DE3681570D1 - Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. - Google Patents

Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Info

Publication number
DE3681570D1
DE3681570D1 DE8686308248T DE3681570T DE3681570D1 DE 3681570 D1 DE3681570 D1 DE 3681570D1 DE 8686308248 T DE8686308248 T DE 8686308248T DE 3681570 T DE3681570 T DE 3681570T DE 3681570 D1 DE3681570 D1 DE 3681570D1
Authority
DE
Germany
Prior art keywords
drug
flux
medical device
administration
period
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686308248T
Other languages
English (en)
Inventor
Robert M Gale
Randall G Berggren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE3681570D1 publication Critical patent/DE3681570D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DE8686308248T 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. Expired - Fee Related DE3681570D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/792,941 US4698062A (en) 1985-10-30 1985-10-30 Medical device for pulsatile transdermal delivery of biologically active agents

Publications (1)

Publication Number Publication Date
DE3681570D1 true DE3681570D1 (de) 1991-10-24

Family

ID=25158559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686308248T Expired - Fee Related DE3681570D1 (de) 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Country Status (11)

Country Link
US (1) US4698062A (de)
EP (1) EP0227252B1 (de)
JP (1) JPS62129058A (de)
KR (1) KR870003798A (de)
AT (1) ATE67417T1 (de)
AU (1) AU582075B2 (de)
CA (1) CA1275216C (de)
DE (1) DE3681570D1 (de)
ES (1) ES2024423B3 (de)
GR (1) GR3002747T3 (de)
ZA (1) ZA868070B (de)

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US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
DE3809978A1 (de) * 1988-03-24 1989-10-05 Lohmann Gmbh & Co Kg Reservoir fuer gesteuerte wirkstoffabgabe, dieses enthaltende vorrichtung, sowie verfahren zu deren herstellung und verwendung der vorrichtung
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
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DE3908431A1 (de) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
US5028435A (en) * 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
EP0522043B1 (de) * 1990-03-30 2003-10-15 Alza Corporation Vorrichtung zur iontophoretischen verabreichung
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
KR960006859B1 (ko) * 1992-03-06 1996-05-23 주식회사 태평양 티로시나제 저해 활성을 갖는 약물의 안정성을 개선하는 방법
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
KR960011044B1 (ko) * 1993-09-27 1996-08-16 재단법인 한국화학연구소 알칸올 투과가 우수한 고분자막
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1170603C (zh) * 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
CN1206004C (zh) 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
EP1911488A3 (de) 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
KR100572539B1 (ko) * 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
PT1041975E (pt) 1997-12-22 2003-01-31 Alza Corp Membranas de controlo de taxa para dispositivos de fornecimento controlado de drogas
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
PL195871B1 (pl) 1998-12-18 2007-11-30 Alza Corp Urządzenie do przezskórnego dostarczania nikotyny
US20070196490A1 (en) * 1999-01-22 2007-08-23 Powderject Research Limited Method of enhancing needleless transdermal powered drug delivery
JP2002541094A (ja) * 1999-04-01 2002-12-03 アルザ・コーポレーション ポリウレタン薬物貯蔵部を含んでなる経皮薬物送達装置
DK1239916T3 (da) 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
DE102004062614B4 (de) * 2004-12-24 2011-12-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit aktivierbarer Übersättigung und kontrollierter Permeationförderung sowie Verfahren zu dessen Herstellung
US20070196456A1 (en) * 2005-09-15 2007-08-23 Visible Assets, Inc. Smart patch
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
KR20090021169A (ko) 2006-05-16 2009-02-27 크놉 뉴로사이언시스 인코포레이티드 Ｒ(+) 및 ｓ(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008113056A2 (en) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
AU2008283929B2 (en) * 2007-08-06 2013-10-10 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
EP2334185A4 (de) 2008-08-19 2011-09-21 Knopp Neurosciences Inc Zusammensetzungen und verfahren zur verwendung von (r)-pramipexol
DK2626093T3 (en) * 2008-08-28 2014-02-24 Hoffmann La Roche DEVICE FOR INCREASING HYPODERMIC insulin absorption
GB0817486D0 (en) * 2008-09-24 2008-10-29 Smith & Nephew Delivery system
MX2011013577A (es) * 2009-06-19 2012-04-10 Knopp Neurosciences Inc Composiciones y metodos para tratar esclerosis lateral amiotrofica.
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
WO2011135532A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
KR101794376B1 (ko) 2010-04-28 2017-11-06 킴벌리-클라크 월드와이드, 인크. ｓｉＲＮＡ 전달용 의료 기구
JP6527305B2 (ja) 2011-01-10 2019-06-05 インヴィオン， インコーポレイテッド 禁煙のためのβ−アドレナリン作動性インバースアゴニストの使用
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
US11110066B2 (en) 2011-10-27 2021-09-07 Sorrento Therapeutics, Inc. Implantable devices for delivery of bioactive agents
EP3574950B1 (de) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermale freisetzung von hochviskosen bioaktiven wirkstoffen
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9675754B2 (en) 2012-10-24 2017-06-13 Nuance Designs, LLC Autoinjector
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
WO2014188329A2 (en) 2013-05-20 2014-11-27 Mylan, Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére

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US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
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US4336243A (en) * 1980-08-11 1982-06-22 G. D. Searle & Co. Transdermal nitroglycerin pad
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US4486193A (en) * 1981-07-22 1984-12-04 Alza Corporation Method for treating ischemic conditions by administering drug by two routes
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Also Published As

Publication number Publication date
ZA868070B (en) 1987-06-24
JPS62129058A (ja) 1987-06-11
KR870003798A (ko) 1987-05-04
EP0227252B1 (de) 1991-09-18
EP0227252A3 (en) 1989-04-05
US4698062A (en) 1987-10-06
EP0227252A2 (de) 1987-07-01
ES2024423B3 (es) 1992-03-01
GR3002747T3 (en) 1993-01-25
ATE67417T1 (de) 1991-10-15
CA1275216C (en) 1990-10-16
AU6432086A (en) 1987-05-07
AU582075B2 (en) 1989-03-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee