KR840008016A - 융합 이미다졸 화합물의 제조방법 - Google Patents

융합 이미다졸 화합물의 제조방법 Download PDF

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KR840008016A
KR840008016A KR1019840001227A KR840001227A KR840008016A KR 840008016 A KR840008016 A KR 840008016A KR 1019840001227 A KR1019840001227 A KR 1019840001227A KR 840001227 A KR840001227 A KR 840001227A KR 840008016 A KR840008016 A KR 840008016A
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compound
salt
formula
alkyl
unsubstituted
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KR1019840001227A
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이꾸오(외 3) 우에다
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후을사와 도모기찌로
후지사와 야꾸힝 고교 가부시끼가이샤
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Publication of KR840008016A publication Critical patent/KR840008016A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

융합 이미다졸 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 구조식(Ⅱ)의 화합물 또는 그 염을 구조식(Ⅲ)의 화합물 또는 그 염과 반응시키거나; 구조식(Ⅳ)의 화합물 또는 그 염을 환화반응시키거나; 또는 구조식(Ⅴ)의 화합물 또는 그 염을 디시아노디아마이드 또는 그 염 또는 아자이드 화합물과 반응시켜서 구조식(Ia)의 화합물 또는 그염을 제조함을 특징으로 하는 구조식(I)의 화합물 또는 그 약학적으로 사용가능한 염을 제조하는 방법.
    상기식에서, A는 저급알킬렌, R1은 수소, 저급알킬, 저급알콕시 또는 할로겐, R2는 수소, 저급알킬, 사이클로(저급)알킬, 피리딜, 할로겐으로 치환되거나 또는 비치환의 아르(저급)알킬, 또는 저급알킬, 저급알콕시, 하이드록시 또는 할로겐으로 치환되거나 또는 비치환의 아릴, R3는 저급알킬 또는 아미노로 치환되거나 또는 비치환의 N-함유 불포화 복소환기, R3 a는 1H-테트라졸-5-일 또는 2,4-디아미노-1, 3,5-트리아진-6-일, X는 산잔기이며, Y는 =C-또는 =N-이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001227A 1983-03-22 1984-03-12 융합 이미다졸 화합물의 제조방법 KR840008016A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8307865 1983-03-22
GB838307865A GB8307865D0 (en) 1983-03-22 1983-03-22 Benzimidazole derivatives

Publications (1)

Publication Number Publication Date
KR840008016A true KR840008016A (ko) 1984-12-12

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KR1019840001227A KR840008016A (ko) 1983-03-22 1984-03-12 융합 이미다졸 화합물의 제조방법

Country Status (13)

Country Link
US (1) US4563455A (ko)
EP (1) EP0125756A3 (ko)
JP (1) JPS59176277A (ko)
KR (1) KR840008016A (ko)
AU (1) AU2587384A (ko)
DK (1) DK110384A (ko)
ES (1) ES530810A0 (ko)
FI (1) FI841082A (ko)
GB (1) GB8307865D0 (ko)
GR (1) GR79774B (ko)
IL (1) IL71310A0 (ko)
NO (1) NO841106L (ko)
ZA (1) ZA841393B (ko)

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JP2007507463A (ja) * 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 誘導性ＮＯシンターゼ阻害剤としてのイミダゾ［４，５−ｂ］ピリジン誘導体
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Also Published As

Publication number Publication date
IL71310A0 (en) 1984-06-29
GR79774B (ko) 1984-10-31
AU2587384A (en) 1984-09-27
GB8307865D0 (en) 1983-04-27
JPS59176277A (ja) 1984-10-05
ZA841393B (en) 1984-10-31
FI841082A (fi) 1984-09-23
DK110384A (da) 1984-09-23
FI841082A0 (fi) 1984-03-19
ES8506001A1 (es) 1985-06-16
EP0125756A2 (en) 1984-11-21
ES530810A0 (es) 1985-06-16
US4563455A (en) 1986-01-07
EP0125756A3 (en) 1987-04-08
NO841106L (no) 1984-09-24
DK110384D0 (da) 1984-02-27

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