GR79249B - - Google Patents

Info

Publication number
GR79249B
GR79249B GR71112A GR830171112A GR79249B GR 79249 B GR79249 B GR 79249B GR 71112 A GR71112 A GR 71112A GR 830171112 A GR830171112 A GR 830171112A GR 79249 B GR79249 B GR 79249B
Authority
GR
Greece
Prior art keywords
acid
debromination
water
dioxides
pka
Prior art date
Application number
GR71112A
Other languages
English (en)
Inventor
P W Henniger
J K Van Der Drift
J C Kapur
H P Fasel
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of GR79249B publication Critical patent/GR79249B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Sink And Installation For Waste Water (AREA)
  • Sewage (AREA)
  • Steroid Compounds (AREA)
GR71112A 1982-04-19 1983-04-18 GR79249B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8211301 1982-04-19

Publications (1)

Publication Number Publication Date
GR79249B true GR79249B (el) 1984-10-22

Family

ID=10529780

Family Applications (2)

Application Number Title Priority Date Filing Date
GR71112A GR79249B (el) 1982-04-19 1983-04-18
GR71113A GR77456B (el) 1982-04-19 1983-04-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
GR71113A GR77456B (el) 1982-04-19 1983-04-18

Country Status (14)

Country Link
US (2) US4619786A (el)
EP (2) EP0093465B1 (el)
JP (3) JPS58201788A (el)
KR (2) KR870000310B1 (el)
AT (2) ATE26447T1 (el)
CA (2) CA1218055A (el)
DE (2) DE3370799D1 (el)
DK (3) DK161891C (el)
ES (3) ES8500621A1 (el)
FI (2) FI80038C (el)
GR (2) GR79249B (el)
IE (2) IE54522B1 (el)
NO (2) NO159657C (el)
PT (2) PT76526B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4760058A (en) * 1984-08-29 1988-07-26 Farmitalia Carlo Erba S.P.A. Penam derivatives
EP0262202B1 (en) * 1986-04-10 1992-07-01 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Method for preparing penicillanic acid derivatives
JPS62249988A (ja) * 1986-04-22 1987-10-30 Taiho Yakuhin Kogyo Kk ２β−ハロゲノメチル−２α−メチルペナム−３α−カルボン酸誘導体の製造法
AR247212A1 (es) * 1991-09-13 1994-11-30 Bago Sa Labor Procedimiento de preparacion de acido 1,1-dioxo penicilanico, sus sales y esteres.
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
FR2706896B1 (el) * 1993-06-23 1996-04-12 Caillot Jean Luc
EP1041075B1 (en) * 1999-03-03 2005-02-02 Astur Pharma S.A. Procedure for the preparation of dioxopenicillanic acid derivatives
CN101768035B (zh) * 2009-01-05 2013-11-27 浙江华海药业股份有限公司 一种制备以及回收芳香甲基联苯化合物的方法
CN104910184B (zh) * 2015-04-27 2017-03-29 齐鲁天和惠世制药有限公司 一种6,6‑二溴青霉烷酸的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164497A (en) * 1972-10-20 1979-08-14 Fujisawa Pharmaceutical Co., Ltd. 2-Substituted penam derivatives
IN149747B (el) * 1977-06-07 1982-04-03 Pfizer
DK155942C (da) * 1977-12-23 1989-10-23 Pfizer Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
NL7908867A (nl) * 1979-12-10 1981-07-01 Gist Brocades Nv Werkwijze voor het bereiden van 6-aminopenicillaanzuur- -1,1-dioxide en zijn zouten.
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
US4360463A (en) * 1981-09-02 1982-11-23 Pfizer Inc. Pure 6,6-diiodopenicillanic acid and process for its preparation

Also Published As

Publication number Publication date
PT76526B (en) 1986-01-21
JPS58201788A (ja) 1983-11-24
DK181691D0 (da) 1991-11-04
GR77456B (el) 1984-09-24
FI831301A0 (fi) 1983-04-18
DK165974B (da) 1993-02-22
DK165295C (da) 1993-03-22
EP0093465A3 (en) 1983-12-07
JPS58201787A (ja) 1983-11-24
FI80038C (fi) 1990-04-10
JPH045035B2 (el) 1992-01-30
FI80038B (fi) 1989-12-29
KR840004435A (ko) 1984-10-15
US4619786A (en) 1986-10-28
NO159657C (no) 1989-01-25
ES8405019A1 (es) 1984-05-16
DK169183D0 (da) 1983-04-18
DK165295B (da) 1992-11-02
DK161891C (da) 1992-02-03
CA1216842A (en) 1987-01-20
ES8505688A1 (es) 1985-06-16
ES521425A0 (es) 1984-11-01
US4528135A (en) 1985-07-09
DK181691A (da) 1991-11-04
NO161565B (no) 1989-05-22
ES521426A0 (es) 1984-05-16
EP0092286A3 (en) 1983-11-30
FI78298B (fi) 1989-03-31
DK169083A (da) 1983-10-20
ATE26447T1 (de) 1987-04-15
DK169183A (da) 1983-10-20
EP0092286A2 (en) 1983-10-26
PT76527B (en) 1985-12-09
KR870000310B1 (ko) 1987-02-26
FI78298C (fi) 1989-07-10
DE3371338D1 (de) 1987-06-11
NO831358L (no) 1983-10-20
DK161891B (da) 1991-08-26
JPH0229678B2 (el) 1990-07-02
DK165974C (da) 1993-08-16
DE3370799D1 (en) 1987-05-14
ES533883A0 (es) 1985-06-16
DK169083D0 (da) 1983-04-18
EP0092286B1 (en) 1987-04-08
IE830869L (en) 1983-10-19
PT76526A (en) 1983-05-01
FI831300A0 (fi) 1983-04-18
NO159657B (no) 1988-10-17
EP0093465B1 (en) 1987-05-06
IE830868L (en) 1983-10-19
FI831300L (fi) 1983-10-20
FI831301L (fi) 1983-10-20
PT76527A (en) 1983-05-01
JPH034078B2 (el) 1991-01-22
JPS6354376A (ja) 1988-03-08
IE54522B1 (en) 1989-11-08
CA1218055A (en) 1987-02-17
KR840008368A (ko) 1984-12-14
EP0093465A2 (en) 1983-11-09
KR870000311B1 (ko) 1987-02-26
NO831359L (no) 1983-10-20
ES8500621A1 (es) 1984-11-01
ATE26982T1 (de) 1987-05-15
NO161565C (no) 1989-08-30
IE54536B1 (en) 1989-11-08

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