PT3532470T - Derivados de oxazol para uso como inibidores de irak e método para a sua preparação - Google Patents

Derivados de oxazol para uso como inibidores de irak e método para a sua preparação

Info

Publication number
PT3532470T
PT3532470T PT177974953T PT17797495T PT3532470T PT 3532470 T PT3532470 T PT 3532470T PT 177974953 T PT177974953 T PT 177974953T PT 17797495 T PT17797495 T PT 17797495T PT 3532470 T PT3532470 T PT 3532470T
Authority
PT
Portugal
Prior art keywords
preparation
oxazole derivatives
irak inhibitors
irak
inhibitors
Prior art date
Application number
PT177974953T
Other languages
English (en)
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of PT3532470T publication Critical patent/PT3532470T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT177974953T 2016-10-26 2017-10-25 Derivados de oxazol para uso como inibidores de irak e método para a sua preparação PT3532470T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662413217P 2016-10-26 2016-10-26

Publications (1)

Publication Number Publication Date
PT3532470T true PT3532470T (pt) 2023-02-28

Family

ID=60302473

Family Applications (1)

Application Number Title Priority Date Filing Date
PT177974953T PT3532470T (pt) 2016-10-26 2017-10-25 Derivados de oxazol para uso como inibidores de irak e método para a sua preparação

Country Status (9)

Country Link
US (4) US10370367B2 (pt)
EP (1) EP3532470B1 (pt)
JP (2) JP7170634B2 (pt)
CN (1) CN110099899B (pt)
CA (1) CA3041587A1 (pt)
DK (1) DK3532470T3 (pt)
ES (1) ES2939232T3 (pt)
PT (1) PT3532470T (pt)
WO (1) WO2018089199A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110862375B (zh) * 2018-08-27 2022-10-25 深圳铂立健医药有限公司 吡唑化合物及其药物组合物和应用
EP4003990A1 (en) * 2019-08-30 2022-06-01 Rigel Pharmaceuticals, Inc. Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations
AU2023237737A1 (en) * 2022-03-23 2024-10-03 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
ATE107176T1 (de) 1989-12-04 1994-07-15 Searle & Co System zur transdermalen albuterol applikation.
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
EP0495421B1 (en) 1991-01-15 1996-08-21 Alcon Laboratories, Inc. Use of carrageenans in topical ophthalmic compositions
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
EP0553769B1 (de) 1992-01-29 1996-01-03 FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG Ballspielschläger, insbesondere Tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2008526723A (ja) * 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Cdk、gsk及びオーロラキナーゼの活性を調節するピラゾール誘導体
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
CN107108561B (zh) 2014-11-20 2020-08-28 默克专利有限公司 用作irak抑制剂的杂芳基化合物及其用途
EP3286181B1 (en) * 2015-04-22 2021-01-27 Rigel Pharmaceuticals, Inc. Pyrazole compounds and method for making and using the compounds
JP2019196309A (ja) * 2016-09-15 2019-11-14 武田薬品工業株式会社 複素環化合物

Also Published As

Publication number Publication date
JP7170634B2 (ja) 2022-11-14
US20190300518A1 (en) 2019-10-03
WO2018089199A1 (en) 2018-05-17
JP7379640B2 (ja) 2023-11-14
JP2019537577A (ja) 2019-12-26
ES2939232T3 (es) 2023-04-20
US20230062818A1 (en) 2023-03-02
US10370367B2 (en) 2019-08-06
US11492349B2 (en) 2022-11-08
JP2023011795A (ja) 2023-01-24
US20180111923A1 (en) 2018-04-26
US20210179601A1 (en) 2021-06-17
US11993594B2 (en) 2024-05-28
CA3041587A1 (en) 2018-05-17
CN110099899A (zh) 2019-08-06
US10941140B2 (en) 2021-03-09
EP3532470A1 (en) 2019-09-04
EP3532470B1 (en) 2022-12-07
DK3532470T3 (da) 2023-02-20
CN110099899B (zh) 2024-01-02

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