ES2054818T3 - Dispositivo mejorado para el suministro transdermal de farmacos. - Google Patents

Dispositivo mejorado para el suministro transdermal de farmacos.

Info

Publication number
ES2054818T3
ES2054818T3 ES88309230T ES88309230T ES2054818T3 ES 2054818 T3 ES2054818 T3 ES 2054818T3 ES 88309230 T ES88309230 T ES 88309230T ES 88309230 T ES88309230 T ES 88309230T ES 2054818 T3 ES2054818 T3 ES 2054818T3
Authority
ES
Spain
Prior art keywords
therapeutic agent
drugs
improved device
activating means
anhydrous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309230T
Other languages
English (en)
Inventor
Eun Soo Lee
Su Il Yum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22379457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2054818(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2054818T3 publication Critical patent/ES2054818T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

SE DESCRIBE UN DISPOSITIVO DE LIBERACION DE MEDICAMENTOS DIFUSIONAL, QUE PUEDE ASEGURAR ESTABILIDAD DEL ADHESIVO Y COMPONENTES DEL SISTEMA, ELIMINACION DE LA EXPLOSION INICIAL DE MEDICAMENTO, Y DE AHI LA IRRITACION, Y ASEGURAR EL RETRASO DEL COMIENZO DEL EFECTO TERAPEUTICO JUNTO CON LIBERACION DE UN AGENTE TERAPEUTICO A UNA VELOCIDAD OPTIMA. EL AGENTE TERAPEUTICO EN UNA PRIMERA FORMA, QUE ES ADECUADA PARA ALMACENAMIENTO, Y LOS MEDIOS DE ACTIVACION ANHIDROS SON INERTES EN UN ENTORNO ANHIDRO. LA HUMEDAD ACTIVA EL SISTEMA, CON LO QUE EL MEDIO ACTIVANTE PROPORCIONA UNA DISOLUCION ACIDA O BASICA, Y LA PRIMERA FORMA DEL AGENTE TERAPEUTICO SE CONVIERTE EN UNA SEGUNDA FORMA QUE ES ADECUADA PARA ABSORCION A TRAVES DE LA PIEL O MUCOSA.
ES88309230T 1987-11-09 1988-10-04 Dispositivo mejorado para el suministro transdermal de farmacos. Expired - Lifetime ES2054818T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/118,577 US4781924A (en) 1987-11-09 1987-11-09 Transdermal drug delivery device

Publications (1)

Publication Number Publication Date
ES2054818T3 true ES2054818T3 (es) 1994-08-16

Family

ID=22379457

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309230T Expired - Lifetime ES2054818T3 (es) 1987-11-09 1988-10-04 Dispositivo mejorado para el suministro transdermal de farmacos.

Country Status (11)

Country Link
US (2) US4781924A (es)
EP (1) EP0316065B1 (es)
JP (1) JP2749832B2 (es)
AT (1) ATE89755T1 (es)
CA (1) CA1333689C (es)
DE (1) DE3881340T2 (es)
DK (1) DK567088A (es)
ES (1) ES2054818T3 (es)
GR (1) GR3007980T3 (es)
IE (1) IE63148B1 (es)
PT (1) PT88962B (es)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965074A (en) * 1985-03-05 1990-10-23 Ciba-Geigy Corporation Method of treating memory impairment
ES2028074T3 (es) * 1986-06-13 1992-07-01 Alza Corporation Activacion por humedad de un sistema de suministro transdermico de farmacos.
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4917676A (en) * 1986-11-20 1990-04-17 Ciba-Geigy Corporation User-activated transdermal therapeutic system
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5364630A (en) * 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
IE62662B1 (en) * 1989-01-06 1995-02-22 Elan Corp Plc Use of nicotine in the treatment of conditions susceptible to said treatment
DE3905051A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)
DE3905050A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii)
DE3908431A1 (de) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
DE3910543A1 (de) * 1989-04-01 1990-10-11 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung
EP0497919B1 (en) * 1989-10-23 1996-12-11 THERATECH, INC. (a Delaware Corporation) Iontophoresis device using a rate-controlling membrane
DE4002281A1 (de) * 1990-01-26 1991-08-01 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit dem wirkstoff tulobuterol
US5147654A (en) * 1990-07-23 1992-09-15 Alza Corporation Oral osmotic device for delivering nicotine
AU661726B2 (en) * 1991-10-16 1995-08-03 Timo Petteri Paronen Peroral drug delivery system
GB2265088B (en) * 1992-03-10 1996-02-07 Kyosti Eero Antero Kontturi Electrochemical device for drug delivery
ZA937452B (en) * 1992-10-15 1994-06-07 Alza Corp Delayed onset transdermal delivery device
US5691377A (en) * 1993-07-30 1997-11-25 University Of Maryland Eastern Shore And University Of Maryland College Park Use of N-methyl-aspartic acid for enhancing growth and altering body composition
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
DE4400769C2 (de) * 1994-01-13 1996-07-18 Lohmann Therapie Syst Lts Verfahren und Vorrichtung zur Herstellung einer flächigen Darreichungsform mit einer Arzneimittelwirkstoffe enthaltenden Zubereitung
EP0755244A1 (en) * 1994-04-13 1997-01-29 Novartis AG Temporally controlled drug delivery systems
GB2290964A (en) * 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
DE4429663C2 (de) * 1994-08-20 1997-09-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Hydrolyseschutz
DE19610293C1 (de) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
DE19814087A1 (de) * 1998-03-30 1999-10-14 Lohmann Therapie Syst Lts Feuchtigkeitsaktivierbares therapeutisches System
DE19814083C2 (de) * 1998-03-30 2002-02-07 Lohmann Therapie Syst Lts Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
KR100315465B1 (ko) * 1998-11-23 2002-02-19 성재갑 수용성고분자와알코올을포함하는주사제용동물구충제조성물
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
WO2000037058A1 (en) 1998-12-18 2000-06-29 Alza Corporation Transparent transdermal nicotine delivery devices
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
ES2244422T3 (es) * 1999-04-01 2005-12-16 Alza Corporation Dispositivos para la administracion transdermica de farmacos que comprenden un deposito de poliuretano para farmacos.
DE19925613A1 (de) * 1999-06-04 2000-12-07 Lohmann Therapie Syst Lts Verbundlaminat und Verfahren zu seiner Herstellung
US6602912B2 (en) 2000-06-30 2003-08-05 Dermatrends, Inc. Transdermal administration of phenylpropanolamine
JP2003528045A (ja) * 1999-12-16 2003-09-24 ダーマトレンズ， インコーポレイテッド フェニルプロパノールアミンの経皮投与
US6673363B2 (en) 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6719997B2 (en) 2000-06-30 2004-04-13 Dermatrends, Inc. Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers
US6582724B2 (en) 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US6586000B2 (en) 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US6682757B1 (en) 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
FR2822711B1 (fr) * 2001-03-28 2003-06-13 Oreal Dispositif de traitement comportant une enveloppe definissant une cavite dans laquelle peut-etre engagee une partie du corps
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
CA2531099A1 (en) 2003-04-10 2004-10-28 Light Bioscience, Llc Photomodulation methods and devices for regulating cell proliferation and gene expression
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
CN101247768A (zh) * 2003-07-31 2008-08-20 莱特生物科学有限公司 用于光动力学治疗烧伤、创伤和相关皮肤病的系统和方法
US7243788B2 (en) 2003-10-22 2007-07-17 Kimberly-Clark Worldwide, Inc. Package for segregating and mixing substances
CN101146523B (zh) 2004-10-21 2010-12-29 杜雷科特公司 透皮给药系统
US8252319B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
WO2006091795A2 (en) * 2005-02-25 2006-08-31 Board Of Regents, The University Of Texas System METHODS AND COMPOSITIONS INVOLVING EXPRESSION OF α1C SUBUNIT OF L-TYPE CALCIUM CHANNELS IN SMOOTH MUSCLE CELLS
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
ES2379117T3 (es) 2006-05-16 2012-04-20 Knopp Neurosciences, Inc. Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
WO2008042228A2 (en) * 2006-09-28 2008-04-10 Med Institute, Inc. Medical devices incorporating a bioactive and methods of preparing such devices
US20080082038A1 (en) * 2006-09-28 2008-04-03 Vance Products Incorporated, D/B/A/ Cook Urological Incorporated Medical Device including a Bioactive in a Non-ionic and an Ionic Form and Methods of Preparation Thereof
EP2068958B1 (en) * 2006-09-28 2016-10-19 Cook Medical Technologies LLC Medical device including an anesthetic and method of preparation thereof
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US20080228151A1 (en) * 2007-02-28 2008-09-18 Jie Zhang Transdermal drug delivery with controlled heat for treating musculoskeletal pain and/or inflammation
JP2010521496A (ja) * 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． キラル精製置換ベンゾチアゾールジアミンの合成
WO2008150995A2 (en) * 2007-06-01 2008-12-11 Zars Pharma, Inc. Transdermal drug delivery systems for delivering anti-inflammatory drugs
DE102007041557B4 (de) * 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend längliche Hohlkörper
DE102008013701A1 (de) * 2008-03-11 2009-09-17 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit stabilisierter Membran
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
WO2010148409A1 (en) * 2009-06-19 2010-12-23 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
DE102010024105A1 (de) * 2010-06-17 2011-12-22 Grünenthal GmbH Transdermale Verabreichung von Memantin
CN103732611B (zh) 2011-01-10 2016-06-01 伊沃恩有限公司 β-肾上腺素能反向激动剂用于戒烟的用途
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9682068B2 (en) 2013-05-20 2017-06-20 Mylan Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
LT3019167T (lt) 2013-07-12 2021-03-25 Knopp Biosciences Llc Eozinofilų ir (arba) bazofilų padidintų kiekių gydymas
AU2014306597B2 (en) 2013-08-13 2018-05-17 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP3038467B1 (en) 2013-08-13 2020-07-29 Knopp Biosciences LLC Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
MX2019001104A (es) 2016-07-27 2019-10-02 Corium Int Inc Sistemas de suministro transdermico de memantina.
CN109789134A (zh) 2016-07-27 2019-05-21 考里安国际公司 与口服递送药代动力学生物等效的透皮递送系统
KR102406536B1 (ko) 2016-07-27 2022-06-08 코리움, 인크. 도네페질 경피 전달 시스템
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE860152C (de) 1951-06-24 1952-12-18 Gustav Nowka Schiffsantrieb durch hydraulische Reaktion mittels Kreiselpumpe
US3252802A (en) 1964-06-11 1966-05-24 Canadian Patents Dev Method of supplementing the feed of growing swine with nicotine
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3734097A (en) 1969-04-01 1973-05-22 Alza Corp Therapeutic adhesive tape
US3901248A (en) 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
US3877468A (en) 1970-07-22 1975-04-15 Leo Ab Chewable tobacco substitute composition
US3731683A (en) 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3742951A (en) 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3870593A (en) * 1972-06-06 1975-03-11 Minnesota Mining & Mfg Stretch-oriented porous films and preparation and use thereof
US3845217A (en) 1972-11-16 1974-10-29 Helsingborg L Ab Buffered smoking substitute compositions
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3870794A (en) 1974-02-20 1975-03-11 Foundation For Behavioral Rese Treatment of certain emotional disorders with nicotine compounds
NL178686C (nl) 1974-04-08 1986-05-01 Duphar Int Res Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking.
US4125623A (en) 1974-04-08 1978-11-14 U.S. Philips Corporation Spasmolytics
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US3926188A (en) 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4012221A (en) * 1975-05-13 1977-03-15 International Copper Research Association Inc. Slow release copper toxicant compositions
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4562075A (en) 1982-05-20 1985-12-31 Nelson Research & Development Co. Penetration enhancers for transdermal drug delivery of systemic agents
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4060084A (en) 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
JPS5397422A (en) * 1977-02-04 1978-08-25 Canon Inc Double priority camera
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4166111A (en) * 1978-06-19 1979-08-28 Environmental Chemicals, Inc. Method and composition for the long term controlled release of a non-persistent organotin pesticide from an inert monolithic thermoplastic material
US4748181A (en) 1979-08-28 1988-05-31 Foundation For Behavioral Research Method for treating hypertension with nicotine
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4661105A (en) * 1981-06-29 1987-04-28 Alza Corporation Medical bandage for administering vasodilator drug
US4484921A (en) * 1982-02-01 1984-11-27 Alza Corporation Theophylline therapy utilizing osmotic delivery
IE54286B1 (en) 1983-01-18 1989-08-16 Elan Corp Plc Drug delivery device
DE3344691A1 (de) 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
US4704282A (en) 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
DE3586707T2 (de) 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
US4573995A (en) 1984-10-09 1986-03-04 Alza Corporation Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
DE3438284A1 (de) * 1984-10-16 1985-03-07 Hans-Harald von 2400 Lübeck Tilly Nikotinhaltiges depotpflaster
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4680172A (en) 1985-03-05 1987-07-14 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4643856A (en) 1985-03-21 1987-02-17 Moleculon, Inc. Process of making gelled cellulose triacetate product
US4665069A (en) 1985-04-02 1987-05-12 Barnett Rosenberg Analgesic composition and method of relieving pain
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4920989A (en) 1985-04-25 1990-05-01 Regents Of The University Of California Method and apparatus for aiding in the reduction of incidence of tobacco smoking
US5016652A (en) 1985-04-25 1991-05-21 The Regents Of The University Of California Method and apparatus for aiding in the reduction of incidence of tobacco smoking
JPS61251619A (ja) 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd ニコチン含有テ−プ製剤
US4655766A (en) * 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4715387A (en) 1985-08-23 1987-12-29 The Regents Of The Univ. Of California Aerosol for use in the reduction of tobacco smoking
AU6630086A (en) 1985-11-14 1987-06-02 David I. Rosen Transdermal application of nicotine
US4797284A (en) 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
DE3786199T2 (de) 1986-04-03 1993-09-23 Hercon Lab Artikel fuer die verabreichung pharmakologisch aktiver substanzen.
DE3629304A1 (de) 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
DE3786998D1 (de) 1986-11-20 1993-09-16 Ciba Geigy Ag Benutzer-aktivierte therapeutische systeme.
DE3743947A1 (de) 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur gesteuerten abgabe von nicotin, verfahren zu ihrer herstellung sowie ihre verwendung
US4839174A (en) 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch

Also Published As

Publication number Publication date
JPH01135717A (ja) 1989-05-29
EP0316065A3 (en) 1990-02-14
DK567088D0 (da) 1988-10-11
GR3007980T3 (es) 1993-08-31
IE882995L (en) 1989-05-09
CA1333689C (en) 1994-12-27
IE63148B1 (en) 1995-03-22
USRE39588E1 (en) 2007-04-24
PT88962A (pt) 1989-11-30
US4781924A (en) 1988-11-01
DE3881340T2 (de) 1993-09-09
ATE89755T1 (de) 1993-06-15
DE3881340D1 (de) 1993-07-01
PT88962B (pt) 1993-11-30
DK567088A (da) 1989-05-10
JP2749832B2 (ja) 1998-05-13
EP0316065A2 (en) 1989-05-17
EP0316065B1 (en) 1993-05-26

Similar Documents

Publication Publication Date Title
ES2054818T3 (es) Dispositivo mejorado para el suministro transdermal de farmacos.
ATE96308T1 (de) Dosierform fuer verabreichung in der humanmedizin.
ES2030026T3 (es) Sistema terapeutico transdermal, su aplicacion y procedimiento para su fabricacion.
KR890003413A (ko) 이중 침투증대제를 가진 경피식 약물투여장치
NO993385D0 (no) Transdermalt terapeutisk system for avgivelse av hormoner
ES2171672T3 (es) Composiciones activadoras de penetracion en la piel mediante la utilizacion de lactilatos de acilo.
IE46069L (en) Adhesive skin patch
DE3669828D1 (de) Mittel und vorrichtung zur steuerung der transdermalen penetration topischer und systematischer wirkstoffe.
FI945311A (fi) Oksibutyniinin transdermaalinen annostelu
SE8605320D0 (sv) Therapeutic device for the administration of medicaments
ZA946698B (en) Medical device for the administration of active ingredients or drugs at very low doses particularly homeopathic drugs
YU47956B (sh) Postupak za izradu transdermalnog terapijskog sistema sa buprenorphinom kao aktivnim sastojkom
ES2171469T3 (es) Composicion administrada por via nasal y preparacion que la contiene.
YU49390A (sh) Postupak za izradu transdermalnog terapijskog sistema sa stupnjevitim otpuštanjem aktivne materije

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 316065

Country of ref document: ES