KR880002483B1 - 3-히드록시-ml-236b 유도체의 제조방법 - Google Patents

3-히드록시-ml-236b 유도체의 제조방법 Download PDF

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Publication number
KR880002483B1
KR880002483B1 KR8205250A KR820005250A KR880002483B1 KR 880002483 B1 KR880002483 B1 KR 880002483B1 KR 8205250 A KR8205250 A KR 8205250A KR 820005250 A KR820005250 A KR 820005250A KR 880002483 B1 KR880002483 B1 KR 880002483B1
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Prior art keywords
nocardia
autotrophica
ferm
kaist
microorganism
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Expired
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KR8205250A
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Korean (ko)
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KR840002451A (ko
Inventor
아끼라 데라하라
미노루 다나까
Original Assignee
가와무라 요시부미
상꾜가부시끼가이샤
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Publication of KR840002451A publication Critical patent/KR840002451A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR8205250A 1981-11-20 1982-11-20 3-히드록시-ml-236b 유도체의 제조방법 Expired KR880002483B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56186641A JPS5889191A (ja) 1981-11-20 1981-11-20 ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP56-186641 1981-11-20

Publications (2)

Publication Number Publication Date
KR840002451A KR840002451A (ko) 1984-07-02
KR880002483B1 true KR880002483B1 (ko) 1988-11-19

Family

ID=16192138

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205250A Expired KR880002483B1 (ko) 1981-11-20 1982-11-20 3-히드록시-ml-236b 유도체의 제조방법

Country Status (18)

Country Link
US (1) US4537859A (https=)
JP (1) JPS5889191A (https=)
KR (1) KR880002483B1 (https=)
AT (1) AT387585B (https=)
AU (1) AU551720B2 (https=)
BE (1) BE895080A (https=)
CA (1) CA1186647A (https=)
CH (1) CH651065A5 (https=)
DE (1) DE3242849A1 (https=)
DK (1) DK159328C (https=)
ES (1) ES8402350A1 (https=)
FI (1) FI70925C (https=)
FR (1) FR2516935A1 (https=)
GB (1) GB2111052B (https=)
IT (1) IT1191235B (https=)
NL (1) NL194373C (https=)
SE (1) SE453996B (https=)
ZA (1) ZA828535B (https=)

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US5041562A (en) * 1989-06-09 1991-08-20 Merck & Co., Inc. 3-keto HMG-CoA reductase inhibitors
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US4970231A (en) * 1989-06-09 1990-11-13 Merck & Co., Inc. 4-substituted HMG-CoA reductase inhibitors
US4937259A (en) * 1989-06-09 1990-06-26 Merck & Co., Inc. Antihypercholesterolemic compounds
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US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
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US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
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SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
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Also Published As

Publication number Publication date
NL194373B (nl) 2001-10-01
FI70925B (fi) 1986-07-18
SE453996B (sv) 1988-03-21
KR840002451A (ko) 1984-07-02
GB2111052A (en) 1983-06-29
IT1191235B (it) 1988-02-24
DE3242849A1 (de) 1983-06-01
BE895080A (fr) 1983-03-16
NL8204505A (nl) 1983-06-16
FI823978L (fi) 1983-05-21
DE3242849C2 (https=) 1989-01-05
ES517542A0 (es) 1984-01-16
ES8402350A1 (es) 1984-01-16
ZA828535B (en) 1983-10-26
FI70925C (fi) 1986-10-27
DK159328B (da) 1990-10-01
DK516182A (da) 1983-05-21
AT387585B (de) 1989-02-10
NL194373C (nl) 2002-02-04
DK159328C (da) 1991-02-25
GB2111052B (en) 1985-05-09
JPH0371116B2 (https=) 1991-11-12
JPS5889191A (ja) 1983-05-27
ATA425182A (de) 1988-07-15
SE8206580D0 (sv) 1982-11-18
CH651065A5 (de) 1985-08-30
AU9061082A (en) 1983-05-26
FR2516935A1 (fr) 1983-05-27
CA1186647A (en) 1985-05-07
FI823978A0 (fi) 1982-11-19
US4537859A (en) 1985-08-27
FR2516935B1 (https=) 1985-02-08
IT8268359A0 (it) 1982-11-22
AU551720B2 (en) 1986-05-08
SE8206580L (sv) 1983-05-21

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