KR860700352A - 2--(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법 - Google Patents

2--(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법

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Publication number
KR860700352A
KR860700352A KR860700499A KR860700499A KR860700352A KR 860700352 A KR860700352 A KR 860700352A KR 860700499 A KR860700499 A KR 860700499A KR 860700499 A KR860700499 A KR 860700499A KR 860700352 A KR860700352 A KR 860700352A
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KR
South Korea
Prior art keywords
group
methyl group
general formula
following general
atom
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KR860700499A
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English (en)
Inventor
히토시(외 3) 우노
Original Assignee
후지와라 도미오
다이니뽄 세이야쿠 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 후지와라 도미오, 다이니뽄 세이야쿠 가부시끼가이샤 filed Critical 후지와라 도미오
Publication of KR860700352A publication Critical patent/KR860700352A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

내용 없음

Description

2-(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 일반식(Ⅱ)로 표시되는 화합물을 다음 일반식(Ⅲ)으로 표시되는 화합물과 반응시켜서 다음의 일반식(Ⅱ)로 표시되는 2-(1-피페라지닐)-4-치환페닐퀴놀린유도체와 그의 생리적으로 허용가능한 염을 제조하는 방법.
    (이때, R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 P-나 m-위치에 트리 플루오로메틸기를 나타내며, R2는 수소원자, 메틸기, 에틸기, 2-하이드록시에틸기나 3-하이드록시프로필기를 나타내고, R1이 p-위치에서 불소원자, p-위치에서 메틸기 또는 p-위치에서 트리플루오로메틸기를 나타낼때, R2는 에틸기, 2-하이드록시에틸기나 3-하이드록시프로필기를 나타낸다.)
    (이때, X는 이탈원자나 이탈기를 나타내며, R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 p-나 m-위치에 트리플루오로메틸기를 나타낸다.)
    (이때, R2는 수소원자, 메틸기, 에틸기, 2-하이드록시에틸기나 3-하이드록시프로필기를 나타낸다.)
  2. 다음 일반식(Ⅰ')로 표시되는 화합물을 다음의 일반식(Ⅳ)로 표시되는 화합물과 반응시켜 다음의 일반식(Ⅰ)로 표시되는 2-(1-피페라지닐)-4-치환페닐퀴놀린유도체와 그의 생리적으로 허용가능한 염을 제조하는 방법.
    (이때 R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 p-나 m-위치에 트리플루오로메틸기를 나타내고, R2는 메틸기, 에틸기, 2-하이드록시에틸기나 3-하이드록시프로필기를 나타낸다.)
    (이때 R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 p-나 m-위치에 트리플루오로 메틸기를 나타낸다.)
    R2'-Y (Ⅳ)
    (이때, Y는 알코올의 반응성에스테르의 잔기를 나타내고, R2'는 메틸기, 에틸기, 2-하이드록시에틸기 또는 3-하이드록시프로필기를 나타낸다.)
  3. 다음일반식(Ⅰ')로 표시되는 화합물과 에틸렌옥사이드를 반응시켜서 다음 일반식(Ⅰ)로 표시되는 2-(1-피페라지닐)-4-치환페닐퀴놀린유도체와 그의 생리적으로 허용가능한 염을 제조하는 방법.
    (이때, R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 p-나 m-위치에 트리플루오로메틸기를 나타내며, R2는 2-하이드록시에틸기를 나타낸다.)
    (이때, R1은 p-위치에 불소원자, p-위치에 염소원자, p-위치에 메틸기 또는 p-나 m-위치에 트리플루오로메틸기를 나타낸다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR860700499A 1984-11-27 1985-11-27 2--(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법 KR860700352A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP???59-259317 1984-11-27
JP25131784 1984-11-27
PCT/JP1985/000654 WO1986003198A1 (en) 1984-11-27 1985-11-27 2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, process for their preparation, and medicinal composition containing same

Publications (1)

Publication Number Publication Date
KR860700352A true KR860700352A (ko) 1986-10-06

Family

ID=17221008

Family Applications (1)

Application Number Title Priority Date Filing Date
KR860700499A KR860700352A (ko) 1984-11-27 1985-11-27 2--(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법

Country Status (5)

Country Link
US (1) US4758566A (ko)
EP (1) EP0204003A4 (ko)
JP (1) JPS61267555A (ko)
KR (1) KR860700352A (ko)
WO (1) WO1986003198A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2647343B1 (fr) * 1989-05-24 1994-05-06 Rhone Poulenc Sante Nouvelle forme pharmaceutique poreuse et sa preparation
JPH069402A (ja) * 1991-05-15 1994-01-18 Hiroyoshi Hidaka 抗潰瘍剤
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
CA2659570C (en) * 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542785A (en) * 1967-05-15 1970-11-24 Ciba Geigy Corp 2-hydroxy-4-aryl-quinolines
US3668207A (en) * 1970-01-22 1972-06-06 Ciba Geigy Corp 2-amino-4-aryl-quinolines
US3957791A (en) * 1972-09-25 1976-05-18 Sandoz, Inc. Hydroxyalkyl-piperazino-quinoline nitrates
US3983121A (en) * 1974-07-01 1976-09-28 Council Of Scientific And Industrial Research 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof
JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS59222418A (ja) * 1983-05-31 1984-12-14 Dainippon Pharmaceut Co Ltd 抗潰瘍剤

Also Published As

Publication number Publication date
EP0204003A4 (en) 1987-06-03
EP0204003A1 (en) 1986-12-10
JPS61267555A (ja) 1986-11-27
WO1986003198A1 (en) 1986-06-05
US4758566A (en) 1988-07-19

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