PL3576753T3 - Sterylna emulsja zawierająca stabilny oligonukleotyd tiofosforanowy - Google Patents
Sterylna emulsja zawierająca stabilny oligonukleotyd tiofosforanowyInfo
- Publication number
- PL3576753T3 PL3576753T3 PL18703305.5T PL18703305T PL3576753T3 PL 3576753 T3 PL3576753 T3 PL 3576753T3 PL 18703305 T PL18703305 T PL 18703305T PL 3576753 T3 PL3576753 T3 PL 3576753T3
- Authority
- PL
- Poland
- Prior art keywords
- phosphorothioate oligonucleotide
- sterile emulsion
- stable
- stable phosphorothioate
- sterile
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- 239000000839 emulsion Substances 0.000 title 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/423,964 US10052343B1 (en) | 2017-02-03 | 2017-02-03 | Sterile formulation comprising a stable phosphorothioate oligonucleotide |
| EP17154670 | 2017-02-03 | ||
| PCT/EP2018/052663 WO2018141908A1 (en) | 2017-02-03 | 2018-02-02 | Sterile formulation comprising a stable phosphorothioate oligonucleotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3576753T3 true PL3576753T3 (pl) | 2024-07-29 |
Family
ID=61163718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18703305.5T PL3576753T3 (pl) | 2017-02-03 | 2018-02-02 | Sterylna emulsja zawierająca stabilny oligonukleotyd tiofosforanowy |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP3576753B1 (pl) |
| JP (1) | JP2020515525A (pl) |
| CN (1) | CN110520134B (pl) |
| AU (1) | AU2018214221B2 (pl) |
| CA (1) | CA3051724A1 (pl) |
| ES (1) | ES2980870T3 (pl) |
| FI (1) | FI3576753T3 (pl) |
| HR (1) | HRP20240849T1 (pl) |
| HU (1) | HUE066897T2 (pl) |
| LT (1) | LT3576753T (pl) |
| PL (1) | PL3576753T3 (pl) |
| PT (1) | PT3576753T (pl) |
| RS (1) | RS65648B1 (pl) |
| SI (1) | SI3576753T1 (pl) |
| SM (1) | SMT202400261T1 (pl) |
| WO (1) | WO2018141908A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021210409A1 (ja) * | 2020-04-14 | 2021-10-21 | 住友化学株式会社 | 核酸オリゴマーを含む組成物 |
| DK4137500T3 (da) * | 2020-04-14 | 2026-04-20 | Sumitomo Chemical Co | Fremgangsmåde til fremstilling af nukleinsyreoligomer |
| US20240067956A1 (en) * | 2021-01-13 | 2024-02-29 | The Regents Of The University Of Colorado, A Body Corporate | Methods and compositions for molecular tracking in individual cells in vivo |
| US20240300993A1 (en) * | 2021-07-06 | 2024-09-12 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| WO2025072748A2 (en) * | 2023-09-29 | 2025-04-03 | Insitro, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease |
| CN122055446A (zh) * | 2024-06-26 | 2026-05-15 | 思合基因(北京)生物科技有限公司 | 一种靶向IRS-1 mRNA的寡聚核苷酸及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136178A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Locust bean gum therapeutic compositions |
| US4136173A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| US4136177A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Xanthan gum therapeutic compositions |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US20030096770A1 (en) | 2001-07-11 | 2003-05-22 | Krotz Achim H. | Enhancement of the stability of oligonucleotides comprising phosphorothioate linkages by addition of water-soluble antioxidants |
| US8580947B2 (en) * | 2009-02-05 | 2013-11-12 | Gene Signal International Sa | Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization |
| WO2017025471A1 (en) * | 2015-08-07 | 2017-02-16 | Gene Signal International Sa | Sterile emulsion comprising a stable phosphorothioate oligonucleotide |
| EP3128007A1 (en) * | 2015-08-07 | 2017-02-08 | Gene Signal International SA | Sterile emulsion comprising a stable phosphorothioate oligonucleotide |
-
2018
- 2018-02-02 PT PT187033055T patent/PT3576753T/pt unknown
- 2018-02-02 PL PL18703305.5T patent/PL3576753T3/pl unknown
- 2018-02-02 RS RS20240710A patent/RS65648B1/sr unknown
- 2018-02-02 SI SI201831117T patent/SI3576753T1/sl unknown
- 2018-02-02 LT LTEPPCT/EP2018/052663T patent/LT3576753T/lt unknown
- 2018-02-02 EP EP18703305.5A patent/EP3576753B1/en active Active
- 2018-02-02 JP JP2019542107A patent/JP2020515525A/ja active Pending
- 2018-02-02 CN CN201880017414.1A patent/CN110520134B/zh active Active
- 2018-02-02 SM SM20240261T patent/SMT202400261T1/it unknown
- 2018-02-02 FI FIEP18703305.5T patent/FI3576753T3/fi active
- 2018-02-02 ES ES18703305T patent/ES2980870T3/es active Active
- 2018-02-02 HU HUE18703305A patent/HUE066897T2/hu unknown
- 2018-02-02 CA CA3051724A patent/CA3051724A1/en active Pending
- 2018-02-02 HR HRP20240849TT patent/HRP20240849T1/hr unknown
- 2018-02-02 WO PCT/EP2018/052663 patent/WO2018141908A1/en not_active Ceased
- 2018-02-02 AU AU2018214221A patent/AU2018214221B2/en active Active
- 2018-02-02 EP EP24169866.1A patent/EP4403219A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN110520134B (zh) | 2023-07-18 |
| FI3576753T3 (fi) | 2024-06-28 |
| EP4403219A2 (en) | 2024-07-24 |
| HRP20240849T1 (hr) | 2024-09-27 |
| CA3051724A1 (en) | 2018-08-09 |
| RS65648B1 (sr) | 2024-07-31 |
| JP2020515525A (ja) | 2020-05-28 |
| LT3576753T (lt) | 2024-07-25 |
| SI3576753T1 (sl) | 2024-08-30 |
| HUE066897T2 (hu) | 2024-09-28 |
| EP3576753A1 (en) | 2019-12-11 |
| EP3576753B1 (en) | 2024-04-17 |
| AU2018214221A1 (en) | 2019-08-15 |
| SMT202400261T1 (it) | 2024-09-16 |
| PT3576753T (pt) | 2024-06-26 |
| EP4403219A3 (en) | 2024-10-09 |
| AU2018214221B2 (en) | 2024-02-01 |
| WO2018141908A1 (en) | 2018-08-09 |
| ES2980870T3 (es) | 2024-10-03 |
| CN110520134A (zh) | 2019-11-29 |
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