KR880013551A - 신규의 조성물 - Google Patents
신규의 조성물 Download PDFInfo
- Publication number
- KR880013551A KR880013551A KR1019880005287A KR880005287A KR880013551A KR 880013551 A KR880013551 A KR 880013551A KR 1019880005287 A KR1019880005287 A KR 1019880005287A KR 880005287 A KR880005287 A KR 880005287A KR 880013551 A KR880013551 A KR 880013551A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- fat
- fats
- polymer
- layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 주어진 화합물의 혈장농도를 나타낸 그래프이며 제2도는 유리에리스로마이신의 혈장농도를 나타낸 그라프이다.
Claims (14)
- 적어도 3개층으로 구성되고 가장 내부의 층은 기본적으로 순수한 지방으로 이루어지고, 중간층은 지방과 폴리머의 혼합물로 이루어지고, 가장 바깥층은 다시 기본적으로 순수한 지방으로 이루어진 것을 특징으로 하는 약물을 분말제, 캡슐제 또는 혼합물의 형태로 재형화할때 약물과립의 표면에의 사용에 적합한 조성물.
- 제1항에서 사용된 지방이 지방산 트리글리세라이드인 조성물.
- 제2항에서 사용된 지방이 탄소수 11-23의 포화지방산의 트리글리세라이드인 조성물.
- 제2항에서 사용된 지방이 탄소수 12-18의 포화지방산의 트리글리세라이드인 조성물.
- 제2항에서 사용된 지방이 글리세릴 트리미리스테이트인 조성물.
- 제1항에서 사용된 폴리머가 프탈산과 셀루로즈유도체의 에스테르인 조성물.
- 제6항에서 사용된 에스테르가 PH4.5이상에서 수용성인 조성물.
- 제6항에서 사용된 에스테르가 하이드록시프로필 메틸 셀루로즈 프탈레이트인 조성물.
- 제1항에서 지방과 폴리머를 함유하는 층의 비율이 완성된 생성물의 50-95 5(중량)인 조성물.
- 제1항에서 지방과 폴리머를 함유하는 층이 전체층의 15-99%(중량)의 폴리머를 함유하는 조성물.
- 제1항에서 완성된 조성물의 주입자분포가 30-200㎛, 적당하게는 50-150㎛ 바람직하게는 80-140㎛인 조성물.
- 제1항의 조성물을 제3항의 지방을 사용하여 펠렛화된 용해성이 나쁜 약물의 표면에 사용하는 방법.
- 유기용매에 용해시킨 지방/지방과 폴리머의 혼합물/및 지방을 유동화 배드기술의 원리를 사용하여 약물과립에 침착시킴을 특징으로 하는 제1항의 조성물을 제조하는 방법.
- 제13항에서 사용된 용매가 할로겐화 탄화수소 특히 메틸렌클로라이드, 아세톤, 저급알콜 또는 이들의 혼합물인 방법.※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI872051 | 1987-05-08 | ||
FI872051A FI77573C (fi) | 1987-05-08 | 1987-05-08 | Ny konsistens. |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880013551A true KR880013551A (ko) | 1988-12-21 |
Family
ID=8524451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880005287A KR880013551A (ko) | 1987-05-08 | 1988-05-06 | 신규의 조성물 |
Country Status (35)
Country | Link |
---|---|
US (1) | US4935247A (ko) |
JP (1) | JPS63287720A (ko) |
KR (1) | KR880013551A (ko) |
AT (1) | AT396329B (ko) |
AU (1) | AU610161B2 (ko) |
BE (1) | BE1000785A3 (ko) |
CH (1) | CH675070A5 (ko) |
CS (1) | CS270588B2 (ko) |
DD (1) | DD284600A5 (ko) |
DE (1) | DE3815562A1 (ko) |
DK (1) | DK247588A (ko) |
EG (1) | EG18603A (ko) |
ES (1) | ES2006649A6 (ko) |
FI (1) | FI77573C (ko) |
FR (1) | FR2630912B1 (ko) |
GB (1) | GB2204241B (ko) |
GR (1) | GR1000303B (ko) |
HU (1) | HU198621B (ko) |
IL (1) | IL86313A (ko) |
IS (1) | IS3339A7 (ko) |
IT (1) | IT1219691B (ko) |
LU (1) | LU87208A1 (ko) |
MA (1) | MA21264A1 (ko) |
MX (1) | MX167185B (ko) |
NL (1) | NL8801185A (ko) |
NO (1) | NO881993L (ko) |
NZ (1) | NZ224529A (ko) |
PH (1) | PH24652A (ko) |
PL (1) | PL272295A1 (ko) |
PT (1) | PT87429B (ko) |
RO (1) | RO101402B (ko) |
RU (1) | RU1836082C (ko) |
SE (1) | SE8801732L (ko) |
YU (1) | YU46457B (ko) |
ZA (1) | ZA883239B (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01299226A (ja) * | 1988-05-27 | 1989-12-04 | Seikagaku Kogyo Co Ltd | サラゾスルファピリジン腸溶顆粒 |
NO882653D0 (no) * | 1988-06-15 | 1988-06-15 | Apothekernes Lab | Doseringsform. |
US5296236A (en) * | 1988-09-16 | 1994-03-22 | Recordati S.A., Chemical And Pharmaceutical Company | Controlled release therapeutic system for a liquid pharmaceutical formulations |
US5055307A (en) * | 1988-12-29 | 1991-10-08 | Asahi Kagaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
US5093128A (en) * | 1989-07-18 | 1992-03-03 | Draguesku Oliver J | Rumen and other stomach chamber bypass nutrients and methods of fabrication |
JP3078859B2 (ja) * | 1990-02-23 | 2000-08-21 | 武田薬品工業株式会社 | 安定な放出制御性製剤用コーティング剤 |
US5084287A (en) * | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
DE4200821A1 (de) * | 1992-01-15 | 1993-07-22 | Bayer Ag | Geschmacksmaskierte pharmazeutische mittel |
GB9201639D0 (en) * | 1992-01-25 | 1992-03-11 | Smithkline Beecham Plc | Pharmaceutical formulations |
EP0689840A1 (de) * | 1994-06-28 | 1996-01-03 | Spirig Ag Pharmazeutische Präparate | Neues orales Erythromycinbase enthaltendes Arzneimittel |
US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
US20060116330A1 (en) * | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
US6242019B1 (en) | 1997-08-14 | 2001-06-05 | Warner-Lambert Company | Taste modified hard confectionery compositions containing functional ingredients |
FR2821747B1 (fr) * | 2001-03-09 | 2004-07-02 | Ethypharm Lab Prod Ethiques | Suspension de telithromycine a gout masque |
FR2821745B1 (fr) * | 2001-03-09 | 2004-07-02 | Ethypharm Lab Prod Ethiques | Granules et granules enrobes au gout masque |
US8168170B2 (en) * | 2002-10-03 | 2012-05-01 | The Procter And Gamble Company | Compositions having an inner core and at least three surrounding layers |
US20050152884A1 (en) * | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
US8877178B2 (en) * | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
AU2006253006B8 (en) * | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
AU2006253007B2 (en) * | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーThe Iams Company | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE835500C (de) * | 1950-05-18 | 1952-03-31 | Otto Doerr Dipl Ing | Verfahren zum Konservieren eines in einem indifferenten Koerper gespeicherten, im Darm zur Wirkung zu bringenden Mittels |
US2828206A (en) * | 1954-02-24 | 1958-03-25 | Roseuberg Adolf | Stabilized fat-soluble vitamins and methods of making same |
US2963402A (en) * | 1955-01-18 | 1960-12-06 | Nysco Lab Inc | Sustained release medicament |
GB821790A (en) * | 1956-11-20 | 1959-10-14 | Smith Kline French Lab | Method of preparing sustained release particles and the product of the method |
US2921883A (en) * | 1957-05-03 | 1960-01-19 | Smith Kline French Lab | Novel coating material for medicaments |
NL270408A (ko) * | 1960-10-20 | |||
NL297088A (ko) * | 1961-01-31 | |||
BE640616A (ko) * | 1962-12-19 | |||
US3256153A (en) * | 1963-02-08 | 1966-06-14 | Smith Kline French Lab | Method of stabilizing wax-fat coating materials and product thereof |
US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
US4330338A (en) * | 1978-10-02 | 1982-05-18 | Purdue Research Foundation | Pharmaceutical coating composition, and preparation and dosages so coated |
IT1148784B (it) * | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
NZ210785A (en) * | 1984-01-13 | 1987-11-27 | Battelle Development Corp | Liquid dispersions of layered controlled release dosage forms |
US4650665A (en) * | 1985-02-08 | 1987-03-17 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
ATE109659T1 (de) * | 1986-03-21 | 1994-08-15 | Eurasiam Lab | Arzneimittelzusammensetzungen. |
-
1987
- 1987-05-08 FI FI872051A patent/FI77573C/fi not_active IP Right Cessation
-
1988
- 1988-04-25 YU YU83188A patent/YU46457B/sh unknown
- 1988-04-27 MX MX011281A patent/MX167185B/es unknown
- 1988-05-05 ZA ZA883239A patent/ZA883239B/xx unknown
- 1988-05-05 EG EG250/88A patent/EG18603A/xx active
- 1988-05-06 ES ES8801414A patent/ES2006649A6/es not_active Expired
- 1988-05-06 DE DE3815562A patent/DE3815562A1/de not_active Withdrawn
- 1988-05-06 NO NO881993A patent/NO881993L/no unknown
- 1988-05-06 AU AU15672/88A patent/AU610161B2/en not_active Ceased
- 1988-05-06 GR GR880100297A patent/GR1000303B/el unknown
- 1988-05-06 CH CH1739/88A patent/CH675070A5/de not_active IP Right Cessation
- 1988-05-06 KR KR1019880005287A patent/KR880013551A/ko not_active Application Discontinuation
- 1988-05-06 FR FR888806173A patent/FR2630912B1/fr not_active Expired - Fee Related
- 1988-05-06 BE BE8800509A patent/BE1000785A3/fr not_active IP Right Cessation
- 1988-05-06 PL PL27229588A patent/PL272295A1/xx unknown
- 1988-05-06 GB GB8810765A patent/GB2204241B/en not_active Expired - Fee Related
- 1988-05-06 LU LU87208A patent/LU87208A1/fr unknown
- 1988-05-06 PT PT87429A patent/PT87429B/pt not_active IP Right Cessation
- 1988-05-06 MA MA21505A patent/MA21264A1/fr unknown
- 1988-05-06 RU SU884355822A patent/RU1836082C/ru active
- 1988-05-06 NL NL8801185A patent/NL8801185A/nl not_active Application Discontinuation
- 1988-05-06 JP JP63111344A patent/JPS63287720A/ja active Pending
- 1988-05-06 IS IS3339A patent/IS3339A7/is unknown
- 1988-05-06 AT AT0119188A patent/AT396329B/de not_active IP Right Cessation
- 1988-05-06 SE SE8801732A patent/SE8801732L/ not_active Application Discontinuation
- 1988-05-06 NZ NZ224529A patent/NZ224529A/xx unknown
- 1988-05-06 RO RO133416A patent/RO101402B/ro unknown
- 1988-05-06 US US07/191,190 patent/US4935247A/en not_active Expired - Fee Related
- 1988-05-06 CS CS883102A patent/CS270588B2/cs unknown
- 1988-05-06 PH PH36902A patent/PH24652A/en unknown
- 1988-05-06 HU HU882313A patent/HU198621B/hu not_active IP Right Cessation
- 1988-05-06 DK DK247588A patent/DK247588A/da not_active Application Discontinuation
- 1988-05-06 DD DD88315493A patent/DD284600A5/de not_active IP Right Cessation
- 1988-05-06 IT IT20479/88A patent/IT1219691B/it active
- 1988-05-09 IL IL86313A patent/IL86313A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |