JPH034078B2 - - Google Patents

Info

Publication number
JPH034078B2
JPH034078B2 JP58069076A JP6907683A JPH034078B2 JP H034078 B2 JPH034078 B2 JP H034078B2 JP 58069076 A JP58069076 A JP 58069076A JP 6907683 A JP6907683 A JP 6907683A JP H034078 B2 JPH034078 B2 JP H034078B2
Authority
JP
Japan
Prior art keywords
mmol
acid
yield
water
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58069076A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58201788A (ja
Inventor
Uorufugangu Henigeru Peetoru
Kareru Fuan Deru Dorifuto Yohanesu
Chanderu Kapyuuru Yadeitsushu
Piiteru Fuaseru Heruman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of JPS58201788A publication Critical patent/JPS58201788A/ja
Publication of JPH034078B2 publication Critical patent/JPH034078B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Sink And Installation For Waste Water (AREA)
  • Sewage (AREA)
  • Steroid Compounds (AREA)
JP58069076A 1982-04-19 1983-04-19 ペニシラン酸１、１−ジオキサイドおよびその誘導体の製造法 Granted JPS58201788A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8211301 1982-04-19
GB8211301 1982-04-19

Publications (2)

Publication Number Publication Date
JPS58201788A JPS58201788A (ja) 1983-11-24
JPH034078B2 true JPH034078B2 (enExample) 1991-01-22

Family

ID=10529780

Family Applications (3)

Application Number Title Priority Date Filing Date
JP58069075A Granted JPS58201787A (ja) 1982-04-19 1983-04-19 ６―α―ブロモ―および（または）６、６―ジブロモ―ペニシラン酸１、１―ジオキシド類の製造方法
JP58069076A Granted JPS58201788A (ja) 1982-04-19 1983-04-19 ペニシラン酸１、１−ジオキサイドおよびその誘導体の製造法
JP62134809A Granted JPS6354376A (ja) 1982-04-19 1987-05-29 ６−ジアゾ−ペニシラン酸１，１−ジオキシドおよびその塩

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP58069075A Granted JPS58201787A (ja) 1982-04-19 1983-04-19 ６―α―ブロモ―および（または）６、６―ジブロモ―ペニシラン酸１、１―ジオキシド類の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP62134809A Granted JPS6354376A (ja) 1982-04-19 1987-05-29 ６−ジアゾ−ペニシラン酸１，１−ジオキシドおよびその塩

Country Status (14)

Country Link
US (2) US4528135A (enExample)
EP (2) EP0093465B1 (enExample)
JP (3) JPS58201787A (enExample)
KR (2) KR870000310B1 (enExample)
AT (2) ATE26447T1 (enExample)
CA (2) CA1216842A (enExample)
DE (2) DE3371338D1 (enExample)
DK (3) DK165295C (enExample)
ES (3) ES8500621A1 (enExample)
FI (2) FI78298C (enExample)
GR (2) GR77456B (enExample)
IE (2) IE54536B1 (enExample)
NO (2) NO159657C (enExample)
PT (2) PT76527B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4760058A (en) * 1984-08-29 1988-07-26 Farmitalia Carlo Erba S.P.A. Penam derivatives
EP0262202B1 (en) * 1986-04-10 1992-07-01 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Method for preparing penicillanic acid derivatives
JPS62249988A (ja) * 1986-04-22 1987-10-30 Taiho Yakuhin Kogyo Kk ２β−ハロゲノメチル−２α−メチルペナム−３α−カルボン酸誘導体の製造法
AR247212A1 (es) * 1991-09-13 1994-11-30 Bago Sa Labor Procedimiento de preparacion de acido 1,1-dioxo penicilanico, sus sales y esteres.
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
FR2706896B1 (enExample) * 1993-06-23 1996-04-12 Caillot Jean Luc
ATE288438T1 (de) * 1999-03-03 2005-02-15 Astur Pharma Sa Verfahren zur herstellung von dioxopenicillansäurederivaten
CN101768035B (zh) * 2009-01-05 2013-11-27 浙江华海药业股份有限公司 一种制备以及回收芳香甲基联苯化合物的方法
CN104910184B (zh) * 2015-04-27 2017-03-29 齐鲁天和惠世制药有限公司 一种6,6‑二溴青霉烷酸的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164497A (en) * 1972-10-20 1979-08-14 Fujisawa Pharmaceutical Co., Ltd. 2-Substituted penam derivatives
IN149747B (enExample) * 1977-06-07 1982-04-03 Pfizer
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
NL7908867A (nl) * 1979-12-10 1981-07-01 Gist Brocades Nv Werkwijze voor het bereiden van 6-aminopenicillaanzuur- -1,1-dioxide en zijn zouten.
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
US4360463A (en) * 1981-09-02 1982-11-23 Pfizer Inc. Pure 6,6-diiodopenicillanic acid and process for its preparation

Also Published As

Publication number Publication date
DK161891B (da) 1991-08-26
EP0093465B1 (en) 1987-05-06
DK169183D0 (da) 1983-04-18
FI80038C (fi) 1990-04-10
EP0092286A3 (en) 1983-11-30
US4528135A (en) 1985-07-09
IE830868L (en) 1983-10-19
KR870000310B1 (ko) 1987-02-26
JPS6354376A (ja) 1988-03-08
DK169083A (da) 1983-10-20
ES8505688A1 (es) 1985-06-16
ES521426A0 (es) 1984-05-16
JPH045035B2 (enExample) 1992-01-30
JPS58201788A (ja) 1983-11-24
IE54536B1 (en) 1989-11-08
FI831300A0 (fi) 1983-04-18
NO159657B (no) 1988-10-17
NO831358L (no) 1983-10-20
FI831301L (fi) 1983-10-20
EP0093465A3 (en) 1983-12-07
NO159657C (no) 1989-01-25
DK169183A (da) 1983-10-20
GR77456B (enExample) 1984-09-24
DK161891C (da) 1992-02-03
ES521425A0 (es) 1984-11-01
EP0093465A2 (en) 1983-11-09
ES8500621A1 (es) 1984-11-01
PT76527A (en) 1983-05-01
ATE26982T1 (de) 1987-05-15
IE54522B1 (en) 1989-11-08
KR840004435A (ko) 1984-10-15
PT76526B (en) 1986-01-21
FI831300L (fi) 1983-10-20
DE3370799D1 (en) 1987-05-14
DK169083D0 (da) 1983-04-18
PT76526A (en) 1983-05-01
DK165974B (da) 1993-02-22
NO161565B (no) 1989-05-22
CA1216842A (en) 1987-01-20
DK165295C (da) 1993-03-22
FI78298B (fi) 1989-03-31
FI80038B (fi) 1989-12-29
FI831301A0 (fi) 1983-04-18
EP0092286A2 (en) 1983-10-26
DK181691D0 (da) 1991-11-04
FI78298C (fi) 1989-07-10
DK181691A (da) 1991-11-04
NO161565C (no) 1989-08-30
EP0092286B1 (en) 1987-04-08
GR79249B (enExample) 1984-10-22
PT76527B (en) 1985-12-09
CA1218055A (en) 1987-02-17
ES8405019A1 (es) 1984-05-16
KR840008368A (ko) 1984-12-14
DE3371338D1 (de) 1987-06-11
KR870000311B1 (ko) 1987-02-26
ES533883A0 (es) 1985-06-16
JPH0229678B2 (enExample) 1990-07-02
DK165295B (da) 1992-11-02
IE830869L (en) 1983-10-19
JPS58201787A (ja) 1983-11-24
ATE26447T1 (de) 1987-04-15
US4619786A (en) 1986-10-28
NO831359L (no) 1983-10-20
DK165974C (da) 1993-08-16

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