ES8400392A1 - Un procedimiento para preparar 2-(2-hidroxi-3-(1,1-dimetim propilamino)proposi-b-fenilpro-pio fenona. - Google Patents

Un procedimiento para preparar 2-(2-hidroxi-3-(1,1-dimetim propilamino)proposi-b-fenilpro-pio fenona.

Info

Publication number
ES8400392A1
ES8400392A1 ES515222A ES515222A ES8400392A1 ES 8400392 A1 ES8400392 A1 ES 8400392A1 ES 515222 A ES515222 A ES 515222A ES 515222 A ES515222 A ES 515222A ES 8400392 A1 ES8400392 A1 ES 8400392A1
Authority
ES
Spain
Prior art keywords
addition salts
propoxy
beta
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515222A
Other languages
English (en)
Other versions
ES515222A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HELOPHARM PETRIK CO KG
Original Assignee
HELOPHARM PETRIK CO KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HELOPHARM PETRIK CO KG filed Critical HELOPHARM PETRIK CO KG
Publication of ES515222A0 publication Critical patent/ES515222A0/es
Publication of ES8400392A1 publication Critical patent/ES8400392A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR 2-2K-HIDROXI-3K-(1,1-DIMET ILPROPILAMINO) PROPOXI-FENILPROPIOFENONA.SE SOMETE A REACCION ETER FENOLICO (II) CON LA 1,1- DIMETILPROPILAMINA, CON LO QUE SE OBTIENE EL COMPUESTO (I) QUE OPCIONALMENTE SE RESUELVE CON ACIDO OPTICAMENTE ACTIVO Y/O SE CONVIERTE CON UN ACIDO EN SAL DE ADICION CORRESPONDIENTE. LA REACCION TIENE LUGAR A TEMPERATURAS QUE VAN DE 10 A 120JC; PREFERENTEMENTE SE EMPLEA UN DISOLVENTE INERTE TAL COMO UN ALCOHOL DE 1-4 ATOMOS DE CARBONO.TRATAMIENTO DE LOS TRANSTORNOS RITMICOS DEL CORAZON.
ES515222A 1981-08-25 1982-08-24 Un procedimiento para preparar 2-(2-hidroxi-3-(1,1-dimetim propilamino)proposi-b-fenilpro-pio fenona. Expired ES8400392A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3133814A DE3133814C2 (de) 1981-08-25 1981-08-25 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-β-phenylpropiophenon, seine Säureadditionssalze und Arzneimittel

Publications (2)

Publication Number Publication Date
ES515222A0 ES515222A0 (es) 1983-11-01
ES8400392A1 true ES8400392A1 (es) 1983-11-01

Family

ID=6140190

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515222A Expired ES8400392A1 (es) 1981-08-25 1982-08-24 Un procedimiento para preparar 2-(2-hidroxi-3-(1,1-dimetim propilamino)proposi-b-fenilpro-pio fenona.

Country Status (24)

Country Link
US (1) US4460605A (es)
EP (1) EP0074014B1 (es)
JP (1) JPS58501324A (es)
KR (1) KR870000957B1 (es)
AT (1) ATE8129T1 (es)
AU (1) AU555818B2 (es)
CA (1) CA1192224A (es)
CS (1) CS241511B2 (es)
DD (1) DD211783A5 (es)
DE (2) DE3133814C2 (es)
DK (1) DK156430C (es)
ES (1) ES8400392A1 (es)
FI (1) FI71123C (es)
GR (1) GR77591B (es)
HU (1) HU193523B (es)
IL (1) IL66518A (es)
NO (1) NO155880C (es)
PL (1) PL135591B1 (es)
PT (1) PT75460B (es)
RO (1) RO87061B (es)
SU (1) SU1331424A3 (es)
WO (1) WO1983000688A1 (es)
YU (1) YU42792B (es)
ZA (1) ZA826025B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226863A1 (de) * 1981-09-18 1983-04-07 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3309595A1 (de) * 1983-03-17 1984-09-20 Basf Ag, 6700 Ludwigshafen Neue aminopropanolderivate von 1-(2-hydroxy-phenyl)-3-phenyl-propanolen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3328376A1 (de) 1983-07-21 1985-01-31 Helopharm W. Petrik & Co Kg, 1000 Berlin Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3348170C2 (es) * 1983-07-21 1993-03-11 Helopharm W. Petrik Gmbh & Co Kg, 1000 Berlin, De
DE3343671A1 (de) * 1983-12-02 1985-06-20 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
US5095151A (en) * 1985-05-21 1992-03-10 American Home Products Corporation Preparation of propranolol hydrochloride macrocrystals
DE3725273A1 (de) * 1987-07-30 1989-02-09 Basf Ag Verfahren zur synthese von enantiomeren des propafenons sowie diese enthaltende therapeutische mittel
US4954347A (en) * 1988-05-03 1990-09-04 Basf K & F Corp. Long lasting composition of propafenone and quinidine for treatment of cardiac conditions
DE3907512C2 (de) * 1989-03-08 1997-08-14 Laevosan Gmbh & Co Kg Neue Aryloxy-alkylamine, deren Herstellung und diese enthaltende Arzneimittel
DE3911069A1 (de) * 1989-04-06 1990-10-11 Knoll Ag Einkristalle von ss-phenylpropiophenonen
DE4000213A1 (de) * 1990-01-05 1991-07-11 Helopharm Petrik Co Kg O-hydroxy-ss-(1-naphthyl)-propiophenonderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
EP2546410B1 (en) 2011-07-11 2013-11-13 Omya International AG Hydrophobised calcium carbonate particles
CN104262178A (zh) * 2014-09-28 2015-01-07 常州瑞明药业有限公司 盐酸普罗帕酮的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2001431C3 (de) * 1970-01-06 1974-12-12 Helopharm W. Petrik & Co Kg, 1000 Berlin 2-(2'-Hydroxy-3'-alkylaminopropoxy)-Omega-phenyl-propiophenone und Verfahren zur Herstellung derselben

Also Published As

Publication number Publication date
GR77591B (es) 1984-09-25
HU193523B (en) 1987-10-28
DK156430B (da) 1989-08-21
YU190782A (en) 1985-06-30
EP0074014B1 (de) 1984-06-27
PL135591B1 (en) 1985-11-30
JPS6240352B2 (es) 1987-08-27
DE3133814A1 (de) 1983-03-10
DD211783A5 (de) 1984-07-25
FI71123C (fi) 1986-11-24
FI831388L (fi) 1983-04-22
KR870000957B1 (ko) 1987-05-14
RO87061A (ro) 1985-08-31
NO155880C (no) 1987-06-17
PT75460A (en) 1982-09-01
ES515222A0 (es) 1983-11-01
FI71123B (fi) 1986-08-14
ATE8129T1 (de) 1984-07-15
US4460605A (en) 1984-07-17
CS241511B2 (en) 1986-03-13
SU1331424A3 (ru) 1987-08-15
EP0074014A1 (de) 1983-03-16
JPS58501324A (ja) 1983-08-11
NO831339L (no) 1983-04-15
FI831388A0 (fi) 1983-04-22
NO155880B (no) 1987-03-09
PL238012A1 (en) 1983-03-28
DK178883A (da) 1983-04-22
DE3260301D1 (en) 1984-08-02
ZA826025B (en) 1983-07-27
DK156430C (da) 1990-01-15
WO1983000688A1 (en) 1983-03-03
RO87061B (ro) 1985-09-01
PT75460B (en) 1984-11-19
AU8711382A (en) 1983-03-03
DE3133814C2 (de) 1983-12-22
KR840001124A (ko) 1984-03-28
CA1192224A (en) 1985-08-20
DK178883D0 (da) 1983-04-22
IL66518A (en) 1985-09-29
YU42792B (en) 1988-12-31
AU555818B2 (en) 1986-10-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401