KR870000310B1 - 페니실란산 1,1-디옥시드 및 염의 제조방법 - Google Patents

페니실란산 1,1-디옥시드 및 염의 제조방법 Download PDF

Info

Publication number
KR870000310B1
KR870000310B1 KR1019830001623A KR830001623A KR870000310B1 KR 870000310 B1 KR870000310 B1 KR 870000310B1 KR 1019830001623 A KR1019830001623 A KR 1019830001623A KR 830001623 A KR830001623 A KR 830001623A KR 870000310 B1 KR870000310 B1 KR 870000310B1
Authority
KR
South Korea
Prior art keywords
acid
zinc
dioxide
yield
experiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830001623A
Other languages
English (en)
Korean (ko)
Other versions
KR840004435A (ko
Inventor
월프강 헨니거어 페터
카렐 판 데르 드립트 요하네스
샨데르 카푸르 야그디슈
피에터 파아셀 헤르망
Original Assignee
기스트-브로카아데스 엔. 뷔
쟝 안토니 판데르 스트라아텐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 기스트-브로카아데스 엔. 뷔, 쟝 안토니 판데르 스트라아텐 filed Critical 기스트-브로카아데스 엔. 뷔
Publication of KR840004435A publication Critical patent/KR840004435A/ko
Application granted granted Critical
Publication of KR870000310B1 publication Critical patent/KR870000310B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Sink And Installation For Waste Water (AREA)
  • Sewage (AREA)
  • Steroid Compounds (AREA)
KR1019830001623A 1982-04-19 1983-04-18 페니실란산 1,1-디옥시드 및 염의 제조방법 Expired KR870000310B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8211301 1982-04-19
GB82-11301 1982-04-19

Publications (2)

Publication Number Publication Date
KR840004435A KR840004435A (ko) 1984-10-15
KR870000310B1 true KR870000310B1 (ko) 1987-02-26

Family

ID=10529780

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019830001623A Expired KR870000310B1 (ko) 1982-04-19 1983-04-18 페니실란산 1,1-디옥시드 및 염의 제조방법
KR1019830001624A Expired KR870000311B1 (ko) 1982-04-19 1983-04-18 6-알파-브로모-및 6,6-디브로모-페니실란산 1,1-디옥시드류의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019830001624A Expired KR870000311B1 (ko) 1982-04-19 1983-04-18 6-알파-브로모-및 6,6-디브로모-페니실란산 1,1-디옥시드류의 제조방법

Country Status (14)

Country Link
US (2) US4528135A (enExample)
EP (2) EP0093465B1 (enExample)
JP (3) JPS58201787A (enExample)
KR (2) KR870000310B1 (enExample)
AT (2) ATE26982T1 (enExample)
CA (2) CA1218055A (enExample)
DE (2) DE3370799D1 (enExample)
DK (3) DK165295C (enExample)
ES (3) ES8500621A1 (enExample)
FI (2) FI80038C (enExample)
GR (2) GR79249B (enExample)
IE (2) IE54536B1 (enExample)
NO (2) NO159657C (enExample)
PT (2) PT76527B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4760058A (en) * 1984-08-29 1988-07-26 Farmitalia Carlo Erba S.P.A. Penam derivatives
US4816580A (en) * 1986-04-10 1989-03-28 Leo Pharmaceutical Products Ltd. A/S Improved method for preparing penicillanic acid derivatives
JPS62249988A (ja) * 1986-04-22 1987-10-30 Taiho Yakuhin Kogyo Kk ２β−ハロゲノメチル−２α−メチルペナム−３α−カルボン酸誘導体の製造法
AR247212A1 (es) * 1991-09-13 1994-11-30 Bago Sa Labor Procedimiento de preparacion de acido 1,1-dioxo penicilanico, sus sales y esteres.
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
FR2706896B1 (enExample) * 1993-06-23 1996-04-12 Caillot Jean Luc
ES2237064T3 (es) * 1999-03-03 2005-07-16 Astur Pharma S.A. Procedimiento para preparar derivados de acido dioxopenicilanico.
CN101768035B (zh) * 2009-01-05 2013-11-27 浙江华海药业股份有限公司 一种制备以及回收芳香甲基联苯化合物的方法
CN104910184B (zh) * 2015-04-27 2017-03-29 齐鲁天和惠世制药有限公司 一种6,6‑二溴青霉烷酸的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164497A (en) * 1972-10-20 1979-08-14 Fujisawa Pharmaceutical Co., Ltd. 2-Substituted penam derivatives
IN149747B (enExample) * 1977-06-07 1982-04-03 Pfizer
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
NL7908867A (nl) * 1979-12-10 1981-07-01 Gist Brocades Nv Werkwijze voor het bereiden van 6-aminopenicillaanzuur- -1,1-dioxide en zijn zouten.
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
US4360463A (en) * 1981-09-02 1982-11-23 Pfizer Inc. Pure 6,6-diiodopenicillanic acid and process for its preparation

Also Published As

Publication number Publication date
GR77456B (enExample) 1984-09-24
CA1218055A (en) 1987-02-17
DK165974C (da) 1993-08-16
JPH0229678B2 (enExample) 1990-07-02
DK169183D0 (da) 1983-04-18
PT76527A (en) 1983-05-01
ES521425A0 (es) 1984-11-01
IE54522B1 (en) 1989-11-08
ES533883A0 (es) 1985-06-16
FI831300A0 (fi) 1983-04-18
FI831300L (fi) 1983-10-20
JPS58201787A (ja) 1983-11-24
NO831359L (no) 1983-10-20
PT76526B (en) 1986-01-21
EP0092286A2 (en) 1983-10-26
GR79249B (enExample) 1984-10-22
DK169183A (da) 1983-10-20
EP0092286A3 (en) 1983-11-30
KR870000311B1 (ko) 1987-02-26
DE3370799D1 (en) 1987-05-14
DK161891B (da) 1991-08-26
DK165974B (da) 1993-02-22
ES8500621A1 (es) 1984-11-01
EP0092286B1 (en) 1987-04-08
JPS6354376A (ja) 1988-03-08
DK165295B (da) 1992-11-02
FI80038B (fi) 1989-12-29
DK181691D0 (da) 1991-11-04
DK169083A (da) 1983-10-20
ATE26982T1 (de) 1987-05-15
KR840008368A (ko) 1984-12-14
PT76527B (en) 1985-12-09
EP0093465A2 (en) 1983-11-09
DK165295C (da) 1993-03-22
NO161565B (no) 1989-05-22
ES8405019A1 (es) 1984-05-16
NO159657B (no) 1988-10-17
FI831301L (fi) 1983-10-20
IE54536B1 (en) 1989-11-08
DK169083D0 (da) 1983-04-18
FI78298C (fi) 1989-07-10
CA1216842A (en) 1987-01-20
IE830869L (en) 1983-10-19
EP0093465A3 (en) 1983-12-07
KR840004435A (ko) 1984-10-15
DK161891C (da) 1992-02-03
US4528135A (en) 1985-07-09
DK181691A (da) 1991-11-04
ES521426A0 (es) 1984-05-16
JPH045035B2 (enExample) 1992-01-30
US4619786A (en) 1986-10-28
FI831301A0 (fi) 1983-04-18
EP0093465B1 (en) 1987-05-06
JPS58201788A (ja) 1983-11-24
NO831358L (no) 1983-10-20
PT76526A (en) 1983-05-01
NO159657C (no) 1989-01-25
DE3371338D1 (de) 1987-06-11
NO161565C (no) 1989-08-30
FI78298B (fi) 1989-03-31
JPH034078B2 (enExample) 1991-01-22
FI80038C (fi) 1990-04-10
ES8505688A1 (es) 1985-06-16
IE830868L (en) 1983-10-19
ATE26447T1 (de) 1987-04-15

Similar Documents

Publication Publication Date Title
KR870000310B1 (ko) 페니실란산 1,1-디옥시드 및 염의 제조방법
DE2258221C2 (de) Verfahren zur Herstellung von Penicillinen und Cepholosporinen mit einem weiteren Substituenten in 6- bzw. 7-Stellung
EP0300614A1 (en) Process for the preparation of substituted indolinone derivatives
AT392072B (de) Verfahren zur herstellung der neuen 7-amino-3propenylcephalosporansaeure sowie von estern und salzen derselben
EP0129360B1 (en) Process for debromination of dibromopenicillanic acid and derivatives
SU1470175A3 (ru) Способ получени 2,4-дихлор-5-фторбензойной кислоты
DE2429166A1 (de) Verfahren zur selektiven spaltung der amidsaeurefunktion eines 7-(amidsaeure)cephalosporins
AU651167B2 (en) Process for the preparation of 2,4,6-triiodo-5-amino-N- alkylisophthalamic acid
JPH0247473B2 (enExample)
US4816580A (en) Improved method for preparing penicillanic acid derivatives
US4247693A (en) Process for preparing 2,4,5,6-tetraaminopyrimidine sulfate
AT391696B (de) Verfahren zur herstellung von s- 3morpholino-4- (3'-tert-butylamino-2'-hydroxypropoxy)-1,2,5thiadiazol
DE69011702T2 (de) Derivate von Aminocarboxylsäure.
PL85296B1 (en) Production of antibacterial agents[gb1314758a]
DE2334343C2 (de) Verfahren zur Herstellung von Pivaloyloxymethyl-6-[ α-(carboxy)phenylacetamido]-penicillanat
JPH08208591A (ja) ２−アミノベンゼンスルホン酸誘導体ならびに２−アミノベンゼンスルホニルクロリド誘導体とその製造法およびその合成中間体としての使用
US3381032A (en) Preparation of 3, 5-dibromo-salicylic acid
KR100230642B1 (ko) 페니실란산 1,1-디옥시드 및 그 염의 제조방법
JPH04273844A (ja) ２，２′−オキシジコハク酸塩の製造方法
KR100390549B1 (ko) 3-할로메틸-3-세펨의 제조방법
KR860001087B1 (ko) 7-아미노-3-(5-메틸-1,3,4-티아디아졸-2-일) 티오메틸-3-세펨-4-카르복실산의 제조방법
JP3167811B2 (ja) １Ｒ，ｃｉｓ−２，２−ジメチル−３−ホルミルシクロプロパン−１−カルボン酸のラクトンの新製造法及び中間体
KR890000522B1 (ko) 페니실란산 1,1-디옥사이드의 제조방법
DE2429184A1 (de) Verfahren zur selektiven spaltung der amidsaeuregruppe eines 7-(amidsaeure)cephalosporins oder 6-(amidsaeure)-penicillins sowie dazu geeignete verbindungen
CH637967A5 (fr) Produit d'addition du n,n-dimethylacetamide et d'un derive d'un acide cephem-4-carboxylique et procede de sa preparation.

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 19930128

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19940227

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19940227