KR840002344A - 4-[n-(하이드록시벤질)아미노메틸] 사이클로헥산-1-카복실산의 제조방법 - Google Patents
4-[n-(하이드록시벤질)아미노메틸] 사이클로헥산-1-카복실산의 제조방법 Download PDFInfo
- Publication number
- KR840002344A KR840002344A KR1019820005231A KR820005231A KR840002344A KR 840002344 A KR840002344 A KR 840002344A KR 1019820005231 A KR1019820005231 A KR 1019820005231A KR 820005231 A KR820005231 A KR 820005231A KR 840002344 A KR840002344 A KR 840002344A
- Authority
- KR
- South Korea
- Prior art keywords
- aminomethyl
- cyclohexane
- carboxylic acid
- hydroxybenzyl
- preparing
- Prior art date
Links
- FDXDPRFMHBTQSZ-UHFFFAOYSA-N 4-[[[hydroxy(phenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid Chemical compound C=1C=CC=CC=1C(O)NCC1CCC(C(O)=O)CC1 FDXDPRFMHBTQSZ-UHFFFAOYSA-N 0.000 title claims 2
- 150000002148 esters Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 3
- 125000006289 hydroxybenzyl group Chemical group 0.000 claims 3
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 2
- BVYNZFIBCBZMKA-UHFFFAOYSA-N 4-(benzamidomethyl)cyclohexane-1-carboxylic acid Chemical class C1CC(C(=O)O)CCC1CNC(=O)C1=CC=CC=C1 BVYNZFIBCBZMKA-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000862 absorption spectrum Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명 화합물(실시예 1)의 적외선 흡수 스펙트럼.
제2도는 본 발명 화합물(실시예 2)의 적외선 흡수 스펙트럼
Claims (1)
- 다음 일반식(Ⅳ)의 4-[N-(하이드록시벤질리덴)아미노메틸) 사이클로헥산-1-카복실산 유도체 또는 이의 염 또는 에스테르를 환원시키고, 임의로 생성된 4-[N-(하이드록시벤질)아미노메틸] 사이클로헥산-1-카복실산을 이의 염 또는 에스테르로 전환시키거나 생성된 4-[N-(하이드록시벤질) 아미노메틸] 사이클로헥산-1-카복실산의 에스테로를 4-[N-(하이드록시벤질) 아미노메틸] 사이클로헥산-1-카복실산 또는 이의 염 또는 다른 에스테르로 절환시킴을 특징으로 하여 다음 일반식(Ⅰ)의 4-[N-(하이드록시벤질) 아미노메틸] 사이클로헥산-1-카복실산 또는 이의 염 또는 에스테르를 제조하는 방법.상기 일반식에서 n은 1 내지 3의 정수이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56186691A JPS58109455A (ja) | 1981-11-20 | 1981-11-20 | N−ベンジルアミノ酸誘導体及びその製造法 |
JP186691 | 1981-11-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840002344A true KR840002344A (ko) | 1984-06-25 |
KR870001086B1 KR870001086B1 (ko) | 1987-06-04 |
Family
ID=16192941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8205231A KR870001086B1 (ko) | 1981-11-20 | 1982-11-19 | 4-[n-(하이드록시벤질)아미노 메틸] 사이클로헥산-1-카복실산의 제조방법 |
Country Status (6)
Country | Link |
---|---|
US (1) | US4464396A (ko) |
EP (1) | EP0080334B1 (ko) |
JP (1) | JPS58109455A (ko) |
KR (1) | KR870001086B1 (ko) |
CA (1) | CA1193280A (ko) |
DE (1) | DE3261007D1 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59193822A (ja) * | 1983-04-15 | 1984-11-02 | Kureha Chem Ind Co Ltd | 腎炎治療剤 |
US4758591A (en) * | 1983-12-26 | 1988-07-19 | Kureha Kagaku Kogyo Kabushiki Kaisha | Dialkanoyloxybenzylidene dialkanoate |
EP2601950A1 (en) * | 2011-12-06 | 2013-06-12 | Sanofi | Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3268405A (en) * | 1961-05-08 | 1966-08-23 | Mitsubishi Chem Ind | 4-aminomethyl-cyclohexane-1-carboxylic acid for inhibiting the activation of plasmin |
US4163060A (en) * | 1974-04-08 | 1979-07-31 | U.S. Philips Corporation | Aralkylamino carboxylic acids and derivatives having spasmolytic activity |
US4055580A (en) * | 1975-08-22 | 1977-10-25 | Rorer Italiana S.P.A. | Derivatives of aminomethylcyclohexanecarboxylic acid |
DE3061205D1 (en) * | 1979-06-16 | 1983-01-05 | Beecham Group Plc | Secondary amines, their preparation and use in pharmaceutical compositions |
ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
US4382955A (en) * | 1980-06-04 | 1983-05-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Derivative of 4-(N-(3,4-dihydroxybenzylidene) aminomethyl cyclohexane-1-carboxylic acid |
JPS5759848A (en) * | 1980-09-29 | 1982-04-10 | Hisamitsu Pharmaceut Co Inc | Cyclohexanecarboxylic acid derivative |
-
1981
- 1981-11-20 JP JP56186691A patent/JPS58109455A/ja active Granted
-
1982
- 1982-11-10 US US06/440,616 patent/US4464396A/en not_active Expired - Lifetime
- 1982-11-15 CA CA000415609A patent/CA1193280A/en not_active Expired
- 1982-11-18 EP EP82306157A patent/EP0080334B1/en not_active Expired
- 1982-11-18 DE DE8282306157T patent/DE3261007D1/de not_active Expired
- 1982-11-19 KR KR8205231A patent/KR870001086B1/ko active
Also Published As
Publication number | Publication date |
---|---|
JPH0155267B2 (ko) | 1989-11-22 |
CA1193280A (en) | 1985-09-10 |
KR870001086B1 (ko) | 1987-06-04 |
EP0080334B1 (en) | 1984-10-17 |
US4464396A (en) | 1984-08-07 |
JPS58109455A (ja) | 1983-06-29 |
DE3261007D1 (de) | 1984-11-22 |
EP0080334A1 (en) | 1983-06-01 |
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