ATE67417T1 - Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. - Google Patents

Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Info

Publication number
ATE67417T1
ATE67417T1 AT86308248T AT86308248T ATE67417T1 AT E67417 T1 ATE67417 T1 AT E67417T1 AT 86308248 T AT86308248 T AT 86308248T AT 86308248 T AT86308248 T AT 86308248T AT E67417 T1 ATE67417 T1 AT E67417T1
Authority
AT
Austria
Prior art keywords
drug
flux
medical device
administration
period
Prior art date
Application number
AT86308248T
Other languages
English (en)
Inventor
Robert M Gale
Randall G Berggren
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE67417T1 publication Critical patent/ATE67417T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT86308248T 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. ATE67417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/792,941 US4698062A (en) 1985-10-30 1985-10-30 Medical device for pulsatile transdermal delivery of biologically active agents
EP86308248A EP0227252B1 (de) 1985-10-30 1986-10-23 Medizinische Einrichtung zur pulsatilen transdermalen Verabreichung von biologisch aktiven Wirkstoffen

Publications (1)

Publication Number Publication Date
ATE67417T1 true ATE67417T1 (de) 1991-10-15

Family

ID=25158559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86308248T ATE67417T1 (de) 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Country Status (11)

Country Link
US (1) US4698062A (de)
EP (1) EP0227252B1 (de)
JP (1) JPS62129058A (de)
KR (1) KR870003798A (de)
AT (1) ATE67417T1 (de)
AU (1) AU582075B2 (de)
CA (1) CA1275216C (de)
DE (1) DE3681570D1 (de)
ES (1) ES2024423B3 (de)
GR (1) GR3002747T3 (de)
ZA (1) ZA868070B (de)

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DE3908431A1 (de) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
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US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
KR960006859B1 (ko) * 1992-03-06 1996-05-23 주식회사 태평양 티로시나제 저해 활성을 갖는 약물의 안정성을 개선하는 방법
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
KR960011044B1 (ko) * 1993-09-27 1996-08-16 재단법인 한국화학연구소 알칸올 투과가 우수한 고분자막
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037686B1 (de) * 1997-12-11 2005-08-17 Alza Corporation Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
ATE406935T1 (de) 1997-12-11 2008-09-15 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
EP1911488A3 (de) 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
WO1999032095A1 (en) 1997-12-22 1999-07-01 Alza Corporation Rate controlling membranes for controlled drug delivery devices
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
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US20070196490A1 (en) * 1999-01-22 2007-08-23 Powderject Research Limited Method of enhancing needleless transdermal powered drug delivery
KR100622332B1 (ko) * 1999-04-01 2006-09-13 알자 코포레이션 폴리우레탄 약물 리저버를 함유하는 경피 약물 수송 장치
HK1048604B (en) 1999-12-10 2006-05-04 Alza Corporation Device and method for enhancing microprotrusion skin piercing
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
DE102004062614B4 (de) * 2004-12-24 2011-12-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit aktivierbarer Übersättigung und kontrollierter Permeationförderung sowie Verfahren zu dessen Herstellung
US20070196456A1 (en) * 2005-09-15 2007-08-23 Visible Assets, Inc. Smart patch
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US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
PL2026803T3 (pl) * 2006-05-16 2012-05-31 Knopp Neurosciences Inc Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania
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EP2137171A4 (de) 2007-03-14 2010-05-19 Knopp Neurosciences Inc Synthese von chiralaufgereinigten substituierten benzothiazoldiaminen
KR20140143461A (ko) * 2007-08-06 2014-12-16 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US9387033B2 (en) * 2008-08-28 2016-07-12 Roche Diabetes Care, Inc. Device and method for enhanced subcutaneous insulin absorption
GB0817486D0 (en) * 2008-09-24 2008-10-29 Smith & Nephew Delivery system
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
US9522262B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
PT2563450T (pt) 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
RU2570280C2 (ru) 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
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US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
PL3542851T3 (pl) 2011-10-27 2022-04-25 Sorrento Therapeutics, Inc. Wszczepialne urządzenia do dostarczania środków biologicznie czynnych
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
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Also Published As

Publication number Publication date
EP0227252A2 (de) 1987-07-01
EP0227252B1 (de) 1991-09-18
AU582075B2 (en) 1989-03-09
JPS62129058A (ja) 1987-06-11
EP0227252A3 (en) 1989-04-05
US4698062A (en) 1987-10-06
DE3681570D1 (de) 1991-10-24
KR870003798A (ko) 1987-05-04
CA1275216C (en) 1990-10-16
ES2024423B3 (es) 1992-03-01
GR3002747T3 (en) 1993-01-25
AU6432086A (en) 1987-05-07
ZA868070B (en) 1987-06-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee