KR840001124A - 2-[2' -하이드록시-3' -(1,1-디메칠프로필아미노)-프로폭시]-β-페닐프로피오페논 및 이의 염을 제조하는 방법 - Google Patents
2-[2' -하이드록시-3' -(1,1-디메칠프로필아미노)-프로폭시]-β-페닐프로피오페논 및 이의 염을 제조하는 방법 Download PDFInfo
- Publication number
- KR840001124A KR840001124A KR1019820003707A KR820003707A KR840001124A KR 840001124 A KR840001124 A KR 840001124A KR 1019820003707 A KR1019820003707 A KR 1019820003707A KR 820003707 A KR820003707 A KR 820003707A KR 840001124 A KR840001124 A KR 840001124A
- Authority
- KR
- South Korea
- Prior art keywords
- propoxy
- hydroxy
- phenylpropiophenone
- preparing
- general formula
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 2
- OSVOQDOCGKKCPJ-UHFFFAOYSA-N 2-[2-hydroxy-3-(2-methylbutan-2-ylamino)propoxy]-1,3-diphenylpropan-1-one Chemical compound C=1C=CC=CC=1C(=O)C(OCC(O)CNC(C)(C)CC)CC1=CC=CC=C1 OSVOQDOCGKKCPJ-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- -1 2- [2'-hydroxy-3 '-(1,1-dimethylpropoxyamino) -propoxy] -β-phenylpropiophenone hydrochloride Chemical compound 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- GELMWIVBBPAMIO-UHFFFAOYSA-N 2-methylbutan-2-amine Chemical compound CCC(C)(C)N GELMWIVBBPAMIO-UHFFFAOYSA-N 0.000 claims 1
- LRMHFDNWKCSEQU-UHFFFAOYSA-N ethoxyethane;phenol Chemical compound CCOCC.OC1=CC=CC=C1 LRMHFDNWKCSEQU-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 다음 일반식(Ⅱ)의 페놀에테르에 다음 일반식(Ⅲ)의 1,1-디메칠프로필아민을 반응시켜 일반식(Ⅰ)의 2-[2'-하이드록시-3'-(1,1-디메칠프로필아미노)-프로폭시]-β-페닐프로피오페논 및 이를 임의의유효산과 같이 용해하거나 산으로 전환시켜 일반식(Ⅰ)의 산부가염을 제조하는 방법.상기식에서, A는나이고, 이때 B는 이탈기를 나타낸다.
- 제1항에 있어서, 일반식(Ⅰ)의 화합물이 2-[2'-하이드록시-3'-(1,1-디메칠프로폭시아미노)-프로폭시]-β-페닐프로피오페논 염산염인 제조방법.
- 제1항 또는 제2항에 있어서, 2-[2'-하이드록시-3'-(1,1-디메칠프로폭시아미노)-프로폭시]-β-페닐프로피오페논 또는 이의 생리학적으로 받아들일수 있는 산부가염을 함유한 약학적제제를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3133814.3 | 1981-08-24 | ||
DE3133814A DE3133814C2 (de) | 1981-08-25 | 1981-08-25 | 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-β-phenylpropiophenon, seine Säureadditionssalze und Arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840001124A true KR840001124A (ko) | 1984-03-28 |
KR870000957B1 KR870000957B1 (ko) | 1987-05-14 |
Family
ID=6140190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8203707A KR870000957B1 (ko) | 1981-08-25 | 1982-08-18 | 2-[2'-하이드록시-3'-(1,1-디메칠프로필아미노)-프로폭시]-β-페닐프로피오페논 및 그의 염을 제조하는 방법 |
Country Status (24)
Country | Link |
---|---|
US (1) | US4460605A (ko) |
EP (1) | EP0074014B1 (ko) |
JP (1) | JPS58501324A (ko) |
KR (1) | KR870000957B1 (ko) |
AT (1) | ATE8129T1 (ko) |
AU (1) | AU555818B2 (ko) |
CA (1) | CA1192224A (ko) |
CS (1) | CS241511B2 (ko) |
DD (1) | DD211783A5 (ko) |
DE (2) | DE3133814C2 (ko) |
DK (1) | DK156430C (ko) |
ES (1) | ES515222A0 (ko) |
FI (1) | FI71123C (ko) |
GR (1) | GR77591B (ko) |
HU (1) | HU193523B (ko) |
IL (1) | IL66518A (ko) |
NO (1) | NO155880C (ko) |
PL (1) | PL135591B1 (ko) |
PT (1) | PT75460B (ko) |
RO (1) | RO87061B (ko) |
SU (1) | SU1331424A3 (ko) |
WO (1) | WO1983000688A1 (ko) |
YU (1) | YU42792B (ko) |
ZA (1) | ZA826025B (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226863A1 (de) * | 1981-09-18 | 1983-04-07 | Basf Ag, 6700 Ludwigshafen | Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
DE3309595A1 (de) * | 1983-03-17 | 1984-09-20 | Basf Ag, 6700 Ludwigshafen | Neue aminopropanolderivate von 1-(2-hydroxy-phenyl)-3-phenyl-propanolen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
DE3348170C2 (ko) * | 1983-07-21 | 1993-03-11 | Helopharm W. Petrik Gmbh & Co Kg, 1000 Berlin, De | |
DE3328376A1 (de) | 1983-07-21 | 1985-01-31 | Helopharm W. Petrik & Co Kg, 1000 Berlin | Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
DE3343671A1 (de) * | 1983-12-02 | 1985-06-20 | Basf Ag, 6700 Ludwigshafen | Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
US5095151A (en) * | 1985-05-21 | 1992-03-10 | American Home Products Corporation | Preparation of propranolol hydrochloride macrocrystals |
DE3725273A1 (de) * | 1987-07-30 | 1989-02-09 | Basf Ag | Verfahren zur synthese von enantiomeren des propafenons sowie diese enthaltende therapeutische mittel |
US4954347A (en) * | 1988-05-03 | 1990-09-04 | Basf K & F Corp. | Long lasting composition of propafenone and quinidine for treatment of cardiac conditions |
DE3907512C2 (de) * | 1989-03-08 | 1997-08-14 | Laevosan Gmbh & Co Kg | Neue Aryloxy-alkylamine, deren Herstellung und diese enthaltende Arzneimittel |
DE3911069A1 (de) * | 1989-04-06 | 1990-10-11 | Knoll Ag | Einkristalle von ss-phenylpropiophenonen |
DE4000213A1 (de) * | 1990-01-05 | 1991-07-11 | Helopharm Petrik Co Kg | O-hydroxy-ss-(1-naphthyl)-propiophenonderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US6168615B1 (en) | 1998-05-04 | 2001-01-02 | Micrus Corporation | Method and apparatus for occlusion and reinforcement of aneurysms |
PT2546410E (pt) | 2011-07-11 | 2014-02-17 | Omya Int Ag | Partículas de carbonato de cálcio hidrofobizado |
CN104262178A (zh) * | 2014-09-28 | 2015-01-07 | 常州瑞明药业有限公司 | 盐酸普罗帕酮的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2001431C3 (de) * | 1970-01-06 | 1974-12-12 | Helopharm W. Petrik & Co Kg, 1000 Berlin | 2-(2'-Hydroxy-3'-alkylaminopropoxy)-Omega-phenyl-propiophenone und Verfahren zur Herstellung derselben |
-
1981
- 1981-08-25 DE DE3133814A patent/DE3133814C2/de not_active Expired
-
1982
- 1982-08-11 IL IL66518A patent/IL66518A/xx not_active IP Right Cessation
- 1982-08-12 AU AU87113/82A patent/AU555818B2/en not_active Ceased
- 1982-08-18 KR KR8203707A patent/KR870000957B1/ko active
- 1982-08-19 ZA ZA826025A patent/ZA826025B/xx unknown
- 1982-08-23 DD DD82250311A patent/DD211783A5/de unknown
- 1982-08-23 PL PL1982238012A patent/PL135591B1/pl unknown
- 1982-08-24 ES ES515222A patent/ES515222A0/es active Granted
- 1982-08-24 JP JP57502643A patent/JPS58501324A/ja active Granted
- 1982-08-24 US US06/410,933 patent/US4460605A/en not_active Expired - Lifetime
- 1982-08-24 AT AT82107750T patent/ATE8129T1/de not_active IP Right Cessation
- 1982-08-24 EP EP82107750A patent/EP0074014B1/de not_active Expired
- 1982-08-24 PT PT75460A patent/PT75460B/pt not_active IP Right Cessation
- 1982-08-24 GR GR69096A patent/GR77591B/el unknown
- 1982-08-24 CS CS826167A patent/CS241511B2/cs unknown
- 1982-08-24 HU HU823093A patent/HU193523B/hu not_active IP Right Cessation
- 1982-08-24 YU YU1907/82A patent/YU42792B/xx unknown
- 1982-08-24 WO PCT/EP1982/000180 patent/WO1983000688A1/en active IP Right Grant
- 1982-08-24 DE DE8282107750T patent/DE3260301D1/de not_active Expired
- 1982-08-25 CA CA000410054A patent/CA1192224A/en not_active Expired
-
1983
- 1983-04-15 NO NO83831339A patent/NO155880C/no unknown
- 1983-04-21 RO RO110735A patent/RO87061B/ro unknown
- 1983-04-22 DK DK178883A patent/DK156430C/da not_active IP Right Cessation
- 1983-04-22 SU SU833583671A patent/SU1331424A3/ru active
- 1983-04-22 FI FI831388A patent/FI71123C/fi not_active IP Right Cessation
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