약물투여장치 KR960014996B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7/088,767 1987-08-24
US07/088,767 US4764379A (en) 1987-08-24 1987-08-24 Transdermal drug delivery device with dual permeation enhancers
US07/088,767 1987-08-24

Publications (2)

Publication Number Publication Date
KR890003413A true KR890003413A (ko) 1989-04-14
KR960014996B1 KR960014996B1 (ko) 1996-10-23

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Country Link
US (1) US4764379A (ko)
EP (1) EP0305026B1 (ko)
JP (1) JP2650713B2 (ko)
KR (1) KR960014996B1 (ko)
AT (1) ATE77250T1 (ko)
AU (1) AU600210B2 (ko)
CA (1) CA1313352C (ko)
DE (1) DE3872109T2 (ko)
ES (1) ES2032553T3 (ko)
GR (1) GR3004941T3 (ko)

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Also Published As

Publication number Publication date
EP0305026B1 (en) 1992-06-17
JPS6468314A (en) 1989-03-14
KR960014996B1 (ko) 1996-10-23
GR3004941T3 (ko) 1993-04-28
CA1313352C (en) 1993-02-02
ES2032553T3 (es) 1993-02-16
AU600210B2 (en) 1990-08-02
DE3872109D1 (de) 1992-07-23
EP0305026A3 (en) 1990-02-14
EP0305026A2 (en) 1989-03-01
DE3872109T2 (de) 1992-12-03
AU1379988A (en) 1989-03-02
JP2650713B2 (ja) 1997-09-03
US4764379A (en) 1988-08-16
ATE77250T1 (de) 1992-07-15

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