KR830007644A - 카보스티릴 화합물의 제조 방법 - Google Patents

카보스티릴 화합물의 제조 방법 Download PDF

Info

Publication number
KR830007644A
KR830007644A KR1019810004359A KR810004359A KR830007644A KR 830007644 A KR830007644 A KR 830007644A KR 1019810004359 A KR1019810004359 A KR 1019810004359A KR 810004359 A KR810004359 A KR 810004359A KR 830007644 A KR830007644 A KR 830007644A
Authority
KR
South Korea
Prior art keywords
formula
compound
bond
group
nucleus
Prior art date
Application number
KR1019810004359A
Other languages
English (en)
Other versions
KR880001657B1 (ko
Inventor
미찌아끼 도미나가
양영웅
히데노리 오가와
가즈유끼 나까가와
Original Assignee
오쯔까 아끼히꼬
오쯔까 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55159016A external-priority patent/JPS5782390A/ja
Priority claimed from JP55179950A external-priority patent/JPS57102888A/ja
Application filed by 오쯔까 아끼히꼬, 오쯔까 세이야꾸 가부시끼 가이샤 filed Critical 오쯔까 아끼히꼬
Publication of KR830007644A publication Critical patent/KR830007644A/ko
Application granted granted Critical
Publication of KR880001657B1 publication Critical patent/KR880001657B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

요약 없음

Description

카보스티릴 화합물의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 카보스티릴핵의 3-및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나;
    카보스티릴핵의 3- 및 4-위치 사이의 결합이 단일 결합 또는 이중결합인 일반식(Ⅰe)화합물을 할로겐화시키거나;
    상기 일반식(Ⅰe) 화합물을 니트로실화시키거나;
    카보스티릴핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰg)의 화합물을 환원시키거나;
    카보스티릴핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰi)의 화합물을 환원시키거나;
    상기 일반식(Ⅰi)의 화합물을 환원시키거나;
    상기 일반식(Ⅰi) 화합물을 일반식(XX)화합물과 반응시키거나;
    카보스틸핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰe)의 화합물을 일반식(ⅩⅩⅠ)의 화합물과 반응시키거나;
    카보스틸핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰm)의 화합물을 일반식(ⅩⅩⅡ)의 화합물과 반응시키거나;
    카보스틸핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰn)의 화합물을 일반식(ⅩⅩⅢ)의 화합물과 반응시키거나;
    카보스틸핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰo)의 화합물을 가수 분해시키거나;
    카보스틸핵의 3- 및 4-위치사이의 결합이 단일결합 또는 이중결합인 일반식(Ⅰp)의 화합물을 가수 분해시키거나;
    또는 상기 단계의 어느 한단계에 따른 생성물을 약학적으로 무독한 염으로 전환시킴을 특징으로 하여 카보스티릴핵의 3- 및 4위치사이의 결합이 단일 결합 또는 이중결합이며, 카보스티릴핵에 부착된하기 일반식(Ⅰa)의 이미다조 피리딜그룹의 위치가 5- 또는 6-위치(단, 이미다조피리딜그룹이 카보스티릴 핵의 5- 위치에 부착되어 있을 경우 R2는 수소, 저급알킬그룹 또는 할로겐원자이어서는 안된다)인 일반식(Ⅰ)의 카보스티릴화합물 또는 약학적으로 무독한 이의 염을 제조하는 방법.
    상기식에서
    R1은 수소원자, 저급알킬그룹, 저급알케닐그룹, 저급알킬닐그룹, 또는 페닐 저급알킬그룹을 나타내며,
    R2는 수소원자 저급알킬그룹, 저급알콕시그룹, 할로겐원자 또는 하이드록시그룹을 나타내며,
    R3은 수소원자, 저급알킬그룹, 할로겐원자, 니트로소그룹, 저급알킬그룹으로 치환될 수 있는 아미노그룹, 저급 알카노일 아미노그룹, N,N-디-저급알킬아미노메틸그룹, 카바모일메틸그룹, 시아노메틸그룹, 또는 카복시메틸 그룹을 나타내며,
    R4는 R5은 같거나 또는 다르며, 각각, 수소원자, 할로겐원자, 저급알킬그룹, 하이드록시그룹, 저급알킬시그룹 또는 니트로그룹을 나타내며,
    R6은 수소원자 또는 저급알킬그룹을 나타내며,
    R14및 R15은 같거나 또는 다르며, 각각 저급알킬그룹을 나타내며,
    R16은 저급알킬 그룹을 나타내며,
    X1은 수소원자를 나타내며,
    X2은 할로겐원자를 나타내며,
    M은 알카리금속을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004359A 1980-11-11 1981-11-11 카보스티릴 화합물의 제조방법 KR880001657B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP159016 1980-11-11
JP55159016A JPS5782390A (en) 1980-11-11 1980-11-11 Carbostyril derivative
JP55179950A JPS57102888A (en) 1980-12-18 1980-12-18 Carbostyril derivative
JP179950 1980-12-18

Publications (2)

Publication Number Publication Date
KR830007644A true KR830007644A (ko) 1983-11-04
KR880001657B1 KR880001657B1 (ko) 1988-09-05

Family

ID=26485945

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004359A KR880001657B1 (ko) 1980-11-11 1981-11-11 카보스티릴 화합물의 제조방법

Country Status (19)

Country Link
US (1) US4414390A (ko)
EP (1) EP0052016B1 (ko)
KR (1) KR880001657B1 (ko)
AT (1) AT382376B (ko)
AU (1) AU547586B2 (ko)
CA (1) CA1164459A (ko)
CH (1) CH653684A5 (ko)
DE (1) DE3152512T1 (ko)
DK (1) DK157193C (ko)
ES (1) ES507545A0 (ko)
FI (1) FI71145C (ko)
IT (1) IT8149680A0 (ko)
MX (1) MX6802E (ko)
NO (1) NO157819C (ko)
PH (1) PH17158A (ko)
PT (1) PT73959B (ko)
SE (1) SE440653B (ko)
SU (1) SU1215621A3 (ko)
WO (1) WO1982001706A1 (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
GB8305245D0 (en) * 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
GB8619902D0 (en) * 1986-08-15 1986-09-24 Pfizer Ltd Quinolone cardiac stimulants
GB8709448D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
EP0767790B1 (en) * 1994-06-20 2001-12-12 Takeda Chemical Industries, Ltd. Condensed imidazole compounds, their production and use
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
PE20100399A1 (es) * 2003-04-02 2010-06-01 Novartis Ag Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
WO2010032195A1 (en) 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
EP3280716B1 (de) * 2015-04-08 2020-02-12 Bayer CropScience AG Imidazo[1,2-a]pyridin-2-yl-derivate als schädlingsbekämpfungsmittel und deren zwischenprodukte
CN108137514A (zh) 2015-07-30 2018-06-08 百时美施贵宝公司 芳基取代的二环杂芳基化合物
KR102468661B1 (ko) 2016-07-14 2022-11-17 브리스톨-마이어스 스큅 컴퍼니 Par4 억제제로서의 트리시클릭 헤테로아릴-치환된 퀴놀린 및 아자퀴놀린 화합물
EP3484878B1 (en) * 2016-07-14 2020-08-19 Bristol-Myers Squibb Company Bicyclic heteroaryl substituted compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1473819A (en) * 1976-01-28 1977-05-18 Gallardo Antonio Sa Derivatives of imidazo 1,2-a pyridine
ES482438A0 (es) * 1978-07-18 1980-04-01 Hoechst Ag Procedimiento para la preparacion de nuevos derivados de 2-(4-aminopiperidino)-3,4-dihidroquinoleina.
ES8100016A1 (es) * 1978-07-18 1980-04-01 Hoechst Ag Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina.
JPS5553284A (en) * 1978-10-12 1980-04-18 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative
GB2031404A (en) * 1978-10-17 1980-04-23 Yoshitomi Pharmaceutical Pyridazinone compounds

Also Published As

Publication number Publication date
SE440653B (sv) 1985-08-12
ES8301967A1 (es) 1983-02-01
KR880001657B1 (ko) 1988-09-05
WO1982001706A1 (en) 1982-05-27
AU7808581A (en) 1982-06-07
PT73959B (en) 1983-04-18
ES507545A0 (es) 1983-02-01
CA1164459A (en) 1984-03-27
SE8204237L (sv) 1982-07-08
MX6802E (es) 1986-07-29
EP0052016B1 (en) 1984-09-05
AU547586B2 (en) 1985-10-24
SU1215621A3 (ru) 1986-02-28
DK307482A (da) 1982-07-08
SE8204237D0 (sv) 1982-07-08
IT8149680A0 (it) 1981-11-11
CH653684A5 (fr) 1986-01-15
ATA908381A (de) 1986-07-15
FI71145C (fi) 1986-11-24
AT382376B (de) 1987-02-25
FI822471L (fi) 1982-07-12
DE3152512T1 (de) 1982-11-18
EP0052016A1 (en) 1982-05-19
DE3152512C2 (ko) 1991-01-03
NO822391L (no) 1982-07-09
PH17158A (en) 1984-06-13
NO157819C (no) 1988-05-25
DK157193C (da) 1990-04-09
PT73959A (en) 1981-12-01
DK157193B (da) 1989-11-20
FI71145B (fi) 1986-08-14
FI822471A0 (fi) 1982-07-12
NO157819B (no) 1988-02-15
US4414390A (en) 1983-11-08

Similar Documents

Publication Publication Date Title
KR830007644A (ko) 카보스티릴 화합물의 제조 방법
JPS54130587A (en) Carbostyryl derivative
KR840008016A (ko) 융합 이미다졸 화합물의 제조방법
KR830000246A (ko) 세팔로스포린 항생제의 개발
KR840007012A (ko) -7카르복시메톡시페닐아세트 아미도 -3-세펨 유도체의 제조방법 및 이를 함유한 항박테리아 제제
KR860007244A (ko) 퀴놀린 카복실산 유도체의 제조방법
KR850005845A (ko) 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법
KR840000534A (ko) 디히드로피리딘 화합물류의 제조방법
KR840007014A (ko) 세팔로스포린 유도체의 제조방법
KR860003223A (ko) 피리미딘 유도체의 제조방법
KR830007631A (ko) 2-피리딘카복스아미드 유도체 및 이들의 제조방법
KR850004493A (ko) 헤테로사이클릭 그룹을 함유하는 이미다조 퀴놀린 유도체의 제조방법
ES8602811A1 (es) Un procedimiento para preparar un compuesto cefemico
KR840004757A (ko) 세파로스포린 유도체의 제조방법
JPS5649364A (en) Carbostyril derivative
KR850004959A (ko) 아릴옥시-n-(아미노알킬)-1-피롤리딘 및 피페리딘 카복스 아미드 및 카보티오 아미드의 제조방법
KR970704860A (ko) 탄화 수소 표지용 벤즈알데히드의 용도
KR870011134A (ko) 에트골린 에스테르 및 이의 제조방법
KR840001166A (ko) 스피로티아졸리딘일 피페라진 유도체 제조방법
GB819886A (en) New phenthiazine derivatives and processes for their preparation
GB774882A (en) Improvements in or relating to phenthiazine derivatives
KR860003212A (ko) 2-피리딘-티올 유도체 및 그의 산부가염의 제조 방법
US3775416A (en) S-triazolo(3,4-a)isoquinolines and derivatives thereof
KR850004760A (ko) 이미다조 퀴놀린 유도체의 제조방법
KR840006801A (ko) 1,1-디치환-2-헤테로 사이콜릭 에탄올 유도체의 제조방법