SE8206580D0 - Framstellning av 3-hydroxi-ml-236b-derivat - Google Patents

Framstellning av 3-hydroxi-ml-236b-derivat

Info

Publication number
SE8206580D0
SE8206580D0 SE8206580A SE8206580A SE8206580D0 SE 8206580 D0 SE8206580 D0 SE 8206580D0 SE 8206580 A SE8206580 A SE 8206580A SE 8206580 A SE8206580 A SE 8206580A SE 8206580 D0 SE8206580 D0 SE 8206580D0
Authority
SE
Sweden
Prior art keywords
carboxylic acid
derivate
hydroxy
preparation
resulting
Prior art date
Application number
SE8206580A
Other languages
English (en)
Other versions
SE453996B (sv
SE8206580L (sv
Inventor
A Terahara
M Tanaka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of SE8206580D0 publication Critical patent/SE8206580D0/sv
Publication of SE8206580L publication Critical patent/SE8206580L/sv
Publication of SE453996B publication Critical patent/SE453996B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
SE8206580A 1981-11-20 1982-11-18 Forfarande for framstellning av 3-hydroxi-ml-236b-derivat SE453996B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56186641A JPS5889191A (ja) 1981-11-20 1981-11-20 ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法

Publications (3)

Publication Number Publication Date
SE8206580D0 true SE8206580D0 (sv) 1982-11-18
SE8206580L SE8206580L (sv) 1983-05-21
SE453996B SE453996B (sv) 1988-03-21

Family

ID=16192138

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8206580A SE453996B (sv) 1981-11-20 1982-11-18 Forfarande for framstellning av 3-hydroxi-ml-236b-derivat

Country Status (18)

Country Link
US (1) US4537859A (sv)
JP (1) JPS5889191A (sv)
KR (1) KR880002483B1 (sv)
AT (1) AT387585B (sv)
AU (1) AU551720B2 (sv)
BE (1) BE895080A (sv)
CA (1) CA1186647A (sv)
CH (1) CH651065A5 (sv)
DE (1) DE3242849A1 (sv)
DK (1) DK159328C (sv)
ES (1) ES517542A0 (sv)
FI (1) FI70925C (sv)
FR (1) FR2516935A1 (sv)
GB (1) GB2111052B (sv)
IT (1) IT1191235B (sv)
NL (1) NL194373C (sv)
SE (1) SE453996B (sv)
ZA (1) ZA828535B (sv)

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US5116870A (en) * 1986-06-23 1992-05-26 Merck & Co., Inc. HMG-CoA reductase inhibitors
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US4940727A (en) * 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
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US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
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US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
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NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI9800144A (sl) 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
ATE360703T1 (de) 1999-01-20 2007-05-15 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von hemmern der hmg-coa reduktase
AU2321600A (en) * 1999-01-29 2000-08-18 Kyowa Hakko Kogyo Co. Ltd. Process for producing hmg-coa reductase inhibitor
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
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US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
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US3392171A (en) * 1964-03-20 1968-07-09 Upjohn Co 4-morpholino-4'-hydroxy bicyclohexyls
US3281330A (en) * 1964-03-20 1966-10-25 Upjohn Co Microbiological process for the oxygenation of cycloalkanes
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b

Also Published As

Publication number Publication date
SE453996B (sv) 1988-03-21
DK159328B (da) 1990-10-01
CA1186647A (en) 1985-05-07
ES8402350A1 (es) 1984-01-16
NL194373B (nl) 2001-10-01
FI823978L (fi) 1983-05-21
DE3242849C2 (sv) 1989-01-05
AU551720B2 (en) 1986-05-08
FI70925C (fi) 1986-10-27
GB2111052B (en) 1985-05-09
KR840002451A (ko) 1984-07-02
ES517542A0 (es) 1984-01-16
BE895080A (fr) 1983-03-16
JPS5889191A (ja) 1983-05-27
IT1191235B (it) 1988-02-24
FR2516935B1 (sv) 1985-02-08
US4537859A (en) 1985-08-27
KR880002483B1 (ko) 1988-11-19
AU9061082A (en) 1983-05-26
DE3242849A1 (de) 1983-06-01
DK159328C (da) 1991-02-25
DK516182A (da) 1983-05-21
NL8204505A (nl) 1983-06-16
GB2111052A (en) 1983-06-29
IT8268359A0 (it) 1982-11-22
AT387585B (de) 1989-02-10
CH651065A5 (de) 1985-08-30
SE8206580L (sv) 1983-05-21
ZA828535B (en) 1983-10-26
FR2516935A1 (fr) 1983-05-27
JPH0371116B2 (sv) 1991-11-12
FI823978A0 (fi) 1982-11-19
FI70925B (fi) 1986-07-18
ATA425182A (de) 1988-07-15
NL194373C (nl) 2002-02-04

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