KR870003773A - 약제학적 조성물 - Google Patents

약제학적 조성물 Download PDF

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KR870003773A
KR870003773A KR1019860008277A KR860008277A KR870003773A KR 870003773 A KR870003773 A KR 870003773A KR 1019860008277 A KR1019860008277 A KR 1019860008277A KR 860008277 A KR860008277 A KR 860008277A KR 870003773 A KR870003773 A KR 870003773A
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South Korea
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composition
liquid
active substance
pharmaceutically active
polysaccharide
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KR1019860008277A
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English (en)
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KR940000229B1 (ko
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마주엘 끌라우드
프리떼이어 마리-끌레어
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제임스 에프.노우톤
래보라토리즈 머크 샵 앤드 돔 시브레
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 생리적 액체의 이온농도 증가의 영향하에서 동일계내 액체-겔 상전이 겔화가 일어나는 타입으로, 수용액중에 적어도 하나의 폴리사카라이드를 함유하며, 비-겔화 액체형태로 투여되어 동일계내에서 겔화되도록 함을 특징으로 하는, 생리적 액체와의 접촉을 목적으로 하는 약제학적 조성물.
  2. 제1항에 있어서, 조성물이 안과용 조성물이고 생리적 액체가 누액임을 특징으로 하는 약제학적 조성물.
  3. 제1 또는 2항에 있어서, 폴리사카라이드가 미생물을 발효시켜 수득되는 조성물.
  4. 제3항에 있어서, 미생물이 슈도모나스 엘로데아(Pseudomonas elodea)인 조성물.
  5. 제1 또는 2항에 있어서, 폴리사카라이드가 이의 염기성 테트라사카라이드 단위로서 그의 β-D-글리코피아노실 잔기상에서 임의로 부분적으로 0-아세틸화될 수 있는 →3)-β-D-Glcp-(1→4)-β-D-GlcpA-(1→4)-β-D-Glcp-(1→4)-α-L-Rhap-(1→를 갖는 조성물.
  6. 제1 내지 5항중 어느 하나에 있어서, 0.1 내지 2.0중량%의 폴리사카라이드를 함유하는 조성물.
  7. 제1 내지 6항중 어느 하나에 있어서, 추가로 장성(tonicikty)조절제를 함유하는 조성물.
  8. 제7항에 있어서, 장성조절제가 만니톨 또는 소르비톨과 같은 당인 조성물.
  9. 제1 내지 8항중 어느 하나에 있어서, 치료 또는 진단용 약제학적 활성물질 적어도 하나를 함유하는 조성물.
  10. 제9항에 있어서, 약제학적 활성물질이 터몰률 또는 이의 유도체인 조성물.
  11. 제9 도는 10항에 있어서, 0.1 내지 2.0중량%의 폴리사카라이드 및 0.001 내지 5중량%의 치료 또는 진단용 약제학적 활성물질 적어도 하나를 함유하는 조성물.
  12. 제1 내지 11항중 어느 하나에 있어서, 약제학적 활성물질이 용액으로 존재하는 조성물.
  13. 제1 내지 11항중 어느 하나에 잇어서, 약제학적 활성물질이 현탁액으로 존재하는 조성물.
  14. 제1 내지 11항중 어느 하나에 있어서, 약제학적 활성물질이 유제로 존재하는 조성물.
  15. 제1 내지 14항중 어느 하나에 청구된 안과용 조성물.
  16. 제1 내지 14항중 어느 하나에 청구된 주사용 조성물.
  17. 제1 내지 14항중 어느 하나에 청구된 점막 적용용 조성물.
  18. 젤라이트〔(Gelrite(상품명); 겔란검〕를 적절한 균질화기에서, 조성물을 구성하는 성분들중 활성성분인 젤라이트 이외의 성분들의 냉 또는 온(80°까지)용액의 소용돌이내에 본무하여 도입시키고, 생성물을 중합물질이 용해될 때까지 비등가열시키고, 생성물의 용적을 적정량으로 조절한 후 형성된 용액을 60℃로 냉각시키고, 필요시 5.0㎛의 셀룰로즈 아세테이트 필터상에서 여과시킴을 특징으로 하여, 생리적 액체의 이온 농도 증가의 영향하에서 동일계내 액체-겔 상전이 겔화가 일어나는 타입으로, 수용액중에 적어도 하나의 폴리사카라이드를 함유하며, 비-겔화 액체형태로 투여되어 동일계내에서 겔화되는, 생리적 액체와의 접촉을 목적으로 하는 약제학적 조성을물 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008277A 1985-10-03 1986-10-02 생리학적 액체와 접촉하여 겔화되는 약제학적 조성물의 제조방법 KR940000229B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8514689 1985-10-03
FR8514689A FR2588189B1 (fr) 1985-10-03 1985-10-03 Composition pharmaceutique de type a transition de phase liquide-gel
FR85-14689 1985-10-03

Publications (2)

Publication Number Publication Date
KR870003773A true KR870003773A (ko) 1987-05-04
KR940000229B1 KR940000229B1 (ko) 1994-01-12

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KR1019860008277A KR940000229B1 (ko) 1985-10-03 1986-10-02 생리학적 액체와 접촉하여 겔화되는 약제학적 조성물의 제조방법

Country Status (25)

Country Link
US (1) US4861760A (ko)
EP (1) EP0227494B1 (ko)
JP (1) JPH0667853B2 (ko)
KR (1) KR940000229B1 (ko)
CN (1) CN1046094C (ko)
AT (1) ATE72990T1 (ko)
AU (1) AU595240B2 (ko)
CA (1) CA1280367C (ko)
CY (1) CY1779A (ko)
DE (2) DE227494T1 (ko)
DK (1) DK170500B1 (ko)
ES (1) ES2002401A6 (ko)
FI (1) FI91217C (ko)
FR (1) FR2588189B1 (ko)
GR (1) GR862444B (ko)
HK (1) HK42594A (ko)
IE (1) IE59464B1 (ko)
IL (1) IL80156A (ko)
LU (1) LU88694I2 (ko)
LV (1) LV5725B4 (ko)
NL (1) NL950012I1 (ko)
NO (2) NO173212C (ko)
NZ (1) NZ217662A (ko)
PT (1) PT83471B (ko)
ZA (1) ZA867464B (ko)

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PT83471A (en) 1986-11-01
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DE3684121D1 (de) 1992-04-09
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