ATE12638T1 - Mb-530b derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Mb-530b derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE12638T1 ATE12638T1 AT82304507T AT82304507T ATE12638T1 AT E12638 T1 ATE12638 T1 AT E12638T1 AT 82304507 T AT82304507 T AT 82304507T AT 82304507 T AT82304507 T AT 82304507T AT E12638 T1 ATE12638 T1 AT E12638T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- chem
- ester
- compounds
- lactone
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LXZBFUBRYYVRQJ-AXHZAXLDSA-M sodium;(3r,5r)-7-[(1s,2s,6r,8s,8ar)-2,6-dimethyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Chemical class [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C=C21 LXZBFUBRYYVRQJ-AXHZAXLDSA-M 0.000 title 1
- -1 MB-530B compound Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 241000235389 Absidia Species 0.000 abstract 1
- 241000908198 Actinomucor Species 0.000 abstract 1
- 241001450911 Circinella Species 0.000 abstract 1
- 241000235555 Cunninghamella Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241001450909 Gongronella Species 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000235575 Mortierella Species 0.000 abstract 1
- 241000235395 Mucor Species 0.000 abstract 1
- 241000235400 Phycomyces Species 0.000 abstract 1
- 241000222644 Pycnoporus <fungus> Species 0.000 abstract 1
- 241001361634 Rhizoctonia Species 0.000 abstract 1
- 241000235527 Rhizopus Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000736854 Syncephalastrum Species 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000005805 hydroxylation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56134558A JPS5835144A (ja) | 1981-08-27 | 1981-08-27 | Ｍｂ−５３０ｂ誘導体およびその製造法 |
| EP82304507A EP0074222B1 (de) | 1981-08-27 | 1982-08-26 | MB-530B Derivate, deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE12638T1 true ATE12638T1 (de) | 1985-04-15 |
Family
ID=15131129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82304507T ATE12638T1 (de) | 1981-08-27 | 1982-08-26 | Mb-530b derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4517373A (de) |
| EP (1) | EP0074222B1 (de) |
| JP (1) | JPS5835144A (de) |
| AT (1) | ATE12638T1 (de) |
| CA (1) | CA1197484A (de) |
| DE (1) | DE3262998D1 (de) |
| IE (1) | IE53740B1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
| US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4771071A (en) * | 1986-05-05 | 1988-09-13 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4864038A (en) * | 1986-05-05 | 1989-09-05 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4847306A (en) * | 1986-05-05 | 1989-07-11 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| EP0245990A3 (de) * | 1986-05-05 | 1989-07-19 | Merck & Co. Inc. | Antihypercholesterolemische Verbindungen |
| US4661483A (en) * | 1986-05-05 | 1987-04-28 | Merck & Co., Inc. | Antihypercholesterolemic lactone compounds, compositions and use |
| EP0245003A3 (de) * | 1986-05-05 | 1989-07-19 | Merck & Co. Inc. | Antihypercholesterolemische Verbindungen |
| EP0245004A3 (de) * | 1986-05-05 | 1989-07-26 | Merck & Co. Inc. | Antihypercholesterolemische Verbindungen |
| US4766145A (en) * | 1986-05-05 | 1988-08-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US5116870A (en) * | 1986-06-23 | 1992-05-26 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| US4940727A (en) * | 1986-06-23 | 1990-07-10 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| USRE36481E (en) * | 1986-06-23 | 2000-01-04 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
| US4736064A (en) * | 1986-09-29 | 1988-04-05 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
| US4833258A (en) * | 1987-02-17 | 1989-05-23 | Merck & Co., Inc. | Intermediates useful in the preparation of HMG-COA reductase inhibitors |
| US4719229A (en) * | 1987-05-13 | 1988-01-12 | Merck & Co., Inc. | Antihypercholesterolemic agents |
| US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| EP0306263B1 (de) * | 1987-09-02 | 1992-03-18 | Merck & Co. Inc. | Inhibitoren von HMG-CoA-Reduktase |
| US4857547A (en) * | 1988-01-07 | 1989-08-15 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5021453A (en) * | 1988-03-02 | 1991-06-04 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| DE68914495T2 (de) * | 1988-03-02 | 1994-10-27 | Merck & Co Inc | Antihypercholesterolemisches Mittel. |
| EP0337548A3 (de) * | 1988-04-15 | 1991-08-14 | Merck & Co. Inc. | Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695) |
| US4997755A (en) * | 1988-04-15 | 1991-03-05 | Merck & Co., Inc. | HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) |
| US4963538A (en) * | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| CA2009043A1 (en) * | 1989-02-01 | 1990-08-01 | Michael J. Ferris | Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives |
| EP0409399B1 (de) * | 1989-06-09 | 1996-03-13 | Merck & Co. Inc. | 3-Keto-HMG-CoA Reduktase-Inhibitoren |
| US4937259A (en) * | 1989-06-09 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US5001241A (en) * | 1989-06-09 | 1991-03-19 | Merck & Co., Inc. | 3-KETO HMG-CoA reductase inhibitors |
| US5041562A (en) * | 1989-06-09 | 1991-08-20 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| US5010105A (en) * | 1989-06-09 | 1991-04-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
| US4997849A (en) * | 1989-06-23 | 1991-03-05 | Merck & Co., Inc. | Microbial transformation of simvastatin |
| US5112857A (en) * | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
| FR2709126B1 (fr) * | 1993-08-18 | 1995-09-29 | Adir | Nouveaux dérivés de naphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (de) * | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンｋおよびその製造法 |
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
| JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
| MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| JPS57185276A (en) * | 1981-05-11 | 1982-11-15 | Sankyo Co Ltd | Dihydro-dum-4 and dihydro-isodum-4 and their derivative |
| US4499289A (en) * | 1982-12-03 | 1985-02-12 | G. D. Searle & Co. | Octahydronapthalenes |
-
1981
- 1981-08-27 JP JP56134558A patent/JPS5835144A/ja active Granted
-
1982
- 1982-08-24 US US06/410,889 patent/US4517373A/en not_active Expired - Lifetime
- 1982-08-26 CA CA000410212A patent/CA1197484A/en not_active Expired
- 1982-08-26 DE DE8282304507T patent/DE3262998D1/de not_active Expired
- 1982-08-26 IE IE2061/82A patent/IE53740B1/en not_active IP Right Cessation
- 1982-08-26 AT AT82304507T patent/ATE12638T1/de not_active IP Right Cessation
- 1982-08-26 EP EP82304507A patent/EP0074222B1/de not_active Expired
-
1986
- 1986-09-17 US US06/908,969 patent/US4820865A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3262998D1 (en) | 1985-05-15 |
| EP0074222B1 (de) | 1985-04-10 |
| US4517373A (en) | 1985-05-14 |
| JPH0371419B2 (de) | 1991-11-13 |
| CA1197484A (en) | 1985-12-03 |
| IE822061L (en) | 1983-02-27 |
| JPS5835144A (ja) | 1983-03-01 |
| IE53740B1 (en) | 1989-02-01 |
| US4820865A (en) | 1989-04-11 |
| EP0074222A1 (de) | 1983-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |